The Mathematical Outcome of The IVF, Including Early Cleavage
Öz
Aim: In this manuscript, the examination of independent factors for the success of IVF (In Vitro Fertilization) was aimed
to be conducted.
Material and Methods: Hormones, including Anti-Mullerian
Hormone (AMH), Follicle Stimulating Hormone(FSH), the
growth stages of the oocyte that turns into an embryo (total
fertilized oocyte, early cleavage, etc.), the medical adjustments
were included. Our dependent factor, the success of fertilization, was categorized into two groups; in other words, binary
logistic regression for pregnancy success was examined.
Results: For the statistical significance of our study, Omnibus
Tests of Model Coefficients (p-value=0,008) and Hosmer and
Lemeshow tests (p-value=0,462) were conducted. Our model
was successful through statistical meaningfulness. With a ChiSquare test with a p-value of close to zero, women’s age groups
were proven different for groups below and over the age of 35
for InVitro Fertilization (IVF)
Discussion and conclusion: Study shows Early Segmentation
increases the chances of pregnancy; In contrast, the woman's
age and FSH reduce the likelihood of pregnancy.
Anahtar Kelimeler
IVF, FSH, early cleavage, binary logistic regression, odds values
Kaynakça
- 1. Zhang J, Wang C, Zhang H, Zhou Y. Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review. Reprod Biol Endocrinol. 2021 Sep 14;19(1):142. doi: 10.1186/s12958-021-00824-y. PMID: 34521412; PMCID: PMC8439041.
- 2. Lundin K, Bergh C, & Hardarson T. Early embryo cleavage is a strong indicator of embryo quality in human IVF. Hum Reprod. 2001 Dec; 16(12):2652-7. doi: 10.1093/ humrep/16.12.2652. PMID: 11726590.
- 3. Van Marion ES, Baart EB, Santos M, van Duijn L, van Santbrink EJP, Steegers-Theunissen RPM, Laven JSE, & Eijkemans MJC. Using the embryo-uterus statistical model to predict pregnancy chances by using cleavage stage morphokinetics and female age: two centre-specific prediction models and mutual validation. Reprod Biol Endocrinol. 2023 Mar 27; 21(1):31. doi: 10.1186/s12958-023-01076-8. PMID: 36973721; PMCID: PMC10041771.
- 4. FISHER, R. A. “STUDENT”.1939, Annals of Eugenics, 9: 1–9. doi:10.1111/j.1469- 1809.1939.tb02192.x
- 5. Guyatt G., Jaeschke R., Heddle N., et al. Basic statistics for clinicians: 1. hypothesis testing. CMAJ. 1995;152(1):27–32.
- 6. Dodson W. C., Whitesides D. B., Hughes C. L., Easley H. A., Haney A. F. Superovulation with intrauterine insemination in the treatment of infertility: a possible alternative to gamete intrafallopian transfer and in vitro fertilization. Fertility and sterility, 1987; 48(3):441-445.
- 7. Duran, E. H., Gürgan, T., Günalp, S., Enginsu, M. E., Yarali, H., & Ayhan, A. A logistic regression model including DNA status and morphology of spermatozoa for prediction of fertilization in vitro. Human reproduction (Oxford, England). 1998; 13(5): 1235-1239.
- 8. Cai S, Natarajan P, Chan JKY, Wong PC, Tan KH, Godfrey KM, Gluckman PD, Shek LPC, Yap F, Kramer MS, Chan SY, Chong YS. Maternal hyperglycemia in singleton pregnancies conceived by IVF may be modified by first-trimester BMI. Hum Reprod. 2017 Sep 1;32(9):1941-1947. doi: 10.1093/humrep/dex243. PMID: 28854717; PMCID: PMC5638004.
- 9. Lekamge D. N., Barry M., Kolo M., Lane M., Gilchrist R. B., Tremellen K. P. Anti-Mül-lerian hormone as a predictor of IVF outcome. Reproductive Biomedicine Online; 2007; 14(5): 602-610.
- 10. Bos-Mikich A., Mattos A. L. G., Ferrari A. N. Early cleavage of human embryos: an effective method for predicting successful IVF/ICSI outcome. Human Reproduction. 2001; 16(12): 2658-2661.