Galektinler ve Mide Kanseri

Ayşe Aksu; İlhan Yaylım

Galektinler ve Mide Kanseri

Öz

Mide kanseri ülkelere göre histopatolojik ve epidemiyolojik farklılıklar gösteren hete¬rojen bir kanser türüdür ve dünya genelinde yaygın olarak görülmektedir. Mide kanseri Helicobacter pylori ve Epstein-Barr virüsü (EBV) enfeksiyonları gibi mikrobiyal, aile öyküsü, A kan grubu, E-kaderin gen mutasyonu içeren genetik ve sigara, alkol tüketimi, yağ, karbonhidrat, nitrat ve tuz oranı yüksek gıda tüketimi gibi çevresel faktörlerin etkisiyle ortaya çıkabilen bir kanser türüdür. Mide kanserinde hayatta kalma oranlarının düşük olması nedeniyle; ileri evre mide kanserine yönelik alternatif tedavilerin geliştirilmesi önemlidir. Günümüzde, kemoterapi, radyoterapi, immünoterapi alanlarında gerçekleşen ilerlemelere karşın iyileşme için ilk tercih genellikle cerrahi tedavidir Galektinler, 130 amino asit (aa) barındıran karbonhidrat tanıma sahaları (crd) içerisinde evrimsel olarak korunmuş β –galaktozidleri bağlayan bir protein sınıfı olarak tanımlanır. Günümüze kadar 12 tanesi insanlarda olmak üzere memelilerde 16 farklı Galektin tanımlanmıştır. Galektinler, yapısal özelliklerine ve polipeptit zincirin CRD sayılarına göre; Prototipik (Gal-1,-2,-5,-7,-10,-11,-13,-14) Tandem-Tekrar (Gal-4,- 2,-8,-9,-12) ve Kimera (Gal-3) olmak üzere üç alt grupta toplanır. Lektin ailesi üyelerinden Galektinler; tümör mikro çevresinde yüksek oranda bulunması, hücre göçü, kanserle ilgili birçok sinyal iletimi ve immün sistemin düzenlenmesinde görev alması gibi özellikleri nedeniyle kanser çalışmalarında araştırılan proteinlerdir. Mide kanserinin oluşum ve gelişim mekanizmasının daha iyi anlaşılması, kişiye özel terapilerin ve hedefe yönelik potansiyel biyobelirteçlerin belirlenmesi amacıyla başta Gal-3 olmak üzere moleküler düzeyde mide kanseri ile ilişkisinin anlaşılabilmesi ve aynı şekilde, Gal-4, Gal-7 Gal-9 gibi diğer Galektin üyelerinin de mide ve diğer kanser türlerindeki rolünü belirlenebilmesi, tanı ve tedavi süreçlerine etkisinin anlaşılabilmesi için daha ileri çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

mide kanseri, galektin, biyobelirteç

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Yardımcı Sağlık ve Rehabilitasyon Bilimi (Diğer)

Bölüm

Derleme

Yazarlar

Ayşe Aksu ^*
Türkiye

İlhan Yaylım
Türkiye

Yayımlanma Tarihi

30 Ocak 2024

Gönderilme Tarihi

16 Ekim 2023

Kabul Tarihi

12 Ocak 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 5 Sayı: 1

IZ

https://izlik.org/JA86GH96EK

APA

Aksu, A., & Yaylım, İ. (2024). Galektinler ve Mide Kanseri. Yeni Yüzyıl Journal of Medical Sciences, 5(1), 8-15. https://izlik.org/JA86GH96EK

AMA

1.Aksu A, Yaylım İ. Galektinler ve Mide Kanseri. JMS. 2024;5(1):8-15. https://izlik.org/JA86GH96EK

Chicago

Aksu, Ayşe, ve İlhan Yaylım. 2024. “Galektinler ve Mide Kanseri”. Yeni Yüzyıl Journal of Medical Sciences 5 (1): 8-15. https://izlik.org/JA86GH96EK.

EndNote

Aksu A, Yaylım İ (01 Ocak 2024) Galektinler ve Mide Kanseri. Yeni Yüzyıl Journal of Medical Sciences 5 1 8–15.

IEEE

[1]A. Aksu ve İ. Yaylım, “Galektinler ve Mide Kanseri”, JMS, c. 5, sy 1, ss. 8–15, Oca. 2024, [çevrimiçi]. Erişim adresi: https://izlik.org/JA86GH96EK

ISNAD

Aksu, Ayşe - Yaylım, İlhan. “Galektinler ve Mide Kanseri”. Yeni Yüzyıl Journal of Medical Sciences 5/1 (01 Ocak 2024): 8-15. https://izlik.org/JA86GH96EK.

JAMA

1.Aksu A, Yaylım İ. Galektinler ve Mide Kanseri. JMS. 2024;5:8–15.

MLA

Aksu, Ayşe, ve İlhan Yaylım. “Galektinler ve Mide Kanseri”. Yeni Yüzyıl Journal of Medical Sciences, c. 5, sy 1, Ocak 2024, ss. 8-15, https://izlik.org/JA86GH96EK.

Vancouver

1.Ayşe Aksu, İlhan Yaylım. Galektinler ve Mide Kanseri. JMS [Internet]. 01 Ocak 2024;5(1):8-15. Erişim adresi: https://izlik.org/JA86GH96EK