Hipoksi-İndüklenebilir Faktör-1 Alfa’nın Doğası ve İnsan Biyolojisindeki Rolü

Yıl 2024, Cilt: 5 Sayı: 2, 48 - 55, 30.04.2024

Nurettin Onur Kutlu , İlhan Yaylım

Öz

Hypoxia-Inducible Factor-1 alpha, oksijen seviyelerine karşı hücresel yanıtta merkezi bir rol oynayan kritik bir transkripsiyon faktörüdür. HIF-1α, ökaryotlar ve tüm omurgalı/
omurgasız canlıların tümünde oksijensiz ortamda hücresel
düzeyde adaptasyon sağlanmasında görevlidir. On beş kromozomda yüzden fazla gene bağlanma noktaları olduğu belirlenmiştir. Metabolizma, anjiyogenez, hematopoez, epitel
hücrelerinin çoğalması ve göçü, eritropoez, bağışıklık, inflamasyon, kanser, epigenetik düzenlenme, apoptosis ve otofajide kritik bir rol oynar. Bu derlemede, HIF-1α'nın yapısı,
düzenlenmesi ile hipoksi, yangı, yaralanma, iskemi ve kanser
gibi patolojik süreçlerle olan etkileşimlerini son bilimsel gelişmeler ışığında sunmayı amaçlıyoruz.

Anahtar Kelimeler

HIF-1 alfa, hipoksi, anjiogenez, metabolizma, yangı, kanser, iskemi

Kaynakça

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