Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme

Ceyda Öner; Seren Kurt; Emine Sena Küs; Ayşe Nur Songür Bozdağ

TR EN

Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme

Öz

Endometriozis, üreme çağındaki kadınların yaklaşık %10’unu etkileyen, östrojene bağımlı kronik inflamatuar bir hastalıktır. Hastalığın patogenezinde östrojen metabolizması bozuklukları, immün disregülasyon, oksidatif stres ve inflamasyon gibi süreçler birbirleriyle etkileşimli biçimde rol oynamaktadır. Son yıllarda bağırsak mikrobiyotasının bu süreçler üzerindeki etkisi, özellikle östrobolom mekanizması ve bağışıklık yanıtının düzenlenmesi bağlamında yoğun biçimde araştırılmaktadır. Bağırsak mikrobiyota kompozisyonunun şekillenmesinde en belirleyici faktörlerden biri olan beslenmenin; omega-3 yağ asitleri, antioksidan vitaminler, polifenoller ve diyet lifi gibi bileşenlerin anti-inflamatuar ve antioksidan etkileri yoluyla hastalık semptomlarını hafifletebileceği bildirilmiştir. Bu derlemede, bağırsak mikrobiyotası ile beslenme arasındaki etkileşim bütüncül bir yaklaşımla ele alınarak, belirli besin ögeleri ve diyet modellerinin endometriozisin gelişiminin önlenmesi ve yönetimindeki potansiyel rolleri güncel literatür doğrultusunda değerlendirilmiştir.

Anahtar Kelimeler

Endometriozis, bağırsak mikrobiyotası, beslenme, östrobolom, inflamasyon, diyet

Etik Beyan

Bu makale için etik kurul gerekli değildir (Derleme olması nedeniyle)

The Role of Nutrition and Gut Microbiota in the Prevention and Management of Endometriosis: A Current Review

Öz

Endometriosis is an estrogen-dependent chronic inflammatory disease that affects approximately 10% of reproductive-age women. Estrogen metabolism disorders, immune dysregulation, oxidative stress, and inflammation interact in its pathogenesis. In recent years, the influence of gut microbiota on these processes has been extensively studied, particularly through the estrobolome mechanism and immune response modulation. Nutrition, being one of the most determinant factors in shaping gut microbiota composition, has been reported to alleviate disease symptoms through the anti-inflammatory and antioxidant effects of components such as omega-3 fatty acids, antioxidant vitamins, polyphenols, and dietary fiber. This review comprehensively evaluates the interaction between gut microbiota and nutrition, and discusses the potential roles of specific nutrients and dietary patterns in the prevention and management of endometriosis in light of current literature.

Anahtar Kelimeler

Endometriosis, gut microbiota, nutrition, estrobolome, inflammation, diet

Kaynakça

1. Smolarz B, Szyłło K, Romanowicz H. Endometriosis: Epidemiology, classification, pathogenesis, treatment and genetics (Review of literature). Int J Mol Sci. 2021;22(19):10554. https://doi.org/10.3390/ijms221910554
2. Jiang I, Yong PJ, Allaire C, Bedaiwy MA. Intricate connections between the microbiota and endometriosis. Int J Mol Sci. 2021;22(11):5644. https://doi.org/10.3390/ijms22115644
3. Salliss ME, Farland LV, Mahnert ND, Herbst-Kralovetz MM. The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain. Hum Reprod Update. 2021;28(1):92-131. https://doi.org/10.1093/humupd/dmab035
4. Szczepanik J, Dłużewska M. The Importance of Diet in the Treatment of Endometriosis. Women. 2024;4(4):453-468. https://doi.org/10.3390/women4040034
5. Akgun N, Sofiyeva N, Yalcın PB, Laganà AS, Oral E. Role of macronutrients, dairy products, fruits and vegetables in occurrence and progression of endometriosis: A summary of current evidence in a systematic review. Facts Views Vis Obgyn.2024; 16(4):409-428. https://doi.org/10.52054/FVVO.16.4.046
6. Giudice LC, Kao LC. Endometriosis. Lancet. 2004;364(9447):1789-1799. https://doi.org/10.1016/S0140- 6736(04)17403-5
7. Nezhat C, Falik R, McKinney S, King LP. Pathophysiology and management of urinary tract endometriosis. Nat Rev Urol. 2017;14(6):359-372. https://doi.org/10.1038/nrurol.2017.58
8. Lee SY, Koo YJ, Lee DH. Classification of endometriosis. Yeungnam Univ J Med. 2021;38(1):10-18. https://doi. org/10.12701/yujm.2020.00444
9. Eskenazi B, Warner M. Epidemiology of endometriosis.Obstet Gynecol Clin North Am. 1997;24(2):235-258. https:// doi.org/10.1016/s0889-8545(05)70302-8
10. Monnin N, Fattet AJ, Koscinski I. Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement. Biomedicines. 2023;11(3):978. https://doi. org/10.3390/biomedicines11030978

11. Treloar SA, O'Connor DT, O'Connor VM, Martin NG. Genetic influences on endometriosis in an Australian twin sample. Fertil Steril. 1999;71(4):701-710. https://doi.org/10.1016/s0015- 0282(98)00540-8
12. Bulun SE, Monsavais D, Pavone ME, et al. Role of estrogen receptor-β in endometriosis. Semin Reprod Med. 2012;30(1):39-45. https://doi.org/10.1055/s-0031-1299596
13. Greygoose E, Metharom P, Kula H, et al. The estrogenimmune Interface in endometriosis. Cells. 2025;14(1):58. https://doi.org/10.3390/cells14010058
14. Knez J, Kovačič B, Goropevšek A. The role of regulatory T-cells in the development of endometriosis. Hum Reprod. 2024;39(7):1367-1380. https://doi.org/10.1093/humrep/deae103
15. Clower L, Fleshman T, Geldenhuys WJ, Santanam N. Targeting oxidative stress involved in endometriosis and its pain. Biomolecules. 2022;12(8):1055. https://doi.org/10.3390/ biom12081055
16. Adak A, Khan MR. An insight into gut microbiota and its functionalities. Cell Mol Life Sci. 2019;76(3):473-493. https:// doi.org/10.1007/s00018-018-2943-4
17. Beam A, Clinger E, Hao L. Effect of diet and dietary components on the composition of the gut microbiota. Nutrients. 2021;13(8):2795. https://doi.org/10.3390/nu13082795
18. Yuanyue W, Dimei Z, Ling Z, Dongyan H, Xiaomei W. Association between endometriosis and gut microbiota: systematic review and meta-analysis. Front Microbiol. 2025;16:1552134. https://doi.org/10.3389/fmicb.2025.1552134
19. Xu J, Li K, Zhang L, et al. Dysbiosis of gut microbiota contributes to chronic stress in endometriosis patients via activating inflammatory pathway. Reprod Dev Med. 2017;1(4):221-227. https://doi.org/10.4103/2096-2924.224916
20. Ata B, Yildiz S, Turkgeldi E, et al. The Endobiota Study: Comparison of vaginal, cervical and gut microbiota between women with stage 3/4 endometriosis and healthy controls. Sci Rep. 2019;9(1):2204. https://doi.org/10.1038/s41598-019-39700-6
21. Banaszak M, Górna I, Woźniak D, et al. Association between gut dysbiosis and the occurrence of SIBO, LIBO, SIFO and IMO. Microorganisms. 2023;11(3):573. https://doi.org/10.3390/ microorganisms11030573
22. Mohling SI, Holcombe J, Furr RS. Intestinal permeability and endometriosis: A pilot investigation. J Endometr Uterine Disord. 2023;3:100045. http://dx.doi.org/10.1016/j.jeud.2023.100045
23. Kumari N, Kumari R, Dua A, et al. From gut to hormones: unraveling the role of gut microbiota in (phyto) estrogen modulation in health and disease. Mol Nutr Food Res. 2024;68(6):2300688.
24. Hu S, Ding Q, Zhang W, et al. Gut microbial betaglucuronidase: a vital regulator in female estrogen metabolism. Gut Microbes. 2023;15(1):2236749. https://doi.org/10.1080/194 90976.2023.2236749
25. Hearn-Yeates F, Horne AW, O'Mahony S, Saunders PTK. The impact of the microbiota-gut-brain axis on endometriosisassociated symptoms: mechanisms and opportunities for personalised management strategies. Reprod Fertil. 2024;5(2):e230085. https://doi.org/10.1530/RAF-23-0085
26. Maulenkul T, Kuandyk A, Makhadiyeva D, et al. Understanding the impact of endometriosis on women's life: an integrative review of systematic reviews. BMC Womens Health. 2024;24(1):524. https://doi.org/10.1186/s12905-024-03369-5
27. Mokhtari T, Irandoost E, Sheikhbahaei F. Stress, pain, anxiety, and depression in endometriosis-Targeting glial activation and inflammation. Int Immunopharmacol. 2024;132:111942. https:// doi.org/10.1016/j.intimp.2024.111942
28. Youseflu S, Jahanian Sadatmahalleh S, Mottaghi A, Nasiri M. Association between dietary inflammatory index and endometriosis risk in a case-control study. J Endometr Pelvic Pain Disord. 2021;13(2):77-82. https://doi. org/10.1177/2284026520984415
29. Cirillo M, Argento FR, Becatti M, et al. Mediterranean diet and oxidative stress: A relationship with pain perception in endometriosis. Int J Mol Sci. 2023;24(19):14601. https://doi.org/10.3390/ijms241914601
30. Ruotolo A, Vannuccini S, Capezzuoli T, et al. Diet characteristics in patients with endometriosis. J Endometr Uterine Disord. 2025;9:100094. https://doi.org/10.1016/j. jeud.2024.100094
31. Seyidova CI, Yarmolinskaya MI. Vitamin A and pregnancy: myths and reality; prospects for the use in patients with endometriosis. A review. J Obstet Womens Dis. 2021;70(6):139-146. https://doi.org/10.17816/JOWD72297
32. Yamagata Y, Takaki E, Shinagawa M, Okada M, Jozaki K, Lee L, et al. Retinoic acid has the potential to suppress endometriosis development. J Ovarian Res. 2015;8(1):49. https://doi.org/10.1186/s13048-015-0179-6
33. Yalçın Bahat P, Ayhan I, Üreyen Özdemir E, et al. Dietary supplements for treatment of endometriosis: A review. Acta Biomed. 2022;93(1):e2022159. https://doi.org/10.23750/abm. v93i1.11237
34. Amini L, Chekini R, Nateghi MR, et al. The effect of combined vitamin C and vitamin E supplementation on oxidative stress markers in women with endometriosis. Pain Res Manag. 2021;2021:5529741. https://doi.org/10.1155/2021/5529741
35. Bayu P, Wibisono JJ. Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis. PLoS One. 2024;19(5):e0301867. https://doi. org/10.1371/journal.pone.0301867
36. Farhangnia P, Noormohammadi M, Delbandi AA. Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis. Reprod Health. 2024;21(1):61. https:// doi.org/10.1186/s12978-024-01797-y
37. Marcinkowska A, Górnicka M. The role of dietary fats in the development and treatment of endometriosis. Life. 2023;13(3):654. https://doi.org/10.3390/life13030654
38. Watson H, Mitra S, Croden FC, et al. A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota. Gut. 2018;67(11):1974-1983. https://doi.org/10.1136/gutjnl-2017-314968
39. Nodler JL, DiVasta AD, Vitonis AF, et al. Supplementation with vitamin D or ω-3 fatty acids in adolescent girls and young women with endometriosis (SAGE). Am J Clin Nutr. 2020;112(1):229-236. https://doi.org/10.1093/ajcn/nqaa096
40. Kizilay G, Uz YH, Seren G, Ulucam E, Yilmaz A, Cukur Z, et al. In vivo effects of curcumin and deferoxamine in experimental endometriosis. Adv Clin Exp Med. 2017;26(2):207-213. https://doi.org/10.17219/acem/31186
41. Vallée A, Lecarpentier Y. Curcumin and endometriosis. Int J Mol Sci. 2020;21(7):2440. https://doi.org/10.3390/ijms21072440
42. Tabanelli R, Brogi S, Calderone V. Improving curcumin bioavailability: current strategies and future perspectives. Pharmaceutics. 2021;13(10):1715. https://doi.org/10.3390/pharmaceutics13101715
43. Hazimeh D, Massoud G, Parish M, et al. Green tea and benign gynecologic disorders: a new trick for an old beverage? Nutrients. 2023;15(6):1439. https://doi.org/10.3390/nu15061439
44. Matsuzaki S, Darcha C. Antifibrotic properties of epigallocatechin-3-gallate in endometriosis. Hum Reprod. 2014;29(8):1677-1687. https://doi.org/10.1093/humrep/deu123
45. Kolahdouz-Mohammadi R, Shidfar F, Khodaverdi S, et al. Resveratrol treatment reduces expression of MCP-1, IL-6, IL-8 and RANTES in endometriotic stromal cells. J Cell Mol Med. 2021;25(2):1116-1127. https://doi.org/10.1111/jcmm.16178
46. Maia H Jr, Haddad C, Pinheiro N, Casoy J. Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain. Int J Womens Health. 2012;4:543-549. https://doi.org/10.2147/IJWH.S36825
47. Ryu S, Bazer FW, Lim W, Song G. Chrysin leads to cell death in endometriosis by regulation of endoplasmic reticulum stress and cytosolic calcium level. J Cell Physiol. 2019;234(3):2480- 2490. https://doi.org/10.1002/jcp.26770
48. Tassinari V, Smeriglio A, Stillittano V, et al. Endometriosis treatment: Role of natural polyphenols as anti-inflammatory agents. Nutrients. 2023;15(13):2967. https://doi.org/10.3390/ nu15132967
49. Cai X, Liu M, Zhang B, Zhao SJ, Jiang SW. Phytoestrogens for the management of endometriosis: findings and issues. Pharmaceuticals. 2021;14(6):569. https://doi.org/10.3390/ph14060569
50. Anastasi E, Scaramuzzino S, Viscardi MF, et al. Efficacy of N-Acetylcysteine on endometriosis-related pain, size reduction of ovarian endometriomas, and fertility outcomes. Int J Environ Res Public Health. 2023;20(6):4686. https://doi.org/10.3390/ ijerph20064686
51. Kechagias KS, Katsikas Triantafyllidis K, Kyriakidou M, et al. The relation between caffeine consumption and endometriosis. Nutrients. 2021;13(10):3457. https://doi. org/10.3390/nu13103457
52. Hemmert R, Schliep KC, Willis S, et al. Modifiable lifestyle factors and risk for incident endometriosis. Paediatr Perinat Epidemiol. 2019;33(1):19-25. https://doi.org/10.1111/ppe.12516
53. Matalliotakis IM, Cakmak H, Fragouli YG, Goumenou AG, Mahutte NG, Arici A. Epidemiological characteristics in women with and without endometriosis in the yale series. Arch Gynecol Obstet. 2008;277(5):389-393. https://doi.org/10.1007/s00404- 007-0479-1
54. Abulughod N, Valakas S, El-Assaad F. Dietary and nutritional interventions for the management of endometriosis. Nutrients. 2024;16(23):3988. https://doi.org/10.3390/nu16233988
55. Hess JM, Stephensen CB, Kratz M, Bolling BW. Exploring the links between diet and inflammation: dairy foods as case studies. Adv Nutr. 2021;12(Suppl 1):1S-13S. https://doi. org/10.1093/advances/nmab108
56. Qi X, Zhang W, Ge M, et al. Relationship between dairy products intake and risk of endometriosis: a systematic review and dose-response meta-analysis. Front Nutr. 2021;8:701860. https://doi.org/10.3389/fnut.2021.701860
57. Davis C, Bryan J, Hodgson J, Murphy K. Definition of the Mediterranean diet; A literature review. Nutrients. 2015;7(11):9139-9153. https://doi.org/10.3390/nu7115459
58. De Filippis F, Pellegrini N, Vannini L, et al. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome. Gut. 2016;65(11):1812-1821. https://doi.org/10.1136/gutjnl-2015-309957
59. Liu M, Peng R, Tian C, et al. Effects of the gut microbiota and its metabolite short-chain fatty acids on endometriosis. Front Cell Infect Microbiol. 2024;14:1373004. https://doi.org/10.3389/fcimb.2024.1373004
60. van Haaps AP, Wijbers JV, Schreurs AMF, Vlek S, Tuynman J, De Bie B, et al. The effect of dietary interventions on pain and quality of life in women diagnosed with endometriosis: a prospective study with control group. Hum Reprod. 2023;38(12):2433-2446. https://doi.org/10.1093/humrep/dead214
61. Bellini M, Tonarelli S, Nagy AG, et al. Low FODMAP diet: Evidence, doubts, and hopes. Nutrients. 2020;12(1):148. https:// doi.org/10.3390/nu12010148
62. Moore JS, Gibson PR, Perry RE, et al. Endometriosis in patients with irritable bowel syndrome: specific symptomatic and demographic profile, and response to the low FODMAP diet. Aust N Z J Obstet Gynaecol. 2017;57(2):201-205. https:// doi.org/10.1111/ajo.12594
63. Van Haaps AP, Brouns F, Schreurs AMF, et al. A gluten-free diet for endometriosis patients lacks evidence to recommend it. AJOG Glob Rep. 2024;4(3):100369. https://doi.org/10.1016/j.xagr.2024.100369
64. Marziali M, Venza M, Lazzaro S, Lazzaro A, Micossi C, Stolfi VM. Gluten-free diet: a new strategy for management of painful endometriosis related symptoms? Minerva Chir. 2012;67(6):499-504.
65. Norfuad FA, Mokhtar MH, Nur Azurah AG. Beneficial effects of probiotics on benign gynaecological disorders: a review. Nutrients. 2023;15(12):2733. https://doi.org/10.3390/nu15122733
66. Xholli A, Cremonini F, Perugi I, Londero AP, Cagnacci A. Gut microbiota and endometriosis: Exploring the relationship and therapeutic implications. Pharmaceuticals. 2023;16(12):1696. https://doi.org/10.3390/ph16121696
67. Yoo S, Jung SC, Kwak K, Kim JS. The role of prebiotics in modulating gut microbiota: implications for human health. Int J Mol Sci. 2024;25(9):4834. https://doi.org/10.3390/ijms25094834

Ayrıntılar

Birincil Dil

Türkçe

Konular

Beslenme Epidemiyolojisi, Sağlık Hizmetleri ve Sistemleri (Diğer)

Bölüm

Derleme

Yazarlar

Ceyda Öner
0009-0001-1758-5418
Türkiye

Seren Kurt
0009-0001-8605-8187
Türkiye

Emine Sena Küs
0009-0004-1760-9864
Türkiye

Ayşe Nur Songür Bozdağ ^*
0000-0001-6412-8650
Türkiye

Yayımlanma Tarihi

30 Ekim 2026

Gönderilme Tarihi

27 Nisan 2026

Kabul Tarihi

6 Ağustos 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 7 Sayı: 4

IZ

https://izlik.org/JA76TW28NG

APA

Öner, C., Kurt, S., Küs, E. S., & Songür Bozdağ, A. N. (2026). Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme. Yeni Yüzyıl Journal of Medical Sciences, 7(4), 150-161. https://izlik.org/JA76TW28NG

AMA

1.Öner C, Kurt S, Küs ES, Songür Bozdağ AN. Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme. JMS. 2026;7(4):150-161. https://izlik.org/JA76TW28NG

Chicago

Öner, Ceyda, Seren Kurt, Emine Sena Küs, ve Ayşe Nur Songür Bozdağ. 2026. “Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme”. Yeni Yüzyıl Journal of Medical Sciences 7 (4): 150-61. https://izlik.org/JA76TW28NG.

EndNote

Öner C, Kurt S, Küs ES, Songür Bozdağ AN (01 Ekim 2026) Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme. Yeni Yüzyıl Journal of Medical Sciences 7 4 150–161.

IEEE

[1]C. Öner, S. Kurt, E. S. Küs, ve A. N. Songür Bozdağ, “Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme”, JMS, c. 7, sy 4, ss. 150–161, Eki. 2026, [çevrimiçi]. Erişim adresi: https://izlik.org/JA76TW28NG

ISNAD

Öner, Ceyda - Kurt, Seren - Küs, Emine Sena - Songür Bozdağ, Ayşe Nur. “Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme”. Yeni Yüzyıl Journal of Medical Sciences 7/4 (01 Ekim 2026): 150-161. https://izlik.org/JA76TW28NG.

JAMA

1.Öner C, Kurt S, Küs ES, Songür Bozdağ AN. Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme. JMS. 2026;7:150–161.

MLA

Öner, Ceyda, vd. “Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme”. Yeni Yüzyıl Journal of Medical Sciences, c. 7, sy 4, Ekim 2026, ss. 150-61, https://izlik.org/JA76TW28NG.

Vancouver

1.Ceyda Öner, Seren Kurt, Emine Sena Küs, Ayşe Nur Songür Bozdağ. Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme. JMS [Internet]. 01 Ekim 2026;7(4):150-61. Erişim adresi: https://izlik.org/JA76TW28NG

Beslenme ve Bağırsak Mikrobiyotasının Endometriozisin Önlenmesi ve Yönetimindeki Rolü: Güncel Bir Derleme

Öz

Anahtar Kelimeler

Etik Beyan

The Role of Nutrition and Gut Microbiota in the Prevention and Management of Endometriosis: A Current Review

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

IZ

Kaynak Göster