The Effect of Antibiotic Use Within the First Year of Life On 3-Year Childhood Obesity

Year 2019, , 505 - 512, 30.09.2019

Cüneyt Ardıç , Oğuzer Usta Esma Omar Cihangir Yıldız

https://doi.org/10.17098/amj.624537

Abstract

Objectives: The aim of the present
study was to research the effect of antibiotic use within first year of life on
3-year obesity or overweight condition in consideration of maternal obesity,
birth weight, gender, the weight gained during pregnancy.

Materials and Methods: This
retrospective cohort study was conducted on 182 healthy children who were born
in Rize (Turkey) province and followed regularly until 3 years of age. The antibiotics
used by the children within first 12 months of their life were determined
through electronic health cards and the association between antibiotic use and
3-year obesity or overweight status was detected.

Results: We used logistic regression
to adjust for potential confounders. In the crude analysis, risk of being
overweighted and obesity was evaluated in the children who were exposed to
antibiotic use within first 12 months of life in comparison within those who
have not used. (odds ratio: 1.40; 95% CI: [ 1.23–1.57]). After multivariate
adjustment, the increased risk remained (adjusted odds ratio: 1.22; 95% CI:
[1.04-1.40]).

Conclusion: The results obtained
indicated that risk of obesity is significantly higher in the 3- year old
children who were exposed to antibiotics within first 12 months of life.
Further studies may focus on prevention of obesity in the children due to
antibiotic use.

Keywords

Antibiotic, childhood obesity, overweight

Yaşamın İlk Yılındaki Antibiyotik Kullanımının 3 Yaş Çocukluk Çağı Obezitesi Üzerine Etkisi

Abstract

Amaç: Bu çalışmanın amacı,
maternal obezite, doğum ağırlığı, cinsiyet, gebelikte kazanılan kilo dikkate
alındığında, yaşamın ilk yılında antibiyotik kullanımının 3 yıllık obezite veya
fazla kilo durumu üzerindeki etkisini araştırmaktır.

Materyal ve
Metot: Bu
retrospektif kohort çalışması, Rize (Türkiye) ilinde doğan ve 3 yaşına kadar
düzenli olarak takip edilen 182 sağlıklı çocuğa uygulandı. Çocukların
yaşamlarının ilk 12 ayı içerisinde kullandıkları antibiyotikler elektronik
sağlık kartları ile belirlendi ve antibiyotik kullanımı ile 3 yıllık obezite
veya fazla kilo durumu arasındaki ilişki tespit edildi.

Bulgular: Potansiyel karışıklıkları
ayarlamak için lojistik regresyon analizi kullanıldı. Ham analizde, yaşamdan
sonraki ilk 12 ay içerisinde antibiyotik kullanımına maruz kalan çocuklarda
kullanılmamış olanlara kıyasla aşırı kilo alma ve şişmanlık riski
değerlendirildi. (oran oranı((OR)): 1.40;% 95 CI: [1.23-1.57]). Çok değişkenli
ayarlama sonrasında, artan risk kaldı (düzeltilmiş oran oranı((AOR)): 1.22;% 95
CI: [1.04-1.40]).

Sonuç: Elde edilen sonuçlar, obezite
riskinin, yaşamın ilk 12 ayında antibiyotik uygulanan 3 yaşındaki çocuklarda
anlamlı derecede yüksek olduğunu göstermiştir. Gelecekteki çalışmalar,
antibiyotik kullanımı nedeniyle çocuklarda obezitenin önlenmesine
odaklanabilir.

Keywords

Antibiyotik, çocukluk çağı obezitesi, fazla kiloluluk

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