The role of lymphatic system on actioıı mechanism of early type allergic reactions

Yıl 2001, Cilt: 7 Sayı: 1-2, 32 - 36, 01.06.2001

Hakani Sabiroğlu Orhan Yılmaz Asmagül Sabiroğlu

Öz

The examination of the roles of some biological active substances in early type allergic reactions was aimed in this study. 24 dogs were used as experimental animals. Levels of histamine, serotonin, bradykinin, kallikrein, kininogen and kininase were measured in blood and lymph samples collected at times before and after sensitization; and at times before and after 5th, 30th, 60th, 180th minutes of anaphylactic shock. İt was found that histamine and serotonine levels in the blood and lymph increased at the 5th minute of anaphylactic shock; but the maximum changes in the components of Kallikrein-Kinin System were detected at the 30th minute. The levels of biological amines in the lymph of dogs with anaphylactic shock were higher than which of in the blood. It was concluded that lymphatic system was very important for determining early type allergic reactions

Anahtar Kelimeler

Anaphylactic shock, Serotonin, Histamine, Kallikrein-kinin.

Erken tip alerjik reaksiyonların etki mekanizmasında lenfatik sistemin rolü

Öz

Erken tip alerjik reaksiyonlarda bazı biyolojik aktif maddelerin rolünün incelenmesinin amaçlandığı bu çalışmada, deney hayvanı olarak 24 adet köpek kullanılmıştır.Sensibilizasyondan önce ve sonra, anaflaktik şoktan önce ve sonraki 5., 30.. 60, ve 180. dakikalarda alman kan ve lenf örneklerinde histamin, serotonin, bradikinin. kallikrein, kininojen ve kininaz düzeyleri ölçülmüştür. Kan ve lenfteki histamin ve serotonin düzeyi anaflaktik şokun 5. dakikasında yükseliş göstermiş; Kallikrein-Kinin Sistemi komponentlerindeki maksimum değişiklik ise ilk 30 dakikada saptanmıştır. Köpeklerdeki anaflaktik şok durumunda biyolojik aminler, kana oranla lenfte daha yüksek bulunmuştur. Erken tip allerjik reaksiyonların saptanmasında lenfatik sistemin çok önemli olduğu sonucuna varılmıştır

Anahtar Kelimeler

Anaflaktik şok, Serotonin, Histamin, Kallikrein-kinin

Kaynakça

• Howell WM: Hla İmmunogenetics and specifıc İgE responses to allergens, Clin Exp Allergy 24: 401-404, (1994).
• Aydın N: Aşırı duyarlılık Reaksiyonları (hipersensitivite). M Arda, A Minbay, N Aydın, Ö Akay, M îzgür ve S Diker (eds) : İmmünoloji, Medisan Yayınevi, Ankara, (1994).
• Kelly KJ, Kurup V, Zacharisen et al: Skin and serologic testing in the diagnosis of latex allergy, J Allergy Clin İmmunol 91: 1140- 1145,(1993).
• Vignola AM, Campbell AM, Chanez P et al: Activation by histamine of bronshial epitelial cells fıom normal subjects, Am J Resp Celi Mol Biol 9: 411-417, (1993).
• Certner J, DeWeck A: Atlas of Immuno-allergology , Horefe- Huber Publications, (1995).
• Arm PJ: Chemical mediators.Leukotriens and eicosanoids. Bıonchial asthma. Weiss Earl B.Stein Myron, (1985).
• Goldberg DM, Spooner RJ: Metods of Enzymatic Analysis, pp.258-265, (1983).
• Boıish L: Cytokines and Allergy, Mosby-Year book, (1991).
• Blıoola KD: Kallikrein, kinins, cytokines. S African J Sci 93: 57- 58, (1997).
• Frank MM: Complement and Kinin, Lange Medical Book, (1991).
• Stephen C: Interferons and cytokines, Colwood House Medical Publications, U.K, (1992).
• Kayaalp SO: Rasyonel Tedavi Yönünden Tıbbi Farmakoloji II. Cilt, 9.baskı, Hacettepe-Taş Kitapçılık Ltd. Şti. Ankara, (2000).
• Isaac M: Where are we going with SSRis. European Neuropsychopharmacology 3: 101-106,(1999).
• Proud D, Togias A, Naclerio RM, et al.: Kinins are geneıated in vivo follovving nasal airway challenge of allergic individuals with allergen. J Clin İnvest 72: 1678-1675, (1989).