A celiac patient presenting with hyperamylasemia: A case report

Year 2013, Volume: 12 Issue: 1, 30 - 31, 01.04.2013

Haşim Nar Ahmet Uyanıkoğlu Timuçin Aydoğan Necati Yenice

Abstract

Celiac disease, also known as gluten-sensitive enteropathy, is characterized by inflammation of the small intestinal mucosa that results from a genetically based immunologic intolerance to ingested gluten. Amylase often increases in acute pancreatitis and salivary inflammation. Amylase elevation in celiac disease is not to be expected. We report a celiac patient who presented with elevated amylase levels. Because the amylase decreased with a gluten-free diet, we believe celiac disease may have been the cause of the amylase elevation in this patient.

Keywords

Amylase elevation, celiac disease

Amilaz yüksekliği ile prezente olan çölyak hastası: Olgu sunumu

Abstract

Çölyak hastalığı (gluten enteropatisi), genetik olarak yatkın bireylerde, glutene karşı immün yanıt sonucu ortaya çıkan otoimmün bir hastalıktır. Amilaz çoğunlukla akut pankreatit ve tükürük bezi inflamasyonunda artar. Çölyak hastalığında amilaz yüksekliği beklenen bir durum de-ğildir. Artmış amilaz düzeyi ile prezente olan ve çölyak teşhisi konulan, diyet sonrası amilaz düzeyleri normale dönen çölyak hastası sunulmuş-tur. Hastada amilaz yüksekliğinin diyetle düzelmesi çölyak hastalığına bağlı olabileceğini düşündürmüştür.

Keywords

Amilaz yüksekliği, çölyak hastalığı

References

• 1- Hernandez L, Green PH. Extraintestinal manifestations of celiac dis- ease. Curr Gastroenterol Rep 2006;8:383-9.
• 2- Mustalahti K. Unusual manifestations of celiac disease. Indian J Pe- diatr 2006;7:711-6.
• 3- Pieper-Bigelow C, Strocchi A, Levitt MD. Where does serum amy- lase come from and where does it go? Gastroenterol Clin North Am 1990;19:793-810.
• 4- Clink D, Weaver D, Bouwman D, et al. Clinical application of organ spesific isoamylases. Am Surg 1982;48:422-5.
• 5- Leeds JS, Hopper AD, Sanders DS. Coeliac disease. Br Med Bull 2008;88:157-70.
• 6- Akın M, Songür Y, Aksakal G. Clinical and laboratory features and extraintestinal manifestations of celiac disease in adults. J Clin Anal Med 2012;3:194-7.
• 7- Yalnız M, Asoğlu M, Demirel U, et al. A case of hyperamylase- mia: Macroamylasemia? Review of the literature. J Clin Exp Invest 2011;2:98-101.
• 8- Gallucci F, Buono R, Ferrara L, et al. Chronic asymptomatic hyperamylasemia unrelated to pancreatic diseases. Adv Med Sci 2010;30:143-5.
• 9- Srivastava R, Fraser C, Gentleman D, et al. Hyperamylasemia: not the usual aspects. BMJ 2005;331:890-1.
• 10- Otsuki M. Usefulness of amylase isoenzyme determination for the diagnosis of pancreatic diseases. Nippon Rinsho 1995;53:1184-91.
• 11- Warshaw AL, Hawboldt MM. Puzzling persistent hyperamyla- semia, probably neither pancreatic nor pathologic. Am J Surg 1988;155:453-6.
• 12- Galasso PJ, Litin SC, O’Brien JF. The macroenzymes: a clinical re- view. Mayo Clin Proc 1993;68:349-54.