Araştırma Makalesi
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Clinical and Histopathological Findings in Elderly Breast Cancer Patients: Single Center Results

Yıl 2022, Cilt: 3 Sayı: 3, 188 - 194, 30.07.2022

Öz

Aim: In the literature, there are clinical and histopathological differences in elderly breast cancer patients compared to younger patients. In our
study, we compared elderly breast cancer patients treated in our hospital
with younger patients in terms of clinical and histopathological features.
Material and Methods: In our study, the results of breast cancer patients
treated between 01.01.2018 and 31.07.2021, Sancaktepe Martyr Prof.
Dr. İlhan Varank Training and Research Hospital was evaluated retrospectively after the approval of the Ethics Committee dated 27/10/2021
and numbered 2021-1999. The clinical features, histopathological findings and surgical treatment methods of the patients were evaluated
from their personal files. The patients were evaluated by dividing them
into young and old patient groups, and 65 years was determined as the
threshold value for the separation of young and old patients.
Results: 142 female breast cancer patients were included in our study,
103 (72.53%) were younger than 65 years old and 39 (27.47%) were
older than 65 years old. The presence of co-morbid disease was significantly higher in the elderly patient group than in the younger patient
group (p=0.0001). It was observed that the diagnosis of breast cancer
was mostly made with clinical findings in both young and old patient
groups, routine breast screening remained in the background, and large
tumor size and lymph node positivity were encountered in both groups.
ER and PR receptor positive, luminal type A, grade II and III tumors
and invasive ductal carcinomas with Ki 67 >15% were detected in elderly patients. Compared to the younger patients in our study, papillary
carcinoma was significantly more common in elderly patients.
Among the surgical treatments applied to elderly patients, axillary sentinel lymph node sampling and breast-conserving surgical treatment
techniques were observed most frequently. Discussion and Conclusion: We believe that the importance of breast
cancer screening programs for young and old women should be increased and treatment protocols for older breast cancer patients should
be determined by taking into account geriatric risks

Kaynakça

  • 1. Wedding U, Höffken K. Care of breast cancer in the elderly woman--what does comprehensive geriatric assessment (CGA) help? Support Care Cancer. 2003;11(12):769-74.
  • 2. Özmen V. Breast Cancer in Turkey: Clinical and Histopathological Characteristics (Analysis of 13.240 Patients). J Breast Health. 2014;10(2):98-105.
  • 3. Plichta JK, Thomas SM, Vernon R, Fayanju OM, Rosenberger LH, Hyslop T, et al. Breast cancer tumor histopathology, stage at presentation, and treatment in the extremes of age. Breast Cancer Res Treat. 2020;180(1):227-35.
  • 4. Spazzapan S, Crivellari D, Bedard P, Lombardi D, Miolo G, Scalone S, et al. Therapeutic management of breast cancer in the elderly. Expert Opin Pharmacother. 2011;12(6):945-60.
  • 5. Baban CK, Devane L, Geraghty J. Change of paradigm in treating elderly with breast cancer: are we undertreating elderly patients? Ir J Med Sci. 2019;188(2):379-88.
  • 6. Biganzoli L, Goldhirsch A, Straehle C, Castiglione-Gertsch M, Therasse P, Aapro M, et al. Adjuvant chemotherapy in elderly patients with breast cancer: a survey of the Breast International Group (BIG). Ann Oncol. 2004;15(2):207-10.
  • 7. Varghese F, Wong J. Breast Cancer in the Elderly. Surg Clin North Am. 2018;98(4):819-33.
  • 8. Lodi M, Scheer L, Reix N, Heitz D, Carin AJ, Thiébaut N, et al. Breast cancer in elderly women and altered clinico-pathological characteristics: a systematic review. Breast Cancer Res Treat. 2017;166(3):657-68.
  • 9. Marchal C, Spaeth D, Verhaeghe JL, Depardieu C, Netter E, Luporsi E, et al. [Diagnostic and therapeutic characteristics of breast cancer in elderly women. Groupe Sein du Centre Alexis Vautrin]. Presse Med. 1996;25(34):1636-42.
  • 10. Yancik R, Ries LA. Cancer in older persons: an international issue in an aging world. Semin Oncol. 2004;31(2):128-36.
  • 11. Cabrera-Galeana P, Soto-Perez-de-Celis E, Reynoso-Noverón N, Villarreal-Garza C, Arce-Salinas C, Matus-Santos J, et al. Clinical characteristics and outcomes of older women with breast cancer in Mexico. J Geriatr Oncol. 2018;9(6):620-5.
  • 12. Blanks RG, Moss SM, McGahan CE, Quinn MJ, Babb PJ. Effect of NHS breast screening programme on mortality from breast cancer in England and Wales, 1990-8: comparison of observed with predicted mortality. Bmj. 2000;321(7262):665-9.
  • 13. Raffin E, Onega T, Bynum J, Austin A, Carmichael D, Bronner K, et al. Are there regional tendencies toward controversial screening practices? A study of prostate and breast cancer screening in a Medicare population. Cancer Epidemiol. 2017;50(Pt A):68-75.
  • 14. Rao VS, Jameel JK, Mahapatra TK, McManus PL, Fox JN, Drew PJ. Surgery is associated with lower morbidity and longer survival in elderly breast cancer patients over 80. Breast J. 2007;13(4):368-73.
  • 15. van de Water W, Markopoulos C, van de Velde CJ, Seynaeve C, Hasenburg A, Rea D, et al. Association between age at diagnosis and disease-specific mortality among postmenopausal women with hormone receptor-positive breast cancer. Jama. 2012;307(6):590-7.
  • 16. Altobelli E, Rapacchietta L, Angeletti PM, Barbante L, Profeta FV, Fagnano R. Breast Cancer Screening Programmes across the WHO European Region: Differences among Countries Based on National Income Level. Int J Environ Res Public Health. 2017;14(4).
  • 17. Richards P, Ward S, Morgan J, Lagord C, Reed M, Collins K, et al. The use of surgery in the treatment of ER+ early stage breast cancer in England: Variation by time, age and patient characteristics. Eur J Surg Oncol. 2016;42(4):489-96.
  • 18. Esserman LJ. The WISDOM Study: breaking the deadlock in the breast cancer screening debate. NPJ Breast Cancer. 2017;3:34.
  • 19. Ihemelandu CU, Leffall LD, Jr., Dewitty RL, Naab TJ, Mezghebe HM, Makambi KH, et al. Molecular breast cancer subtypes in premenopausal and postmenopausal African-American women: age-specific prevalence and survival. J Surg Res. 2007;143(1):109-18.
  • 20. Kim SJ, Park YM. Breast cancer in elderly Korean women: clinicopathological and biological features. Breast Dis. 2020;39(2):71-83.
  • 21. Albrand G, Terret C. Early breast cancer in the elderly: assessment and management considerations. Drugs Aging. 2008;25(1):35-45.
  • 22. Lavelle K, Todd C, Moran A, Howell A, Bundred N, Campbell M. Non-standard management of breast cancer increases with age in the UK: a population based cohort of women > or =65 years. Br J Cancer. 2007;96(8):1197-203.
Yıl 2022, Cilt: 3 Sayı: 3, 188 - 194, 30.07.2022

Öz

Kaynakça

  • 1. Wedding U, Höffken K. Care of breast cancer in the elderly woman--what does comprehensive geriatric assessment (CGA) help? Support Care Cancer. 2003;11(12):769-74.
  • 2. Özmen V. Breast Cancer in Turkey: Clinical and Histopathological Characteristics (Analysis of 13.240 Patients). J Breast Health. 2014;10(2):98-105.
  • 3. Plichta JK, Thomas SM, Vernon R, Fayanju OM, Rosenberger LH, Hyslop T, et al. Breast cancer tumor histopathology, stage at presentation, and treatment in the extremes of age. Breast Cancer Res Treat. 2020;180(1):227-35.
  • 4. Spazzapan S, Crivellari D, Bedard P, Lombardi D, Miolo G, Scalone S, et al. Therapeutic management of breast cancer in the elderly. Expert Opin Pharmacother. 2011;12(6):945-60.
  • 5. Baban CK, Devane L, Geraghty J. Change of paradigm in treating elderly with breast cancer: are we undertreating elderly patients? Ir J Med Sci. 2019;188(2):379-88.
  • 6. Biganzoli L, Goldhirsch A, Straehle C, Castiglione-Gertsch M, Therasse P, Aapro M, et al. Adjuvant chemotherapy in elderly patients with breast cancer: a survey of the Breast International Group (BIG). Ann Oncol. 2004;15(2):207-10.
  • 7. Varghese F, Wong J. Breast Cancer in the Elderly. Surg Clin North Am. 2018;98(4):819-33.
  • 8. Lodi M, Scheer L, Reix N, Heitz D, Carin AJ, Thiébaut N, et al. Breast cancer in elderly women and altered clinico-pathological characteristics: a systematic review. Breast Cancer Res Treat. 2017;166(3):657-68.
  • 9. Marchal C, Spaeth D, Verhaeghe JL, Depardieu C, Netter E, Luporsi E, et al. [Diagnostic and therapeutic characteristics of breast cancer in elderly women. Groupe Sein du Centre Alexis Vautrin]. Presse Med. 1996;25(34):1636-42.
  • 10. Yancik R, Ries LA. Cancer in older persons: an international issue in an aging world. Semin Oncol. 2004;31(2):128-36.
  • 11. Cabrera-Galeana P, Soto-Perez-de-Celis E, Reynoso-Noverón N, Villarreal-Garza C, Arce-Salinas C, Matus-Santos J, et al. Clinical characteristics and outcomes of older women with breast cancer in Mexico. J Geriatr Oncol. 2018;9(6):620-5.
  • 12. Blanks RG, Moss SM, McGahan CE, Quinn MJ, Babb PJ. Effect of NHS breast screening programme on mortality from breast cancer in England and Wales, 1990-8: comparison of observed with predicted mortality. Bmj. 2000;321(7262):665-9.
  • 13. Raffin E, Onega T, Bynum J, Austin A, Carmichael D, Bronner K, et al. Are there regional tendencies toward controversial screening practices? A study of prostate and breast cancer screening in a Medicare population. Cancer Epidemiol. 2017;50(Pt A):68-75.
  • 14. Rao VS, Jameel JK, Mahapatra TK, McManus PL, Fox JN, Drew PJ. Surgery is associated with lower morbidity and longer survival in elderly breast cancer patients over 80. Breast J. 2007;13(4):368-73.
  • 15. van de Water W, Markopoulos C, van de Velde CJ, Seynaeve C, Hasenburg A, Rea D, et al. Association between age at diagnosis and disease-specific mortality among postmenopausal women with hormone receptor-positive breast cancer. Jama. 2012;307(6):590-7.
  • 16. Altobelli E, Rapacchietta L, Angeletti PM, Barbante L, Profeta FV, Fagnano R. Breast Cancer Screening Programmes across the WHO European Region: Differences among Countries Based on National Income Level. Int J Environ Res Public Health. 2017;14(4).
  • 17. Richards P, Ward S, Morgan J, Lagord C, Reed M, Collins K, et al. The use of surgery in the treatment of ER+ early stage breast cancer in England: Variation by time, age and patient characteristics. Eur J Surg Oncol. 2016;42(4):489-96.
  • 18. Esserman LJ. The WISDOM Study: breaking the deadlock in the breast cancer screening debate. NPJ Breast Cancer. 2017;3:34.
  • 19. Ihemelandu CU, Leffall LD, Jr., Dewitty RL, Naab TJ, Mezghebe HM, Makambi KH, et al. Molecular breast cancer subtypes in premenopausal and postmenopausal African-American women: age-specific prevalence and survival. J Surg Res. 2007;143(1):109-18.
  • 20. Kim SJ, Park YM. Breast cancer in elderly Korean women: clinicopathological and biological features. Breast Dis. 2020;39(2):71-83.
  • 21. Albrand G, Terret C. Early breast cancer in the elderly: assessment and management considerations. Drugs Aging. 2008;25(1):35-45.
  • 22. Lavelle K, Todd C, Moran A, Howell A, Bundred N, Campbell M. Non-standard management of breast cancer increases with age in the UK: a population based cohort of women > or =65 years. Br J Cancer. 2007;96(8):1197-203.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Hizmetleri ve Sistemleri (Diğer)
Bölüm Araştırma Makaleleri
Yazarlar

Elbrus Zarbaliyev 0000-0002-4595-8314

Yayımlanma Tarihi 30 Temmuz 2022
Gönderilme Tarihi 6 Mayıs 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 3 Sayı: 3

Kaynak Göster

AMA Zarbaliyev E. Clinical and Histopathological Findings in Elderly Breast Cancer Patients: Single Center Results. JMS. Temmuz 2022;3(3):188-194.