Pan-immune inflammatory value predicts atrial fibrillation recurrence after direct current cardioversion

Şükriye Uslu; Görkem Kuş; Gülsüm Meral Yılmaz Öztekin; Göksel Çağırcı; Şakir Arslan

Pan-immune inflammatory value predicts atrial fibrillation recurrence after direct current cardioversion

Abstract

Aims: We aimed to determine whether there is a relationship between the pan-immune inflammatory value (PIV) and the recurrence of atrial fibrillation (AF) after successful direct current cardioversion (DCCV). Methods: The study included 113 patients with persistent AF who underwent successful DCCV between 2015 and 2023. Results: During the 12-month follow-up, AF recurrence was observed in 38 patients (33.6%). Median PIV was significantly higher in patients who developed recurrence than in those who maintained sinus rhythm (SR) (416.1 vs. 277.0; p=0.0012). The optimal PIV cut-off value was 318.6, providing 76.3% sensitivity and 36.5% specificity. Cox regression analysis identified PIV (HR 1.736, p=0.0260) and coronary artery disease (CAD) (HR 2.276, p=0.0332) as independent predictors of AF recurrence. Conclusion: As a simple and cost-effective biomarker, PIV is an independent predictor of recurrence after DCCV in patients with persistent AF. These findings suggest its potential use in clinical practice for risk stratification of patients undergoing DCCV, enabling more personalized post-cardioversion management strategies.

Keywords

Ethical Statement

The study was conducted with the permission of the Health Science University, Antalya Training and Research Hospital Medical Research Scientific Ethics Committee (Decision no: 14/17, Date: 28/08/2025). All procedures were carried out in accordance with the ethical rules and the principles of the Declaration of Helsinki.

Thanks

The authors would like to thank Professor Mehmet Ziya Fırat, PhD, for his valuable assistance with the statistical analysis of this study.

References

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Details

Primary Language

English

Subjects

Cardiology

Journal Section

Research Article

Authors

Şükriye Uslu ^*
0000-0001-7504-7637
Türkiye

Görkem Kuş
0000-0002-6058-5501
Türkiye

Gülsüm Meral Yılmaz Öztekin
0000-0001-9540-5075
Türkiye

Göksel Çağırcı
0000-0001-9768-918X
Türkiye

Şakir Arslan
0000-0002-2907-4957
Türkiye

Publication Date

July 16, 2026

Submission Date

May 19, 2026

Acceptance Date

June 25, 2026

Published in Issue

Year 2026 Volume: 8 Number: 4

IZ

https://izlik.org/JA44PU47ZE

Cite

RIS / Bibtex

APA

Uslu, Ş., Kuş, G., Yılmaz Öztekin, G. M., Çağırcı, G., & Arslan, Ş. (2026). Pan-immune inflammatory value predicts atrial fibrillation recurrence after direct current cardioversion. Anatolian Current Medical Journal, 8(4), 733-739. https://izlik.org/JA44PU47ZE

AMA

1.Uslu Ş, Kuş G, Yılmaz Öztekin GM, Çağırcı G, Arslan Ş. Pan-immune inflammatory value predicts atrial fibrillation recurrence after direct current cardioversion. Anatolian Curr Med J / ACMJ / acmj. 2026;8(4):733-739. https://izlik.org/JA44PU47ZE

Chicago

Uslu, Şükriye, Görkem Kuş, Gülsüm Meral Yılmaz Öztekin, Göksel Çağırcı, and Şakir Arslan. 2026. “Pan-Immune Inflammatory Value Predicts Atrial Fibrillation Recurrence After Direct Current Cardioversion”. Anatolian Current Medical Journal 8 (4): 733-39. https://izlik.org/JA44PU47ZE.

EndNote

Uslu Ş, Kuş G, Yılmaz Öztekin GM, Çağırcı G, Arslan Ş (July 1, 2026) Pan-immune inflammatory value predicts atrial fibrillation recurrence after direct current cardioversion. Anatolian Current Medical Journal 8 4 733–739.

IEEE

[1]Ş. Uslu, G. Kuş, G. M. Yılmaz Öztekin, G. Çağırcı, and Ş. Arslan, “Pan-immune inflammatory value predicts atrial fibrillation recurrence after direct current cardioversion”, Anatolian Curr Med J / ACMJ / acmj, vol. 8, no. 4, pp. 733–739, July 2026, [Online]. Available: https://izlik.org/JA44PU47ZE

ISNAD

Uslu, Şükriye - Kuş, Görkem - Yılmaz Öztekin, Gülsüm Meral - Çağırcı, Göksel - Arslan, Şakir. “Pan-Immune Inflammatory Value Predicts Atrial Fibrillation Recurrence After Direct Current Cardioversion”. Anatolian Current Medical Journal 8/4 (July 1, 2026): 733-739. https://izlik.org/JA44PU47ZE.

JAMA

1.Uslu Ş, Kuş G, Yılmaz Öztekin GM, Çağırcı G, Arslan Ş. Pan-immune inflammatory value predicts atrial fibrillation recurrence after direct current cardioversion. Anatolian Curr Med J / ACMJ / acmj. 2026;8:733–739.

MLA

Uslu, Şükriye, et al. “Pan-Immune Inflammatory Value Predicts Atrial Fibrillation Recurrence After Direct Current Cardioversion”. Anatolian Current Medical Journal, vol. 8, no. 4, July 2026, pp. 733-9, https://izlik.org/JA44PU47ZE.

Vancouver

1.Şükriye Uslu, Görkem Kuş, Gülsüm Meral Yılmaz Öztekin, Göksel Çağırcı, Şakir Arslan. Pan-immune inflammatory value predicts atrial fibrillation recurrence after direct current cardioversion. Anatolian Curr Med J / ACMJ / acmj [Internet]. 2026 Jul. 1;8(4):733-9. Available from: https://izlik.org/JA44PU47ZE