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Ağır Metallerin Üreme Sistemi Üzerine Etkileri

Yıl 2013, Cilt: 24 Sayı: 2, 91 - 94, 01.06.2013

Orhan Yılmaz Hikmet Dinç

Öz

The reproductive system is sensitive to chemical pollutants that are widely distributed in the environment. Industrialization is an important factor responsible for boom in the environmental pollution in last four decades. Exposure to some heavy metals has been associated to a huge variety of adverse effects including infertility. The effects of heavy metals on reproductive system have become great health problem. Hence, the aim of this review is to highlight the effects of some metals on reproductive system.

Anahtar Kelimeler

Heavy metal Reproductive system Infertility

Kaynakça

  • Arabi M, Heydarnejad MS (2007). In vitro mercury exposure on spermatozoa from normospermic individuals. Pakistan J Biol Sci, 10, 2448-2453.
  • Ashiru OA, Odusanya OO (2009). Fertility and occupational hazards: review of the literature. African J Reprod Health, 13, 159-165.
  • Bonde JP, Kolstad H (1997). Fertility of Danish battery workers exposed to lead. Int J Epidemiol, 26, 1281-1288.
  • Bonde JP (2010). Male reproductive organs a re at risk from environmental hazards. Asian J Androl, 12, 152-156.
  • Boujbiha MAM, Hamden K, Guermazi F, Bouslama A, Omezzine A, El Feki A (2011). Impairment of spermatogenesis in rats by mercuric chloride: involvement of low 17β-estradiol level in induction of acute oxidative stress. Biol Trace Elem Res, 142, 598-610.
  • Bu TL, Mi YL, Zeng WD, Zhang CQ (2011). Protective effects of quercetin on cadmium induced oxidative toxicity on germ cells in male mice. Anat Rec Adv Integ Anat Evol Biol, 294, 520-526.
  • Castellini C, Mourvaki E, Sartini B, Cardinali R, Moretti E, Collodel G, et al. (2009). In vitro toxic effects of metal compounds on kinetic traits and ultrastructure of rabbit spermatozoa. Reprod Toxicol, 27, 46-54.
  • Çevik M, Tuncer PB (2005). Evcil hayvanlarda seminal plazmanın fiziko- kimyasal yapısı ve üreme fonksiyonları üzerindeki etkileri. Lalahan Hay Arş Ens Derg, 45, 63-72.
  • Dorostghoal M, Dezfoolian A, Sorooshnia F (2011). Effects of maternal lead acetate exposure during lactation on postnatal development of testis in offspring wistar rats. Iranian J Basic Med Sci, 14, 122-131.
  • Dökmeci I (2001). Toksikoloji, Zehirlenmelerde Tanı ve Tedavi. 3. Baskı, Nobel Tıp Kitabevleri, İstanbul.
  • Elbetieha A, Al-Thani AS, Al-Thani RK, Darmani H, Owais W (2008). Effects of chronic exposure to cobalt chloride on the fertility and testes in mice. J App Biol Sci, 2, 01-06.
  • Ema M, Kobayashi N, Naya M, Hanai S, Nakanishi J (2010). Reproductive and developmental toxicity studies of manufactured nanomaterials. Reprod Toxicol, 30, 343-352.
  • Fortoul TI, Bizarro-Nevares P, Acevedo-Nava S, Pinon-Zarate G, Rodriguez-Lara V, Colin-Baranque L, et al. (2007). Ultrastructual findings in murine seminiferous tubules as a consequence of subchronic vanadium pentoxide inhalation. Reprod Toxicol, 23, 588- 592.
  • Giaccio L, Cicchella D, De Vivo B, Lombardi G, De Rosa M (2012). Does heavy metals pollution affects semen quality in men? A case of study in the metropolitan area of Naples (Italy). J Geo Exp, 112, 218-225.
  • Hallinger KK, Cristol DA (2011). The role of weather in mediating the effect of mercury exposure on reproductive success in tree swallows. Ecotoxicol, 20, 1368-1377.
  • Hamlin HJ, Guilette LJ (2010). Birth defects in wildlife: The role of environmental contaminants as inducers of reproductive and developmental dysfunction. Sys Biol Reprod Med, 56, 113-121.
  • Hovatta O, Venalainen ER, Kuusimaki L, Heikkila J, Reima I (1998). Aluminium, lead and cadmium concentrations in seminal plasma and spermatozoa, and semen quality in Finnish men. Human Reprod, 13, 115-119.
  • Huang YL, Tseng WC, Lin TH (2001). In vitro effects of metal ions (Fe 2+ , Mn 2+ , Pb 2+ ) on sperm motility and lipid peroxidation in human semen. J Toxicol Environ Health, Part A, 62, 259-267.
  • Jurasovic J, Cvitkovic P, Pizent A, Colak B, Telisman S (2004). Semen quality and reproductive endocrine function with regard to blood cadmium in Croatian male subjects. Biometals, 17, 735-743.
  • Kaya S, Pirinççi İ, Bilgili A (1998). Veteriner Hekimliğinde Toksikoloji, Medisan, Ankara.
  • Kayhan FE, Muşlu MN, Koç ND (2009). Bazı ağır metallerin sucul organizmalar üzerinde yarattığı stres ve biyolojik yanıtlar. J Fisheries Sci, 3, 153-162.
  • Kumar S (2008). Is environmental exposure associated with reproductive health impairments? J Turkish-German Gynecol Assoc, 9, 60-69.
  • Küçükeşmen Ç (2007). Dental amalgamın insan organizması üzerindeki etkileri. SDÜ Tıp Fak Derg, 14, 52-61.
  • Lavranos G, Balla M, Tzortzopoulou A, Syriou V, Angelopoulou R (2012). Investigating ROS sources in male infertility: a common end for numerous pathways. Reprod Toxicol, 34, 298-307.
  • Mathur N, Pandey G, Jain GC (2010). Male reproductive toxicity of some selected metals: A review. J Biol Sci, 10, 396-404.
  • Meeker JD, Rossano MG, Protas B, Diamaond MP, Puscheck E, Daly D, et al. (2008). Cadmium, lead and other metals in relation to semen quality: human evidence for molybdenum as a male reproductive toxicant. Environ Health Perspect, 116, 1473-1479.
  • Mendiola J, Moreno JM, Roca M, Vergara-Juarez N, Martinez-Garcia MJ, Garcia-Sanchez A, et al. (2011). Relationships between heavy metal concentrations in three different body fluids and male reproductive parameters: a pilot study. Environ Health,10 (6), 1-7.
  • Monsees TK. Franz M, Gebhardt S, Winterstein U, Hayatpour J (2000). Sertoli cells as a target for reproductive hazards. Androl, 32, 239-246.
  • Morgan AM, El-Tawil OS (2003). Effects of ammonium metavanadate on fertility and reproductive performance of adult male and female rats. Pharmacol Res, 47, 75-85.
  • Nava-Hernandez MP, Hauad-Marroquin LA, Bassol-Mayagoitia S, Garcia-Arenas G, Mercado-Hernandez R, Echavarri-Guzman M et al. (2009). Lead-, cadmium-, and arsenic-induced DNA damage in rat germinal cells. DNA Cell Biol, 28, 241-248.
  • Paksy K, Varga B, Lazar P (1996). Zinc protection against cadmiuminduced infertility in female rats. Effect of zinc and cadmium on the progesterone production of cultured granulosa cells. BioMetals, 10, 27
  • Pizent A, Tariba B, Zivkovic T (2012). Reproductive toxicity of metals in men. Arh Hig Rada Toksikol, 63, Supplement 1, 35-46.
  • Scheuhammer AM (1987). The chronic toxicity of aluminium, cadmium, mercury and lead in birds: A review. Environ Pollut, 46, 263-295.
  • Şener S, Yıldırım M (2000). Veteriner Toksikoloji. Teknik Yayıncılık, İstanbul.
  • Thaxton JP, Parkhurt CR (1973). Abnormal mating behavior and reproductive dysfunction caused by mercury in Japanese quail. Proc Soc Exper Biol Med, 144, 252-255.
  • Tiwari AK, Pragya P, Ram KR, Chowdhuri DK (2011). Environmental chemical mediated male reproductive toxicity: Drosophila melanogaster as an alternate animal model. Theriogenelogy, 76. 1972
  • Yılmaz O (1995). Bursa yöresinden sağlanan insan karaciğer ve böbreklerinde ağır metal kalıntı düzeyleri : I. Cıva. YYU Sağ Bil Enst Derg. 1, 6-11.
  • Yılmaz O (2002). Cadmium and lead levels in human liver and kidney samples obtained from Bursa Province. Int J Environ Health Res, 12, 181-18
  • Westermark T (1975). Mercury content of bird feathers before and after Swedish Ban on alkyl mercury in agriculture. Ambio, 4, 87-92.
  • Wirth JJ, Rossano MG, Daly DC, Paneth N, Puscheck E, Potter RC, Diamond MP (2007). Ambient manganese exposure is negatively associated with human sperm motility and concentration. Epidemiol, 18, 270-273.
  • Wirth JJ, Mijal RS (2010). Adverse effects of low level heavy metal exposure on male reproductive function. Sys Biol Reprod Med, 56, 14716

Ağır Metallerin Üreme Sistemi Üzerine Etkileri

Yıl 2013, Cilt: 24 Sayı: 2, 91 - 94, 01.06.2013

Orhan Yılmaz Hikmet Dinç

Öz

Üreme sistemi, çevreye yayılan kimyasal kirleticiler karşı duyarlıdır. Endüstrileşme, son kırk yılda çevre kirliliğinin artmasından sorumlu önemli bir etkendir. Bazı ağır metallere maruz kalma, infertilite de dahil çok farklı istenmeyen etkilere yol açar. Ağır metallerin üreme sistemi üzerine olan etkileri büyük sağlık sorunu haline gelmiştir. Bu nedenle bu derlemenin amacı, üreme sistemi üzerine bazı metallerin etkilerine dikkat çekmektir.

Anahtar Kelimeler

Ağır metal Üreme sistemi Kısırlık

Kaynakça

  • Arabi M, Heydarnejad MS (2007). In vitro mercury exposure on spermatozoa from normospermic individuals. Pakistan J Biol Sci, 10, 2448-2453.
  • Ashiru OA, Odusanya OO (2009). Fertility and occupational hazards: review of the literature. African J Reprod Health, 13, 159-165.
  • Bonde JP, Kolstad H (1997). Fertility of Danish battery workers exposed to lead. Int J Epidemiol, 26, 1281-1288.
  • Bonde JP (2010). Male reproductive organs a re at risk from environmental hazards. Asian J Androl, 12, 152-156.
  • Boujbiha MAM, Hamden K, Guermazi F, Bouslama A, Omezzine A, El Feki A (2011). Impairment of spermatogenesis in rats by mercuric chloride: involvement of low 17β-estradiol level in induction of acute oxidative stress. Biol Trace Elem Res, 142, 598-610.
  • Bu TL, Mi YL, Zeng WD, Zhang CQ (2011). Protective effects of quercetin on cadmium induced oxidative toxicity on germ cells in male mice. Anat Rec Adv Integ Anat Evol Biol, 294, 520-526.
  • Castellini C, Mourvaki E, Sartini B, Cardinali R, Moretti E, Collodel G, et al. (2009). In vitro toxic effects of metal compounds on kinetic traits and ultrastructure of rabbit spermatozoa. Reprod Toxicol, 27, 46-54.
  • Çevik M, Tuncer PB (2005). Evcil hayvanlarda seminal plazmanın fiziko- kimyasal yapısı ve üreme fonksiyonları üzerindeki etkileri. Lalahan Hay Arş Ens Derg, 45, 63-72.
  • Dorostghoal M, Dezfoolian A, Sorooshnia F (2011). Effects of maternal lead acetate exposure during lactation on postnatal development of testis in offspring wistar rats. Iranian J Basic Med Sci, 14, 122-131.
  • Dökmeci I (2001). Toksikoloji, Zehirlenmelerde Tanı ve Tedavi. 3. Baskı, Nobel Tıp Kitabevleri, İstanbul.
  • Elbetieha A, Al-Thani AS, Al-Thani RK, Darmani H, Owais W (2008). Effects of chronic exposure to cobalt chloride on the fertility and testes in mice. J App Biol Sci, 2, 01-06.
  • Ema M, Kobayashi N, Naya M, Hanai S, Nakanishi J (2010). Reproductive and developmental toxicity studies of manufactured nanomaterials. Reprod Toxicol, 30, 343-352.
  • Fortoul TI, Bizarro-Nevares P, Acevedo-Nava S, Pinon-Zarate G, Rodriguez-Lara V, Colin-Baranque L, et al. (2007). Ultrastructual findings in murine seminiferous tubules as a consequence of subchronic vanadium pentoxide inhalation. Reprod Toxicol, 23, 588- 592.
  • Giaccio L, Cicchella D, De Vivo B, Lombardi G, De Rosa M (2012). Does heavy metals pollution affects semen quality in men? A case of study in the metropolitan area of Naples (Italy). J Geo Exp, 112, 218-225.
  • Hallinger KK, Cristol DA (2011). The role of weather in mediating the effect of mercury exposure on reproductive success in tree swallows. Ecotoxicol, 20, 1368-1377.
  • Hamlin HJ, Guilette LJ (2010). Birth defects in wildlife: The role of environmental contaminants as inducers of reproductive and developmental dysfunction. Sys Biol Reprod Med, 56, 113-121.
  • Hovatta O, Venalainen ER, Kuusimaki L, Heikkila J, Reima I (1998). Aluminium, lead and cadmium concentrations in seminal plasma and spermatozoa, and semen quality in Finnish men. Human Reprod, 13, 115-119.
  • Huang YL, Tseng WC, Lin TH (2001). In vitro effects of metal ions (Fe 2+ , Mn 2+ , Pb 2+ ) on sperm motility and lipid peroxidation in human semen. J Toxicol Environ Health, Part A, 62, 259-267.
  • Jurasovic J, Cvitkovic P, Pizent A, Colak B, Telisman S (2004). Semen quality and reproductive endocrine function with regard to blood cadmium in Croatian male subjects. Biometals, 17, 735-743.
  • Kaya S, Pirinççi İ, Bilgili A (1998). Veteriner Hekimliğinde Toksikoloji, Medisan, Ankara.
  • Kayhan FE, Muşlu MN, Koç ND (2009). Bazı ağır metallerin sucul organizmalar üzerinde yarattığı stres ve biyolojik yanıtlar. J Fisheries Sci, 3, 153-162.
  • Kumar S (2008). Is environmental exposure associated with reproductive health impairments? J Turkish-German Gynecol Assoc, 9, 60-69.
  • Küçükeşmen Ç (2007). Dental amalgamın insan organizması üzerindeki etkileri. SDÜ Tıp Fak Derg, 14, 52-61.
  • Lavranos G, Balla M, Tzortzopoulou A, Syriou V, Angelopoulou R (2012). Investigating ROS sources in male infertility: a common end for numerous pathways. Reprod Toxicol, 34, 298-307.
  • Mathur N, Pandey G, Jain GC (2010). Male reproductive toxicity of some selected metals: A review. J Biol Sci, 10, 396-404.
  • Meeker JD, Rossano MG, Protas B, Diamaond MP, Puscheck E, Daly D, et al. (2008). Cadmium, lead and other metals in relation to semen quality: human evidence for molybdenum as a male reproductive toxicant. Environ Health Perspect, 116, 1473-1479.
  • Mendiola J, Moreno JM, Roca M, Vergara-Juarez N, Martinez-Garcia MJ, Garcia-Sanchez A, et al. (2011). Relationships between heavy metal concentrations in three different body fluids and male reproductive parameters: a pilot study. Environ Health,10 (6), 1-7.
  • Monsees TK. Franz M, Gebhardt S, Winterstein U, Hayatpour J (2000). Sertoli cells as a target for reproductive hazards. Androl, 32, 239-246.
  • Morgan AM, El-Tawil OS (2003). Effects of ammonium metavanadate on fertility and reproductive performance of adult male and female rats. Pharmacol Res, 47, 75-85.
  • Nava-Hernandez MP, Hauad-Marroquin LA, Bassol-Mayagoitia S, Garcia-Arenas G, Mercado-Hernandez R, Echavarri-Guzman M et al. (2009). Lead-, cadmium-, and arsenic-induced DNA damage in rat germinal cells. DNA Cell Biol, 28, 241-248.
  • Paksy K, Varga B, Lazar P (1996). Zinc protection against cadmiuminduced infertility in female rats. Effect of zinc and cadmium on the progesterone production of cultured granulosa cells. BioMetals, 10, 27
  • Pizent A, Tariba B, Zivkovic T (2012). Reproductive toxicity of metals in men. Arh Hig Rada Toksikol, 63, Supplement 1, 35-46.
  • Scheuhammer AM (1987). The chronic toxicity of aluminium, cadmium, mercury and lead in birds: A review. Environ Pollut, 46, 263-295.
  • Şener S, Yıldırım M (2000). Veteriner Toksikoloji. Teknik Yayıncılık, İstanbul.
  • Thaxton JP, Parkhurt CR (1973). Abnormal mating behavior and reproductive dysfunction caused by mercury in Japanese quail. Proc Soc Exper Biol Med, 144, 252-255.
  • Tiwari AK, Pragya P, Ram KR, Chowdhuri DK (2011). Environmental chemical mediated male reproductive toxicity: Drosophila melanogaster as an alternate animal model. Theriogenelogy, 76. 1972
  • Yılmaz O (1995). Bursa yöresinden sağlanan insan karaciğer ve böbreklerinde ağır metal kalıntı düzeyleri : I. Cıva. YYU Sağ Bil Enst Derg. 1, 6-11.
  • Yılmaz O (2002). Cadmium and lead levels in human liver and kidney samples obtained from Bursa Province. Int J Environ Health Res, 12, 181-18
  • Westermark T (1975). Mercury content of bird feathers before and after Swedish Ban on alkyl mercury in agriculture. Ambio, 4, 87-92.
  • Wirth JJ, Rossano MG, Daly DC, Paneth N, Puscheck E, Potter RC, Diamond MP (2007). Ambient manganese exposure is negatively associated with human sperm motility and concentration. Epidemiol, 18, 270-273.
  • Wirth JJ, Mijal RS (2010). Adverse effects of low level heavy metal exposure on male reproductive function. Sys Biol Reprod Med, 56, 14716
Toplam 41 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Orhan Yılmaz Bu kişi benim

Hikmet Dinç Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 24 Sayı: 2

Kaynak Göster

APA Yılmaz, O., & Dinç, H. (2013). Ağır Metallerin Üreme Sistemi Üzerine Etkileri. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi, 24(2), 91-94.
AMA Yılmaz O, Dinç H. Ağır Metallerin Üreme Sistemi Üzerine Etkileri. YYU Vet Fak Derg. Haziran 2013;24(2):91-94.
Chicago Yılmaz, Orhan, ve Hikmet Dinç. “Ağır Metallerin Üreme Sistemi Üzerine Etkileri”. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi 24, sy. 2 (Haziran 2013): 91-94.
EndNote Yılmaz O, Dinç H (01 Haziran 2013) Ağır Metallerin Üreme Sistemi Üzerine Etkileri. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi 24 2 91–94.
IEEE O. Yılmaz ve H. Dinç, “Ağır Metallerin Üreme Sistemi Üzerine Etkileri”, YYU Vet Fak Derg, c. 24, sy. 2, ss. 91–94, 2013.
ISNAD Yılmaz, Orhan - Dinç, Hikmet. “Ağır Metallerin Üreme Sistemi Üzerine Etkileri”. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi 24/2 (Haziran 2013), 91-94.
JAMA Yılmaz O, Dinç H. Ağır Metallerin Üreme Sistemi Üzerine Etkileri. YYU Vet Fak Derg. 2013;24:91–94.
MLA Yılmaz, Orhan ve Hikmet Dinç. “Ağır Metallerin Üreme Sistemi Üzerine Etkileri”. Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi, c. 24, sy. 2, 2013, ss. 91-94.
Vancouver Yılmaz O, Dinç H. Ağır Metallerin Üreme Sistemi Üzerine Etkileri. YYU Vet Fak Derg. 2013;24(2):91-4.