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Dejeneratif Lomber Hastalıklarda Uygulanan Spinal Enstrümantasyon Sonrası Gelişen Komşu Segment Dejenerasyonu: İnsidans ve Risk Faktörleri

Yıl 2022, Cilt: 48 Sayı: 2, 225 - 229, 15.09.2022
https://doi.org/10.32708/uutfd.1130154

Öz

Posterior spinal enstrümantasyon, dejeneratif omurga patolojilerinin tedavisi için oldukça yaygın uygulanan cerrahi bir prosedürdür. Spinal enstrümantasyon sonrası komşu segment dejenerasyonu (KSD) gelişimi önemli bir problem olarak karşımıza çıkmaktadır. Bu çalışmanın amacı KSD gelişimi için risk faktörlerinin değerlendirilmesidir. Bu çalışmada posterior segmental enstrümantasyon uygulanan ve cerrahi işlemi üzerinden 4 yıldan fazla geçen 126 hasta retrospektif olarak incelenmiştir. Bu hastalar KSD ve n-KSD olarak iki gruba ayrılmıştır. İki grubun hasta karakteristikleri, preoperatif ve postoperatif radyolojik parametreleri ve cerrahi farklılıkları karşılaştırılarak KSD gelişimi için prediktif faktörler ortaya konulmaya çalışıldı. Çalışmaya dahil edilen hastaların on beşinde (%11.9) KSD geliştiği görüldü. Her iki grup arasında cinsiyet, diyabetes mellitus, sigara kullanımı ve osteoporoz açısından anlamlı farklılık yok idi (p>0.05). Lojistik regresyon analizine göre preoperatif yüksek vücut kitle indeksi, preoperatif komşu segmentteki faset dejenerasyonu varlığı, postoperatif lomber lordozda azalma ve 4 seviyeden daha fazla posterior enstürman uygulanması KSD gelişimi için bağımsız risk faktörleridir. Spinal enstrümantasyon cerrahisi öncesi yukarıda bahsedilen risk faktörlerinin bilinmesi, cerrahi açıdan daha uygun sonuçlar alınabilmesi için önlem almaya imkan tanımaktadır. Hastaların ve işlemi uygulayacak cerrahların modifiye edilebilecek risk faktörleri açısından gerekli önlemleri almaları uzun dönem komplikasyonları azaltabileceğini düşünmekteyiz.

Kaynakça

  • 1. Ahn DK, Park HS, Choi DJ, Kim KS, Yang SJ: Survival and prognostic analysis of adjacent segments after spinal fusion. Clinics in Orthopedic Surgery 2:140-147, 2010
  • 2. Akamaru T, Kawahara N, Yoon ST, Minamide A, Kim KS, Tomita K, Hutton WC: Adjacent segment motion after a simulated lumbar fusion in different sagittal alignments: a biomechanical analysis. Spine 28:1560-1566, 2003
  • 3. Alentado VJ, Lubelski D, Healy AT, Orr RD, Steinmetz MP, Benzel EC, Mroz TE: Predisposing characteristics of adjacent segment disease after lumbar fusion. Spine 41:1167-1172, 2016
  • 4. Chen B-L, Wei F-X, Ueyama K, Xie D-H, Sannohe A, Liu S-Y: Adjacent segment degeneration after single-segment PLIF: the risk factor for degeneration and its impact on clinical outcomes. European Spine Journal 20:1946-1950, 2011
  • 5. Ekman P, Möller H, Shalabi A, Yu YX, Hedlund R: A prospective randomised study on the long-term effect of lumbar fusion on adjacent disc degeneration. European spine journal 18:1175-1186, 2009
  • 6. Ghasemi AA: Adjacent segment degeneration after posterior lumbar fusion: An analysis of possible risk factors. Clinical Neurology and Neurosurgery 143:15-18, 2016
  • 7. Hashimoto K, Aizawa T, Kanno H, Itoi E: Adjacent segment degeneration after fusion spinal surgery—a systematic review. International orthopaedics 43:987-993, 2019
  • 8. Kim JY, Paik HK, Ahn SS, Kang MS, Kim KH, Park JY, Chin DK, Kim KS, Cho YE, Kuh SU: Paraspinal muscle, facet joint, and disc problems: risk factors for adjacent segment degeneration after lumbar fusion. The Spine Journal 16:867-875, 2016
  • 9. Lawrence BD, Wang J, Arnold PM, Hermsmeyer J, Norvell DC, Brodke DS: Predicting the risk of adjacent segment pathology after lumbar fusion: a systematic review. Spine 37:S123-S132, 2012
  • 10. Lee CS, Hwang CJ, Lee S-W, Ahn Y-J, Kim Y-T, Lee D-H, Lee MY: Risk factors for adjacent segment disease after lumbar fusion. European spine journal 18:1637-1643, 2009
  • 11. Liang J, Dong Y, Zhao H: Risk factors for predicting symptomatic adjacent segment degeneration requiring surgery in patients after posterior lumbar fusion. Journal of Orthopaedic Surgery and Research 9:1-6, 2014
  • 12. Park P, Garton HJ, Gala VC, Hoff JT, McGillicuddy JE: Adjacent segment disease after lumbar or lumbosacral fusion: review of the literature. Spine 29:1938-1944, 2004
  • 13. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N: Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976) 26:1873-1878, 2001
  • 14. Scemama C, Magrino B, Gillet P, Guigui P: Risk of adjacent-segment disease requiring surgery after short lumbar fusion: results of the French Spine Surgery Society Series. Journal of Neurosurgery: Spine 25:46-51, 2016
  • 15. Soh J, Lee JC, Shin BJ: Analysis of risk factors for adjacent segment degeneration occurring more than 5 years after fusion with pedicle screw fixation for degenerative lumbar spine. Asian Spine Journal 7:273, 2013
  • 16. Umehara S, Zindrick MR, Patwardhan AG, Havey RM, Vrbos LA, Knight GW, Miyano S, Kirincic M, Kaneda K, Lorenz MA: The biomechanical effect of postoperative hypolordosis in instrumented lumbar fusion on instrumented and adjacent spinal segments. Spine 25:1617-1624, 2000
  • 17. Untch C, Liu Q, Hart R: Segmental motion adjacent to an instrumented lumbar fusion: the effect of extension of fusion to the sacrum. Spine 29:2376-2381, 2004
  • 18. Wang H, Ma L, Yang D, Wang T, Liu S, Yang S, Ding W: Incidence and risk factors of adjacent segment disease following posterior decompression and instrumented fusion for degenerative lumbar disorders. Medicine 962017
  • 19. Zhong Z-M, Deviren V, Tay B, Burch S, Berven SH: Adjacent segment disease after instrumented fusion for adult lumbar spondylolisthesis: incidence and risk factors. Clinical neurology and neurosurgery 156:29-34, 2017

Adjacent Segment Degeneration Following Spinal Fusion for Degenerative Lumbar Disease: Incidence and Risk Factors

Yıl 2022, Cilt: 48 Sayı: 2, 225 - 229, 15.09.2022
https://doi.org/10.32708/uutfd.1130154

Öz

Posterior spinal instrumentation is a fairly common surgical procedure for the treatment of degenerative spine pathologies. The development of adjacent segment degeneration (ASD) after spinal instrumentation is an important problem. The aim of this study is to evaluate the risk factors for the development of ASD. In this study, 126 patients who underwent posterior segmental instrumentation and who had undergone surgery for more than 4 years were reviewed retrospectively. These patients were divided into two groups as ASD and non-ASD. By comparing the patient characteristics, preoperative and postoperative radiological parameters and surgical differences of the two groups, predictive factors for the development of ASD were tried to be revealed. Fifteen of the patients (11.9%) included in the study had ASD. There was no significant difference between the two groups in terms of gender, diabetes mellitus, smoking and osteoporosis (p>0.05). According to logistic regression analysis, preoperative high body mass index, presence of facet degeneration in the preoperative adjacent segment, decrease in postoperative lumbar lordosis, and posterior instrumentation of more than 4 levels are independent risk factors for the development of ASD. Knowing the above-mentioned risk factors before spinal instrumentation surgery allows taking precautions to obtain more appropriate surgical results. We think that taking the necessary precautions in terms of risk factors that can be modified by the patients and the surgeons who will perform the procedure can reduce long-term complications.

Kaynakça

  • 1. Ahn DK, Park HS, Choi DJ, Kim KS, Yang SJ: Survival and prognostic analysis of adjacent segments after spinal fusion. Clinics in Orthopedic Surgery 2:140-147, 2010
  • 2. Akamaru T, Kawahara N, Yoon ST, Minamide A, Kim KS, Tomita K, Hutton WC: Adjacent segment motion after a simulated lumbar fusion in different sagittal alignments: a biomechanical analysis. Spine 28:1560-1566, 2003
  • 3. Alentado VJ, Lubelski D, Healy AT, Orr RD, Steinmetz MP, Benzel EC, Mroz TE: Predisposing characteristics of adjacent segment disease after lumbar fusion. Spine 41:1167-1172, 2016
  • 4. Chen B-L, Wei F-X, Ueyama K, Xie D-H, Sannohe A, Liu S-Y: Adjacent segment degeneration after single-segment PLIF: the risk factor for degeneration and its impact on clinical outcomes. European Spine Journal 20:1946-1950, 2011
  • 5. Ekman P, Möller H, Shalabi A, Yu YX, Hedlund R: A prospective randomised study on the long-term effect of lumbar fusion on adjacent disc degeneration. European spine journal 18:1175-1186, 2009
  • 6. Ghasemi AA: Adjacent segment degeneration after posterior lumbar fusion: An analysis of possible risk factors. Clinical Neurology and Neurosurgery 143:15-18, 2016
  • 7. Hashimoto K, Aizawa T, Kanno H, Itoi E: Adjacent segment degeneration after fusion spinal surgery—a systematic review. International orthopaedics 43:987-993, 2019
  • 8. Kim JY, Paik HK, Ahn SS, Kang MS, Kim KH, Park JY, Chin DK, Kim KS, Cho YE, Kuh SU: Paraspinal muscle, facet joint, and disc problems: risk factors for adjacent segment degeneration after lumbar fusion. The Spine Journal 16:867-875, 2016
  • 9. Lawrence BD, Wang J, Arnold PM, Hermsmeyer J, Norvell DC, Brodke DS: Predicting the risk of adjacent segment pathology after lumbar fusion: a systematic review. Spine 37:S123-S132, 2012
  • 10. Lee CS, Hwang CJ, Lee S-W, Ahn Y-J, Kim Y-T, Lee D-H, Lee MY: Risk factors for adjacent segment disease after lumbar fusion. European spine journal 18:1637-1643, 2009
  • 11. Liang J, Dong Y, Zhao H: Risk factors for predicting symptomatic adjacent segment degeneration requiring surgery in patients after posterior lumbar fusion. Journal of Orthopaedic Surgery and Research 9:1-6, 2014
  • 12. Park P, Garton HJ, Gala VC, Hoff JT, McGillicuddy JE: Adjacent segment disease after lumbar or lumbosacral fusion: review of the literature. Spine 29:1938-1944, 2004
  • 13. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N: Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976) 26:1873-1878, 2001
  • 14. Scemama C, Magrino B, Gillet P, Guigui P: Risk of adjacent-segment disease requiring surgery after short lumbar fusion: results of the French Spine Surgery Society Series. Journal of Neurosurgery: Spine 25:46-51, 2016
  • 15. Soh J, Lee JC, Shin BJ: Analysis of risk factors for adjacent segment degeneration occurring more than 5 years after fusion with pedicle screw fixation for degenerative lumbar spine. Asian Spine Journal 7:273, 2013
  • 16. Umehara S, Zindrick MR, Patwardhan AG, Havey RM, Vrbos LA, Knight GW, Miyano S, Kirincic M, Kaneda K, Lorenz MA: The biomechanical effect of postoperative hypolordosis in instrumented lumbar fusion on instrumented and adjacent spinal segments. Spine 25:1617-1624, 2000
  • 17. Untch C, Liu Q, Hart R: Segmental motion adjacent to an instrumented lumbar fusion: the effect of extension of fusion to the sacrum. Spine 29:2376-2381, 2004
  • 18. Wang H, Ma L, Yang D, Wang T, Liu S, Yang S, Ding W: Incidence and risk factors of adjacent segment disease following posterior decompression and instrumented fusion for degenerative lumbar disorders. Medicine 962017
  • 19. Zhong Z-M, Deviren V, Tay B, Burch S, Berven SH: Adjacent segment disease after instrumented fusion for adult lumbar spondylolisthesis: incidence and risk factors. Clinical neurology and neurosurgery 156:29-34, 2017
Toplam 19 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Ortopedi, Radyoloji ve Organ Görüntüleme
Bölüm Özgün Araştırma Makaleleri
Yazarlar

Mehmet Emin Akyüz 0000-0003-0626-3509

Mustafa Nevzat Firidin 0000-0002-0927-8848

Yayımlanma Tarihi 15 Eylül 2022
Kabul Tarihi 1 Ağustos 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 48 Sayı: 2

Kaynak Göster

APA Akyüz, M. E., & Firidin, M. N. (2022). Dejeneratif Lomber Hastalıklarda Uygulanan Spinal Enstrümantasyon Sonrası Gelişen Komşu Segment Dejenerasyonu: İnsidans ve Risk Faktörleri. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 48(2), 225-229. https://doi.org/10.32708/uutfd.1130154
AMA Akyüz ME, Firidin MN. Dejeneratif Lomber Hastalıklarda Uygulanan Spinal Enstrümantasyon Sonrası Gelişen Komşu Segment Dejenerasyonu: İnsidans ve Risk Faktörleri. Uludağ Tıp Derg. Eylül 2022;48(2):225-229. doi:10.32708/uutfd.1130154
Chicago Akyüz, Mehmet Emin, ve Mustafa Nevzat Firidin. “Dejeneratif Lomber Hastalıklarda Uygulanan Spinal Enstrümantasyon Sonrası Gelişen Komşu Segment Dejenerasyonu: İnsidans Ve Risk Faktörleri”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 48, sy. 2 (Eylül 2022): 225-29. https://doi.org/10.32708/uutfd.1130154.
EndNote Akyüz ME, Firidin MN (01 Eylül 2022) Dejeneratif Lomber Hastalıklarda Uygulanan Spinal Enstrümantasyon Sonrası Gelişen Komşu Segment Dejenerasyonu: İnsidans ve Risk Faktörleri. Uludağ Üniversitesi Tıp Fakültesi Dergisi 48 2 225–229.
IEEE M. E. Akyüz ve M. N. Firidin, “Dejeneratif Lomber Hastalıklarda Uygulanan Spinal Enstrümantasyon Sonrası Gelişen Komşu Segment Dejenerasyonu: İnsidans ve Risk Faktörleri”, Uludağ Tıp Derg, c. 48, sy. 2, ss. 225–229, 2022, doi: 10.32708/uutfd.1130154.
ISNAD Akyüz, Mehmet Emin - Firidin, Mustafa Nevzat. “Dejeneratif Lomber Hastalıklarda Uygulanan Spinal Enstrümantasyon Sonrası Gelişen Komşu Segment Dejenerasyonu: İnsidans Ve Risk Faktörleri”. Uludağ Üniversitesi Tıp Fakültesi Dergisi 48/2 (Eylül 2022), 225-229. https://doi.org/10.32708/uutfd.1130154.
JAMA Akyüz ME, Firidin MN. Dejeneratif Lomber Hastalıklarda Uygulanan Spinal Enstrümantasyon Sonrası Gelişen Komşu Segment Dejenerasyonu: İnsidans ve Risk Faktörleri. Uludağ Tıp Derg. 2022;48:225–229.
MLA Akyüz, Mehmet Emin ve Mustafa Nevzat Firidin. “Dejeneratif Lomber Hastalıklarda Uygulanan Spinal Enstrümantasyon Sonrası Gelişen Komşu Segment Dejenerasyonu: İnsidans Ve Risk Faktörleri”. Uludağ Üniversitesi Tıp Fakültesi Dergisi, c. 48, sy. 2, 2022, ss. 225-9, doi:10.32708/uutfd.1130154.
Vancouver Akyüz ME, Firidin MN. Dejeneratif Lomber Hastalıklarda Uygulanan Spinal Enstrümantasyon Sonrası Gelişen Komşu Segment Dejenerasyonu: İnsidans ve Risk Faktörleri. Uludağ Tıp Derg. 2022;48(2):225-9.

ISSN: 1300-414X, e-ISSN: 2645-9027

Uludağ Üniversitesi Tıp Fakültesi Dergisi "Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License" ile lisanslanmaktadır.


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Journal of Uludag University Medical Faculty is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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