Paraoxonase 1 and Arylesterase Levels in Patients with Ulcerative Colitis and Their Relationships with the Disease Activity

Yıl 2019, Cilt: 18 Sayı: 1, 33 - 37, 29.04.2019

Volkan Gökbulut Hakan Dursun Mustafa Kaplan Erkin Öztaş

https://doi.org/10.17941/agd.543505

Öz

Background and Aims: In this study, we studied serum paraoxanase 1 and arylesterase levels in patients with ulcerative colitis and their relationship with disease activity. Material and Methods: Thirty-eight patients with active ulcerative colitis and 38 healthy controls were included in this study. Paraoxanase 1 and arylesterase enzyme activities in both active and remission phases were studied. Paraoxanase 1 and arylesterase enzyme activities in the active disease phase, the remission phase, and the control group were compared. Results: The mean patient age in the study group was 40.3±14.6 years (19-78); 20 patients were male (52.6%) and 18 were female (47.4%). The demographic characteristics of the patients in the control group were similar to those of the study group. The mean serum paraoxanase 1 level was 65.8±15.0 U/L, and the mean serum arylesterase level was 151.0±236.6 U/mL in patients in the active phase. The mean serum paraoxanase 1 level was 82.4±58.4 U/L, and the mean serum arylesterase level was 94.1±134.6 U/mL in patients in the remission phase. The mean serum paraoxanase 1 level was 131.7±63.5 U/L, and the mean serum arylesterase level was 287.3±295.6 U/mL in the control group. There was no statistically significant difference in mean paraoxanase 1 and arylesterase levels between patients in the active and remission phases (p > 0.05). The mean levels of paraoxanase 1 and arylesterase in patients in the active and remission phases were significantly lower than those in healthy controls (p < 0.05). Conclusion: In patients with ulcerative colitis, paraoxanase 1 and arylesterase enzyme activities were found to be significantly lower than those in the control group, but there was no relationship between disease activity and paraoxanase 1 and arylesterase enzyme activities.

Anahtar Kelimeler

PON1, inflammatory bowel disease, ulcerative colitis

Ülseratif Kolitli Hastalarda Paraoksonaz 1 ve Arilesteraz Seviyeleri ve Bu Parametrelerin Hastalık Aktivitesi ile İlişkileri

Öz

Giriş
ve Amaç:  Bu çalışmada ülseratif kolitli hastalarda serum
paraoksonaz 1 ve arilesteraz düzeyleri ve bu parametrelerin hastalık aktivitesi
ile ilişkileri araştırıldı. Gereç
ve Yöntem: Çalışmaya 38 aktif dönemde ülseratif kolit hastası ve 38
sağlıklı kontrol grubu hastası dahil edildi. 
Çalışma grubu hastalarından hem aktif dönemde hem de remisyon sağlanınca
paraoksonaz 1 ve arilesteraz enzim aktiviteleri
çalışıldı. Paraoksonaz 1 ve arilesteraz enzim aktiviteleri aktif
dönem, remisyon dönemi ve kontrol grubu arasında kıyaslandı.  Bulgular:
Çalışma grubu hastalarının yaş ortalaması 40.3±14.6 yıl (19-78) olup hastaların
20’si erkek (%52.6) ve 18’i kadın (%47.4) idi. Kontrol grubu hastalarının demografik
özellikleri çalışma grubuna benzerdi. Aktif dönemdeki ülseratif kolit hastalarının
ortalama serum paraoksonaz 1 değeri
65.8±15.0 U/L, ortalama serum arilesteraz değeri
ise 151.0±236.6 U/mL olarak tespit edildi. Remisyon
dönemindeki hastalarda ortalama serum paraoksonaz
1 değeri 82.4±58.4 U/L, ortalama serum arilesteraz
değeri
ise 94.1±134.6
U/mL olarak
tespit edildi. Kontrol grubundaki hastalarda ortalama serum paraoksonaz 1 değeri 131.7±63.5 U/L, ortalama
serum arilesteraz değeri ise 287.3±295.6
U/mL olarak tespit edildi. Ülseratif kolitli hastalarda ortalama paraoksonaz 1 ve arilesteraz düzeyleri aktif ve remisyon dönemi arasında istatistiksel
olarak anlamlı fark göstermedi (p>0.05). Aktif ve remisyon dönemindeki ülseratif
kolitli hastalarda ortalama paraoksonaz 1
ve arilesteraz değerleri kontrol
grubundaki sağlıklı bireylere göre istatistiksel olarak anlamlı şekilde düşük
bulundu (p<0.05). Sonuç:
ülseratif
kolitli hastalarda paraoksonaz 1 ve arilesteraz aktivitelerinin kontrol grubuna göre istatiksel
olarak anlamlı şekilde azaldığı ancak hastalık aktivitesi ile paraoksonaz 1 ve arilesteraz aktiviteleri arasında ilişki bulunmadığı
gösterilmiştir.

Anahtar Kelimeler

Paraoksonaz 1, inflamatuvar barsak hastalığı, ülseratif kolit

Kaynakça

• Kaynaklar
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