Sığırlarda Solunum Sistemi Hastalığının Tedavisinde Tulathromycin ve Tilmicosin'in Etkisi

Yıl 2010, Cilt: 21 Sayı: 3, 159 - 162, 01.09.2010

İsmail Aytekın Nuri Mamak Ali Cesur Onmaz Fatih Sakın Savas Aslan

Öz

Anahtar Kelimeler

-

Sığırlarda Solunum Sistemi Hastalığının Tedavisinde Tulathromycin ve Tilmicosin'in Etkisi

Öz

Bu çalışmada, sığırlarda solunum sistemi hastalıklarının bakteriyel etiyolojisinin belirlenmesi ve tedavisinde tulathromycin ile tilmicosin uygulamasının klinik etkinliklerinin karşılaştırılması amaçlandı. Solunum sistemi hastalığı belirlenen toplam 40 adet hayvandan burun sıvapları alındı ve bu örneklerden bakteriyel etken izolasyonu yapıldı. Etken izolasyonu sonucu Pasteurella haemolytica %27.5, Pasteurella multocida %22.5, Klebsiella pneumonia %10, Pasteurella haemolytica+streptococcus spp. %10, Pasteurella multocida+streptococcus spp. %5, Streptococcus spp. %5 olarak izole edildi. Çalışmada solunum sistemi hastalığı olan 20 adet hayvana tek doz 2.5 mg/kg tulathromycine (grup 1) ve diğer 20 adet hayvana 10 mg/kg tilmicosin (grup 2) tek doz derialtı yolla uygulandı. Tulathromycin uygulanan grup 1’in hayvanlarında beş gün içerisinde iyileşme oranı %85, tilmicosin uygulanan grup 2’deki hayvanlarda ise %80 olarak tespit edildi. Sonuç olarak, bovine respiratory disease hastalığının tedavisinde hem tulathromycin hemde tilmicosinin etkili olduğu belirlendi

Anahtar Kelimeler

Solunum sistemi hastalığı, Etiyoloji, Tulathromycin, Tilmicosin, Tedavi

Kaynakça

• Ames TR (1997). Dairy calf pneumonia: The disease and its impact. Vet Clin North Am Food Anim Pract, 13 (3), 379–391.
• Apley M (1997). Antimicrobial therapy of bovine respiratory disease. Vet Clin North Am Food Anim Pract, 13 (3), 549–574.
• Booker CW, Abutarbush SM, Schunicht OC et al. (2007). Evaluation of the efficacy of tulathromycin as a metaphylactic antimicrobial in feedlot calves. Vet Ther, 8 (3), 183-200.
• Booker CW, Jim GK, Guichon PT, Schunicht OC, Thorlakson BE, Lockwood PW (1997). Evaluation of florfenicol for the treatment of undifferentiated fever in feedlot calves in western Canada. Can Vet J, 38, 555-560.
• Bryson DG (1985). Calf pneumonia. Vet Clin North Am Food Anim Pract, 1, 237–257.
• Donachie W (2000). Bacteriology of bovine respiratory disease. Br Cattle Vet Assoc J Cattle Pract, 8, 5–7.
• Godinho KS, Rae A, Windsor GD, Tilt N, Rowan TG and Sunderland SJ (2005). Efficacy of tulathromycin in the treatment of bovine respiratory disease associated with induced M. bovis infections in young dairy calves. Vet Ther, 6, 96-112.
• Godinho KS, Sarasola P, Sherington J, Rowan TG, Sunderland SJ (2005). Evaluation of tulathromycin for treatment and prevention of bovine respiratory disease under natural conditions. Revue Med Vet, 156, 437-444.
• Godinho KS, Wolf RMLG, Sherington J, Rowan TG, Sunderland SJ, Evans NA (2005). Efficacy of tulathromycin in the treatment and prevention of natural outbreaks of bovine respiratory disease in european cattle. Vet Ther, 6 (2), 122-135.
• Gökçe G, Şahin M, Genç O, Sural E (1997). Buzağı pneumonilerinin tedavisinde tilmicosin ve danofloxacin’in etkileri üzerine karşılaştırmalı çalışmalar. Kafkas Üniv Vet Fak Derg, 3 (2), 151- 155.
• İçen H, Sekin S, Şimşek A, Yeşilmen S, Işık N (2009). Viral and bacterial pathogen isolated and identified from pneumonic calves in region of Diyarbakir and its treatment with tulathromycin. J Anim Vet Adv, 8 (9), 1717-1722.
• Kelly AP, Janzen ED (1986). A review of morbidity and mortality rates and disease occurrence in North American feedlot cattle. Can Vet J, 27, 496–500.
• Kilgore WR, Spensley MS, Sun F, Nutsch RG, Rooney KA, Skogerboe TL (2005). Therapeutic efficacy of tulathromycin, a novel triamilide antimicrobial, against bovine respiratory disease in feeder calves. Vet Ther, 6 (2), 143–153.
• Knowles TG (1995). A review of post transport mortality among younger calves. Vet Rec, 137, 406–407.
• Letavic MA, Bronk BS, Bertsche CD et al. (2002). Synthesis and activity of a novel class of tribasic macrocyclic antibiotics: The triamilides. Bioorg Med Chem Lett, 12, 2771–2774.
• Loneragan GH, Gould DH, Mason GL et al. (2001). İnvolvement of microbial respiratory pathogens in acute interstitial pneumonia in feedlot cattle. Am J Vet Res, 62 (10), 1519–1524.
• Mosier DA (1997). Bacterial pneumonia, bovine respiratory disease update. Vet Clin North Am, 13(3), 483–493.
• Nicholas RAJ, Ayling RD (2003). Mycoplasma bovis: Disease, diagnosis, and control. Res Vet Sci, 74, 105–112.
• Norcia LJL, Silvia AM, Santoro SL, Retsema J (2004). In vitro microbiological characterization of a novel azalide, two triamilides and an azalide ketal against bovine and porcine respiratory pathogens. J Antibiotics, 57 (4), 280–288.
• Nowakowski MA, Inskeep PB, Risk JE et al. (2004). Pharmacokinetics tulathromycin, a new triamilide antibiotic, in cattle. Vet Ther, 5 (1), 60–74. tissue concentrations of
• Picavet T, Muylle E, Devriese LA, Geryl J (1991). Efficacy of tilmicosin in treatment of pulmonary infections in calves. Vet Rec, 129 (18), 400-403.
• Robb EJ, Tucker CM, Corley L et al. (2007). Efficacy of tulathromycin versus enrofloxacin for initial treatment of naturally occurring bovine respiratory disease in feeder calves. Vet Ther, 8 (2), 127- 135.
• Schunicht OC, Booker CW, Guichon PT et al. (2007). An evaluation of the relative efficacy of tulathromycin for the treatment of undifferentiated fever in feedlot calves in Nebraska. Can Vet J, 48, 600-666.
• Skogerboe TL, Rooney KA, Nutsch RG, Weigel DJ, Gajewski K, Kilgore WR (2005). Comparative efficacy of tulathromycin versus florfenicol and tilmicosin against undifferentiated bovine respiratory disease in feedlot cattle. Vet Ther, 6 (2), 180-196.
• Veber B, Vallee E, Desmonts JM, Pocidalo JJ, Azoulay-Dupuis E (1993). Correlation between macrolide lung pharmacokinetics and therapeutic efficacy in a mouse model of pneumococcal pneumonia. J Antimicrob Chemother, 32, 473–482.
• Zhanel GG, Dueck M, Hoban DJ et al. (2001). Review of macrolides and ketolides: Focus on respiratory tract infections. Drugs, 61, 443–498.