PREOPERATİF AĞRI YÖNETİMİNDE PREGABALİNİN ROLÜ: ETKİ MEKANİZMALARI VE KLİNİK SONUÇLAR

Year 2025, Volume: 8 Issue: 3, 282 - 286, 22.10.2025

Yağmur Kara , Füsun Eroglu , Berit Gökçe Ceylan

https://doi.org/10.53446/actamednicomedia.1648658

Abstract

Amaç: İnfraklaviküler blok, el ve ön kol cerrahisinde yaygın olarak kullanılan bir tekniktir. Nöropatik ve kronik ağrı üzerine etkinliği bilinen pregabalin, preoperatif uygulandığında postoperatif ağrıyı azaltmak için potansiyel bir ajan olarak ortaya çıkmıştır. Bu çalışma, ameliyattan bir saat önce uygulanan tek doz 150 mg pregabalinin, infraklaviküler blok ile el ve ön kol cerrahisi geçiren hastalarda blok özellikleri ve postoperatif analjezi gereksinimi üzerindeki etkisini değerlendirmeyi amaçlamıştır.
Yöntem: İnfraklaviküler blok altında el ve ön kol cerrahisi geçiren ASA I-II olarak sınıflandırılan 18-65 yaş arası hastaların tıbbi kayıtları retrospektif olarak analiz edildi. Olguların tamamına bölge antisepsisi sağlanarak 30 ml volüm (Bupivakain+Lidokain) verilerek ultrasonografi eşliğinde infraklavikuler blok yapıldı. Hastalar iki gruba ayrıldı: 150 mg pregabalin ile preemptif anestezi alan 30 hastadan oluşan pregabalin grubu (Grup P) ve pregabalin almayan 30 hastadan oluşan kontrol grubu (Grup C). Hemodinamik parametreler, postoperatif ağrı yoğunluğu, ilk ağrı başlangıç zamanı ve ilk analjezik gereksinimi zamanı anestezi kayıtları ve hasta takip formlarına dayanarak belgelendi.
Bulgular: Postoperatif vizüel analog skala skorlaru Grup P'de 12. ve 24. saatlerde daha düşüktü (p<0,05). İlk analjezik uygulama süresi Grup P'de Grup C'ye kıyasla önemli ölçüde daha uzundu.
Sonuç: Ameliyattan bir saat önce uygulanan tek doz 150 mg pregabalin, periferik rejyonel blok ile ameliyata giren hastalarda postoperatif ağrıyı ve analjezik gereksinimini azaltmaktadır.
Anahtar Kelimeler: İnfraklaviküler blok, postoperatif ağrı, preempeitif analjezi, pregabalin

Keywords

İnfraklaviküler blok , postoperatif ağrı , preemptif analjezi , pregabalin

RETROSPECTIVE REVIEW OF THE ROLE OF PREGABALIN IN PREOPERATIVE PAIN MANAGEMENT: MECHANISMS OF ACTION AND CLINICAL OUTCOMES

Abstract

Objective: Infraclavicular block is a commonly utilized technique in hand and forearm surgeries. Pregabalin, acknowledged for its efficacy in managing neuropathic and chronic pain, has emerged as a potential intervention for reducing postoperative pain when administered preoperatively. This study aimed to evaluate the impact of a single 150 mg dose of pregabalin, administered one hour prior to surgery, on block characteristics and postoperative analgesia requirement in patients undergoing hand and forearm surgery with infraclavicular block.
Methods: The medical records of patients aged 18-65 years, classified as ASA I-II, who underwent hand and forearm surgeries under infraclavicular block, were retrospectively analyzed. All patients received regional antisepsis, a 30 ml volume (Bupivacaine+Lidocaine) was administered, and an ultrasound-guided infraclavicular block was performed. Patients were categorized into two groups: the pregabalin group (Group P), comprising 30 patients who received preemptive anesthesia with 150 mg pregabalin, and the control group (Group C), consisting of 30 patients who did not receive pregabalin. Hemodynamic parameters, postoperative pain intensity, time of initial pain onset, and time of first analgesic requirement were documented based on anesthesia records and patient follow-up forms.
Results: Postoperative visual analog scale scores were lower in Group P at the 12th and 24th hours (p<0.05). The time to the first analgesic application was significantly longer in Group P compared to Group C.
Conclusion: A single dose of 150 mg pregabalin administered one hour before surgery appears to reduce postoperative pain and analgesic requirements in patients undergoing surgery with peripheral regional block.

Keywords

Infraclavicular block , postoperative pain , preemptive analgesia , pregabalin

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