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Bioactive Peptides Isolated from Microalgae Spirulina platensis and their Biofunctional Activities

Year 2016, Volume: 14 Issue: 4, 412 - 417, 01.12.2016

Abstract

Spirulina platensis is symbiotic, multicellular, and filamentous blue-green microalgae. It is a rich source of some highvalue bioactive molecules containing essential amino acids, pigments like β-carotene and phycobiliproteins and polyunsaturated fatty acids PUFAs such as eicosapentaenoic acid EPA and docosahexaenoic acid DHA . Spirulina platensis and bioactive peptides derived from these microalgae are gaining more attention because of their nutritional and various medicinal properties like antioxidant, antihypertensive, antimicrobial, anti-diabetes and antiobesity activities. This study provides an overview about bioactive peptides derived from microalgae Spirulina platensis and their some biological activities with health benefits

References

  • Ravi, M., De, S.L., Azharuddin, S., Paul, S.F.D., 2010. The beneficial effects of Spirulina focusing on properties. Nutrition and Dietary Supplements 2: 73-83. and antioxidant
  • Agustini, T.W., Suzery, M., Sutrisnanto, D., Ma’rufa, W.F., Hadiyanto, 2015. Comparative study of bioactive substances extracted from fresh and dried Spirulina sp. Procedia Environmental Sciences 23: 282-289.
  • Vo, T.S., Ngo, D.H., Kim, S.K., 2015. Nutritional and pharmaceutical properties of microalgal Spirulina. In Chapter 9: Handbook of Marine Microalgae, Edited by S.K. Kim,the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK, 568p.
  • Samarakoon, K., Jeon, Y.J., 2012. Bio- functionalities of proteins derived from marine algae - A review. Food Research International 48: 948-960.
  • Priyadarshani, I., Rath, B., 2012. Commercial and industrial applications of microalgae - A review. Journal of Algal Biomass Utilization 3(4): 89-100.
  • Yücetepe, A., Saroğlu, Ö., Bildik, F., Özçelik, B., 2016. Ultrasound assisted extraction of protein from Spirulina platensis; Determination of total phenolic contents and antioxidant activity of protein extracts and optimization of process parameters. The 1st Food Chemistry Conference: Shaping the Future of Food Quality, Health and Safety, October 30-November 1, 2016, Amsterdam, Holland.
  • Wang, L., Pan, B., Sheng, J., Xu, J., Hu, Q., 2007. Antioxidant activity of Spirulina platensis extracts by supercritical carbon dioxide extraction. Food Chemistry 105: 36-41.
  • El-Desouki, N.I., Tabl, G.A., Abdel-Aziz, K.K., Salim, E.I., Nazeeh, N., 2015. Improvement in beta-islets of Langerhans in alloxan-induced diabetic rats by erythropoietin and Spirulina. The Journal of Basic & Applied Zoology 71: 20-31.
  • Benelhadj, S., Gharsallaoui, A., Degraeve, P., Attia, H., Ghorbel, D., 2016. Effect of pH on the functional properties of Arthrospira (Spirulina) platensis protein isolate. Food Chemistry 194: 1056–1063.
  • Silveira, S.T., Burkert, J.F.M., Costa, J.A.V., Burkert, C.A.V., Kalil, S.J., 2007. Optimization of phycocyanin extraction from Spirulina platensis using factorial design. Bioresource Technology 98: 1629-1634.
  • Chaiklahan, R., Chirasuwan, N., Bunnaga, B., 2012. Stability of phycocyanin extracted from Spirulina sp.: Influence of temperature, pH and preservatives. Process Biochemistry 47: 659-664.
  • Yücetepe, A., Özçelik, B., 2016. Nutritional properties of microalgae. Gıda, Metabolizma & Sağlık: Biyoaktif Bileşenler ve Doğal Katkılar Kongresi, 28 Kasım 2016, İstanbul, Turkey, Book of Proceedings, 163-166p.
  • Becker, E.W., 2007. Micro-algae as a source of protein. Biotechnology Advances 25: 207–210.
  • http://www.egemacc.com/tcpdf/examples/pdf.php? a=79&lng=1. Erişim tarihi: 24.11.2016
  • Ngo, D.H., Vo, T.S., Ngo, D.G., 2012. Biological activities and potential health benefits of bioactive peptides International Journal of Biological Macromolecules 51: 378-383. marine organisms.
  • Kim, S.K., Wijesekara, I., 2010. Development and biological activities of marine-derived bioactive peptides: A review. Journal of Functional Foods 2: 1-9.
  • Wijesinghe, W.A.J.P., Jeon, Y.J., 2012. Enzyme- assistant components: A useful approach for recovery of industrially important metabolites from seaweeds: A review. Fitoterapia 83: 6-12. of bioactive of antioxidant peptides from
  • Wang, Z.J., Zhang, X.W., 2016. Inhibitory effects of small (Arthrospira) platensis on cancer cell growth. Food & Function 7(2): 781-788. from Spirulina
  • Lu J., Ren D.F., Xue, Y.L., Sawano, Y., Miyakawa, T., Tanokura, M., 2010. Isolation of an antihypertensive peptide from alcalase digest of Spirulina platensis. Journal of Agricultural and Food Chemistry 58(12): 7166-7171.
  • Kim, N.H., Jung, S.H., Kim, J., Kim, S.H., Ahn, H.J., Bin, S.K., 2014. Purification of an iron- chelating hydrolysates. Journal of the Korean Society for Applied Biological Chemistry 57(1): 91-95. protein
  • Lu, J., Ren, D.F., Wang, J.Z., Tanokura, M., 2010. Purification and characterization of an angiotensin ı -converting enzyme inhibitory peptide derived from Spirulina platensis.Progress in Biochemistry and Biophysics 37(5): 568-574.
  • Estrada, J.E.P., Bescos, P.B., Fresno, A.M.V., 2001. Antioxidant activity of different fractions of Spirulina platensis protean extract. Il Farmaco 56: 497-500.
  • Gad, A.S., Khadrawy, Y.A., El-Nekeety, A.A., Mohamed, S.R., Hassan, N.S., Abdel-Wahhab, M.A., hepatoprotective effects of whey protein and Spirulina in rats. Nutrition 27: 582-589. activity and
  • El-Tantawy, W.H., 2015. Antioxidant effects of Spirulina supplement against lead acetate-induced hepatic injury in rats. Journal of Traditional and Complementary Medicine 1-5.
  • Bermejo, P., Pinero, E., Villar, A.M., 2008. Iron- chelating ability and antioxidant properties of phycocyanin isolated from a protean extract of Spirulina platensis. Food Chemistry 110: 436-445.
  • Ercan, P., El, S.N., 2016. Inhibitory effects of chickpea and Tribulus terrestris on lipase, alpha- amylase and alpha-glucosidase. Food Chemistry 205: 163-169.
  • Layam, A., Reddy, C.L.K., 2006. Antidiabetic property of Spirulina. Diabetologia Croatica 35-2.
  • Pagnussatt, F.A., Ponte, E.M.D., Garda-Buffon, J., Furlong, B., 2014. Inhibition of Fusarium graminearum growth and mycotoxin production by phenolic extract from Spirulina sp. Pesticide Biochemistry and Physiology 108: 21-26.

Mikroalg Spirulina platensis’ten Elde Edilen Biyoaktif Peptitler ve Biyofonksiyonel Aktiviteleri

Year 2016, Volume: 14 Issue: 4, 412 - 417, 01.12.2016

Abstract

Spirulina platensis simbiyotik, çok hücreli ve ipliksi yapıda mavi-yeşil mikroalgdir. Esansiyel aminoasitler, β-karoten ve fikobiliproteinler gibi pigmentler ve eikosapentaenoik EPA ve dokosaheksaenoik asit DHA gibi çoklu doymamış yağ asitleri gibi bazı değerli biyoaktif bileşiklerin zengin bir kaynağıdır. Spirulina platensis ve ondan elde edilen biyoaktif peptitler besinsel ve antioksidan, antihipertansif, antimikrobiyal, antidiyabetik ve antiobezite etkiler gibi bazı medikal faydaları nedeniyle sağlıklı gıda bileşeni olarak gittikçe önem kazanmaktadır. Bu çalışma, Spirulina platensis’ten elde edilen biyoaktif peptitler ve onların bazı sağlık faydaları hakkında bilgi vermeyi amaçlamaktadır

References

  • Ravi, M., De, S.L., Azharuddin, S., Paul, S.F.D., 2010. The beneficial effects of Spirulina focusing on properties. Nutrition and Dietary Supplements 2: 73-83. and antioxidant
  • Agustini, T.W., Suzery, M., Sutrisnanto, D., Ma’rufa, W.F., Hadiyanto, 2015. Comparative study of bioactive substances extracted from fresh and dried Spirulina sp. Procedia Environmental Sciences 23: 282-289.
  • Vo, T.S., Ngo, D.H., Kim, S.K., 2015. Nutritional and pharmaceutical properties of microalgal Spirulina. In Chapter 9: Handbook of Marine Microalgae, Edited by S.K. Kim,the Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK, 568p.
  • Samarakoon, K., Jeon, Y.J., 2012. Bio- functionalities of proteins derived from marine algae - A review. Food Research International 48: 948-960.
  • Priyadarshani, I., Rath, B., 2012. Commercial and industrial applications of microalgae - A review. Journal of Algal Biomass Utilization 3(4): 89-100.
  • Yücetepe, A., Saroğlu, Ö., Bildik, F., Özçelik, B., 2016. Ultrasound assisted extraction of protein from Spirulina platensis; Determination of total phenolic contents and antioxidant activity of protein extracts and optimization of process parameters. The 1st Food Chemistry Conference: Shaping the Future of Food Quality, Health and Safety, October 30-November 1, 2016, Amsterdam, Holland.
  • Wang, L., Pan, B., Sheng, J., Xu, J., Hu, Q., 2007. Antioxidant activity of Spirulina platensis extracts by supercritical carbon dioxide extraction. Food Chemistry 105: 36-41.
  • El-Desouki, N.I., Tabl, G.A., Abdel-Aziz, K.K., Salim, E.I., Nazeeh, N., 2015. Improvement in beta-islets of Langerhans in alloxan-induced diabetic rats by erythropoietin and Spirulina. The Journal of Basic & Applied Zoology 71: 20-31.
  • Benelhadj, S., Gharsallaoui, A., Degraeve, P., Attia, H., Ghorbel, D., 2016. Effect of pH on the functional properties of Arthrospira (Spirulina) platensis protein isolate. Food Chemistry 194: 1056–1063.
  • Silveira, S.T., Burkert, J.F.M., Costa, J.A.V., Burkert, C.A.V., Kalil, S.J., 2007. Optimization of phycocyanin extraction from Spirulina platensis using factorial design. Bioresource Technology 98: 1629-1634.
  • Chaiklahan, R., Chirasuwan, N., Bunnaga, B., 2012. Stability of phycocyanin extracted from Spirulina sp.: Influence of temperature, pH and preservatives. Process Biochemistry 47: 659-664.
  • Yücetepe, A., Özçelik, B., 2016. Nutritional properties of microalgae. Gıda, Metabolizma & Sağlık: Biyoaktif Bileşenler ve Doğal Katkılar Kongresi, 28 Kasım 2016, İstanbul, Turkey, Book of Proceedings, 163-166p.
  • Becker, E.W., 2007. Micro-algae as a source of protein. Biotechnology Advances 25: 207–210.
  • http://www.egemacc.com/tcpdf/examples/pdf.php? a=79&lng=1. Erişim tarihi: 24.11.2016
  • Ngo, D.H., Vo, T.S., Ngo, D.G., 2012. Biological activities and potential health benefits of bioactive peptides International Journal of Biological Macromolecules 51: 378-383. marine organisms.
  • Kim, S.K., Wijesekara, I., 2010. Development and biological activities of marine-derived bioactive peptides: A review. Journal of Functional Foods 2: 1-9.
  • Wijesinghe, W.A.J.P., Jeon, Y.J., 2012. Enzyme- assistant components: A useful approach for recovery of industrially important metabolites from seaweeds: A review. Fitoterapia 83: 6-12. of bioactive of antioxidant peptides from
  • Wang, Z.J., Zhang, X.W., 2016. Inhibitory effects of small (Arthrospira) platensis on cancer cell growth. Food & Function 7(2): 781-788. from Spirulina
  • Lu J., Ren D.F., Xue, Y.L., Sawano, Y., Miyakawa, T., Tanokura, M., 2010. Isolation of an antihypertensive peptide from alcalase digest of Spirulina platensis. Journal of Agricultural and Food Chemistry 58(12): 7166-7171.
  • Kim, N.H., Jung, S.H., Kim, J., Kim, S.H., Ahn, H.J., Bin, S.K., 2014. Purification of an iron- chelating hydrolysates. Journal of the Korean Society for Applied Biological Chemistry 57(1): 91-95. protein
  • Lu, J., Ren, D.F., Wang, J.Z., Tanokura, M., 2010. Purification and characterization of an angiotensin ı -converting enzyme inhibitory peptide derived from Spirulina platensis.Progress in Biochemistry and Biophysics 37(5): 568-574.
  • Estrada, J.E.P., Bescos, P.B., Fresno, A.M.V., 2001. Antioxidant activity of different fractions of Spirulina platensis protean extract. Il Farmaco 56: 497-500.
  • Gad, A.S., Khadrawy, Y.A., El-Nekeety, A.A., Mohamed, S.R., Hassan, N.S., Abdel-Wahhab, M.A., hepatoprotective effects of whey protein and Spirulina in rats. Nutrition 27: 582-589. activity and
  • El-Tantawy, W.H., 2015. Antioxidant effects of Spirulina supplement against lead acetate-induced hepatic injury in rats. Journal of Traditional and Complementary Medicine 1-5.
  • Bermejo, P., Pinero, E., Villar, A.M., 2008. Iron- chelating ability and antioxidant properties of phycocyanin isolated from a protean extract of Spirulina platensis. Food Chemistry 110: 436-445.
  • Ercan, P., El, S.N., 2016. Inhibitory effects of chickpea and Tribulus terrestris on lipase, alpha- amylase and alpha-glucosidase. Food Chemistry 205: 163-169.
  • Layam, A., Reddy, C.L.K., 2006. Antidiabetic property of Spirulina. Diabetologia Croatica 35-2.
  • Pagnussatt, F.A., Ponte, E.M.D., Garda-Buffon, J., Furlong, B., 2014. Inhibition of Fusarium graminearum growth and mycotoxin production by phenolic extract from Spirulina sp. Pesticide Biochemistry and Physiology 108: 21-26.
There are 28 citations in total.

Details

Primary Language English
Journal Section Collection
Authors

Aysun Yücetepe This is me

Beraat Özçelik This is me

Publication Date December 1, 2016
Published in Issue Year 2016 Volume: 14 Issue: 4

Cite

APA Yücetepe, A., & Özçelik, B. (2016). Bioactive Peptides Isolated from Microalgae Spirulina platensis and their Biofunctional Activities. Akademik Gıda, 14(4), 412-417.
AMA Yücetepe A, Özçelik B. Bioactive Peptides Isolated from Microalgae Spirulina platensis and their Biofunctional Activities. Akademik Gıda. December 2016;14(4):412-417.
Chicago Yücetepe, Aysun, and Beraat Özçelik. “Bioactive Peptides Isolated from Microalgae Spirulina Platensis and Their Biofunctional Activities”. Akademik Gıda 14, no. 4 (December 2016): 412-17.
EndNote Yücetepe A, Özçelik B (December 1, 2016) Bioactive Peptides Isolated from Microalgae Spirulina platensis and their Biofunctional Activities. Akademik Gıda 14 4 412–417.
IEEE A. Yücetepe and B. Özçelik, “Bioactive Peptides Isolated from Microalgae Spirulina platensis and their Biofunctional Activities”, Akademik Gıda, vol. 14, no. 4, pp. 412–417, 2016.
ISNAD Yücetepe, Aysun - Özçelik, Beraat. “Bioactive Peptides Isolated from Microalgae Spirulina Platensis and Their Biofunctional Activities”. Akademik Gıda 14/4 (December 2016), 412-417.
JAMA Yücetepe A, Özçelik B. Bioactive Peptides Isolated from Microalgae Spirulina platensis and their Biofunctional Activities. Akademik Gıda. 2016;14:412–417.
MLA Yücetepe, Aysun and Beraat Özçelik. “Bioactive Peptides Isolated from Microalgae Spirulina Platensis and Their Biofunctional Activities”. Akademik Gıda, vol. 14, no. 4, 2016, pp. 412-7.
Vancouver Yücetepe A, Özçelik B. Bioactive Peptides Isolated from Microalgae Spirulina platensis and their Biofunctional Activities. Akademik Gıda. 2016;14(4):412-7.

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