Oleuropein ve Farmakolojik Etkileri

Year 2022, , 369 - 382, 31.05.2022

Murat Arı

https://doi.org/10.46237/amusbfd.995192

Cited By: 1

Abstract

İnsanları fiziksel, sosyal ve psikolojik olarak etkileyen birçok hastalıkların başında gelen kanser, dünyada sık belirlenen ölüm nedenlerinden birisi haline gelmiştir. Bu açıdan bakıldığında, sebze, meyve, zeytinyağı gibi tüketimin daha fazla olduğu akdeniz diyeti önem taşımaktadır. Çeşitli triaçilgliseroleri içeren, az miktarda serbest yağ asidi ihtiva eden ve antioksidan, antikanserojen, anti-enflamatuar, antimikrobiyal, antiviral gibi pek çok farmakolojik etkilere sahip olan oleuropein başta kanser olmak üzere pek çok hastalıktan korunmak için önemli bir fenolik bileşiktir. Bu derlemede, oleuropeinin terapötikpekçok etkilerine ilişkin mevcut güncel çalışmaları analiz etmek amaçlanmıştır.

Keywords

Antioksidanlar, Oleuropein, Antioksidanlar, Kanser

Oleuropein and its Pharmacological Effects

Abstract

Cancer, which is one of the many diseases that affect people physically, socially and psychologically, has become one of the common causes of death in the world from this point of view, the Mediterranean diet with higher consumption such as vegetables, fruits and olive oil is important. Oleuropein, which contains various triacylglycerols, contains a small amount of free fatty acids and has many pharmacological effects such as antioxidant, anticancer, anti-inflammatory, antimicrobial and antiviral, is an important phenolic compound to protect against many diseases, especially cancer. In this review, it is aimed to analyze the current studies on many therapeutic effects of oleuropein.

Keywords

Oleuropein, Antioxidant, Cancer

References

• 1. Ünlüel, İ., Aydın, Ö. (2016). Bir zeytin fenoliği olanoleuropeinin sağlığımız üzerine etkileri. Zeytin Bilimi Dergisi,6(2), 77-14.
• 2. Bouaziz, M., Hammami, H., Bouallagui, Z., Jemai, H., Sayadi, S. (2008). Production of antioxidantsfromoliveprocessing by-products. Electronic Journal of Environmental, Agricultural, and Food Chemistry,7(8), 3231-3236.
• 3. Marsillo, V., Lanza, B. (1998). Characterisation of an oleuropeindegradingstrain of Lactobacillusplantarum. Combinedeffects of compoundspresent in olivefermentingbrines (phenols, glucoseandNaCl) on bacterialactivity. Journal of the Science of Food and Agriculture, 76, 520-524.
• 4. Brenes, M., DeCastro, A. (1998). Transformation of oleuropein and its hydrolysi sproducts during Spanish-style green olive processing. Journal of the Science of Food and Agriculture, 77, 353–358.
• 5. Durlu-Özkaya, F., Özkaya, M. (2011). Oleuropein using as anadditive for feed and products used for humans. Journal of Food ProcessingTechnology,2, 113.
• 6. Tripoli, E., Giammanco, M., Tabacchi, G., DiMajo, D., Giammanco, S., La Guardia, M. (2005). The phenolic compounds of oliveoil: structure, biological activity and beneficial effects on human health. Nutrition Research Reviews,18,98–112.
• 7. Vinha, A. F., Ferreres, F., Silva, B. M., Valentão, P., Gonçalves, A., Pereira, J.A., et al. (2005). Phenolic profiles of Portuguese olive fruits (Olea europaea L.): Influences of cultivar and geographical origin. Food Chemistry, 89, 561-568.
• 8. Han, J., Talorete, T., Yamada, P., Isoda, H. (2009). Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on humanbreast cancer MCF-7 cells. Cytotechnology,59,45-53.
• 9. Yıldız, G., Uylaşer, V. (2011). Doğal bir antimikrobiyel: oleuropein. Uludağ Üniversitesi Ziraat Fakültesi Dergisi, 25(1), 131-142.
• 10. Köçkar, F., Aydoğan Türkoğlu, S., Aydın, M. (2010). Oleuropeinin prostat (PC-3), meme (MCF-7) ve hepatoma (HEP3B) kanser hücrelerinde anti-tümör etkisinin belirlenmesi. Biyoloji Bilimleri Araştırma Dergisi, 3(2), 185-190.
• 11. Malik, N. S. A., Bradford J. M. (2006). Changes in oleuropein levels during differentiation and development of floral buds in ‘Arbequina’ olives, Scientia Horticulturae 110, 274–278
• 12. Winkelhausen, E. R., Pospiech, G., Laufenberg, G. (2005). Antifungalactivity of phenoliccompoundsextractedfromdriedolivepomace. Bulletin of the Chemistand Technologist of Macedonia, 24(1), 41-46.
• 13. Visioli, F., Bellosta, S., Galli, C. (1998). Oleuropein, the bitter principles of olives, enhances nitric oxide production by mouse macrophages. Life Science,62, 541–546.
• 14. Carluccio, M. A., Siculella, L., Ancora, M. A., Massaro, M., Scoditti, E., Storelli, C., et al. (2003). Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of mediterranean diet phytochemicals. Arterioscler Thrombosis and Vascular Biology, 23, 622–629.
• 15. Owen, R. W., Giacosa, A., Hull, W. E., Haubner, R., Würtele, G., Spiegelhalder, B., et al. (2000). Olive oil consumption and health: the possible role of antioxidants. Lancet Oncology, 1, 107–112.
• 16. Tripoli, E., Giammanco, M., Tabacchi, G., Di Majo, D., Giammanco, S., La Guardia, M. (2005). The phenolic composition of olive oil: structure, biological activity, and beneficial effects onhuman health. Nutritions Research Reviews, 18, 98–112.
• 17. Fredrickson, W. R. (2006). F and S Group, Inc. Method and composition for antiviral therapy with olive leaves. U.S. Patent,6, 117,884.
• 18. Andreadou, I., Iliodromitis, E. K., Mikros, E., Constantinou, M., Agalias, A., Magiatis, P., et al. (2006).The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits. The Journal of Nutrition, 136, 2213–2219.
• 19. Andreadou, I., Sigala, F., Iliodromitis, E. K., Papaefthimiou, M., Sigalas, C., Aligiannis, N., et al. (2007). Acute doxorubicin cardiotoxicity is successfullytreated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress. Journal of Molecular and Cellular Cardiology,42, 549–558.
• 20. Omar, S. H. (2010). Oleuropein in olive and its pharmacological effects. Scientia Pharmaceutica,78, 133-154.
• 21. Gürel, D. K. (2007). Çukurova Üniversitesi Tıp Fakültesi Balcalı Hastanesi Erişkin Onkoloji, Hematoloji Kliniklerinde Kemoterapi Uygulanan Hastaların Yaşam Kalitesi ve Bunu etkileyen Faktörlerin İncelenmesi. (Yayımlanmamış Yüksek Lisans Tezi) Çukurova Üniversitesi Sağlık Bilimleri Enstitüsü, ADANA.
• 22. Arı, M., Öğüt, S., Kaçar Döger, F. (2017). Kanserin önlenmesinde antioksidanların rolü. Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 1,(2),67-74.
• 23. Yıldız, G., Uylaşer, V. (2011). Doğal bir antimikrobiyal:oleuropein. Journal of Agricultural Faculty of Uludag University, 25(1), 131-42.
• 24. Tsuruo, T., Naito, M., Tomida, A., Fujita, N., Mashima, T., Sakamoto, H., et al. (2003). Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal. Cancer Science,94, 15-21.
• 25. Türk, G. (2013). Kemoterapötiklerin erkek üreme sistemi üzerindeki yan etkileri ve koruyucu stratejiler. Marmara Pharmaceutical Journal,17, 73-92.
• 26. Aitken, R. J., Roman, S. D. (2008). Antioxidant systems and oxidative stress in the testes. Oxidative Medicine and Cellular Longevity, 1, 15-24.
• 27. Barbaro, B., Toietta, G., Maggio, R., Ariciello, M., Tarocchi, M., Galli, A., et al. (2014). Effects of the olive-derived polyphenol oleuropein on human health. International Journal of Molecular Sciences,15, 18508- 18524.
• 28. Somunoğlu, S. (2009). Meme kanseri: Belirtileri ve erken tanıda kullanılan tarama yöntemleri. Fırat Sağlık Hizmetleri Dergisi,4, 103-122.
• 29. Saip, P., Keskin, S., Özkan, M., Kaplan, M. A., Aydoğan, F., Demirağ, G.G., ve ark. (2011). Türkiye’de meme kanserli hastaların tanı ve tedavi yöntemlerine ulaşım hızı; çok merkezli gözlemsel çalışma. The Journal of Breast Health,7, 109-117.
• 30. Gölbaşı, Z., Çetin, R., Kalkan, S., Durmu, Ģ. T. (2010). Üniversite öğrencisi kızların meme kanseri ve kendi kendine meme muayenesi ile ilgili bilgi ve davranışları. The Journal of Breast Health,6, 69-73.
• 31. Dikmen, M., Öztürk, N., Öztürk Y. (2008). Nar meyve kabuğu ekstresinin MCF7 hücre proliferasyonu üzerine sitotoksik ve inhibitör etkileri. Ankara Üniversitesi Eczacılık Fakültesi Dergisi,37(3), 179-190.
• 32. Han, J., Terence, K. P. N., Yamada, T. P., Isoda, H. (2009). Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells. Cytotechnology, 59, 45-53.
• 33. Hassan, Z. K., Elamin, M. H., Daghestani, M. H., Omer, S. A, Al-Olayan, E.M., Elobeid, M. A., et al. (2012). Oleuropein induces anti-metastatic effects in breast cancer. Asian Pasific Journal of Cancer Prevention, 13, 4555-4559.
• 34. Elamin, M. H., Daghestani, M. H., Omer, S. A., Elobeid, M. A., Virk, P., Al-Olayan, E.M., et al. (2013). Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells. Food and chemical toxicology,53, 310-316.
• 35. Hassan, Z. K., Elamin, M. H., Omer, S. A., Daghestani, M. H., Al-Olayan, E. S., Elobeid M.A., et al. (2013). Oleuropein induces apoptosis via the p53 pathway in breast cancer cells. Asian Pasific Journal of Cancer Prevention, 14, 6739-6742.
• 36. Arı, M., Karul, A., Sakarya, S. (2018). Investigation of antiproliferative, apoptoticantioxidanteffects of oleuropeinand vitamin D on breastcancercelllines (MCF-7). 2nd international cell death research congress: MDPI, Nov 01.04, 2018, İzmir, Turkey, Book of proceedings, 1534.
• 37. De Lorgeril, M., Salen, P., Martin, J. L., Monjaud, I., Boucher, P., Mamelle, N. (1998). Mediterranean dietary pattern in a randomized trial: prolonged survival and possible reduced cancer rate. Archives of Internal Medicine, 158, 1181–1187.
• 38. Corona, G. Deiana, M. Incani, A. Vauzour, D. Dessì, M.A. Spencer, J.P. (2007). Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochemical and Biophysical Research Communications, 362, 606–611.
• 39. Owen, R. W., Haubner, R., Würtele, G., Hull, E., Spiegelhalder, B., Bartsch, H. (2004). Olives and olive oil in cancer prevention. European Journal of Cancer Prevent,13, 319–326.
• 40. Bektay, M. Y., Güler, E. M., Gökçe, M., Kiziltas, M. V. (2021). Investigation of the genotoxic, cytotoxic, apoptotic, and oxidant effects of olive leaf extracts on liver cancer cell lines. Turkish Journal of Pharmaceutical Sciences, 18, 6, 781-789.
• 41. Psaltopoulou, T., Kosti, R. I., Haidopoulos, D., Dimopoulos, M., Panagiotakos, D. B. (2011). Olive oil intake is inversely related to cancer prevalence: A systematic review and a meta-analysis of 13,800 patients and 23,340 controls in19 observational studies. Lipids in Health and Disease, 10, 127.
• 42. Köçkar, F., Aydoğan Türkoğlu, S., Aydın, M. (2010). Oleuropein’in Prostat (PC-3), Meme (MCF-7) ve Hepatoma (HEP3B) kanser hücrelerinde anti-tümör etkisinin belirlenmesi. Biyoloji Bilimleri Araştırma Dergisi, 3, 2, 185-190.
• 43. Nan, J. N., Ververis, K., Bollu, S., Rodd, A. L., Swarup, O., Karagiannis, T. C. (2014). Biological effects of the olive polyphenol, hydroxytyrosol: An extra view from genome-wide transcriptome analysis. Hellenic Journal of Nucear Medicine, 17, 62–69.
• 44. Escrich, E., Moral, R., Grau, L., Costa, I., Solanas, M. (2007). Molecular mechanisms of the effects of olive oil and other dietary lipids on cancer. Molecular Nutrition & Food Research, 51, 1279–1292.
• 45. Caramia, G., Gori, A., Valli, E., Cerretani, L. (2006). Virgin olive oil in preventive medicine: From legend to epigenetics. European Journal of Lipid Science and Technology, 114, 375–388.
• 46. Tunca, B., Tezcan, G., Cecener, G., Egeli, U., Ak, S., Malyer, H., et al. (2012). Olea europaealeaf extract alters microRNA expression in human glioblastoma cells. Journal of Cancer Research and Clinical Oncology, 2012, 138, 1831–1844.
• 47. Fabiani, R., Rosignoli, P., Bartolomeo, A., Fuccelli, R., Servili, M., Montedoro, G. F., Morozzi, G. (2008) Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosoll, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells. Journal of Nutrition, 138, 8, 1411-1416.
• 48. Seçme, M., Eroglu, C., Dodurga, Y., Bagcı, G. (2016). Investigation of anticancer mechanism of oleuropein via cell cycle and apoptotic pathways in SH-SY5Y neuroblastoma cells.Gene, 585, 93-99.
• 49. Casaburi, I., Puoci, F., Chimento, A., Sirianni, R., Ruggiero, C., Avena, P.,et al. (2013). Potential of olive oil phenols as chemopreventive and therapeutic agents against cancer: A review of in vitrostudies. Molecular Nutition &. Food Research,57, 71–83.
• 50. Kimura, Y., Sumiyoshi, M. (2009). Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. Journal of Nutrition, 139, 2079–2086.
• 51. Shamshoum, H., Vlavcheski, F., Tsiani, E. (2017). Anticancer effects of oleuropein. International Union Biochemistry and Molecular Biology, 43, 4, 517-528.
• 52. Witztum, J.L. (1994). The oxidation hypothesis of atherosclerosis. Lancet,344, 793–795.
• 53. Moschandreas, J., Vissers, M. N., Wiseman, S., Van Putte, K. P., Kafatos, A. (2002). Extra virgin olive oil and markers of oxidation in Greek smokers: a randomized cross-over study. European Journal of Clinical Nutrition, 56(10), 1024–1029.
• 54. Patrick, L., Uzick, M. (2001). Cardiovascular disease: C-reactive protein and the inflammatory disease paradigm: HMG-CoA reductase inhibitors, alpha-tocopherol, red yeast rice, and olive oil. A review of the literature. Alternative Medicine. Review, 6(3), 248–271.
• 55. Fito, M., Cladellas, M., De La Torre, R., Marti, J., Alcantara, M., Pujadas-Pastardes, M., et al. (2005). Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial. Atherosclerosis, 181(1), 149–158.
• 56. Bianco, A., Coccioli, F., Guiso, M., Marra, C. (2001). The occurrence in olive oil of a new class of phenolic compounds: hydroxy-isochromans. Food Chemistry, 77, 405–411.
• 57. Marrugat, J., Covas, M. I., Fito, M., Schroder, H., Miro-Casas, E., Gimeno, E., et al. (2004). Effects of differing phenolic content in dietary olive oils on and LDL oxidation-a randomized controlled trial. European Journal of Nutrition,43, 140–147.
• 58. Weinbrenner, T., Fito, M., De La Torre, R., Saez, G. T., Rijken, P., Tormos, C., et al. (2004). Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men. Journal of Nutrition, 134(9), 2314– 2321.
• 59. Covas, M. I., De La Torre, K., Farre-Albaladejo, M., Kaikkonen, J., Fito, M., Lopez-Sabater, C., et al. (2006). Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans. Free Radical Biology and Medicine,40(4), 608–616.
• 60. Ochoa, J. J., Quiles, J. L., Ramirez-Tortosa, M. C., Mataix, J., Huertas, J. R. (2002). Dietary oil high in oleic acid but with different unsaponifiable fraction contents have different effects in fatty acid composition and peroxidation in rabit LDL. Nutrition,18(1), 60–65.
• 61. Salvini, S., Sera, F., Caruso, D., Giovannelli, L., Visioli, F., Saieva, C., et al. (2006). Daily consumption of a high-phenol extra virgin olive oil reduces oxidative DNA damage in postmenopausal women. British Journal of Nutrition,95(4), 742– 751.
• 62. Visioli, F., Caruso, D., Grande, S., Bosisio, R., Villa, M., Galli, G., et al. (2005). Virgin olive oil study (VOLOS): vasoprotective potential of extra virgin olive oil in mildly dyslipidemic patients. European Journal of Nutrition, 44(2), 121–127.
• 63. Bogani, P., Galli, C., Villa, M., Visioli, F. (2007). Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosis, 190(1), 181–186.
• 64. Groff, J. L., Gropper, S. S. (2000). Advanced nutrition and human metabolism. 3rd ed., Wadsworth Thomson Learning, Belmont, CA, USA, 584p.
• 65. Bogani, P., Galli, C., Villa, M., Visioli, F. (2007). Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosis, 190 (1), 181–186.
• 66. Moreno, J. J. (2003). Effect of olive oil minor components on oxidative stress and arachidonic acid mobilization and metabolism by macrophages. Free Radical Biology and Medicine,35, 1073–1081.
• 67. Bisignano, G., Tomaino, A., Lo Cascio, R., Crisafi, G., Uccella, N., Saija, A. (1999). On the in-vitro antimicrobial activity of oleuropein and hydroxytyrosol. Journal Pharmacy and Pharmacology, 51, 971–974.
• 68. Furneri, P. M., Marino, A., Saija, A., Ucella, N., Bisignano, G. (2002). In vitro antimycoplasmal activity of oleuropein. International Journal od Antimicrobal Agents, 20, 293–296.
• 69. Fredrickson, W. R. (2000). F and S Group, Inc. Method and composition for antiviral Therapy with olive leaves. U.S. Patent.6, 117, 884.
• 70. Katsiki, M., Chondrogianni, N., Chinou, I., Rivett, A. J., Gonos, E. S. (2007). The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts., Rejuvenation Research,10,157–172.
• 71. Moosmann, B., Behl C. (1999). The Antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties. Proceedings of the National Academy of Sciences, USA, 96, 8867–8872.
• 72. Visioli F, Galli C. (2001). Antiatherogenic components of olive oil. Current Atherosclerosis Reports, 3, 64–67.
• 73. Carluccio, M. A., Siculella, L., Ancora, M. A., Massaro, M., Scoditti, E., Storelli, C., et al. (2003). Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thrombosis and Vascular Biology,23(4), 622–629.
• 74. Visioli, F., Bellomo, G., Galli, C. (1998). Free radical-scavenging properties of olive oil polyphenols. Biochemical and Biophysical Research Communications, 247, 60–64.
• 75. Omar, S. H. (2010). Cardioprotective and neuroprotective roles of oleuropein in olive. Saudi Pharmaceutical Journal,18, 111–121.
• 76. Goulas, V., Exarchou, V., Troganis, A. N., Psomiadou, E., Fotsis, T., Briasoulis, E., et al. (2009). Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Molecular Nutrition & Food Reserach, 53, 600–608.
• 77. Acquaviva, R., Di Giacomo, C., Sorrenti, V., Galvano, F., Santangelo, R., Cardile, V., et al. (2012). Antiproliferative effect of oleuropein in prostate cell lines. International Journal of Oncology,41, 31–38.
• 78. Omar, S. H. (2010). Oleuropein in olive and its pharmacological effects. Scientica Pharmaceutica, 78, 133–154.
• 79. Lee-Huang, S., Huang, P. L., Zhang, D., Lee, J. W., Bao, J., Sun, Y., et al. (2007). Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. fusion [corrected] inhibition. Biochemical and Biophysical Reserach Communications, 354, 872–878.
• 80. Daccache, A., Lion, C., Sibille, N., Gerard, M., Slomianny, C., Lippens, G., et al. (2011). Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochemistry International,58, 700–707.