Year 2019, Volume 7, Issue 3, Pages 1976 - 1984 2019-07-31

The Relationship between HMGB1, Cancer and Its Treatment
HMGB1’in Kanser ve Tedavisiyle İlişkisi

Eylem Taşkın Güven [1] , Celal Güven [2] , Salih Tunç Kaya [3] , Yusuf Sevgiler [4]

8 22

High mobility group box-1 (HMGB1), one of nonhiston protein, plays role as danger signals, and alarming shortly named as DAMP. HMGB1 released from damaged and cancer cells triggers mitogen activated kinases (MAPK) to act intracellular effect by binding the receptor for advanced glycation end products (RAGE) and toll like receptor (TLR). HMGB1 is essential to develop resistant against anticancer drugs. In addition, there is evidence that HMGB1 participate in developing to heart failure-induced by Adriamycin, one of anticancer drug against for solid cancer. Therefore, HMGB1 could be a good candidate for drug-resistant against to cancer and/or anticancer drug toxicity. The aim of the present review is to explain the relationship between HMBG1, cancer and Adriamycin used for cancer’s treatment.

Yüksek mobilite grup kutusu 1 (HMGB1) histon olmayan DNA proteini olup, kısaca DAMP olarak ifade edilen (Damage-associated molecular pattern) tehlike sinyali veya alarmı olarak görev yapar. Hasarlanmış veya kanserli hücrelerden salınan HMGB1, gelişmiş glikasyon son ürünleri için reseptör (RAGE) ve Toll benzeri reseptörlerine (TLRs) bağlanarak mitojenle aktive olan kinaz (MAPK)’ları aktive ederek hücre içi etkilerini oluşturur. HMGB1 kanser ilaçlarına karşı gelişen dirençte önemli rol oynar. Aynı zamanda, yumuşak doku kanserlerine karşı kullanılan ilaçlardan biri olan adriyamisinin (ADR) neden olduğu kalp yetmezliğinin gelişiminde de önemli rol oynağına dair kanıtlar mevcuttur. Dolayısıyla HMGB1 kanser tedavisinde ilaçlara karşı gelişen direncin ve/veya ilacın toksik etkisine karşı iyi bir terapötik ajan adayıdır. Bu derlemenin amacı, HMGB1 ile kanser ve tedavisinde kullanılan bir ilaç olan ADR arasındaki ilişkiyi açıklamaktır.

  • [1] K. Amornsupak, T. Insawang, P. Thuwajit, P. O-Charoenrat, S. A. Eccles and C. Thuwajit, “Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells,” BMC Cancer, vol. 14, no. pp. 955, 2014.
  • [2] Y. Luo, Y. Chihara, K. Fujimoto, T. Sasahira, M. Kuwada, R. Fujiwara, K. Fujii, H. Ohmori and H. Kuniyasu, “High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy,” Eur J Cancer, vol. 49, no. 3, pp. 741-751, 2013.
  • [3] D. Du, J. Yan, J. Ren, H. Lv, Y. Li, S. Xu, Y. Wang, S. Ma, J. Qu, W. Tang, Z. Hu and S. Yu, “Synthesis, biological evaluation, and molecular modeling of glycyrrhizin derivatives as potent high-mobility group box-1 inhibitors with anti-heart-failure activity in vivo,” J Med Chem, vol. 56, no. 1, pp. 97-108, 2013.
  • [4] A. Tripathi, K. Shrinet and A. Kumar, “HMGB1 protein as a novel target for cancer,” Toxicol Rep, vol. 6, no. pp. 253-261, 2019.
  • [5] R. Kang, R. Chen, Q. Zhang, W. Hou, S. Wu, L. Cao, J. Huang, Y. Yu, X. G. Fan, Z. Yan, X. Sun, H. Wang, Q. Wang, A. Tsung, T. R. Billiar, H. J. Zeh, 3rd, M. T. Lotze and D. Tang, “HMGB1 in health and disease,” Mol Aspects Med, vol. 40, no. pp. 1-116, 2014.
  • [6] L. Wu and L. Yang, “The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications,” Oncol Lett, vol. 15, no. 5, pp. 6799-6805, 2018.
  • [7] Y. Yao, X. Xu, G. Zhang, Y. Zhang, W. Qian and T. Rui, “Role of HMGB1 in doxorubicin-induced myocardial apoptosis and its regulation pathway,” Basic Res Cardiol, vol. 107, no. 3, pp. 267, 2012.
  • [8] K. L. Simpson, C. Cawthorne, C. Zhou, C. L. Hodgkinson, M. J. Walker, F. Trapani, M. Kadirvel, G. Brown, M. J. Dawson, M. MacFarlane, K. J. Williams, A. D. Whetton and C. Dive, “A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers,” Cell Death Dis, vol. 4, no. pp. e613, 2013.
  • [9] Y. G. Ma, X. W. Zhang, H. Y. Bao, S. S. Yu, Z. W. Hu and W. Sun, “[Blocking extracellular HMGB1 activity protects against doxorubicin induced cardiac injury in mice],” Yao Xue Xue Bao, vol. 47, no. 11, pp. 1489-1495, 2012.
  • [10] T. Narumi, T. Shishido, Y. Otaki, S. Kadowaki, Y. Honda, A. Funayama, S. Honda, H. Hasegawa, D. Kinoshita, M. Yokoyama, S. Nishiyama, H. Takahashi, T. Arimoto, T. Miyamoto, T. Watanabe, A. Tanaka, C. H. Woo, J. Abe, Y. Takeishi and I. Kubota, “High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis,” J Mol Cell Cardiol, vol. 82, no. pp. 1-12, 2015.
  • [11] K. Sturgeon, G. Muthukumaran, D. Ding, A. Bajulaiye, V. Ferrari and J. R. Libonati, “Moderate-intensity treadmill exercise training decreases murine cardiomyocyte cross-sectional area,” Physiol Rep, vol. 3, no. 5, pp. 2015.
  • [12] A. Kondratskyi, K. Kondratska, R. Skryma and N. Prevarskaya, “Ion channels in the regulation of apoptosis,” Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 1848, no. 10, Part B, pp. 2532-2546, 2015.
  • [13] A. Meyer, N. Eberle, J. Bullerdiek, I. Nolte and D. Simon, “High-mobility group B1 proteins in canine lymphoma: prognostic value of initial and sequential serum levels in treatment outcome following combination chemotherapy,” Vet Comp Oncol, vol. 8, no. 2, pp. 127-137, 2010.
  • [14] N. Kawahara, T. Tanaka, A. Yokomizo, H. Nanri, M. Ono, M. Wada, K. Kohno, K. Takenaka, K. Sugimachi and M. Kuwano, “Enhanced coexpression of thioredoxin and high mobility group protein 1 genes in human hepatocellular carcinoma and the possible association with decreased sensitivity to cisplatin,” Cancer Res, vol. 56, no. 23, pp. 5330-5333, 1996.
  • [15] F. Lu, J. Zhang, M. Ji, P. Li, Y. Du, H. Wang, S. Zang, D. Ma, X. Sun and C. Ji, “miR-181b increases drug sensitivity in acute myeloid leukemia via targeting HMGB1 and Mcl-1,” Int J Oncol, vol. 45, no. 1, pp. 383-392, 2014.
  • [16] D. Garcia and R. J. Shaw, “AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance,” Mol Cell, vol. 66, no. 6, pp. 789-800, 2017.
  • [17] K. Gao, Y. Chi, W. Sun, M. Takeda and J. Yao, “5'-AMP-activated protein kinase attenuates adriamycin-induced oxidative podocyte injury through thioredoxin-mediated suppression of the apoptosis signal-regulating kinase 1-P38 signaling pathway,” Mol Pharmacol, vol. 85, no. 3, pp. 460-471, 2014.
  • [18] N. Dursun, E. Taskin, M. B. Yerer Aycan and L. Sahin, “Selenium-mediated cardioprotection against adriamycin-induced mitochondrial damage,” Drug Chem Toxicol, vol. 34, no. 2, pp. 199-207, 2011.
  • [19] C. Guven, E. Taskin and H. Akcakaya, “Melatonin Prevents Mitochondrial Damage Induced by Doxorubicin in Mouse Fibroblasts Through Ampk-Ppar Gamma-Dependent Mechanisms,” Med Sci Monit, vol. 22, no. pp. 438-446, 2016.
  • [20] E. Taskin and N. Dursun, “The protection of selenium on adriamycin-induced mitochondrial damage in rat,” Biol Trace Elem Res, vol. 147, no. 1-3, pp. 165-171, 2012.
  • [21] E. Taskin and N. Dursun, “Recovery of adriamycin induced mitochondrial dysfunction in liver by selenium,” Cytotechnology, vol. 67, no. 6, pp. 977-986, 2015.
  • [22] E. Taskin, E. K. Kindap, K. Ozdogan, M. B. Aycan and N. Dursun, “Acute adriamycin-induced cardiotoxicity is exacerbated by angiotension II,” Cytotechnology, vol. 68, no. 1, pp. 33-43, 2016.
  • [23] E. Taskin, K. Ozdogan, E. Kunduz Kindap and N. Dursun, “The restoration of kidney mitochondria function by inhibition of angiotensin-II production in rats with acute adriamycin-induced nephrotoxicity,” Ren Fail, vol. 36, no. 4, pp. 606-612, 2014.
  • [24] H. Yapislar, E. Taskin, S. Ozdas, D. Akin and E. Sonmez, “Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite,” Biol Trace Elem Res, vol. no. pp. 2015.
  • [25] Y. Zhang, G. Duan and S. Feng, “MicroRNA-301a modulates doxorubicin resistance in osteosarcoma cells by targeting AMP-activated protein kinase alpha 1,” Biochem Biophys Res Commun, vol. 459, no. 3, pp. 367-373, 2015.
  • [26] S. Gratia, L. Kay, L. Potenza, A. Seffouh, V. Novel-Chate, C. Schnebelen, P. Sestili, U. Schlattner and M. Tokarska-Schlattner, “Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress,” Cardiovasc Res, vol. 95, no. 3, pp. 290-299, 2012.
  • [27] X. Wang, X. L. Wang, H. L. Chen, D. Wu, J. X. Chen, X. X. Wang, R. L. Li, J. H. He, L. Mo, X. Cen, Y. Q. Wei and W. Jiang, “Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK,” Biochem Pharmacol, vol. 88, no. 3, pp. 334-350, 2014.
  • [28] D. N. Dhanasekaran and E. P. Reddy, “JNK signaling in apoptosis,” Oncogene, vol. 27, no. 48, pp. 6245-6251, 2008.
  • [29] P. Luo, Y. Zhu, M. Chen, H. Yan, B. Yang, X. Yang and Q. He, “HMGB1 contributes to adriamycin-induced cardiotoxicity via up-regulating autophagy,” Toxicol Lett, vol. 292, no. pp. 115-122, 2018.
  • [30] H. Xu, Y. Yao, Z. Su, Y. Yang, R. Kao, C. M. Martin and T. Rui, “Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK,” Am J Physiol Heart Circ Physiol, vol. 300, no. 3, pp. H913-921, 2011.
Primary Language tr
Subjects Engineering
Journal Section Articles
Authors

Orcid: 0000-0001-8172-4980
Author: Eylem Taşkın Güven (Primary Author)
Institution: NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, FİZYOLOJİ ANABİLİM DALI
Country: Turkey


Orcid: 0000-0003-0499-7787
Author: Celal Güven
Institution: NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, BİYOFİZİK ANABİLİM DALI
Country: Turkey


Orcid: 0000-0002-4133-407X
Author: Salih Tunç Kaya
Institution: DÜZCE ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, BİYOLOJİ BÖLÜMÜ
Country: Turkey


Orcid: 0000-0002-4373-2389
Author: Yusuf Sevgiler
Institution: ADIYAMAN ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, BİYOLOJİ BÖLÜMÜ
Country: Turkey


Dates

Publication Date: July 31, 2019

Bibtex @review { dubited579185, journal = {Düzce Üniversitesi Bilim ve Teknoloji Dergisi}, issn = {}, eissn = {2148-2446}, address = {Duzce University}, year = {2019}, volume = {7}, pages = {1976 - 1984}, doi = {10.29130/dubited.579185}, title = {HMGB1’in Kanser ve Tedavisiyle İlişkisi}, key = {cite}, author = {Taşkın Güven, Eylem and Güven, Celal and Kaya, Salih Tunç and Sevgiler, Yusuf} }
APA Taşkın Güven, E , Güven, C , Kaya, S , Sevgiler, Y . (2019). HMGB1’in Kanser ve Tedavisiyle İlişkisi. Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 7 (3), 1976-1984. DOI: 10.29130/dubited.579185
MLA Taşkın Güven, E , Güven, C , Kaya, S , Sevgiler, Y . "HMGB1’in Kanser ve Tedavisiyle İlişkisi". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 (2019): 1976-1984 <http://dergipark.org.tr/dubited/issue/46290/579185>
Chicago Taşkın Güven, E , Güven, C , Kaya, S , Sevgiler, Y . "HMGB1’in Kanser ve Tedavisiyle İlişkisi". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 (2019): 1976-1984
RIS TY - JOUR T1 - HMGB1’in Kanser ve Tedavisiyle İlişkisi AU - Eylem Taşkın Güven , Celal Güven , Salih Tunç Kaya , Yusuf Sevgiler Y1 - 2019 PY - 2019 N1 - doi: 10.29130/dubited.579185 DO - 10.29130/dubited.579185 T2 - Düzce Üniversitesi Bilim ve Teknoloji Dergisi JF - Journal JO - JOR SP - 1976 EP - 1984 VL - 7 IS - 3 SN - -2148-2446 M3 - doi: 10.29130/dubited.579185 UR - https://doi.org/10.29130/dubited.579185 Y2 - 2019 ER -
EndNote %0 Duzce University Journal of Science and Technology HMGB1’in Kanser ve Tedavisiyle İlişkisi %A Eylem Taşkın Güven , Celal Güven , Salih Tunç Kaya , Yusuf Sevgiler %T HMGB1’in Kanser ve Tedavisiyle İlişkisi %D 2019 %J Düzce Üniversitesi Bilim ve Teknoloji Dergisi %P -2148-2446 %V 7 %N 3 %R doi: 10.29130/dubited.579185 %U 10.29130/dubited.579185
ISNAD Taşkın Güven, Eylem , Güven, Celal , Kaya, Salih Tunç , Sevgiler, Yusuf . "HMGB1’in Kanser ve Tedavisiyle İlişkisi". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 / 3 (July 2019): 1976-1984. https://doi.org/10.29130/dubited.579185
AMA Taşkın Güven E , Güven C , Kaya S , Sevgiler Y . HMGB1’in Kanser ve Tedavisiyle İlişkisi. DUBİTED. 2019; 7(3): 1976-1984.
Vancouver Taşkın Güven E , Güven C , Kaya S , Sevgiler Y . HMGB1’in Kanser ve Tedavisiyle İlişkisi. Düzce Üniversitesi Bilim ve Teknoloji Dergisi. 2019; 7(3): 1984-1976.