Prognostic value of the uric acid-to-albumin ratio, prognostic nutritional index, and systemic inflammation response index in patients monitored in a pulmonary intensive care unit due to acute respiratory failure

Damla Serçe Unat; Ömer Selim Unat; Nilay Erten Turan

Prognostic value of the uric acid-to-albumin ratio, prognostic nutritional index, and systemic inflammation response index in patients monitored in a pulmonary intensive care unit due to acute respiratory failure

Abstract

Aims: This study aimed to evaluate the prognostic value of the uric acid-to-albumin ratio (UAR), systemic inflammation response index (SIRI), and prognostic nutritional index (PNI) in patients admitted to a pulmonary intensive care unit (ICU) due to acute respiratory failure (ARF). Methods: This retrospective observational study included 175 patients admitted to the pulmonary ICU with ARF. UAR, SIRI, and PNI were calculated from admission laboratory values. The primary outcome was 28-day clinical prognosis (good vs. poor), and the secondary outcome was 28-day all-cause mortality. Receiver operating characteristic (ROC) curve analysis and multivariable logistic regression were used to assess discriminative and independent predictive performance. Results: Of 175 patients, 99 had poor prognosis and 60 died within 28 days. Patients with poor prognosis had significantly lower PNI (36.4 vs. 38.5; p=0,021) and higher SIRI (7.61 vs. 5.15; p=0.014), while UAR did not differ significantly between groups (p=0.233). ROC analysis demonstrated modest discriminative ability for poor prognosis for both PNI (AUC=0,602; p=0.021) and SIRI (AUC=0.609; p=0.014). In the adjusted multivariable model, lower PNI showed a borderline association with poor prognosis (OR=0.953; 95% CI 0.904-1.005; p=0.080). No evaluated biomarker demonstrated significant discriminative ability for 28-day mortality. Conclusion: Impaired immunonutritional status, as reflected by a low PNI, was associated with poor 28-day prognosis and showed a borderline association after adjustment. PNI and SIRI demonstrated only modest prognostic performance and should be considered supportive rather than standalone prognostic markers. Further prospective multicenter studies are warranted.

Keywords

Supporting Institution

None

Ethical Statement

The research protocol received approval from the institutional ethics committee before the initiation of the study. All procedures were conducted in line with internationally recognized ethical standards for research involving human subjects. As the analysis relied on previously recorded clinical data, the need for written informed consent was waived.

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Details

Primary Language

English

Subjects

Respiratory Diseases, Intensive Care

Journal Section

Research Article

Authors

Damla Serçe Unat ^*
0000-0003-4743-5469
Türkiye

Ömer Selim Unat
0000-0002-5708-2233
Türkiye

Nilay Erten Turan
0009-0000-4463-7650
Türkiye

Publication Date

May 22, 2026

Submission Date

March 10, 2026

Acceptance Date

May 18, 2026

Published in Issue

Year 2026 Volume: 8 Number: 3

IZ

https://izlik.org/JA82KE84YR

Cite

RIS / Bibtex

APA

Serçe Unat, D., Unat, Ö. S., & Erten Turan, N. (2026). Prognostic value of the uric acid-to-albumin ratio, prognostic nutritional index, and systemic inflammation response index in patients monitored in a pulmonary intensive care unit due to acute respiratory failure. Anatolian Current Medical Journal, 8(3), 553-559. https://izlik.org/JA82KE84YR

AMA

1.Serçe Unat D, Unat ÖS, Erten Turan N. Prognostic value of the uric acid-to-albumin ratio, prognostic nutritional index, and systemic inflammation response index in patients monitored in a pulmonary intensive care unit due to acute respiratory failure. Anatolian Curr Med J / ACMJ / acmj. 2026;8(3):553-559. https://izlik.org/JA82KE84YR

Chicago

Serçe Unat, Damla, Ömer Selim Unat, and Nilay Erten Turan. 2026. “Prognostic Value of the Uric Acid-to-Albumin Ratio, Prognostic Nutritional Index, and Systemic Inflammation Response Index in Patients Monitored in a Pulmonary Intensive Care Unit Due to Acute Respiratory Failure”. Anatolian Current Medical Journal 8 (3): 553-59. https://izlik.org/JA82KE84YR.

EndNote

Serçe Unat D, Unat ÖS, Erten Turan N (May 1, 2026) Prognostic value of the uric acid-to-albumin ratio, prognostic nutritional index, and systemic inflammation response index in patients monitored in a pulmonary intensive care unit due to acute respiratory failure. Anatolian Current Medical Journal 8 3 553–559.

IEEE

[1]D. Serçe Unat, Ö. S. Unat, and N. Erten Turan, “Prognostic value of the uric acid-to-albumin ratio, prognostic nutritional index, and systemic inflammation response index in patients monitored in a pulmonary intensive care unit due to acute respiratory failure”, Anatolian Curr Med J / ACMJ / acmj, vol. 8, no. 3, pp. 553–559, May 2026, [Online]. Available: https://izlik.org/JA82KE84YR

ISNAD

Serçe Unat, Damla - Unat, Ömer Selim - Erten Turan, Nilay. “Prognostic Value of the Uric Acid-to-Albumin Ratio, Prognostic Nutritional Index, and Systemic Inflammation Response Index in Patients Monitored in a Pulmonary Intensive Care Unit Due to Acute Respiratory Failure”. Anatolian Current Medical Journal 8/3 (May 1, 2026): 553-559. https://izlik.org/JA82KE84YR.

JAMA

1.Serçe Unat D, Unat ÖS, Erten Turan N. Prognostic value of the uric acid-to-albumin ratio, prognostic nutritional index, and systemic inflammation response index in patients monitored in a pulmonary intensive care unit due to acute respiratory failure. Anatolian Curr Med J / ACMJ / acmj. 2026;8:553–559.

MLA

Serçe Unat, Damla, et al. “Prognostic Value of the Uric Acid-to-Albumin Ratio, Prognostic Nutritional Index, and Systemic Inflammation Response Index in Patients Monitored in a Pulmonary Intensive Care Unit Due to Acute Respiratory Failure”. Anatolian Current Medical Journal, vol. 8, no. 3, May 2026, pp. 553-9, https://izlik.org/JA82KE84YR.

Vancouver

1.Damla Serçe Unat, Ömer Selim Unat, Nilay Erten Turan. Prognostic value of the uric acid-to-albumin ratio, prognostic nutritional index, and systemic inflammation response index in patients monitored in a pulmonary intensive care unit due to acute respiratory failure. Anatolian Curr Med J / ACMJ / acmj [Internet]. 2026 May 1;8(3):553-9. Available from: https://izlik.org/JA82KE84YR