Epidural Magnesium Sulfate Does Increase Cerebrospinal Fluid Ionized Magnesium Concentration of Rabbit: An Experimental Study
Öz
Aim: This study was designed to investigate the ability of
MgSO4, administered by epidural catheter, to pass into cerebrospinal
fluid (CSF), and to evaluate motor block effect in rabbits.
Methods: Group 150 (n= 6): 150 mg/mL MgSO4 was administered
via epidural catheter, then the catheter was flushed using
0.20 mL of saline. Group 300 (n= 6): 300 mg/mL MgSO4 was
administered via epidural catheter, then the catheter was flushed.
Group 450 (n=6): 450 mg/mL MgSO4 was administered via epidural
catheter, then the catheter was flushed. Rabbit ear arteries
were cannulated for arterial blood samples. 0.1 mL CSF sample
was taken from cisterna magna. The motor block was scored
using Drummond Moore scale. After administration of drug,
motor block was evaluated and CSF and plasma were taken at
0, 240, 360 and 480. minutes. Pharmacokinetic parameters were
also calculated and statistically evaluated.
Results: In our study, spinal CSF ionized magnesium levels were
increased compared to basal Mg2+ levels in each group respectively
as follows; by 25% for 150 mg, 60% for 300 mg, and 127%
for 450 mg. Moreover compared to basal Mg2+ levels the plasma
ionized Mg2+ levels in each group were shown to increase by 13%
for 150 mg, 87% for 300 mg, 200% for 450 mg. 450 mg magnesium
sulphate administered epidurally generated motor block.
Conclusion: This study has established that epidural administration
of MgSO4 increases the spinal CSF ionized Mg2+ concentration,
epidural MgSO4 passes through systemic circulation,
and epidural administration of 450 mg MgSO4 generates motor
block in rabbits.
Anahtar Kelimeler
Epidural, magnesium sulphate, cerebrospinal fluid, blood-brain barrier, rabbit.
Kaynakça
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