Prognostic value of SCORE2 and SCORE2-OP in patients with severe aortic stenosis undergoing transcatheter or surgical aortic valve replacement

Anar Mammadli; Ayşe İrem Demirtola; Duygu İnan; İhsan Demirtaş; Berk Erdinç; Onur Yıldırım; Alev Kılıçgedik

Prognostic value of SCORE2 and SCORE2-OP in patients with severe aortic stenosis undergoing transcatheter or surgical aortic valve replacement

Abstract

Aims: Despite advances in valve intervention strategies, mortality in patients with severe aortic stenosis remains considerable. The present study investigated whether age-appropriate SCORE2 risk classification provides prognostic information in patients with severe AS undergoing either transcatheter or surgical aortic valve replacement. Methods: This retrospective single-center study included 168 consecutive patients with severe AS who underwent surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI). Cardiovascular risk was estimated using age-appropriate SCORE2 algorithms (SCORE2 for patients aged <70 years and SCORE2-OP for those ≥70 years). Patients were classified into non-very high-risk and very high-risk groups. The primary endpoint was all-cause mortality during follow-up. Survival analyses were performed using Kaplan-Meier methods and Cox proportional hazards regression. Results: Among 168 patients (median age 73 [63-80] years; 51% male), 116 (69%) were classified as very high risk. During a median follow-up of 10 (4-16) months, 28 patients (17%) died. Mortality was higher in the very high-risk group (21% vs. 8%; p =0.02), with lower cumulative survival (log-rank p=0.03). In Cox analysis, very high SCORE2 risk predicted mortality (HR 3.22, 95% CI 1.11-9.30; p=0.031) and remained significant after adjustment (HR 3.40, 95% CI 1.11-10.41; p=0.032). Model discrimination improved after adjustment (AUC 0.60 to 0.70). Conclusion: Very high SCORE2 risk remained significantly associated with mid-term mortality in patients with severe AS undergoing TAVI or SAVR, suggesting that global cardiovascular risk assessment may provide complementary prognostic information after valve intervention.

Keywords

Supporting Institution

None

Project Number

None

Ethical Statement

Ethical approval for the study was obtained from the local institutional ethics committee (Approval No: 2022.12.386).

Thanks

None

References

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Details

Primary Language

English

Subjects

Cardiology

Journal Section

Research Article

Authors

Anar Mammadli
0000-0002-1351-1905
Türkiye

Ayşe İrem Demirtola ^*
0000-0003-4846-0770
Türkiye

Duygu İnan
0000-0003-3921-6469
Türkiye

İhsan Demirtaş
0009-0009-4025-8958
Türkiye

Berk Erdinç
0000-0001-7422-0610
Türkiye

Onur Yıldırım
0000-0002-9750-5413
Türkiye

Alev Kılıçgedik
0000-0002-0654-8128
Türkiye

Publication Date

July 16, 2026

Submission Date

March 30, 2026

Acceptance Date

June 7, 2026

Published in Issue

Year 2026 Volume: 8 Number: 4

IZ

https://izlik.org/JA69DZ39SE

Cite

RIS / Bibtex

APA

Mammadli, A., Demirtola, A. İ., İnan, D., Demirtaş, İ., Erdinç, B., Yıldırım, O., & Kılıçgedik, A. (2026). Prognostic value of SCORE2 and SCORE2-OP in patients with severe aortic stenosis undergoing transcatheter or surgical aortic valve replacement. Anatolian Current Medical Journal, 8(4), 668-674. https://izlik.org/JA69DZ39SE

AMA

1.Mammadli A, Demirtola Aİ, İnan D, et al. Prognostic value of SCORE2 and SCORE2-OP in patients with severe aortic stenosis undergoing transcatheter or surgical aortic valve replacement. Anatolian Curr Med J / ACMJ / acmj. 2026;8(4):668-674. https://izlik.org/JA69DZ39SE

Chicago

Mammadli, Anar, Ayşe İrem Demirtola, Duygu İnan, et al. 2026. “Prognostic Value of SCORE2 and SCORE2-OP in Patients With Severe Aortic Stenosis Undergoing Transcatheter or Surgical Aortic Valve Replacement”. Anatolian Current Medical Journal 8 (4): 668-74. https://izlik.org/JA69DZ39SE.

EndNote

Mammadli A, Demirtola Aİ, İnan D, Demirtaş İ, Erdinç B, Yıldırım O, Kılıçgedik A (July 1, 2026) Prognostic value of SCORE2 and SCORE2-OP in patients with severe aortic stenosis undergoing transcatheter or surgical aortic valve replacement. Anatolian Current Medical Journal 8 4 668–674.

IEEE

[1]A. Mammadli et al., “Prognostic value of SCORE2 and SCORE2-OP in patients with severe aortic stenosis undergoing transcatheter or surgical aortic valve replacement”, Anatolian Curr Med J / ACMJ / acmj, vol. 8, no. 4, pp. 668–674, July 2026, [Online]. Available: https://izlik.org/JA69DZ39SE

ISNAD

Mammadli, Anar - Demirtola, Ayşe İrem - İnan, Duygu - Demirtaş, İhsan - Erdinç, Berk - Yıldırım, Onur - Kılıçgedik, Alev. “Prognostic Value of SCORE2 and SCORE2-OP in Patients With Severe Aortic Stenosis Undergoing Transcatheter or Surgical Aortic Valve Replacement”. Anatolian Current Medical Journal 8/4 (July 1, 2026): 668-674. https://izlik.org/JA69DZ39SE.

JAMA

1.Mammadli A, Demirtola Aİ, İnan D, Demirtaş İ, Erdinç B, Yıldırım O, Kılıçgedik A. Prognostic value of SCORE2 and SCORE2-OP in patients with severe aortic stenosis undergoing transcatheter or surgical aortic valve replacement. Anatolian Curr Med J / ACMJ / acmj. 2026;8:668–674.

MLA

Mammadli, Anar, et al. “Prognostic Value of SCORE2 and SCORE2-OP in Patients With Severe Aortic Stenosis Undergoing Transcatheter or Surgical Aortic Valve Replacement”. Anatolian Current Medical Journal, vol. 8, no. 4, July 2026, pp. 668-74, https://izlik.org/JA69DZ39SE.

Vancouver

1.Anar Mammadli, Ayşe İrem Demirtola, Duygu İnan, İhsan Demirtaş, Berk Erdinç, Onur Yıldırım, Alev Kılıçgedik. Prognostic value of SCORE2 and SCORE2-OP in patients with severe aortic stenosis undergoing transcatheter or surgical aortic valve replacement. Anatolian Curr Med J / ACMJ / acmj [Internet]. 2026 Jul. 1;8(4):668-74. Available from: https://izlik.org/JA69DZ39SE