Assessment of tumor location in adjuvant treatment decision for stage II colon cancer

Abstract

Aims: In stage II colon cancer, the aim is to evaluate the impact of tumor location and other clinicopathological factors on prognosis and survival. Methods: The study included a total of 93 patients diagnosed with stage II colon cancer between January 2018 and December 2022, comprising 41 females and 52 males. Clinicopathological factors related to the patients were retrospectively investigated. Factors found to be significant in univariate analysis were further evaluated through multivariate analysis to identify independent factors. Results: As a result of univariate analysis, variables such as tumor location (right-left colon), perineural invasion, surgical margin, intestinal obstruction, and lymph node dissection were found to be statistically significant for the risk of death (p<0.05). These variables, identified as significant in univariate analyses, were included in the multivariate cox regression model. According to the result of the multivariate cox regression model, individuals with intestinal obstruction were determined to have a 7.07 times higher risk of death (HR: 7.07; 95% CI: 2.42-20.62; p < 0.001). Conclusion: We observed an association between left colon tumors in stage II patients and poorer survival, and we noted that intestinal obstruction has an independent prognostic effect on survival.

Keywords

• Adjuvant chemotherapy
• colon cancer
• prognosis
• tumor localization

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