Ketozisli ineklerde glikoz ve dekzametazonun tiroit hormon düzeylerine olası etkilerinin araştırılması

Yıl 2007, Cilt: 10 Sayı: 1-2, 10 - 17, 15.06.2007

M. Taner Ura Burhanettin Baydaş

Öz

Bu çalışmada, klinik ketozis saptanan ineklerde glikoz ve dekzametazon ile tedavinin tiroit hormonlarının periferik metabolizmalarına olası etkileri araştırıldı. Çalışmada kontrol grubu için sağlıklı ve deney gruplan için ise klinik ketozis tespit edilen Holstain ırkı inekler kullanıldı. Deney grubu inekler, tedavi öncesi, glikoz verilen glikoz grubu ve glikozla birlikte dekzametazon verilen dekzametazon grubu olmak üzere üç grup halinde değerlendirildi. Tüm ineklerin vena jugularislerinden plastik tüplere 5’er mİ kan alındı. Pıhtılaştıktan sonra serumlan çıkanldı ve analizler yapılıncaya kadar derin dondurucuda muhafaza edildi. Tiroit hormonlanndan T4, T3 ve rT3 RİA metoduyla, serbest T4 ve T3 ise immunoassay yöntemiyle saptandı. Analizler sonucunda T4 değerleri açısından gruplar arasında anlamlı bir fark bulunmadı P>0.05 . Kontrol ve tedavi öncesi gruplarında sırasıyla T3 değerleri 178,7 ± 22,5 ve 116,8 ± 23,54 ng/dl olarak tespit edildi ve aradaki fark istatistiksel olarak anlamlı bulundu P

Anahtar Kelimeler

Ketozis, tiroit hormonlan, kortizon, glikoz, sığır

Investigation of likely effects of glucose and dexamethasone on thyroid hormone levels in cows with clinic ketosis

Öz

This study was carried out to determine the likely effect of glucose and dexamethasone on peripheral metabolism of thyroid hormone in ketotic cows. In the study, healthy cows Holstain were used for control and ketotic ones for experiment groups. The ketotic cows were divided into three groups; pretreatment, treatment with glucose glucose group and treatment with glucose plus dexamethasone Dexamethason group . Blood samples were taken from ali cows by venipuncture, and extracted serum samples were deep-frozen and stored at -20 degrees C until the analyses were performed. Serum thyroxine T4 , triiodothyronine T3 and reverse triiodothyronine rT3 levels were measured by RÎA, and free T4 and T3 by enzyme immuonoassay using DPC commerical Kits. Thyroxine variation were not found to be statistically significant between the groups P>0.05 . In the control and pretreatment group T3 levels were determined 178,7 ± 22,5 and 116,8 ± 23,54 ng/dl respectively, and variations between these two groups were observed to be significant P

Anahtar Kelimeler

Ketosis, thyroid hormones, cortisol, glucose, cattle

Kaynakça

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