Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler

Güneş Özen Eroğlu; İlham Yaylım; Uğur Gezer; Dürdane Serap Kuruca

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Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler

Öz

Meme kanseri, kadınlarda en yaygın görülen kanserlerden biridir ve dünyadaki en yüksek insidansa sahip kanser türüdür. Meme kanseri gelişiminde cinsiyet, yaş, östrojen düzeyi, aile öyküsü, gen mutasyonları ve sağlıksız yaşam tarzı gibi çok sayıda risk faktörü bulunmaktadır. Mevcut tedavi seçenekleri cerrahi, radyoterapi, hormonal tedaviler, kemoterapi ve hedefe yönelik tedavilerdir. Hedefe yönelik tedavilerin içinde immünoterapi son yıllarda oldukça yaygın bir tedavi stratejisi olarak karşımıza çıkmaktadır. Meme kanseri immün sistemden bağımsız bir kanser olduğu düşüncesinin aksine, artık meme kanserinin immün temelli bir kanser türü olduğu bilinmektedir. Bu kapsamda diğer kanser türlerinde olduğu gibi, meme kanserinde de immünoterapinin hedeflediği moleküllerden programlanmış hücre ölümü-1 (PD-1) ve programlanmış hücre ölümü ligandı-1 (PD-L1) ile yapılan çok sayıda çalışma bulunmaktadır. PD-1 ve PD-L1 hedefli tedaviler günümüzde meme kanseri tedavisinde uygulanmaktadır. Meme kanseri alt tipleri olarak ele alındığında; farklı alt tipler arasında heterojen bir dağılım olmakla birlikte tümör hücrelerinde artmış PD-L1 ekspresyonu gözlenmektedir. Ayrıca, PDL1 ekspresyonu, genç yaş, ileri evre, tümör infiltre eden lenfositlerin (TIL’ler) varlığı ve agresif moleküler alt tipler ile pozitif korelasyon göstermektedir. Şimdilik sadece üçlü negatif meme kanserinin (TNMK) tedavisinde yer alan immünoterapi, yapılacak daha fazla araştırma sonucunda, diğer meme kanseri alt tiplerinde de kombinasyon ya da tek tedavi olarak yer alabilecektir. Meme kanseri tedavisinde, PD-1 ve PD-L1 düzenlemesinin ayrıntılı mekanizmasını anlamak; tedavilere direncin üstesinden gelinmesi ve daha iyi klinik sonuçlara ulaşılması açısından büyük önem taşımaktadır. Bu derlemede meme kanserinde PD-1 ve PD-L1 hedefli tedavilerin incelenmesi hedeflenmiştir.

Anahtar Kelimeler

meme kanseri, PD-1, PD-L1, immünoterapi

PD-1/PD-L1 Targeted Therapies in Breast Cancer

Öz

Breast cancer is one of the most common cancers among women and has the highest incidence globally. Many risk factors for breast cancer progression include gender, age, estrogen level, family history, gene mutations, and unhealthy lifestyle. Besides, current treatment options are surgery, radiotherapy, hormonal treatments, chemotherapy, and targeted therapies. Among the targeted therapies, Immunotherapy has emerged as a very common treatment strategy in recent years. Contrary to the thought that breast cancer is an immune system-independent cancer, it is presently acknowledged that breast cancer is an immune-based cancer type. In this context—as in other cancer types—many studies are conducted with programmed cell death-1 (PD-1) and programmed cell death ligand 1 (PD-L1) molecules targeted by Immunotherapy in breast cancer. PD-1 and PD-L1 targeted therapies are currently used to treat breast cancer. Although there is a heterogeneous distribution among different subtypes, increased PD-L1 expression is observed in tumor cells—when considering breast cancer subtypes. Moreover, PD-L1 expression correlates positively with young age, advanced stage, presence of tumor-infiltrating lymphocytes (TILs), and aggressive molecular subtypes. Therefore, Immunotherapy, which is currently only used in the treatment of triple-negative breast cancer (TNBC), may be used as a combination of treatment or single treatment procedure in other breast cancer subtypes—after further research. To better understand the detailed mechanism of PD-1 and PD-L1 regulation in breast cancer treatment, overcoming resistance to treatments and achieving better clinical outcomes is important. This review aims to investigate PD-1 and PD-L1 targeted therapies in breast cancer.

Anahtar Kelimeler

breast cancer, PD-1, PD-L1, immunotherapy

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri (Diğer)

Bölüm

Derleme

Yazarlar

Güneş Özen Eroğlu
0000-0003-3681-9336
Türkiye

İlham Yaylım Bu kişi benim
0000-0003-2615-0202
Türkiye

Uğur Gezer
0000-0001-8471-5254
Türkiye

Dürdane Serap Kuruca
0000-0001-7878-9994
Türkiye

Yayımlanma Tarihi

30 Nisan 2023

Gönderilme Tarihi

27 Aralık 2022

Kabul Tarihi

24 Nisan 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 4 Sayı: 2

IZ

https://izlik.org/JA97BW75PS

APA

Özen Eroğlu, G., Yaylım, İ., Gezer, U., & Kuruca, D. S. (2023). Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler. Yeni Yüzyıl Journal of Medical Sciences, 4(2), 55-61. https://izlik.org/JA97BW75PS

AMA

1.Özen Eroğlu G, Yaylım İ, Gezer U, Kuruca DS. Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler. JMS. 2023;4(2):55-61. https://izlik.org/JA97BW75PS

Chicago

Özen Eroğlu, Güneş, İlham Yaylım, Uğur Gezer, ve Dürdane Serap Kuruca. 2023. “Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler”. Yeni Yüzyıl Journal of Medical Sciences 4 (2): 55-61. https://izlik.org/JA97BW75PS.

EndNote

Özen Eroğlu G, Yaylım İ, Gezer U, Kuruca DS (01 Nisan 2023) Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler. Yeni Yüzyıl Journal of Medical Sciences 4 2 55–61.

IEEE

[1]G. Özen Eroğlu, İ. Yaylım, U. Gezer, ve D. S. Kuruca, “Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler”, JMS, c. 4, sy 2, ss. 55–61, Nis. 2023, [çevrimiçi]. Erişim adresi: https://izlik.org/JA97BW75PS

ISNAD

Özen Eroğlu, Güneş - Yaylım, İlham - Gezer, Uğur - Kuruca, Dürdane Serap. “Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler”. Yeni Yüzyıl Journal of Medical Sciences 4/2 (01 Nisan 2023): 55-61. https://izlik.org/JA97BW75PS.

JAMA

1.Özen Eroğlu G, Yaylım İ, Gezer U, Kuruca DS. Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler. JMS. 2023;4:55–61.

MLA

Özen Eroğlu, Güneş, vd. “Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler”. Yeni Yüzyıl Journal of Medical Sciences, c. 4, sy 2, Nisan 2023, ss. 55-61, https://izlik.org/JA97BW75PS.

Vancouver

1.Güneş Özen Eroğlu, İlham Yaylım, Uğur Gezer, Dürdane Serap Kuruca. Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler. JMS [Internet]. 01 Nisan 2023;4(2):55-61. Erişim adresi: https://izlik.org/JA97BW75PS

Meme Kanserinde PD-1/PD-L1 Hedefli Tedaviler

Öz

Anahtar Kelimeler

PD-1/PD-L1 Targeted Therapies in Breast Cancer

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

IZ

Kaynak Göster