Sensörinöral İşitme Kaybında Gen Terapi Yaklaşımları

Yıl 2022, Cilt: 3 Sayı: 1, 22 - 33, 30.01.2022

Kübra Kelleci

Öz

İşitme kaybı, insanın sosyal ve bilişsel gelişimini ciddi şekilde
etkileyen dünya genelinde görülen en yaygın halk sağlık
problemlerinden biridir. İleri derece işitme kaybı ile karakterize
edilen sensörinöral işitme kaybı (SNİK), yetişkinlerde çok sık
görülmesine karşın tedavi yöntemleri harici işitme cihazı ve
koklear implant kullanımı ile sınırlıdır.
Moleküler genetik alanında meydana gelen gelişmeler, gen
düzenleme, gen susturma ve gen replasmanı gibi yöntemler
sayesinde özellikle iç kulak saç hücre rejenerasyonu
araştırmalarında büyük bir atılım yaparak, işitme ile ilgili
hastalıkların önlenmesinde ve tedavisinde yeni ve etkili bir
yol sağlamıştır. Bu çalışmada, genetik, ototoksisite, gürültü ve
yaşlılığa bağlı sensörinöral işitme kaybı yaşayan bireylerde,
işitme kaybını ortadan kaldırmak amacıyla araştırılan gen terapi
yaklaşımları derlenmiştir.

Anahtar Kelimeler

Gen terapi, İç kulak, İşitme kaybı

Kaynakça

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