İmmunoterapi ve Radyoterapi Kombinasyonu

Süreyya Sarıhan

doi:10.32708/uutfd.710919

Derleme

Immunotherapy and Radiotherapy Combination

Yıl 2020, Cilt: 46 Sayı: 2, 225 - 235, 01.08.2020

Süreyya Sarıhan

https://doi.org/10.32708/uutfd.710919

Cited By: 1

Öz

Immunotherapy is a treatment proven to be effective in terms of response, duration of response and survival in many types of cancer by strengthening the immune system. The response rates are 20%, and new treatments that produce synergistic effect with immunotherapy are needed in resistant patients. Antigenic stimulation released from tumor cells with radiotherapy can complement immunotherapy by making the tumor more easily recognized by the immune system. The systemic effect of radiotherapy on metastases other than the irradiated target is defined as “abscopal” effect and the main purpose of immuno-radiotherapy is to evoke the “abscopal” effect. The significant contribution of immuno-radiotherapy to response and survival has been shown primarily in malignant melanoma and lung cancers, and is seen as a promising treatment method in other solit tumors as well.

Anahtar Kelimeler

immunotherapy, radiotherapy, combined modality therapy

Kaynakça

1. Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature, 2011; 480 (7378): 480-9.
2. Li Z, Song W, Rubinstein M, Liu D. Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing. J Hematol Oncol. 2018, 21;11(1):142.
3. Kang SP, Gergich K, Lubiniecki GM, et al. Pembrolizumab KEYNOTE-001: an adaptive study leading to accelerated approval for two indications and a companion diagnostic. Ann Oncol, 2017; 28(6): 1388-1398.
4. Eton O, Legha SS, Bedikian AY, et al. Sequential biochemotherapy versus chemotherapy for metastatic melanoma: results from a phase III randomized trial. J Clin Oncol, 2002; 20 (8): 2045-52.
5. Hamid O, Robert C, Daud A, et al. Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001. Ann Oncol, 2019; 30 (4): 582-588.
6. Ascierto PA, Long GV, Robert C, et al. Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy: Three-Year Follow-up of a Randomized Phase 3 Trial. JAMA Oncol, 2019; 5 (2): 187-194.
7. www.nccn.org
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9. Eggermont AM, Chiarion-Sileni V, Grob JJ, et al. Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial. Lancet Oncol, 2015; 16 (5): 522-30.
10. Eggermont AMM, Chiarion-Sileni V, Grob JJ, Adjuvant ipilimumab versus placebo after complete resection of stage III melanoma: long-term follow-up results of the European Organisation for Research and Treatment of Cancer 18071 double-blind phase 3 randomised trial. Eur J Cancer, 2019; 119: 1-10.
11. Eggermont AMM, Blank CU, Mandala M, et al. Prognostic and predictive value of AJCC-8 staging in the phase III EORTC1325/KEYNOTE-054 trial of pembrolizumab vs placebo in resected high-risk stage III melanoma. Eur J Cancer, 2019; 116: 148-157.
12. Weber J, Mandala M, del Vecchio M, et al. Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma. N Eng J Med, 2017; 377 (19): 1824-1835.
13. Gandara DR, Chansky K, Albain KS, et al. Consolidation docetaxel after concurrent chemoradiotherapy in stage IIIB non-small-cell lung cancer: phase II Southwest Oncology Group Study S9504. J Clin Oncol, 2003; 21 (10): 2004-10.
14. Bradley JD, Paulus R, Komaki R, et al. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol, 2015; 16 (2): 187-99.
15. Antonia SJ, Villegas A, Daniel D, et al. PACIFIC Investigators. Durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer. N Engl J Med, 2017; 377: 1919–1929.
16. Bradley JD, Hu C, Komaki RR, et al. Long-Term Results of NRG Oncology RTOG 0617: Standard- Versus High-Dose Chemoradiotherapy With or Without Cetuximab for Unresectable Stage III Non-Small-Cell Lung Cancer. J Clin Oncol, 2020; 38 (7): 706-714.
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İmmunoterapi ve Radyoterapi Kombinasyonu

Yıl 2020, Cilt: 46 Sayı: 2, 225 - 235, 01.08.2020

Süreyya Sarıhan

https://doi.org/10.32708/uutfd.710919

Cited By: 1

Öz

İmmunoterapi, bağışıklık sisteminin güçlendirilmesi ile birçok kanser türünde yanıt, yanıt süresi ve sağkalım açısından etkinliği kanıtlanmış bir tedavidir. Yanıt oranları %20 olup dirençli hastalarda immunoterapi ile sinerjik etki yaratan yeni tedavilere gereksinim vardır. Radyoterapi ile tümör hücrelerinden salınan antijenik uyarı tümörün bağışıklık sistemi tarafından daha kolay tanınmasını sağlayarak immunoterapinin tamamlayıcısı olabilir. Radyoterapinin, ışınlanan hedef dışındaki metastazlar üzerindeki sistemik etkisi “abscopal” etki olarak tanımlanmış olup immuno-radyoterapinin temel amacı “abscopal” etkiyi uyandırmaktır. İmmuno-radyoterapinin yanıt ve sağkalıma anlamlı katkısı öncelikle malign melanom ve akciğer kanserlerinde gösterilmiş olup diğer solid tümörlerde de gelecek vaat eden önemli bir tedavi yöntemi olarak görülmektedir.

Anahtar Kelimeler

immunoterapi, radyoterapi, kombine model tedavi

Kaynakça

1. Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature, 2011; 480 (7378): 480-9.
2. Li Z, Song W, Rubinstein M, Liu D. Recent updates in cancer immunotherapy: a comprehensive review and perspective of the 2018 China Cancer Immunotherapy Workshop in Beijing. J Hematol Oncol. 2018, 21;11(1):142.
3. Kang SP, Gergich K, Lubiniecki GM, et al. Pembrolizumab KEYNOTE-001: an adaptive study leading to accelerated approval for two indications and a companion diagnostic. Ann Oncol, 2017; 28(6): 1388-1398.
4. Eton O, Legha SS, Bedikian AY, et al. Sequential biochemotherapy versus chemotherapy for metastatic melanoma: results from a phase III randomized trial. J Clin Oncol, 2002; 20 (8): 2045-52.
5. Hamid O, Robert C, Daud A, et al. Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001. Ann Oncol, 2019; 30 (4): 582-588.
6. Ascierto PA, Long GV, Robert C, et al. Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy: Three-Year Follow-up of a Randomized Phase 3 Trial. JAMA Oncol, 2019; 5 (2): 187-194.
7. www.nccn.org
8. Garon EB, Hellman MD, Rizvi NA, et al. Five-Year Overall Survival for Patients With Advanced Non‒Small-Cell Lung Cancer Treated With Pembrolizumab: Results From the Phase I KEYNOTE-001 Study. J Clin Oncol, 2019; 37 (28): 2518-2527.
9. Eggermont AM, Chiarion-Sileni V, Grob JJ, et al. Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial. Lancet Oncol, 2015; 16 (5): 522-30.
10. Eggermont AMM, Chiarion-Sileni V, Grob JJ, Adjuvant ipilimumab versus placebo after complete resection of stage III melanoma: long-term follow-up results of the European Organisation for Research and Treatment of Cancer 18071 double-blind phase 3 randomised trial. Eur J Cancer, 2019; 119: 1-10.
11. Eggermont AMM, Blank CU, Mandala M, et al. Prognostic and predictive value of AJCC-8 staging in the phase III EORTC1325/KEYNOTE-054 trial of pembrolizumab vs placebo in resected high-risk stage III melanoma. Eur J Cancer, 2019; 116: 148-157.
12. Weber J, Mandala M, del Vecchio M, et al. Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma. N Eng J Med, 2017; 377 (19): 1824-1835.
13. Gandara DR, Chansky K, Albain KS, et al. Consolidation docetaxel after concurrent chemoradiotherapy in stage IIIB non-small-cell lung cancer: phase II Southwest Oncology Group Study S9504. J Clin Oncol, 2003; 21 (10): 2004-10.
14. Bradley JD, Paulus R, Komaki R, et al. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol, 2015; 16 (2): 187-99.
15. Antonia SJ, Villegas A, Daniel D, et al. PACIFIC Investigators. Durvalumab after chemoradiotherapy in stage III non-small-cell lung cancer. N Engl J Med, 2017; 377: 1919–1929.
16. Bradley JD, Hu C, Komaki RR, et al. Long-Term Results of NRG Oncology RTOG 0617: Standard- Versus High-Dose Chemoradiotherapy With or Without Cetuximab for Unresectable Stage III Non-Small-Cell Lung Cancer. J Clin Oncol, 2020; 38 (7): 706-714.
17. Meng X, Feng R, Yang L, et al. The Role of Radiation Oncology in Immuno-Oncology. Oncologist, 2019; 24 (Suppl1): S42-S52.
18. Vanpouille-Box C, Formenti SC, Demaria S. Toward Precision Radiotherapy for Use with Immune Checkpoint Blockers. Clin Cancer Res, 2018; 24 (2): 259-265.
19. Yang H, Jin T, Li M, et al. Synergistic effect of immunotherapy and radiotherapy in non-small cell lung cancer: current clinical trials and prospective challenges, Precision Clinical Medicine, 2019; 1–14
20. Bath C. In Era of Immunotherapy, Radiation Therapy May Become Essential Component of Systemic Treatments of Cancer, February 25, 2019, www.ascopost.com/issues
21. Lee Y, Auh SL, Wang Y, et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: Changing strategies for cancer treatment. Blood 2009; 114:589–595.
22. Wang X, Schoenhals JE, Li A, et al. Suppression of type I IFN signaling in tumors mediates resistance to anti-PD-1 treatment that can be overcome by radiotherapy. Cancer Res, 2017; 77:839–850.
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61. Ribeiro Gomes J, Schmerling RA, Haddad CK, et al. Analysis of the abscopal effect with anti-PD1 therapy in patients with metastatic solid tumors. J Immunother, 2016; 39:367–372.
62. Grimaldi AM, Simeone E, Giannarelli D, et al. Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy. Oncoimmunology, 2014; 3: e28780.
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66. Liniker E, Menzies AM, Kong BY, et al. Activity and safety of radiotherapy with anti-PD-1 drug therapy in patients with metastatic melanoma. Oncoimmunology, 2016; 5:e1214788.
67. Ahmed KA, Stallworth DG, Kim Y, et al. Clinical outcomes of melanoma brain metastases treated with stereotactic radiation and anti-PD-1 therapy. Ann Oncol, 2016; 27:434–441.
68. Qian JM, Yu JB, Kluger HM, Chiang VL. Timing and type of immune checkpoint therapy affect the early radiographic response of melanoma brain metastases to steriotactic radiosurgery. Cancer, 2016; 122 (19): 3051-8.
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70. Iorgulescu JB, Harary M, Zogg CK, et al. Improved risk-adjusted for melanoma brain metastases in the era of checkpoint blockade immunotherapies: results from a National Cohort. Cancer Immunol Res, 2018; 6 (9): 1039-1045.
71. Margolin K, Ernstoff MS, Hamid O, et al. Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial. Lancet Oncol, 2012; 13 (5):459–465.
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73. Long GV, Atkinson V, Lo S, et al. Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study. Lancet Oncol, 2018; 19 (5): 672-681.
74. Ahmed KA, Abuodeh YA, Echevarria MI, et al. Clinical outcomes of melanoma brain metastases treated with stereotactic radiosurgery and anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitor, or conventional chemotherapy. Ann Oncol, 2016; 27 (12): 2288-2294.
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101. www.clinicaltrials.gov

Toplam 101 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Konular	Onkoloji ve Karsinogenez
Bölüm	Derleme Makaleler
Yazarlar	Süreyya Sarıhan 0000-0003-4816-5798
Yayımlanma Tarihi	1 Ağustos 2020
Kabul Tarihi	17 Haziran 2020
Yayımlandığı Sayı	Yıl 2020 Cilt: 46 Sayı: 2

Kaynak Göster

APA	Sarıhan, S. (2020). İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46(2), 225-235. https://doi.org/10.32708/uutfd.710919
AMA	Sarıhan S. İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Tıp Derg. Ağustos 2020;46(2):225-235. doi:10.32708/uutfd.710919
Chicago	Sarıhan, Süreyya. “İmmunoterapi Ve Radyoterapi Kombinasyonu”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46, sy. 2 (Ağustos 2020): 225-35. https://doi.org/10.32708/uutfd.710919.
EndNote	Sarıhan S (01 Ağustos 2020) İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46 2 225–235.
IEEE	S. Sarıhan, “İmmunoterapi ve Radyoterapi Kombinasyonu”, Uludağ Tıp Derg, c. 46, sy. 2, ss. 225–235, 2020, doi: 10.32708/uutfd.710919.
ISNAD	Sarıhan, Süreyya. “İmmunoterapi Ve Radyoterapi Kombinasyonu”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46/2 (Ağustos 2020), 225-235. https://doi.org/10.32708/uutfd.710919.
JAMA	Sarıhan S. İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Tıp Derg. 2020;46:225–235.
MLA	Sarıhan, Süreyya. “İmmunoterapi Ve Radyoterapi Kombinasyonu”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, c. 46, sy. 2, 2020, ss. 225-3, doi:10.32708/uutfd.710919.
Vancouver	Sarıhan S. İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Tıp Derg. 2020;46(2):225-3.

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Radiotherapy could increase the efficacy of immunotherapy in non-small cell lung cancer

Turkish Journal of Internal Medicine

https://doi.org/10.46310/tjim.1076459

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ISSN: 1300-414X, e-ISSN: 2645-9027

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Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

2023