Exploring the Potential of Furofuran Lignans Isolated from Beilschmiedia pulverulenta for Drug Development: A Computational Approach

Year 2023, Volume: 33 Issue: 3, 491 - 502, 30.09.2023

Abubakar Siddiq Salihu Wan Mohd Nuzul Hakimi Wan Salleh

https://doi.org/10.29133/yyutbd.1294240

Cited By: 1

https://izlik.org/JA26TU53DN

Abstract

Natural products have played a significant role in drug discovery and continue to be an important source of lead for new drugs. In recent years, computer-based drug discovery methods have emerged as an effective approach for identifying small molecule leads with desirable pharmacokinetic and toxicity profiles. This study investigated the pharmacological and bioactivity of five furofuran lignans, namely, epiexcelsin, sesamin, sesartemin, syringaresinol, and yangambin, isolated from the plant Beilschmiedia pulverulenta. In silico studies were conducted to predict the pharmacological activities, toxicity, and drug likeliness properties of the lead compounds. The results showed that all compounds had promising pharmacokinetic activities, with epiexcelsin exhibiting strong binding affinity (-8.13 kcal mol-1) and inhibitory activity (1.1 µM) against estrogen receptor-α, and predicted to be bioavailable and effective lead. The findings of this study provide important insights into the potential therapeutic uses of natural medicinal plants and emphasize the potential of combining traditional medicinal knowledge with modern scientific approaches in drug discovery. Overall, the furofuran lignans isolated from Beilschmiedia pulverulenta represent a promising source of natural compounds for the development of effective drugs.

Keywords

Beilschmiedia pulverulenta , Estrogen receptor-α , furofuran lignans , Sesamin , Syringaresinol

Supporting Institution

Fundamental University Research Grant (GPUF2022)

Project Number

2022-0130-102-01

Thanks

The authors also would like to thank the Department of Chemistry, Faculty of Science and Mathematics, UPSI for research facilities.

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