Year 2019, Volume 20, Issue , Pages 63 - 66 2019-02-01

CURRENT STATUS OF GERMLINE STEM CELLS IN ADULT MAMMALIAN OVARY

ENES TAYLAN [1] , Yodo Sugishita [2] , Kenan Kirteke [3]

18 67

The evolutionary and biological mechanisms underlying female reproductive aging have long been a matter of interest. Reproductive biologists have tackled with the relatively limited fertile period in female lifespan compared to male fertility that continues until the late ages. For more than five decades, it has been believed that females are born with a fixed number of germ cells that constitute ovarian follicle reserve and depletion of this reserve causes menopause. However, researchers recently reported findings that support the presence of oogenesis in postnatal mammalian ovaries, which caused a paradigm shift in our current knowledge of reproductive biology. In this minireview, we provide a brief history of one of the central dogmas in reproductive biology and subsequently present recent studies on the existence of germline stem cells in the mammalian ovary.

Dişi üreme sistemi yaşlanmasının altında yatan evrimsel ve biyolojik mekanizmalar uzun süredir ilgi çeken bir konu olmuştur. Üreme biyolojisi konusunda çalışan biyologlar, erkeklerde ileri yaşlara kadar devam eden fertilite ile karşılaştırıldığında dişi yaşamında görece olarak sınırlı bir dönemde görülen fertilite konusunu aydınlığa kavuşturmaya çalışmaktadırlar. 50 yılı aşkın bir süredir dişilerin ovaryan folikül rezervini oluşturan sabit sayıda germ hücresi ile dünyaya geldiklerine inanılmaktadır. Ancak, son dönemde araştırıcılar memeli ovaryumlarında doğum sonrası oogenez varlığını destekleyen ve üreme biyolojisi ile ilgili günümüz bilgilerimizde değişime yol açan bulgular elde etmişlerdir. Bu derleme çalışmasında, üreme biyolojisindeki santral dogmalardan bir tanesi ile ilgili kısa bir tarihsel bilgi verilmiş ve memeli ovaryumlarında germ hattı kök hücrelerinin varlığı ile ilgili son dönem çalışmaları sunulmuştur.

Ovary, fertility preservation, stem cells, female germline
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Primary Language en
Subjects Biology
Journal Section Review/Derleme
Authors

Orcid: 0000-0002-0445-1250
Author: ENES TAYLAN (Primary Author)
Institution: Laboratory of Molecular Reproduction and Fertility Preservation, Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine
Country: United States


Orcid: 0000-0003-4315-1370
Author: Yodo Sugishita
Institution: Department of Obstetrics and Gynecology, St. Marianna University School of Medicine
Country: Japan


Orcid: 0000-0002-2153-7646
Author: Kenan Kirteke
Institution: ADNAN MENDERES UNIVERSITY
Country: Turkey


Bibtex @review { trkjnat483495, journal = {Trakya University Journal of Natural Sciences}, issn = {2147-0294}, eissn = {2528-9691}, address = {Trakya University}, year = {2019}, volume = {20}, pages = {63 - 66}, doi = {10.23902/trkjnat.483495}, title = {CURRENT STATUS OF GERMLINE STEM CELLS IN ADULT MAMMALIAN OVARY}, key = {cite}, author = {TAYLAN, ENES and Sugishita, Yodo and Kirteke, Kenan} }
APA TAYLAN, E , Sugishita, Y , Kirteke, K . (2019). CURRENT STATUS OF GERMLINE STEM CELLS IN ADULT MAMMALIAN OVARY. Trakya University Journal of Natural Sciences, 20 (), 63-66. DOI: 10.23902/trkjnat.483495
MLA TAYLAN, E , Sugishita, Y , Kirteke, K . "CURRENT STATUS OF GERMLINE STEM CELLS IN ADULT MAMMALIAN OVARY". Trakya University Journal of Natural Sciences 20 (2019): 63-66 <http://dergipark.org.tr/trkjnat/issue/39830/483495>
Chicago TAYLAN, E , Sugishita, Y , Kirteke, K . "CURRENT STATUS OF GERMLINE STEM CELLS IN ADULT MAMMALIAN OVARY". Trakya University Journal of Natural Sciences 20 (2019): 63-66
RIS TY - JOUR T1 - CURRENT STATUS OF GERMLINE STEM CELLS IN ADULT MAMMALIAN OVARY AU - ENES TAYLAN , Yodo Sugishita , Kenan Kirteke Y1 - 2019 PY - 2019 N1 - doi: 10.23902/trkjnat.483495 DO - 10.23902/trkjnat.483495 T2 - Trakya University Journal of Natural Sciences JF - Journal JO - JOR SP - 63 EP - 66 VL - 20 IS - SN - 2147-0294-2528-9691 M3 - doi: 10.23902/trkjnat.483495 UR - https://doi.org/10.23902/trkjnat.483495 Y2 - 2019 ER -
EndNote %0 Trakya University Journal of Natural Sciences CURRENT STATUS OF GERMLINE STEM CELLS IN ADULT MAMMALIAN OVARY %A ENES TAYLAN , Yodo Sugishita , Kenan Kirteke %T CURRENT STATUS OF GERMLINE STEM CELLS IN ADULT MAMMALIAN OVARY %D 2019 %J Trakya University Journal of Natural Sciences %P 2147-0294-2528-9691 %V 20 %N %R doi: 10.23902/trkjnat.483495 %U 10.23902/trkjnat.483495
ISNAD TAYLAN, ENES , Sugishita, Yodo , Kirteke, Kenan . "CURRENT STATUS OF GERMLINE STEM CELLS IN ADULT MAMMALIAN OVARY". Trakya University Journal of Natural Sciences 20 / (February 2019): 63-66. https://doi.org/10.23902/trkjnat.483495