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Dispnede Güvenli Opioid Kullanımı ve Bakımı

Yıl 2023, Cilt: 27 Sayı: 1, 34 - 44, 30.04.2023

Öz

ÖZET
Dispne yaşam kalitesini ve temel insan ihtiyaçlarını olumsuz yönde etkileyen yaygın subjektif bir semptomdur. Dispnenin nedenleri arasında akciğer hastalıkları başta olmak üzere kardiyovasküler hastalıklar, kanser, nöromüsküler, metabolik, nörolojik, psikolojik, sosyal ya da çevresel birçok faktör vardır. Farmakolojik ve nonfarmakolojik yöntemleri olan dispnenin tedavisinde sıklıkla kullanılan opioidler ventilasyonu, anksiyeteyi ve santral dispne algısını azaltarak etki gösterir. Ülkemizde Sağlık Uygulamaları Tebliği kapsamında yer alan opioidler kurum tarafından karşılanmaktadır. Ancak opioidlerin gelişmekte olan ve gelişmemiş ülkelerdeki erişim sorunu, doktorların reçete ederken, hemşirelerin uygularken yaşamış olduğu tedirginlik ve opiofobi medikal opioid kullanımını azaltmaktadır. Oysa opioidlerin ciddi yan etkilere neden olmadan kanıt temelli opioid dozları, uygulama yolları, ideal monitörizasyon ve holistik bakım ile dispne tedavisinde güvenle kullanılabileceğini kanıtlayan birçok çalışma mevcuttur. Opioid kullanımının önündeki bilgi eksiliğinden ve güvensizlikten kaynaklanan engeller sağlık personelinin eğitimi ile giderilmelidir. Buradan yola çıkarak son yıllarda yapılan çalışma sonuçlarının ele alındığı bu derlemenin amacı, opioidlerin dispne tedavisindeki yerini, kullanımının önündeki engelleri, güvenli kullanımını ve bakımını incelemektir

Kaynakça

  • 1. Baker Rogers J, Modi, P, Minteer, JF. Dyspnea in Palliative Care. StatPearls Publishing. Yayınlanma Tarihi: 2022. Erişim Tarihi: 12.09.2022. Erişim Adresi: https://www.ncbi.nlm.nih.gov/books/NBK526122/
  • 2. Parshall MB, Schwartzstein, RM, Adams L, Banzett, RB, Manning, HL, Bourbeau, J et al. An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. American Journal of Respiratory And Critical Care Medicine 2012;185(4):435–452.
  • 3. Annakkaya AN, Tozkoparan E, Deniz Ö, Bedirhan İ, Bilgiç H, Ekiz K ve ark. Postoperatif solunumsal komplikasyonlar. Toraks Dergisi 2005;6(2),104-108.
  • 4. Thomas JR, vonGunten CF. Clinical management of dyspneoa. Lancet Onco 2002;3(4),223–228.
  • 5. Uysal N, Şenel G, Karaca Ş, Kadıoğulları N, Koçak N, Oğuz G. Palyatif bakım kliniğinde yatan hastalarda görülen semptomlar ve palyatif bakımın semptom kontrolüne etkisi. Ağrı 2015;27(2),104-110.
  • 6. Kılıçaslan İ, Bozan H, Oktay C, Göksu E. Türkiye’de acil servise başvuran hastaların demografik özellikleri. Türkiye Acil Tıp Dergisi 2005;5(1),5-13.
  • 7. Damani A, Ghoshal A, Salins N, Deodhar J, Muckaden M. Prevalence and intensity of dyspnea in advanced cancer and its impact on quality of life. Indian Journal of Palliative Care 2018;24(1), 44–50.
  • 8. Buckholz GT, vonGunten CF. Nonpharmacological management of dyspnea. Current Opinion in Supportive and Palliative Care 2009;3(2),98-102.
  • 9. Hui D, Bohlke K, Bao T, Campbell TC, Coyne PJ, Currow DC. et al. Management of dyspnea in advanced cancer: ASCO Guideline. Journal of Clinical Oncology 2021;39(12),1389–1411.
  • 10. Berterame S, Erthal J, Thomas J, Fellner S, Vosse B, Clare P., et al. Use of and barriers to Access to opioid analgesics: a worldwide, regional, and national study. Lancet 2016;387(10028),1644-1656
  • 11. Kocatepe V, Oruç Ö, Bağcı P, Oğuztan SY, Birol S, Aydın Ünlü P. Palyatif bakım ünitesinde çalışan hekim ve hemşirelerin dispne tedavisinde morfin kullanımı ile ilgili yaklaşımlarının incelenmesi. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 2022;11(2),387-394
  • 12. Genberg J, Davies JM, Ahmadi Z, Currow D, Johnson MJ, Tanash H, et al. Indications and patterns of use of benzodiazepines and opioids in severe interstitial lung disease: a population-based longitudinal study. ERJ open research 2021;7(1),00716-2020.
  • 13. Ahmadi Z, Bernelid E, Currow DC, Ekström M. Prescription of opioids for breathlessness in end-stage COPD: a national population-based study. J Chron Obstruct Pulmon Dis. 2016;11,2651-2657.
  • 14. Carette H, Zysman M, Morelot-Panzini C, Perrin J, Gomez E, Guillaumot A, et al. Initiatives BPCO (bronchopneumopathie chronique obstructive) Scientific Committee and Investigators. Prevalence and management of chronic breathlessness in COPD in a tertiary care center. BMC Pulm Med. 2019;19(1),95.
  • 15. Verberkt CA, van den Beuken-vanEverdingen M, Schols J, Datla S, Dirksen CD, Johnson MJ, et al. Respiratory adverse effects of opioids for breathlessness: a systematic review and meta-analysis. The European Respiratory Journal 2017;50(5), 1-18.
  • 16. Ekström M, Nilsson F, Abernethy AA, Currow DC. Effects of opioids on breathlessness and exercise capacity in chronic obstructive pulmonary disease. A systematic review. Annals of the American Thoracic Society 2015;12(7),1079–1092.
  • 17. Rocker G, Young J, Donahue M, Farquhar M, Simpson C. Perspectives of patients, family caregivers and physicians about the use of opioids for refractory dyspnea in advanced chronic obstructive pulmonary disease. CMAJ: Canadian Medical Association Journal 2012;184(9),497–504.
  • 18. Bertrand S, Meynet G, Taffé P, Della Santa, V, Fishman D, Fournier Y, et al. Opiophobia in Emergency Department Healthcare Providers: A Survey in Western Switzerland. J Clin Med. 2021;10(7),1353.
  • 19. Charalambous A, Zorpas M, Cloconi C, Kading Y. Healthcare professionals' perceptions on the use of opioid analgesics for the treatment of cancer-related pain in Cyprus: A mixed-method study. SAGE open medicine 2019;7,2050312119841823.
  • 20. Yamaguchi T, Matsunuma R, Matsuda Y, Tasaki J, Ikari T, Miwa S, et al. Systemic Opioids for Dyspnea in Cancer Patients: A Real-world Observational Study. J Pain Symptom Manage. 2023; S0885-3924(23)00004-0.
  • 21. Jennings AL, Davies AN, Higgins JP, Gibbs JS, Broadley KE. A systematic review of the use of opioids in the management of dyspnoea. Thorax 2002;57(11),939–944.
  • 22. Indelicato RA. The advanced practice nurse’s role in palliative care and the management of dyspnea. Topics in Advanced Practice Nursing Ejournal 2006;6(4),1-11.
  • 23. Ferreira D, Kochovska S, Honson A, Phillips, J, Currow D. Patients' and their caregivers' experiences with regular, low-dose, sustained-release morphine for chronic breathlessness associated with COPD: a qualitative study. BMJ Open Respiratory Research 2022;9(1),1-11.
  • 24. Grønset R, Vollmer WM, Hardie JA, Ólafsdóttir IS, Lamprecht B, Buist AS, et al. Predictors of dyspnoea prevalence: results from the BOLD study. European Respiratory Journal 2014;43(6),1610-1620.
  • 25. Santos M, Kitzman DW, Matsushita K, Loehr L, Sueta CA, Shah AM. Prognostic importance of dyspnea for cardiovascular outcomes and mortality in persons without prevalent cardiopulmonary disease: The atherosclerosis risk in communities study. PloSone 2016;11(10),1-15.
  • 26. Gök Metin Z, Arıkan Dönmez A. Dyspnea Management in Patients with Cancer. Turk Journal of Oncology 2016;31(2),61-67.
  • 27. Gündüz C, Erdinç M. Dipsnenin pulmoner nedenlerine yaklaşım. Ege Tıp Dergisi 2014;53,7-13.
  • 28. Berliner D, Schneider N, Welte T, Bauersachs J. The differential diagnosis of dyspnea. Deutsches Arzteblatt International 2016;113(49),834–845.
  • 29. Biber Ç. Pulmoner rehabilitasyonda dispne algısının değerlendirmesi. Güncel Göğüs Hastalıkları Serisi 2019;7(1),19-25.
  • 30. Thomas JR, vonGunten, CF. Management of dyspnea. The Journal of Supportive Oncology 2003;1(1),23–34.
  • 31. Kara D, Yıldız H. Dispne semptomunun değerlendirilmesinde dispne ölçeklerinin etkinlikleri ve kullanım sıklıkları. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 2013;2(1),137-149.
  • 32. Kılıç FS. Opioidler, ağrı, opioidlerin suistimali ve yanlış kullanımı. Osmangazi Tıp Dergisi 2017;39(3),125-129.
  • 33. Yıldırım D. Opioid İlaç Kullanan Hastalarda Gelişen Konstipasyonun Yönetiminde Abdominal Masaj Uygulamasının Etkisi. [DoktoraTezi], İstanbul: İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü; 2018.
  • 34. International Narcotics Control Board. International Narcotics Control Board Report 2021. Yayınlanma Tarihi: 2022. Erişim Tarihi: 12.09.2022 Erişim Adresi: https://www.incb.org/incb/en/publications/annual-reports/annual-report-2021.html
  • 35. Sosyal Güvenlik Kurumu. Ödemesi yapılacak ilaçlar listesi (Ek-4/A). Yayınlanma Tarihi:2021 Erişim Tarihi: 23.10.2022. Erişim Adresi: https://www.resmigazete.gov.tr/eskiler/2021/04/20210428M1-1.htm
  • 36. Şenel, G, Oğuz G, Koçak N, Karaca Ş, Kaya M, Kadıoğulları N. Palyatif bakım kliniğinde yatan kanser hastalarında ağrı tedavisi ve opioid kullanımı. Ağrı 2016;28(4),171–176.
  • 37. Baldemir R, Akçaboy EY, Çelik Ş, Noyan Ö, Akçaboy, ZN, Baydar Ö. Doktorların opiofobiye yaklaşımlarının değerlendirilmesi: Bir eğitim araştırma hastanesinden anket sonuçları. Ağrı 2019;31(1),23–31.
  • 38. Şen S, Usta E, Aygin D. Attitudes of surgical nurses toward postoperative opioid use: A qualitative study. Journal of Human Sciences 2020;17(3),912-920.
  • 39. Reisli R, Akkaya ÖT, Arcan S, Can ÖS, Çetingök H, Güleç MS ve ark. Akut postoperatif ağrının farmakolojik tedavisi: Türk Algoloji-Ağrı Derneği Klinik Uyg. Kılavuzu. Ağrı 2021;33(1),1-51.
  • 40. Klein C, Lang U, Bükki J, Sittl R, Ostgathe C. Pain management and symptom-oriented drug therapy in palliative care. Breast Care (Basel, Switzerland), 2011;6(1),27–34.
  • 41. Mercadante S. Management of cancerpain. Internal and Emergency Medicine 2010;5(1)31–35.
  • 42. Clemens KE, Klaschik E. Effect of hydromorphone on ventilation in palliative care patients with dyspnea. Support Care Cancer 2008;16(1),93–99.
  • 43. Clemens, KE, Klaschik E. Morphine in the management of dyspnoea in ALS. A pilot study. European Journal of Neurology 2008;15(5), 445–450.
  • 44. Clemens, KE, Quednau I, Klaschik E. Use of oxygen and opioids in the palliation of dyspnoea in hypoxic and non-hypoxic palliative care patients: a prospective study. Support Care in Cancer 2009;17(4),367–377.
  • 45. Hui D, Xu A, Frisbee-Hume S, Chisholm G, Morgado M, Reddy S, et al. Effects of prophylactic subcutaneous fentanyl on exercise-induced breakthrough dyspnea in cancer patients: a preliminary double-blind, randomized, controlled trial. Journal of Pain and Symptom Management 2014;47(2),209–217.
  • 46. Barnes H, McDonald J, Smallwood N, Manser R. Opioids for the palliation of refractory breathlessness in adults with advanced disease and terminal illness. The Cochrane Database of Systematic Reviews 2016;3(3),1-86.
  • 47. Abdallah SJ, Wilkinson-Maitland C, Saad N, Li PZ, Smith BM, Bourbeau J, et al. Effect of morphine on breathlessness and exercise endurance in advanced COPD: a randomized crossover trial. The European Respiratory Journal 2017;50(4),1-13.
  • 48. Yamaguchi T, Matsuda Y, Matsuoka, H, Hisanaga T, Osaka I, Watanabe H, et al. Efficacy of immediate-release oxycodone for dyspnoea in the cancer patient: cancer dyspnoea relief (CDR) trial. Japanese Journal of Clinical Oncology 2018;48(12),1070–1075.
  • 49. Yamamoto Y, Watanabe H, Sakurai A, Deguchi Y, Hirano S, Okumura Y, et al. Effect of continuous intravenous oxycodone infusion in opioid-naïve cancer patients with dyspnea. Japanese Journal of Clinical Oncology 2018;48(8),748–752.
  • 50. Verberkt CA, van den Beuken-vanEverdingen M, Schols J, Hameleers N, Wouters E, Janssen D. Effect of sustained-release morphine for refractory breathlessness in chronic obstructive pulmonary disease on health status: A randomized clinical trial. JAMA Internal Medicine 2020;180(10),1306–1314.
  • 51. Mori M, Kawaguchi T, Imai K, Yokomichi N, Yamaguchi T, Suzuki K, et al. How successful is parenteral oxycodone for relieving terminal cancer dyspnea compared with morphine? A multicenter prospective observational study. Journal of Pain and Symptom Management 2021;62(2),336–345.
  • 52. Afolabi TM, Nahata MC, Pai V. Nebulized opioids for the palliation of dyspnea in terminally ill patients. American Journal of Health-System Pharmacy 2017;74(14),1053–1061.
  • 53. Bausewein C, Simon ST. Inhaled nebulized and intranasal opioids for the relief of breathlessness. Current Opinion in Supportive and Palliative Care 2014;8(3),208–212.
  • 54. Simon, ST, Köskeroglu P, Gaertner J, Voltz R. Fentanyl for the relief of refractory breathlessness: a systematic review. Journal of Pain and Symptom Management 2013;46(6),874–886.
  • 55. Lavonas EJ, Drennan IR, Gabrielli A, Heffner AC, Hoyte CO, Orkin AM, et al. Part 10: Special Circumstances of Resuscitation:2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132(2),501-518.
  • 56. Karaman H. Opioid kullanımına bağlı yan etkiler ve tedavileri. Ağrı 2017;1,1-11.
  • 57. Aygin D. Bulantı ve Kusma. Yoğun Bakım Hemşireliği Dergisi 2016;20(1),44-56.
  • 58. Sözeri Öztürk E, Kutlutürkan S. Kanser ağrısının yönetiminde opioidlerin kullanımına bağlı gelişen konstipasyonun yönetimi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2018;9(2),105-109.
  • 59. Yıldırım D, Can G. Opioid ilaç kullanan hastalarda gelişen konstipasyonun yönetimi. Balıkesir Sağlık Bilimleri Dergisi 2019;8(1),27-32.
  • 60. Aygin D. Var G. Travmalı hastada ağrı yönetimi. Sakarya Medical Journal 2012;2(2),61-70.
  • 61. Ganesh A, Maxwell LG. Pathophysiology and management of opioid-induced pruritus. Drugs 2007;67(16),2323–2333.
  • 62. Yürügen B. Ağrı ve opioid analjeziklerin kullanımına bağlı olarak ortaya çıkan komplikasyonlarda hemşirelik yaklaşımları. Atatürk Üniversitesi Hemşirelik Yüksekokulu Dergisi 2001;4(1),1-6.
  • 63. Benyamin R, Trescot AM, Datta S., Buenaventura R, Adlaka R, Sehgal N, et al. Opioid complications and side effects. Pain Physician 2008;11(2),105-120.
  • 64. Eyigör C. Opioidlerin kullanım ilkeleri, yan etki yönetimi ve yeni opioidler. The Journal of The Turkısh Socıety of Algology 2015;1,1-11.
  • 65. Jungquist CR, Quinlan-Colwell A, Vallerand A, Carlisle HL, Cooney M, Dempsey SJ, et al. American Society for Pain Management Nursing Guidelines on Monitoring for Opioid-Induced Advancing Sedation and Respiratory Depression: Revisions. Pain Management Nursing 2020;21(1),7-25.

Safe Opioid Use and Care in Dyspnea

Yıl 2023, Cilt: 27 Sayı: 1, 34 - 44, 30.04.2023

Öz

ABSTRACT
Dyspnea is a common subjective symptom that negatively affects the quality of life and basic human needs. Among the causes of dyspnea are cardiovascular diseases, cancer, neuromuscular, metabolic, neurological, psychological, social, or environmental factors, especially lung diseases. Opioids, which are frequently used in the treatment of dyspnea with pharmacological and non-pharmacological methods, act by reducing ventilation, anxiety, and the perception of central dyspnea. In our country, opioids within the scope of the Communiqué on Health Practices are covered by the institution. However, the problem of access to opioids in developing and undeveloped countries, the anxiety experienced by doctors while prescribing and nurses while applying them, and opiophobia reduce the use of medical opioids. However, there are many studies that prove that opioids can be safely used in the treatment of dyspnea with evidence-based opioid doses, administration routes, ideal monitoring, and holistic care without causing serious side effects. Obstacles arising from lack of knowledge and insecurity in the use of opioids should be eliminated with the education of healthcare professionals. From this point of view, the aim of this review, in which the results of recent studies are discussed, is to examine the place of opioids in the treatment of dyspnea, the barriers to their use, their safe use, and care.

Kaynakça

  • 1. Baker Rogers J, Modi, P, Minteer, JF. Dyspnea in Palliative Care. StatPearls Publishing. Yayınlanma Tarihi: 2022. Erişim Tarihi: 12.09.2022. Erişim Adresi: https://www.ncbi.nlm.nih.gov/books/NBK526122/
  • 2. Parshall MB, Schwartzstein, RM, Adams L, Banzett, RB, Manning, HL, Bourbeau, J et al. An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea. American Journal of Respiratory And Critical Care Medicine 2012;185(4):435–452.
  • 3. Annakkaya AN, Tozkoparan E, Deniz Ö, Bedirhan İ, Bilgiç H, Ekiz K ve ark. Postoperatif solunumsal komplikasyonlar. Toraks Dergisi 2005;6(2),104-108.
  • 4. Thomas JR, vonGunten CF. Clinical management of dyspneoa. Lancet Onco 2002;3(4),223–228.
  • 5. Uysal N, Şenel G, Karaca Ş, Kadıoğulları N, Koçak N, Oğuz G. Palyatif bakım kliniğinde yatan hastalarda görülen semptomlar ve palyatif bakımın semptom kontrolüne etkisi. Ağrı 2015;27(2),104-110.
  • 6. Kılıçaslan İ, Bozan H, Oktay C, Göksu E. Türkiye’de acil servise başvuran hastaların demografik özellikleri. Türkiye Acil Tıp Dergisi 2005;5(1),5-13.
  • 7. Damani A, Ghoshal A, Salins N, Deodhar J, Muckaden M. Prevalence and intensity of dyspnea in advanced cancer and its impact on quality of life. Indian Journal of Palliative Care 2018;24(1), 44–50.
  • 8. Buckholz GT, vonGunten CF. Nonpharmacological management of dyspnea. Current Opinion in Supportive and Palliative Care 2009;3(2),98-102.
  • 9. Hui D, Bohlke K, Bao T, Campbell TC, Coyne PJ, Currow DC. et al. Management of dyspnea in advanced cancer: ASCO Guideline. Journal of Clinical Oncology 2021;39(12),1389–1411.
  • 10. Berterame S, Erthal J, Thomas J, Fellner S, Vosse B, Clare P., et al. Use of and barriers to Access to opioid analgesics: a worldwide, regional, and national study. Lancet 2016;387(10028),1644-1656
  • 11. Kocatepe V, Oruç Ö, Bağcı P, Oğuztan SY, Birol S, Aydın Ünlü P. Palyatif bakım ünitesinde çalışan hekim ve hemşirelerin dispne tedavisinde morfin kullanımı ile ilgili yaklaşımlarının incelenmesi. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 2022;11(2),387-394
  • 12. Genberg J, Davies JM, Ahmadi Z, Currow D, Johnson MJ, Tanash H, et al. Indications and patterns of use of benzodiazepines and opioids in severe interstitial lung disease: a population-based longitudinal study. ERJ open research 2021;7(1),00716-2020.
  • 13. Ahmadi Z, Bernelid E, Currow DC, Ekström M. Prescription of opioids for breathlessness in end-stage COPD: a national population-based study. J Chron Obstruct Pulmon Dis. 2016;11,2651-2657.
  • 14. Carette H, Zysman M, Morelot-Panzini C, Perrin J, Gomez E, Guillaumot A, et al. Initiatives BPCO (bronchopneumopathie chronique obstructive) Scientific Committee and Investigators. Prevalence and management of chronic breathlessness in COPD in a tertiary care center. BMC Pulm Med. 2019;19(1),95.
  • 15. Verberkt CA, van den Beuken-vanEverdingen M, Schols J, Datla S, Dirksen CD, Johnson MJ, et al. Respiratory adverse effects of opioids for breathlessness: a systematic review and meta-analysis. The European Respiratory Journal 2017;50(5), 1-18.
  • 16. Ekström M, Nilsson F, Abernethy AA, Currow DC. Effects of opioids on breathlessness and exercise capacity in chronic obstructive pulmonary disease. A systematic review. Annals of the American Thoracic Society 2015;12(7),1079–1092.
  • 17. Rocker G, Young J, Donahue M, Farquhar M, Simpson C. Perspectives of patients, family caregivers and physicians about the use of opioids for refractory dyspnea in advanced chronic obstructive pulmonary disease. CMAJ: Canadian Medical Association Journal 2012;184(9),497–504.
  • 18. Bertrand S, Meynet G, Taffé P, Della Santa, V, Fishman D, Fournier Y, et al. Opiophobia in Emergency Department Healthcare Providers: A Survey in Western Switzerland. J Clin Med. 2021;10(7),1353.
  • 19. Charalambous A, Zorpas M, Cloconi C, Kading Y. Healthcare professionals' perceptions on the use of opioid analgesics for the treatment of cancer-related pain in Cyprus: A mixed-method study. SAGE open medicine 2019;7,2050312119841823.
  • 20. Yamaguchi T, Matsunuma R, Matsuda Y, Tasaki J, Ikari T, Miwa S, et al. Systemic Opioids for Dyspnea in Cancer Patients: A Real-world Observational Study. J Pain Symptom Manage. 2023; S0885-3924(23)00004-0.
  • 21. Jennings AL, Davies AN, Higgins JP, Gibbs JS, Broadley KE. A systematic review of the use of opioids in the management of dyspnoea. Thorax 2002;57(11),939–944.
  • 22. Indelicato RA. The advanced practice nurse’s role in palliative care and the management of dyspnea. Topics in Advanced Practice Nursing Ejournal 2006;6(4),1-11.
  • 23. Ferreira D, Kochovska S, Honson A, Phillips, J, Currow D. Patients' and their caregivers' experiences with regular, low-dose, sustained-release morphine for chronic breathlessness associated with COPD: a qualitative study. BMJ Open Respiratory Research 2022;9(1),1-11.
  • 24. Grønset R, Vollmer WM, Hardie JA, Ólafsdóttir IS, Lamprecht B, Buist AS, et al. Predictors of dyspnoea prevalence: results from the BOLD study. European Respiratory Journal 2014;43(6),1610-1620.
  • 25. Santos M, Kitzman DW, Matsushita K, Loehr L, Sueta CA, Shah AM. Prognostic importance of dyspnea for cardiovascular outcomes and mortality in persons without prevalent cardiopulmonary disease: The atherosclerosis risk in communities study. PloSone 2016;11(10),1-15.
  • 26. Gök Metin Z, Arıkan Dönmez A. Dyspnea Management in Patients with Cancer. Turk Journal of Oncology 2016;31(2),61-67.
  • 27. Gündüz C, Erdinç M. Dipsnenin pulmoner nedenlerine yaklaşım. Ege Tıp Dergisi 2014;53,7-13.
  • 28. Berliner D, Schneider N, Welte T, Bauersachs J. The differential diagnosis of dyspnea. Deutsches Arzteblatt International 2016;113(49),834–845.
  • 29. Biber Ç. Pulmoner rehabilitasyonda dispne algısının değerlendirmesi. Güncel Göğüs Hastalıkları Serisi 2019;7(1),19-25.
  • 30. Thomas JR, vonGunten, CF. Management of dyspnea. The Journal of Supportive Oncology 2003;1(1),23–34.
  • 31. Kara D, Yıldız H. Dispne semptomunun değerlendirilmesinde dispne ölçeklerinin etkinlikleri ve kullanım sıklıkları. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 2013;2(1),137-149.
  • 32. Kılıç FS. Opioidler, ağrı, opioidlerin suistimali ve yanlış kullanımı. Osmangazi Tıp Dergisi 2017;39(3),125-129.
  • 33. Yıldırım D. Opioid İlaç Kullanan Hastalarda Gelişen Konstipasyonun Yönetiminde Abdominal Masaj Uygulamasının Etkisi. [DoktoraTezi], İstanbul: İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü; 2018.
  • 34. International Narcotics Control Board. International Narcotics Control Board Report 2021. Yayınlanma Tarihi: 2022. Erişim Tarihi: 12.09.2022 Erişim Adresi: https://www.incb.org/incb/en/publications/annual-reports/annual-report-2021.html
  • 35. Sosyal Güvenlik Kurumu. Ödemesi yapılacak ilaçlar listesi (Ek-4/A). Yayınlanma Tarihi:2021 Erişim Tarihi: 23.10.2022. Erişim Adresi: https://www.resmigazete.gov.tr/eskiler/2021/04/20210428M1-1.htm
  • 36. Şenel, G, Oğuz G, Koçak N, Karaca Ş, Kaya M, Kadıoğulları N. Palyatif bakım kliniğinde yatan kanser hastalarında ağrı tedavisi ve opioid kullanımı. Ağrı 2016;28(4),171–176.
  • 37. Baldemir R, Akçaboy EY, Çelik Ş, Noyan Ö, Akçaboy, ZN, Baydar Ö. Doktorların opiofobiye yaklaşımlarının değerlendirilmesi: Bir eğitim araştırma hastanesinden anket sonuçları. Ağrı 2019;31(1),23–31.
  • 38. Şen S, Usta E, Aygin D. Attitudes of surgical nurses toward postoperative opioid use: A qualitative study. Journal of Human Sciences 2020;17(3),912-920.
  • 39. Reisli R, Akkaya ÖT, Arcan S, Can ÖS, Çetingök H, Güleç MS ve ark. Akut postoperatif ağrının farmakolojik tedavisi: Türk Algoloji-Ağrı Derneği Klinik Uyg. Kılavuzu. Ağrı 2021;33(1),1-51.
  • 40. Klein C, Lang U, Bükki J, Sittl R, Ostgathe C. Pain management and symptom-oriented drug therapy in palliative care. Breast Care (Basel, Switzerland), 2011;6(1),27–34.
  • 41. Mercadante S. Management of cancerpain. Internal and Emergency Medicine 2010;5(1)31–35.
  • 42. Clemens KE, Klaschik E. Effect of hydromorphone on ventilation in palliative care patients with dyspnea. Support Care Cancer 2008;16(1),93–99.
  • 43. Clemens, KE, Klaschik E. Morphine in the management of dyspnoea in ALS. A pilot study. European Journal of Neurology 2008;15(5), 445–450.
  • 44. Clemens, KE, Quednau I, Klaschik E. Use of oxygen and opioids in the palliation of dyspnoea in hypoxic and non-hypoxic palliative care patients: a prospective study. Support Care in Cancer 2009;17(4),367–377.
  • 45. Hui D, Xu A, Frisbee-Hume S, Chisholm G, Morgado M, Reddy S, et al. Effects of prophylactic subcutaneous fentanyl on exercise-induced breakthrough dyspnea in cancer patients: a preliminary double-blind, randomized, controlled trial. Journal of Pain and Symptom Management 2014;47(2),209–217.
  • 46. Barnes H, McDonald J, Smallwood N, Manser R. Opioids for the palliation of refractory breathlessness in adults with advanced disease and terminal illness. The Cochrane Database of Systematic Reviews 2016;3(3),1-86.
  • 47. Abdallah SJ, Wilkinson-Maitland C, Saad N, Li PZ, Smith BM, Bourbeau J, et al. Effect of morphine on breathlessness and exercise endurance in advanced COPD: a randomized crossover trial. The European Respiratory Journal 2017;50(4),1-13.
  • 48. Yamaguchi T, Matsuda Y, Matsuoka, H, Hisanaga T, Osaka I, Watanabe H, et al. Efficacy of immediate-release oxycodone for dyspnoea in the cancer patient: cancer dyspnoea relief (CDR) trial. Japanese Journal of Clinical Oncology 2018;48(12),1070–1075.
  • 49. Yamamoto Y, Watanabe H, Sakurai A, Deguchi Y, Hirano S, Okumura Y, et al. Effect of continuous intravenous oxycodone infusion in opioid-naïve cancer patients with dyspnea. Japanese Journal of Clinical Oncology 2018;48(8),748–752.
  • 50. Verberkt CA, van den Beuken-vanEverdingen M, Schols J, Hameleers N, Wouters E, Janssen D. Effect of sustained-release morphine for refractory breathlessness in chronic obstructive pulmonary disease on health status: A randomized clinical trial. JAMA Internal Medicine 2020;180(10),1306–1314.
  • 51. Mori M, Kawaguchi T, Imai K, Yokomichi N, Yamaguchi T, Suzuki K, et al. How successful is parenteral oxycodone for relieving terminal cancer dyspnea compared with morphine? A multicenter prospective observational study. Journal of Pain and Symptom Management 2021;62(2),336–345.
  • 52. Afolabi TM, Nahata MC, Pai V. Nebulized opioids for the palliation of dyspnea in terminally ill patients. American Journal of Health-System Pharmacy 2017;74(14),1053–1061.
  • 53. Bausewein C, Simon ST. Inhaled nebulized and intranasal opioids for the relief of breathlessness. Current Opinion in Supportive and Palliative Care 2014;8(3),208–212.
  • 54. Simon, ST, Köskeroglu P, Gaertner J, Voltz R. Fentanyl for the relief of refractory breathlessness: a systematic review. Journal of Pain and Symptom Management 2013;46(6),874–886.
  • 55. Lavonas EJ, Drennan IR, Gabrielli A, Heffner AC, Hoyte CO, Orkin AM, et al. Part 10: Special Circumstances of Resuscitation:2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2015;132(2),501-518.
  • 56. Karaman H. Opioid kullanımına bağlı yan etkiler ve tedavileri. Ağrı 2017;1,1-11.
  • 57. Aygin D. Bulantı ve Kusma. Yoğun Bakım Hemşireliği Dergisi 2016;20(1),44-56.
  • 58. Sözeri Öztürk E, Kutlutürkan S. Kanser ağrısının yönetiminde opioidlerin kullanımına bağlı gelişen konstipasyonun yönetimi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 2018;9(2),105-109.
  • 59. Yıldırım D, Can G. Opioid ilaç kullanan hastalarda gelişen konstipasyonun yönetimi. Balıkesir Sağlık Bilimleri Dergisi 2019;8(1),27-32.
  • 60. Aygin D. Var G. Travmalı hastada ağrı yönetimi. Sakarya Medical Journal 2012;2(2),61-70.
  • 61. Ganesh A, Maxwell LG. Pathophysiology and management of opioid-induced pruritus. Drugs 2007;67(16),2323–2333.
  • 62. Yürügen B. Ağrı ve opioid analjeziklerin kullanımına bağlı olarak ortaya çıkan komplikasyonlarda hemşirelik yaklaşımları. Atatürk Üniversitesi Hemşirelik Yüksekokulu Dergisi 2001;4(1),1-6.
  • 63. Benyamin R, Trescot AM, Datta S., Buenaventura R, Adlaka R, Sehgal N, et al. Opioid complications and side effects. Pain Physician 2008;11(2),105-120.
  • 64. Eyigör C. Opioidlerin kullanım ilkeleri, yan etki yönetimi ve yeni opioidler. The Journal of The Turkısh Socıety of Algology 2015;1,1-11.
  • 65. Jungquist CR, Quinlan-Colwell A, Vallerand A, Carlisle HL, Cooney M, Dempsey SJ, et al. American Society for Pain Management Nursing Guidelines on Monitoring for Opioid-Induced Advancing Sedation and Respiratory Depression: Revisions. Pain Management Nursing 2020;21(1),7-25.
Toplam 65 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Hemşirelik
Bölüm Derleme
Yazarlar

Derya Kurak 0000-0002-9443-9801

Büşra Ateş 0000-0002-1627-7413

Dilek Aygin 0000-0003-4620-3412

Yayımlanma Tarihi 30 Nisan 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 27 Sayı: 1

Kaynak Göster

Bu derginin içeriği Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı kapsamında lisanslanmıştır.

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