Meme Kanseri Hastalarında ABO ve Rhesus Kan Grubunun Klinikopatolojik Etkisi: Retrospektif Çalışma

Year 2019, , 152 - 156, 22.03.2019

Ömer Parlak , Servet Kocaöz

https://doi.org/10.17098/amj.542143

Abstract

Amaç: Son zamanlarda ABO kan grubu antijenleri ile belirli tipte
insan kanserleri arasındaki ilişki, özellikle pankreas ve mide kanserine
yakalanma riski, araştırmaya olan ilgiyi giderek artmaktadır. Bu çalışmanın amacı,
hastanemizde meme kanseri nedeniyle ameliyat yapılan 209 hastanın A, B, O ve Rh
kan grupları ile meme kanseri arasındaki ilişkiyi araştırmaktır.

Materyal ve Metot: 01 Ocak 2007 ile 31 Aralık 2012
tarihleri arasında Meme kanseri nedeniyle ameliyat edilen 209 hastanın
dosyaları geriye dönük olarak incelendi. Hastaların yaşı, ABO ve Rh kan gurubu,
ameliyat şekli ve klinik verileri hastane bilgi sistemi arşiv kayıtlarından
elde edildi. Histopatolojik olarak, tümör çapı, tümör tipi, tümörün grade’i,
lenf nodu metastazı varlığı, östrojen reseptörü (ER), progesteron reseptörü
(PR), HER2 durumu kaydedildi.

Bulgular: Hastaların ortalama yaşı 57,22 olarak
bulunmuştur. Rh (+) hastalarda Rh (-) hastalara göre invaziv karsinomlar ve
lenf nodu metastazı daha yüksek oranda saptanmıştır (Sırasıyla p=0,008, p=0,043). A kan grubunda östrojen reseptörü pozitifliği diğer kan
gruplarına göre anlamlı olarak yüksek bulunmuştur (p=0,049).

Sonuç: A kan grubundan olan kişilerde meme
kanseri daha fazla görülmekle birlikte, diğer gruplara göre A kan grubunda ER
pozitifliği yüksektir. 0 kan grubunda ise ER pozitifliği düşüktür. Rh(+)
hastalarda invaziv meme kanseri ve lenf nodu metastazı daha yaygındır.  

Keywords

Meme Kanseri, ABO Kan grubu, Rh

Clinicopathologic İnfluence with ABO Blood Group and Rhesus Blood Group Status in Patients on Breast Cancer: A Retrospective Study

Abstract

Objectives: Recently, the relationship between
ABO blood group antigens and certain types of human cancers, especially the
risk of developing pancreatic and gastric cancer, increases interest in
research. The aim of this study was to investigate the relationship between the
A, B, O and Rh blood groups and breast cancer in 209 patients who were operated
for breast cancer in our hospital.

Materials and
Methods: The records of 209 patients who were operated for
breast cancer between January 1, 2007 and December 31, 2012 were analyzed
retrospectively. The age of the patients, ABO and Rh blood group, type of
operation and clinical data were obtained from hospital information system
archive records. Histopathologically, tumor size, tumor type, tumor grade,
presence of lymph node metastasis, estrogen receptor (ER), progesterone
receptor (PR), HER2 status were recorded.

Results: The mean age
of the patients was 57.22 years. In Rh (+) patients, invasive carcinomas and
lymph node metastasis were higher than Rh (-) patients (Respectively p = 0.008, p = 0.043). Estrogen receptor positivity was significantly higher
in A blood group compared to other blood groups (p = 0.049).

Conclusion: Although
breast cancer is more common in people with A blood group, ER positivity is
higher in A blood group compared to other groups. In the blood group O, ER
positivity is low. Invasive breast cancer and lymph node metastasis are more
common in Rh (+) patients

Keywords

Breast cancer, ABO Blood group, Rh

References

• Global Burden of Disease Cancer Collaboration, Fitzmaurice C. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2018 Jun 2.
• Fletcher SW. Breast cancer screening: a 35-year perspective. Epidemiol Rev. 2011;33:165-75.
• Hsieh CC, Trichopoulos D, Katsouyanni K, Yuasa S. Age at menarche, age at menopause, height and obesity as risk factors for breast cancer: associations and interactions in an international case-control study. Int J Cancer. 1990 Nov 15;46(5):796-800.
• Li CI, Malone KE, Daling JR, et al. Timing of menarche and first full-term birth in relation to breast cancer risk. Am J Epidemiol. 2008 Jan 15;167(2):230-9. Edgren G, Hjalgrim H, Rostgaard K, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. Am J Epidemiol. 2010 Dec 1;172(11):1280-5.
• Zhang BL, He N, Huang YB, Song FJ, Chen KX. ABO blood groups and risk of cancer: a systematic review and meta-analysis. Asian Pac J Cancer Prev. 2014;15(11):4643-50.
• Miao SY, Zhou W, Chen L, Wang S, Liu XA. Influence of ABO blood group and Rhesus factor on breast cancer risk: a meta-analysis of 9665 breast cancer patients and 244,768 controls. Asia Pac J Clin Oncol. 2014 Jun;10(2):101-8.
• Park S, Kim KS, Kim JS, et al; Korean Breast Cancer Society. Prognostic value of ABO blood types in young patients with breast cancer; a nationwide study in Korean Breast Cancer Society. Med Oncol. 2017 Jun;34(6):118.
• Zouine S, Marnissi F, Otmani N, et al. ABO blood groups in relation to breast carcinoma incidence and associated prognostic factors in Moroccan women. Med Oncol. 2016 Jul;33(7):67.
• Stamatakos M, Kontzoglou K, Safioleas P, Safioleas C, Manti C, Safioleas M. Breast cancer incidence in Greek women in relation to ABO blood groups and Rh factor. Int Semin Surg Oncol. 2009 Aug 18;6:14.
• Sharma G, Choudhary R, Bharti D. Studies showing the relationship between ABO blood groups and major types of cancers. Asian J Exp Sci. 2007; 21(1): 129-13.
• Mehdi LM, Saleh HS, Al-Fartosi KG, et al. Relationship between ABO blood group and breast cancer at AL-Nassyria city/Iraq. J Thi Qar Sci. 2008; 1(1): 1-5.
• Gates MA, Xu M, Chen WY, et al. ABO blood group and breast cancer incidence and survival. Int J Cancer. 2012; 130(9): 2129-37.
• S. Mostafa Shiryazdi, Saeed Kargar, Mohammad Ali Dehghan, Hosein Neamatzadeh, Mohaddeseh Aboueian-Jahromi. Frequency Distribution of ABO/Rh Blood Group Systems in Breast Cancer, Yazd, 2007-2013, Zahedan Journal of Research in Medical Sciences, 2015 X; X(X): 29-32.
• Holdsworth PJ, Thorogood J, Benson EA, Clayden AD. Blood group as a prognostic indicator in breast cancer. Br Med J (Clin Res Ed) 1985; 290: 671-73.
• Leo F, Maragakes M, Nuhara A, Pecora-Saipe T. The role of endothelin in cancer with a focus on prostate cancer and breast cancer. Georgetown J Health Sci 2006; 3: 1
• Nelson J, Bagnato A, Battistini B, Nisen P. The endothelin axis: emerging role in cancer. Nat Rev Cancer 2003; 3: 110–16
• Y. Urun, G. Utkan, K. Altundag, O. Arslan, H. Onur, et al. ABO and Rh blood groups frequency in women with HER2 positive breast cancer, Journal of BUON 17: 457-60, 2012 .
• Stamatakos M, Kontzoglou K, Safioleas P, Safioleas C,Manti C, Safioleas M. Breast cancer incidence in Greek women in relation to ABO blood groups and Rh factor. Int Semin Surg Oncol 2009; 6: 14.
• Sultan Ayoub Meo, Faryal Suraya, Badar Jamil, Fwziah Al Rouq, Anusha Sultan Meo, et al. Association of ABO and Rh blood groups with breast cancer, Saudi Journal of Biological Sciences, 24 (2017) 1609-13.