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Rubella, cytomegalovirus and toxoplasmosis seroprevalence in pregnants in Çorum Province

Year 2022, , 202 - 205, 29.03.2022
https://doi.org/10.38053/acmj.1062754

Abstract

Aim: Toxoplasma gondii (T. gondii), rubella virus and cytomegalovirus (CMV) are important factors that can be transmitted from mother to baby and cause clinical findings in fetus or newborn. In our study, it was aimed to determine the seroprevalence of T. gondii, rubella virus and cytomegalovirus in pregnant women who applied to our hospital.
Material and Method: In our study, the serological test results of the blood samples of pregnant women used in the diagnosis of T. gondii, rubella virus and CMV infections in Microbiology Laboratory of Hitit University Erol Olçok Training and Research Hospital, were retrospectively analyzed in a five years period between 2016 and 2021.
Results: In our study, when T. gondii, rubella virus and CMV test results were examined in pregnant women who applied to our hospital, 18.9% positivity for anti-T. gondii IgG, 88.7% for anti-rubella virus IgG and 99.7% for anti-CMV IgG rates have been determined. The positivity of IgM tests of the same agents was determined as 1%, 0.85% and 1.08%, respectively.
Conclusion: Regional epidemiological data are important in terms of determining which of the routine screening approach or the risk of infection factors on the baby will be more important. We think that our study, which includes regional data, will contribute to the literature on this subject.

References

  • Fuchs FE, Pauly M, Black AP, et al. Seroprevalence of ToRCH Pathogens in Southeast Asia. Microorganisms 2021; 9: 574.
  • Singh L, Mishra S, Prasanna S, et al. Seroprevalence of TORCH infections in antenatal and HIV positive patient populations. Med J Armed Forces India 2015; 71: 135-38.
  • Pleyer U, Gross U, Schluter D, et al. Toxoplasmosis in Germany. Dtsch Arztebl Int 2019; 116: 435-44.
  • Beder D, Esenkaya Tasbent F. General Features and Laboratory Diagnosis of Toxoplasma gondii Infection. Turkiye Parazitol Derg 2020; 44: 94-101.
  • Marsico C, Kimberlin DW. Congenital Cytomegalovirus infection: advances and challenges in diagnosis, prevention and treatment. Ital J Pediatr 2017; 43: 38.
  • Çeltek NY, Tetikçok R, Günal Ö, et al. Türkiye’nin Orta Karadeniz Bölgesi’nde Gebelerde Rubella, CMV ve Toksoplazmozis Seroprevalansı (Seroprevalence for Rubella, CMV and Toxoplasmosis Among Pregnant Women in Central Black Sea Region of Turkey). Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 2014; 6: 54-62.
  • Karabulut A, Polat Y, Türk M, et al. Evaluation of rubella, Toxoplasma gondii, and cytomegalovirus seroprevalences among pregnant women in Denizli province. Turk J Med Sci 2011; 41: 159-64.
  • George S, Viswanathan R, Sapkal GN. Molecular aspects of the teratogenesis of rubella virus. Biol Res 2019; 52
  • Mawson AR, Croft AM. Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism. Int J Environ Res Public Health 2019; 16 : 3543.
  • Karacan M, Batukan M, Çebi Z, et al. Screening cytomegalovirus, rubella and toxoplasma infections in pregnant women with unknown pre-pregnancy serological status. Archives of Gynecology and Obstetrics 2014; 290: 1115-20.
  • Duran B, Toktamış A, Erden Ö, et al. Doğum öncesi bakımda tartışmalı bir konu: TORCH taraması. CÜ Tıp Fakültesi Dergisi 2002; 24 :185-90.
  • Numan O, Vural F, Aka N, et al. TORCH seroprevalence among patients attending Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals. North Clin Istanb 2015; 2: 203-09.
  • Mehmet O, Doğan Y, Bademkiran MH, et al. Diyarbakır ilindeki gebe kadınlarda toksoplazma, rubella ve sitomegalovirus seroprevalansı. Dicle Tıp Dergisi 46 :189-94.
  • Saricaoğlu EM, Memikoğlu KO. Gebelik ve toksoplazmoz. Ankara Üniversitesi Tıp Fakültesi Mecmuası 2018; 71 :17-22.
  • Rahmanian V, Rahmanian K, Jahromi AS, et al. Seroprevalence of Toxoplasma gondii infection: An umbrella review of updated systematic reviews and meta-analyses. J Family Med Prim Care 2020; 9: 3848-55.
  • Cinar Tanriverdi E, Goktug Kadioglu B, et al. Retrospective evaluation of anti-Toxoplasma gondii antibody among first trimester pregnant women admitted to Nenehatun Maternity Hospital between 2013-2017 in Erzurum. Turkiye Parazitol Derg 2018; 42: 101-05.
  • Alver O, Payaslioglu M, Ener B. Investigation of Toxoplasma gondii Seropositivity in Uludag University Hospital between 2009-2016. Turkiye Parazitol Derg 2019; 43 :8-12.
  • Madendağ Y, Erarslan Şahin M, et al. Hastanemize başvuran gebelerde toksoplazma, sitomegalovirus ve rubella seroprevalansının araştırılması. Perinatoloji Dergisi. 2018; 26: 7-10.
  • Tamer GS, Dundar D, Caliskan E. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in western region of Turkey. Clin Invest Med 2009 ;32 :43-47.
  • Ocak S, Zeteroglu S, Ozer C, at al. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in southern Turkey. Scand J Infect Dis 2007; 39: 231-34.
  • Bigna JJ, Tochie JN, Tounouga DN, et al. Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis. Sci Rep 2020; 10 :12102.
  • Leung AKC, Hon KL, Leong KF. Rubella (German measles) revisited. Hong Kong Med J 2019; 25: 134-41.
  • Tekin A, Deveci Ö, Yula E. The seroprevalence of antibodies against Toxoplasma gondii and Rubella virus among childbearing age women in Mardin province. J Clin Exp Invest 2010; 1: 2.
  • Toklu GD. Antibodies frequency against toxoplasmosis, rubella virus and cytomegalovirus in pregnant women. J Clin Anal Med 2013; 4: 38-40.
  • Şener K, Kılıç A, Güney Ç, et al. Genişletilmiş bağışıklama programı öncesi rubella (kızamıkçık) seroprevalansı. TAF Prev Med Bull 2007; 6: 1-6.
  • Lachmann R, Loenenbach A, Waterboer T, et al. Cytomegalovirus (CMV) seroprevalence in the adult population of Germany. PLoS One 2018; 13 :e0200267.
  • Griffiths PD. Burden of disease associated with human cytomegalovirus and prospects for elimination by universal immunisation. Lancet Infect Dis. 2012; 12 :790-98.
  • Ludwig A, Hengel H. Epidemiological impact and disease burden of congenital cytomegalovirus infection in Europe. Euro Surveill. 2009; 14: 26-32.
  • Manicklal S, Emery VC, Lazzarotto T, et al. The “silent” global burden of congenital cytomegalovirus. Clin Microbiol Rev. 2013; 26: 86-102.
  • Efe Ş, Kurdoğlu Z, Korkmaz G. Van yöresindeki gebelerde Sitomegalovirus, Rubella ve Toksoplazma antikorlarının seroprevalansı. Van Tıp Derg. 2009;16: 6-9.
  • Kılınç Ç, Guckan R, Idil O, et al. Amasya Bölgesindeki Gebelerde Toksoplazma ve Sitomegalovirus Seroprevelansı Toxoplasma and Cytomegalovirus seroprevalence in pregnant women in Amasya district. Eur J Health Sci 2015; 72-5.
  • Şentürk Ş, Balik G, Şahin FK, et al. Rize Yöresindeki Gebe Kadınlarda Sitomegalovirus Seroprevalansı. Bozok Tıp Derg 2015; 5: 22-6.
  • Yilmazer M, Altindiş M, Cevrioğlu S, et al. Afyon Bölgesinde Yaşayan Gebe Kadınlarda Toksoplazma, Sitomegalovirus, Rubella, Hepatit B, Hepatit C Seropozitiflik Oranları. Kocatepe Tıp Derg 2004; 5.
Year 2022, , 202 - 205, 29.03.2022
https://doi.org/10.38053/acmj.1062754

Abstract

References

  • Fuchs FE, Pauly M, Black AP, et al. Seroprevalence of ToRCH Pathogens in Southeast Asia. Microorganisms 2021; 9: 574.
  • Singh L, Mishra S, Prasanna S, et al. Seroprevalence of TORCH infections in antenatal and HIV positive patient populations. Med J Armed Forces India 2015; 71: 135-38.
  • Pleyer U, Gross U, Schluter D, et al. Toxoplasmosis in Germany. Dtsch Arztebl Int 2019; 116: 435-44.
  • Beder D, Esenkaya Tasbent F. General Features and Laboratory Diagnosis of Toxoplasma gondii Infection. Turkiye Parazitol Derg 2020; 44: 94-101.
  • Marsico C, Kimberlin DW. Congenital Cytomegalovirus infection: advances and challenges in diagnosis, prevention and treatment. Ital J Pediatr 2017; 43: 38.
  • Çeltek NY, Tetikçok R, Günal Ö, et al. Türkiye’nin Orta Karadeniz Bölgesi’nde Gebelerde Rubella, CMV ve Toksoplazmozis Seroprevalansı (Seroprevalence for Rubella, CMV and Toxoplasmosis Among Pregnant Women in Central Black Sea Region of Turkey). Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 2014; 6: 54-62.
  • Karabulut A, Polat Y, Türk M, et al. Evaluation of rubella, Toxoplasma gondii, and cytomegalovirus seroprevalences among pregnant women in Denizli province. Turk J Med Sci 2011; 41: 159-64.
  • George S, Viswanathan R, Sapkal GN. Molecular aspects of the teratogenesis of rubella virus. Biol Res 2019; 52
  • Mawson AR, Croft AM. Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism. Int J Environ Res Public Health 2019; 16 : 3543.
  • Karacan M, Batukan M, Çebi Z, et al. Screening cytomegalovirus, rubella and toxoplasma infections in pregnant women with unknown pre-pregnancy serological status. Archives of Gynecology and Obstetrics 2014; 290: 1115-20.
  • Duran B, Toktamış A, Erden Ö, et al. Doğum öncesi bakımda tartışmalı bir konu: TORCH taraması. CÜ Tıp Fakültesi Dergisi 2002; 24 :185-90.
  • Numan O, Vural F, Aka N, et al. TORCH seroprevalence among patients attending Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals. North Clin Istanb 2015; 2: 203-09.
  • Mehmet O, Doğan Y, Bademkiran MH, et al. Diyarbakır ilindeki gebe kadınlarda toksoplazma, rubella ve sitomegalovirus seroprevalansı. Dicle Tıp Dergisi 46 :189-94.
  • Saricaoğlu EM, Memikoğlu KO. Gebelik ve toksoplazmoz. Ankara Üniversitesi Tıp Fakültesi Mecmuası 2018; 71 :17-22.
  • Rahmanian V, Rahmanian K, Jahromi AS, et al. Seroprevalence of Toxoplasma gondii infection: An umbrella review of updated systematic reviews and meta-analyses. J Family Med Prim Care 2020; 9: 3848-55.
  • Cinar Tanriverdi E, Goktug Kadioglu B, et al. Retrospective evaluation of anti-Toxoplasma gondii antibody among first trimester pregnant women admitted to Nenehatun Maternity Hospital between 2013-2017 in Erzurum. Turkiye Parazitol Derg 2018; 42: 101-05.
  • Alver O, Payaslioglu M, Ener B. Investigation of Toxoplasma gondii Seropositivity in Uludag University Hospital between 2009-2016. Turkiye Parazitol Derg 2019; 43 :8-12.
  • Madendağ Y, Erarslan Şahin M, et al. Hastanemize başvuran gebelerde toksoplazma, sitomegalovirus ve rubella seroprevalansının araştırılması. Perinatoloji Dergisi. 2018; 26: 7-10.
  • Tamer GS, Dundar D, Caliskan E. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in western region of Turkey. Clin Invest Med 2009 ;32 :43-47.
  • Ocak S, Zeteroglu S, Ozer C, at al. Seroprevalence of Toxoplasma gondii, rubella and cytomegalovirus among pregnant women in southern Turkey. Scand J Infect Dis 2007; 39: 231-34.
  • Bigna JJ, Tochie JN, Tounouga DN, et al. Global, regional, and country seroprevalence of Toxoplasma gondii in pregnant women: a systematic review, modelling and meta-analysis. Sci Rep 2020; 10 :12102.
  • Leung AKC, Hon KL, Leong KF. Rubella (German measles) revisited. Hong Kong Med J 2019; 25: 134-41.
  • Tekin A, Deveci Ö, Yula E. The seroprevalence of antibodies against Toxoplasma gondii and Rubella virus among childbearing age women in Mardin province. J Clin Exp Invest 2010; 1: 2.
  • Toklu GD. Antibodies frequency against toxoplasmosis, rubella virus and cytomegalovirus in pregnant women. J Clin Anal Med 2013; 4: 38-40.
  • Şener K, Kılıç A, Güney Ç, et al. Genişletilmiş bağışıklama programı öncesi rubella (kızamıkçık) seroprevalansı. TAF Prev Med Bull 2007; 6: 1-6.
  • Lachmann R, Loenenbach A, Waterboer T, et al. Cytomegalovirus (CMV) seroprevalence in the adult population of Germany. PLoS One 2018; 13 :e0200267.
  • Griffiths PD. Burden of disease associated with human cytomegalovirus and prospects for elimination by universal immunisation. Lancet Infect Dis. 2012; 12 :790-98.
  • Ludwig A, Hengel H. Epidemiological impact and disease burden of congenital cytomegalovirus infection in Europe. Euro Surveill. 2009; 14: 26-32.
  • Manicklal S, Emery VC, Lazzarotto T, et al. The “silent” global burden of congenital cytomegalovirus. Clin Microbiol Rev. 2013; 26: 86-102.
  • Efe Ş, Kurdoğlu Z, Korkmaz G. Van yöresindeki gebelerde Sitomegalovirus, Rubella ve Toksoplazma antikorlarının seroprevalansı. Van Tıp Derg. 2009;16: 6-9.
  • Kılınç Ç, Guckan R, Idil O, et al. Amasya Bölgesindeki Gebelerde Toksoplazma ve Sitomegalovirus Seroprevelansı Toxoplasma and Cytomegalovirus seroprevalence in pregnant women in Amasya district. Eur J Health Sci 2015; 72-5.
  • Şentürk Ş, Balik G, Şahin FK, et al. Rize Yöresindeki Gebe Kadınlarda Sitomegalovirus Seroprevalansı. Bozok Tıp Derg 2015; 5: 22-6.
  • Yilmazer M, Altindiş M, Cevrioğlu S, et al. Afyon Bölgesinde Yaşayan Gebe Kadınlarda Toksoplazma, Sitomegalovirus, Rubella, Hepatit B, Hepatit C Seropozitiflik Oranları. Kocatepe Tıp Derg 2004; 5.
There are 33 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Articles
Authors

Hande Kahraman 0000-0002-0061-8412

Ünsal Savcı 0000-0003-2319-8171

Publication Date March 29, 2022
Published in Issue Year 2022

Cite

AMA Kahraman H, Savcı Ü. Rubella, cytomegalovirus and toxoplasmosis seroprevalence in pregnants in Çorum Province. Anatolian Curr Med J / ACMJ / acmj. March 2022;4(2):202-205. doi:10.38053/acmj.1062754

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