Kanser İlişkili Yeni Hedef Molekül SLAMF7

Yıl 2024, Cilt: 5 Sayı: 1, 1 - 7, 30.01.2024

Seda Bulut İlhan Yaylım

Öz

Kanser hücre için kontrolsüz büyüme getirisi sağlayan, geniş bir çeşitlilik ve karmaşık süreçlerle karakterize edilir.
Hastalığın erken teşhisi, prognozun iyileştirilmesi, sağkalım süresinin ve tedavi şansının artırılması gibi hedeflere
ulaşmak için bu karmaşık süreçlerin aydınlatılması gerekmektedir. Bu nedenle kanserin, nasıl ve neden başladığını,
metastazın ve nüksün nasıl oluştuğunu anlamak önemlidir. Biyobelirteçler, kanser hücrelerinin varlığını, türünü
ve agresifliğini belirlemekte ve kişiye özel, hedefe yönelik
tedavi ajanlarının seçilmesinde yardımcı olmaktadır.
Sinyalleme lenfositik aktivasyon molekülü aile üyesi 7
(SLAMF7 [CD319, CS1, CRACC]), çok çeşitli hücre tiplerinde bulunan bir yüzey glikoproteini olup, farklı kanser türlerinde ekspresyon göstermektedir. Bu ekspresyonun hastalığın seyri ve tedavi yanıtları ile ilişkili olduğu
düşünülmektedir. SLAMF7’nin immün hücrelerle olan
etkileşimleri, kanser hücrelerinin büyümesi, yayılması ve
hayatta kalmasıyla ilişkilidir. Ayrıca, SLAMF7’nin kanser
mekanizmasındaki rolü, hedefe yönelik tedavi stratejilerinin geliştirilmesi için daha iyi anlaşılmalıdır.
Bu derleme, SLAMF7’nin özelliklerini detaylı bir şekilde
ele alırken, kanser biyolojisi ve tedavisindeki potansiyel
önemini vurgulamakta ve bu alanda gelecekte yapılacak
araştırmalar için bir temel oluşturmaktadır.

Anahtar Kelimeler

: SLAMF7, CS1, CRACC, SLAM ailesi, kanser

Kaynakça

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