Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler

Tuğçe Küçükali; Hande Erensoy; Serap Ayaz Seyhan; Dilek Bilgiç Alkaya

EN TR

Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler

Öz

Kemik rejenerasyonu, özellikle kemiğin doğal iyileşme kapasitesinin yetersiz olduğu kritik büyüklükteki defektlerin tedavisinde, ortopedide önemli bir klinik zorluk olmaya devam etmektedir. Doğal kemiğin mineral fazını yakından taklit eden bir kalsiyum fosfat seramiği olan hidroksiapatit (HAp), mükemmel biyo-uyumluluğu ve osteokondüktif özellikleri nedeniyle yaygın olarak kullanılmaktadır. Bununla birlikte, kırılganlığı ve sınırlı mekanik dayanıklılığı uygulamasını kısıtlamaktadır. Bu sınırlamaların üstesinden gelmek için, glukozamin (GS) ve kondroitin sülfat (CS) gibi biyolojik olarak aktif glikozaminoglikanların ile umut vadeden bir strateji olarak ortaya çıkmıştır. Bu biyomoleküller sadece hücre dışı matris organizasyonunda önemli bir rol oynamakla kalmaz, aynı zamanda osteoblast proliferasyonu, ve inflamasyon gibi hücresel süreçleri aktif olarak düzenlemektedir. Bu inceleme, HAp–GS–CS bazlı kompozit sistemlerdeki son gelişmeleri, tasarım, yapı ve biyolojik performanslarına odaklanarak değerlendirmektedir.

Anahtar Kelimeler

Hidroksiapatit, Glukozamin, Kondroitin sülfat, Nanokompozit

Kaynakça

1. Wang B, Liu W, Xing D, Li R, Lv C, Li Y. et al. Injectable nanohydroxyapatite-chitosan-gelatin micro-scaffolds induce regeneration of knee subchondral bone lesions. Scientific reports. 2017;7(1):16709.
2. Şimşek A, Çakmak G, Cila E. Kemik greftleri ve kemik greftlerinin yerini tutabilecek maddeler. Totbid Dergisi. 2004;3:3-4.
3. Dorozhkin SV. Calcium orthophosphates as bioceramics: state of the art. Journal of functional biomaterials. 2010;1(1):22107. DOI: 10.3390/jfb1010022
4. Kawsar M, Hossain M S, Alam MK, Bahadur NM, Shaikh MAA., Ahmed S.. Synthesis of pure and doped nano-calcium phosphates using different conventional methods for biomedical applications: A review. Journal of Materials Chemistry B. 2024;12(14):3376-3391 DOI: 10.1039/D3TB02846A
5. Komur B, Altun E, Aydogdu M, Bilgiç D, Gokce H, Ekren N, et al. Hydroxyapatite synthesis from fish bones: Atlantic salmon (Salmon Salar). Acta Physica Polonica A. 2017;131.3:400-402. DOI: 10.12693/aphyspola.131.400
6. Hussin MSF, Abdullah HZ, Idris MI, Wahap MAA. Extraction of natural hydroxyapatite for biomedical applications-A review. Heliyon. 2022;8(8). DOI: 10.1016/j.heliyon.2022.e10356
7. Elkhenany H, Soliman MW, Atta D, El-Badri N. Innovative marine‐sourced hydroxyapatite, Chitosan, collagen, and gelatin for eco-friendly bone and cartilage regeneration. Journal of Biomedical Materials Research Part A. 2025;113(1):e37833. DOI: 10.1002/jbm.a.37833
8. Vasiliadis HS, Tsikopoulos K. Glucosamine and chondroitin for the treatment of osteoarthritis. World journal of orthopedics. 2017;8(1):1. DOI:10.5312/wjo.v8.i1.1
9. Sharma A, Brand D, Fairbank J, Ye H, Lavy C, Czernuszka J. A self-organising biomimetic collagen/nano-hydroxyapatiteglycosaminoglycan scaffold for spinal fusion. Journal of materials science. 2017;52(21):12574-12592. DOI: 10.1007/ s10853-017-1229-9
10. He D, Xiao X, Liu F, Liu R. Chondroitin sulfate templatemediated biomimetic synthesis of nano-flake hydroxyapatite. Applied surface science. 2008;255(2):361-364. DOI: 10.1016/j. apsusc.2008.06.151

11. Abourehab MA, Baisakhiya S, Aggarwal A, Singh A, Abdelgawad MA, Deepak A, et al. Chondroitin sulfate-based composites: a tour d’horizon of their biomedical applications. Journal of Materials Chemistry B. 2022;10(44):9125-9178.
12. Sikkema R, Keohan B, Zhitomirsky I. Hyaluronic-acidbased organic-inorganic composites for biomedical applications. Materials. 2021;14(17):4982.
13. Igarashı M, Kaga I, Takamorı Y, Sakamoto K, Miyazawa K, Nagaoka I. Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes. International journal of molecular medicine. 2011; 27(6):821-827.
14. Guo Y, Peng X, Cao B, Liu Q, Li S, Chen Z, et al. A bilayer scaffold of collagen and nanohydroxyapatite promotes osteochondral defect repair in rabbit knee joints. Bone & Joint Research. 2025;14(2):155-165. DOI:10.1302/2046-3758.142. bjr-2024-0171.r1
15. Fendi F, Abdullah B, Suryani S, Usman AN, Tahir D. Development and application of hydroxyapatite-based scaffolds for bone tissue regeneration: A systematic literature review. Bone. 2024;183:117075. DOI:10.1016/j.bone.2024.117075
16. Elder S, Gottipati A, Zelenka H, Bumgardner J. Attachment, proliferation, and chondroinduction of mesenchymal stem cells on porous chitosan-calcium phosphate scaffolds. The open orthopaedics journal. 2013;7:275.
17. Monteiro B. Glycosaminoglycan-based scaffolds for bone repair [dissertation]. University of Sheffield;2021
18. Hu Y, Chen J, Fan T, Zhang Y, Zhao Y, Shi X, Zhang Q. Biomimetic mineralized hierarchical hybrid scaffolds based on in situ synthesis of nano-hydroxyapatite/chitosan/chondroitin sulfate/hyaluronic acid for bone tissue engineering. Colloids and Surfaces B: Biointerfaces. 2017;157:93-100. DOI: 10.1016/j. colsurfb.2017.05.059
19. Panigrahi P, Kalita N Mishra, L, Mishra M, Gupta M, Sahoo H. Bioinspired hydroxyapatite nanoparticle: Functionalization with chondroitin sulfate–thiol/amine moieties for synergistic bone tissue regeneration and oxidative stress mitigation. International Journal of Biological Macromolecules. 2025;149299. DOI:10.1016/j.ijbiomac.2025.149299
20. Tian Y, Ma H, Yu X, Feng B, Yang Z, Zhang W, et al. Biological response of 3D-printed β-tricalcium phosphate bioceramic scaffolds with the hollow tube structure. Biomedical Materials 2023;18(3):034102. DOI: 10.1088/1748-605X/ acc374
21. Cao Y, Zhang H, Qiu M, Zheng Y, Shi X, Yang J. Biomimetic injectable and bilayered hydrogel scaffold based on collagen and chondroitin sulfate for the repair of osteochondral defects. International Journal of Biological Macromolecules. 2024;257:128593. DOI: 10.1016/j.ijbiomac.2023.128593
22. Venkatesan J, Pallela R, Bhatnagar I, Kim SK. Chitosanamylopectin/hydroxyapatite and chitosan–chondroitin sulphate/hydroxyapatite composite scaffolds for bone tissue engineering. International journal of biological macromolecules. 2012;51(5):1033-1042. DOI: 10.1016/j.ijbiomac.2012.08.020.
23. Kuo YC, Leou SN. Chondrogenesis of articular chondrocytes in hydroxyapatite/chitin/chitosan scaffolds supplemented with pituitary extract. Engineering in Life Sciences. 2010;10(1):6574. DOI:10.1002/elsc.200900048
24. Behere I, Vaidya A, Ingavle G. Chondroitin sulfate and hyaluronic acid–based PolyHIPE scaffolds for improved osteogenesis and chondrogenesis in vitro. ACS Applied Bio Materials. 2024;7(8):5222-5236. DOI: 10.1021/acsabm.4c00393
25. Chen S, Chen W, Chen Y, Mo X, Fan C. Chondroitin sulfate modified 3D porous electrospun nanofiber scaffolds promote cartilage regeneration. Materials Science and Engineering: C. 2021;118:111312. DOI: 10.1016/j.msec.2020.111312
26. Xiao X, He D, Liu F, Liu R. Preparation and characterization of hydroxyapatite/chondroitin sulfate composites by biomimetic synthesis. Materials Chemistry and Physics. 2008;112(3): 838843. DOI: 10.1016/j.matchemphys.2008.06.055
27. Liu Z, Pei J, Sheng Y, Niu T, Wu P, Liu Y, et al. Composite 3D-Printed Scaffold Based on Glucosamine-Loaded Hyaluronic Acid Methacrylate for Osteochondral Regeneration. ACS Applied Bio Materials. 2026;9 (3):1558-1568. DOI: 10.1021/ acsabm.5c02113
28. Kavya KC, Dixit R, Jayakumar R, Nair SV, Chennazhi KP. Synthesis and characterization of chitosan/chondroitin sulfate/ nano-SiO2 composite scaffold for bone tissue engineering. Journal of biomedical nanotechnology. 2012;8(1):149-160. DOI: 10.1166/jbn.2012.1363
29. Pitrolino KA, Felfel R M, Pellizzeri LM, McLaren J, Popov AA, Sottile et al. Development and in vitro assessment of a bilayered chitosan-nano-hydroxyapatite osteochondral scaffold. Carbohydrate polymers. 2022;282:119126. DOI: 10.1016/j. carbpol.2022.119126
30. He X, Han Q, Zhang Y, Zhang H, Liu J, Zhou X. Effect of collagen-based scaffolds with hydroxyapatite on the repair of cartilage defects in the rabbit knee joint. Journal of Orthopaedic Surgery and Research. 2024;19(1):818. DOI: 10.1186/s13018024-05323-5
31. Kuo YC, Lin CY. Effect of genipin-crosslinked chitinchitosan scaffolds with hydroxyapatite modifications on the cultivation of bovine knee chondrocytes. Biotechnology and bioengineering. 2006;95(1):132-144. DOI:10.1002/bit.21007
32. Yu CC, Chang JJ, Lee YH, Lin YC, Wu MH, Yang MC, et al. Electrospun scaffolds composing of alginate, chitosan, collagen and hydroxyapatite for applying in bone tissue engineering. Materials Letters. matlet.2012.11.040 2013;93:133-136. DOI: 10.1016/j.
33. Sadeghianmaryan A, Naghieh S, Yazdanpanah Z, Sardroud HA, Sharma NK, Wilson LD, et al. Fabrication of chitosan/ alginate/hydroxyapatite hybrid scaffolds using 3D printing and impregnating techniques for potential cartilage regeneration. International Journal of Biological Macromolecules. 2022;204:62-75. DOI: 10.1016/j.ijbiomac.2022.01.201
34. Anh NTH, Trinh TP, Tan LV, Tho NTM, Van Cuong N. Facile synthesis of hydroxyapatite from bovine bone and gelatin/ chitosan-hydroxyapatite scaffold for potential tissue engineering application. Vietnam Journal of Chemistry. 2022;60(2):198-205. DOI: doi.org/10.1002/vjch.202100126
35. Mutlu TK, Özçınar BM, Köksal İ, Çakır R. Investigating the interaction of preosteoblast cells with poly-L lysine surfacemodified chitosan/hydroxyapatite scaffolds and their potential applications in bone tissue engineering. Process Biochemistry. 2025;157:33-41.
36. Oliveira JM, Rodrigues MT, Silva SS, Malafaya PB, Gomes ME, Viegas C et al. Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engineering applications: Scaffold design and its performance when seeded with goat bone marrow stromal cells. Biomaterials. 2006;27(36):6123-6137. DOI: 10.1016/j.biomaterials.2006.07.034
37. Han Q, Qiu M, Cui Y, Liu M. Preparation, microstructure and cytotoxicity research on hydroxyapatite/chitosan-chondroitin sulfate. Chem. Res. J. 2017;2(4):118-124.
38. Aminatun A, Handayani FD, Widiyanti P, Winarni D, Siswanto S. In vivo approach on femur bone regeneration of white rat (Rattus norvegicus) with the use of hydroxyapatite from cuttlefish bone (Sepia spp.) as bone filler. Veterinary World. 2019;12(6):809.
39. Tat SK, Pelletier JP, Vergés J, Lajeunesse D, Montell E, Fahmi, et al. Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study. Arthritis research & therapy. 2007; 9(6):R117. DOI:10.1186/ar2325
40. Henrotin Y, Mathy M, Sanchez C, Lambert C. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinical recommendations. Therapeutic advances in musculoskeletal disease. 10.1177/1759720X10383076 2010;2(6):335-348.
41. Clegg DO, Reda DJ, Harris CL, Klein M A, O'Dell J R, Hooper M M, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine. 2006;354(8):795-808. DOI:10.1056/ NEJMoa052771.
42. Sawitzke AD, Shi H, Finco MF, Dunlop DD, Bingham III CO, Harris, et al. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 2008;58(10):3183-3191. DOI: 10.1002/ art.23973
43. Jackson CG, Plaas AH, Sandy JD, Hua C, Kim-Rolands S, Barnhill, et al. The human pharmacokinetics of oral ingestion of glucosamine and chondroitin sulfate taken separately or in combination. Osteoarthritis and Cartilage. 2010;18(3):297-302. DOI: 10.1016/j.joca.2009.10.013
44. Мc Alindon TE, La Valley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. Jama. 2000;283(11):1469-1475.
45. Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster J Y. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive metaanalysis. Archives of internal medicine. 2003;163(13):15141522. DOI: 10.1001/archinte.163.13.1514 46. Towheed T E, Anastassiades T P. Glucosamine and chondroitin for treating symptoms of osteoarthritis: evidence is widely touted but incomplete. Jama. 2000;283(11):1483-1484. DOI: 10.1001/jama.283.11.1483
46. Towheed T E, Anastassiades T P. Glucosamine and chondroitin for treating symptoms of osteoarthritis: evidence is widely touted but incomplete. Jama. 2000;283(11):1483-1484. DOI: 10.1001/jama.283.11.1483

Ayrıntılar

Birincil Dil

Türkçe

Konular

Yardımcı Sağlık ve Rehabilitasyon Bilimi (Diğer)

Bölüm

Derleme

Yazarlar

Tuğçe Küçükali
Türkiye

Hande Erensoy
Türkiye

Serap Ayaz Seyhan
Türkiye

Dilek Bilgiç Alkaya ^*
Türkiye

Yayımlanma Tarihi

29 Temmuz 2026

Gönderilme Tarihi

30 Nisan 2026

Kabul Tarihi

17 Haziran 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 7 Sayı: 3

IZ

https://izlik.org/JA54SU47WG

APA

Küçükali, T., Erensoy, H., Ayaz Seyhan, S., & Bilgiç Alkaya, D. (2026). Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler. Yeni Yüzyıl Journal of Medical Sciences, 7(3), 93-105. https://izlik.org/JA54SU47WG

AMA

1.Küçükali T, Erensoy H, Ayaz Seyhan S, Bilgiç Alkaya D. Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler. JMS. 2026;7(3):93-105. https://izlik.org/JA54SU47WG

Chicago

Küçükali, Tuğçe, Hande Erensoy, Serap Ayaz Seyhan, ve Dilek Bilgiç Alkaya. 2026. “Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler”. Yeni Yüzyıl Journal of Medical Sciences 7 (3): 93-105. https://izlik.org/JA54SU47WG.

EndNote

Küçükali T, Erensoy H, Ayaz Seyhan S, Bilgiç Alkaya D (01 Temmuz 2026) Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler. Yeni Yüzyıl Journal of Medical Sciences 7 3 93–105.

IEEE

[1]T. Küçükali, H. Erensoy, S. Ayaz Seyhan, ve D. Bilgiç Alkaya, “Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler”, JMS, c. 7, sy 3, ss. 93–105, Tem. 2026, [çevrimiçi]. Erişim adresi: https://izlik.org/JA54SU47WG

ISNAD

Küçükali, Tuğçe - Erensoy, Hande - Ayaz Seyhan, Serap - Bilgiç Alkaya, Dilek. “Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler”. Yeni Yüzyıl Journal of Medical Sciences 7/3 (01 Temmuz 2026): 93-105. https://izlik.org/JA54SU47WG.

JAMA

1.Küçükali T, Erensoy H, Ayaz Seyhan S, Bilgiç Alkaya D. Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler. JMS. 2026;7:93–105.

MLA

Küçükali, Tuğçe, vd. “Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler”. Yeni Yüzyıl Journal of Medical Sciences, c. 7, sy 3, Temmuz 2026, ss. 93-105, https://izlik.org/JA54SU47WG.

Vancouver

1.Tuğçe Küçükali, Hande Erensoy, Serap Ayaz Seyhan, Dilek Bilgiç Alkaya. Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler. JMS [Internet]. 01 Temmuz 2026;7(3):93-105. Erişim adresi: https://izlik.org/JA54SU47WG

Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler

Hydroxyapatite–Glucosamine–Chondroitin Sulfate Composites: Current Trends in Bone Regeneration

Öz

Hidroksiapatit–Glukozamin–Kondroitin Sülfat Kompozitleri: Kemik Rejenerasyonunda Güncel Eğilimler

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

IZ

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