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Berberin ve bağırsak mikrobiyomu arasındaki ilişkinin araştırılması: Son çalışmalara yakından bir bakış

Year 2024, Volume: 29 Issue: 3, 372 - 386, 23.09.2024
https://doi.org/10.21673/anadoluklin.1410170

Abstract

Amaç: Berberin, kan şekeri düzenleme ve iltihap azaltma özellikleriyle bilinir ve ayrıca bağırsak mikrobiyota çeşitliliğini artırır ve mikrobiyal profilleri onarır. Ancak, hastalıklara özgü etkileri üzerine kapsamlı incelemeler sınırlıdır. Bu çalışma, berberinin çeşitli hastalıklardaki mikrobiyota çeşitliliği üzerindeki etkisini araştırmayı ve bu konuda yeni bir bakış açısı sunmayı amaçlamaktadır.

Yöntem: 2018-2023 yılları arasında PubMed, Web of Science, ScienceDirect ve Google Scholar gibi veritabanlarında, berberin ve bağırsak mikrobiyotası ile ilgili anahtar kelimeler kullanılarak bir literatür taraması yapılmıştır. İlgisiz konular hariç tutularak 84 başlık ve özet incelenmiş, 33 makale belirlenen kriterlere göre detaylı olarak gözden geçirilmiştir.

Bulgular: Berberin, Bacteroidetes ve Akkermansia gibi yararlı türleri destekler, antimikrobiyal özellikler gösterir ve belirli patojenleri hedef alır. Özellikle obez ve Tip 2 diyabetik farelerde yapılan çalışmalar, bağırsak mikrobiyotası ve çeşitliliğinde iyileşme potansiyeline işaret etmektedir. Ancak, optimal dozaj belirsizdir ve bireysel mikrobiyal yanıtlar farklılık gösterebilir, bazen disbiyotik profillere yol açabilir.

Sonuç: Berberin, bağırsak mikrobiyota çeşitliliğini artırma ve patojenlerle mücadelede umut vadetmektedir. Bununla birlikte, terapötik potansiyelini doğrulamak ve uzun vadeli klinik sonuçlar elde etmek için daha fazla araştırma gereklidir.

References

  • Zhang L, Wu X, Yang R, et al. Effects of Berberine on the Gastrointestinal Microbiota. Front Cell Infect Microbiol. 2021;10:588517.
  • Cheng H, Liu J, Tan Y, Feng W, Peng C. Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine. J Pharm Anal. 2022;12(4):541-55.
  • Singh A, Bajpai V, Srivastava M, Arya KR, Kumar B. Rapid screening and distribution of bioactive compounds in different parts of Berberis petiolaris using direct analysis in real time mass spectrometry. J Pharm Anal. 2015;5(5):332-5.
  • Potdar D, Hirwani RR, Dhulap S. Phyto-chemical and pharmacological applications of Berberis aristata. Fitoterapia. 2012;83(5):817-30.
  • Habtemariam S. The hidden treasure in Europe’s garden plants: Case examples; Berberis darwinni and Bergenia cordifolia. Med Aromat Plants. 2013;2(4):1000130.
  • Suau R, Rico R, López-Romero JM, Nájera F, Cuevas A. Isoquinoline alkaloids from Berberis vulgaris subsp. australis. Phytochemistry. 1998;49(8):2545-9.
  • Habtemariam S. The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches. Biomedicines. 2020;8(4):90.
  • Neag MA, Mocan A, Echeverría J, et al. Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders. Front Pharmacol. 2018;9:557.
  • Zhang X, Han Y, Huang W, Jin M, Gao Z. The influence of the gut microbiota on the bioavailability of oral drugs. Acta Pharm Sin B. 2021;11(7):1789-812.
  • Yang F, Gao R, Luo X, Liu R, Xiong D. Berberine influences multiple diseases by modifying gut microbiota. Front Nutr. 2023;10:1187718.
  • Xu X, Yi H, Wu J, et al. Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomed Pharmacother. 2021;133:110984.
  • Och A, Och M, Nowak R, Podgórska D, Podgórski R. Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease. Molecules. 2022;27(4):1351.
  • Ai X, Yu P, Peng L, et al. Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases. Front Pharmacol. 2021;12:762654.
  • Zhao JV, Yeung WF, Chan YH, et al. Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial. Nutrients. 2021;13(8):2550.
  • Dehau T, Cherlet M, Croubels S, van Immerseel F, Goossens E. A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens. mSystems. 2023;8(1):e0123922.
  • Lotti S, Dinu M, Colombini B, Amedei A, Sofi F. Circadian rhythms, gut microbiota, and diet: Possible implications for health. Nutr Metab Cardiovasc Dis. 2023;33(8):1490-500.
  • Wang H, Zhang H, Gao Z, Zhang Q, Gu C. The mechanism of berberine alleviating metabolic disorder based on gut microbiome. Front Cell Infect Microbiol. 2022;12:854885.
  • Ilyas Z, Perna S, Al-Thawadi S, et al. The effect of Berberine on weight loss in order to prevent obesity: A systematic review. Biomed Pharmacother. 2020;127:110137.
  • Milani C, Duranti S, Bottacini F, et al. The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota. Microbiol Mol Biol Rev. 2017;81(4):e00036-17.
  • Wang Y, Zheng J, Hou H, et al. Effects of berberine on intestinal flora of non-alcoholic fatty liver induced by high-fat diet through 16S rRNA gene segmentation. J King Saud Univ Sci. 2020;32(5):2603-2609.
  • Li S, Wang N, Tan HY, et al. Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease. Clin Transl Med. 2020;10(4):e112.
  • Hu H, Xu K, Wang K, Zhang F, Bai X. Dissecting the Effect of Berberine on the Intestinal Microbiome in the Weaned Piglets by Metagenomic Sequencing. Front Microbiol. 2022;13:862882.
  • Habtemariam S. Berberine pharmacology and the gut microbiota: A hidden therapeutic link. Pharmacol Res. 2020;155:104722.
  • Yao Y, Chen H, Yan L, Wang W, Wang D. Berberine alleviates type 2 diabetic symptoms by altering gut microbiota and reducing aromatic amino acids. Biomed Pharmacother. 2020;131:110669.
  • Solnier J, Zhang Y, Kuo YC, et al. Characterization and Pharmacokinetic Assessment of a New Berberine Formulation with Enhanced Absorption In Vitro and in Human Volunteers. Pharmaceutics. 2023;15(11):2567.
  • Li C, Ai G, Wang Y, et al. Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: Impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-κB pathway. Pharmacol Res. 2020;152:104603.
  • Xu JH, Liu XZ, Pan W, Zou DJ. Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. Mol Med Rep. 2017;15(5):2765-87.
  • Huang M, He Y, Tian L, et al. Gut microbiota-SCFAs-brain axis associated with the antidepressant activity of berberine in CUMS rats. J Affect Disord. 2023;325:141-50.
  • Zhang F, Ma T, Cui P, et al. Diversity of the Gut Microbiota in Dihydrotestosterone-Induced PCOS Rats and the Pharmacologic Effects of Diane-35, Probiotics, and Berberine. Front Microbiol. 2019;10:175.
  • Fang X, Wu H, Wang X, et al. Modulation of Gut Microbiota and Metabolites by Berberine in Treating Mice With Disturbances in Glucose and Lipid Metabolism. Front Pharmacol. 2022;13:870407.
  • Zhang Y, Gu Y, Ren H, et al. Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). Nat Commun. 2020;11(1):5015.
  • Wang S, Ren H, Zhong H, et al. Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study. Gut Microbes. 2022;14(1):2003176.
  • Dehau T, Cherlet M, Croubels S, Van De Vliet M, Goossens E, Van Immerseel F. Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites. Front Pharmacol. 2023;14:1281090.
  • Habtemariam S. Berberine and inflammatory bowel disease: A concise review. Pharmacol Res. 2016;113(Pt A):592-9.
  • Wu C, Zhao Y, Zhang Y, et al. Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine (BBR) and facilitates to predict BBR’s cholesterol-decreasing efficacy in patients. J Adv Res. 2021;37:197-208.
  • Yang YN, Wang QC, Xu W, Yu J, Zhang H, Wu C. The berberine-enriched gut commensal Blautia producta ameliorates high-fat diet (HFD)-induced hyperlipidemia and stimulates liver LDLR expression. Biomed Pharmacother. 2022;155:113749.
  • Wang Y, Shou JW, Li XY, et al. Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism. Metabolism. 2017;70:72-84.
  • Dong C, Yu J, Yang Y, et al. Berberine, a potential prebiotic to indirectly promote Akkermansia growth through stimulating gut mucin secretion. Biomed Pharmacother. 2021;139:111595.
  • Hong B, Jiang JD. Treating chronic diseases by regulating the gut microbiota. Engineering. 2022;18:17-20.
  • Zhu L, Zhang D, Zhu H, et al. Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe-/- mice. Atherosclerosis. 2018;268:117-26.
  • Zhang W, Xu JH, Yu T, Chen QK. Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice. Biomed Pharmacother. 2019;118:109131.
  • Sun H, Wang N, Cang Z, et al. Modulation of microbiota-gut-brain axis by berberine resulting in improved metabolic status in high-fat diet-fed rats. Obes Facts. 2017;9(6):365-78.
  • Ming J, Yu X, Xu X, et al. Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. Genome Med. 2021;13(1):125.
  • Lyu Y, Li D, Yuan X, et al. Effects of combination treatment with metformin and berberine on hypoglycemic activity and gut microbiota modulation in db/db mice. Phytomedicine. 2022;101:154099.
  • Zhang X, Zhao Y, Xu J, et al. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. Sci Rep. 2015;5:14405.
  • Huang T, Yan X, Yan X, et al. Modulation of gut microbiota by berberine and decocted Coptis chinensis Franch. in a high-fat diet-induced metabolic syndrome rat model. J Tradit Chin Med. 2017;4(2):149-57.
  • Shi Y, Hu J, Geng J, et al. Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-/- mice. Biomed Pharmacother. 2018;107:1556-63.
  • Shu X, Li M, Cao Y, et al. Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation. Front Pharmacol. 2021;12:750826.
  • Xie Z, Liu X, Huang X, et al. Remodelling of gut microbiota by Berberine attenuates trimethylamine N-oxide-induced platelet hyperreaction and thrombus formation. Eur J Pharmacol. 2021;911:174526.
  • Li J, Li J, Ni J, et al. Berberine Relieves Metabolic Syndrome in Mice by Inhibiting Liver Inflammation Caused by a High-Fat Diet and Potential Association With Gut Microbiota. Front Microbiol. 2022;12:752512.
  • Zhao JD, Li Y, Sun M, et al. Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats. World J Gastroenterol. 2021;27(8):708-24.
  • Wang H, Guan L, Li J, Lai M, Wen X. The Effects of Berberine on the Gut Microbiota in Apc min/+ Mice Fed with a High Fat Diet. Molecules. 2018;23(9):2298.
  • Wang Z, Wu F, Zhou Q, et al. Berberine Improves Vascular Dysfunction by Inhibiting Trimethylamine-N-oxide via Regulating the Gut Microbiota in Angiotensin II-Induced Hypertensive Mice. Front Microbiol. 2022;13:814855.
  • Cui H, Cai Y, Wang L, et al. Berberine Regulates Treg/Th17 Balance to Treat Ulcerative Colitis Through Modulating the Gut Microbiota in the Colon. Front Pharmacol. 2018;9:571.
  • Guo HH, Shen HR, Wang LL, et al. Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases. Biomed Pharmacother. 2023;163:114754.
  • Ding Y, Yanagi K, Cheng C, Alaniz RC, Lee K, Jayaraman A. Interactions between gut microbiota and non-alcoholic liver disease: The role of microbiota-derived metabolites. Pharmacol Res. 2019;141:521-9.
  • Guo Y, Zhang Y, Huang W, Selwyn FP, Klaassen CD. Dose-response effect of berberine on bile acid profile and gut microbiota in mice. BMC Complement Altern Med. 2016;16(1):394.
  • Li J, Meng P, Zhang J, He M. Effect of Berberine Hydrochloride on the Diversity of Intestinal Flora in Parkinson’s Disease Patients. Contrast Media Mol Imaging. 2022;2022:8381870.
  • Yue SJ, Liu J, Wang WX, et al. Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. Biomed Pharmacother. 2019;116:109002.
  • Hitch TCA, Hall LJ, Walsh SK, et al. Microbiome-based interventions to modulate gut ecology and the immune system. Mucosal Immunol. 2022;15(6):1095-113.
  • Shreiner AB, Kao JY, Young VB. The gut microbiome in health and in disease. Curr Opin Gastroenterol. 2015;31(1):69-75.
  • Sudheer S, Gangwar P, Usmani Z, et al. Shaping the gut microbiota by bioactive phytochemicals: An emerging approach for the prevention and treatment of human diseases. Biochimie. 2022;193:38-63.
  • Afzaal M, Saeed F, Shah YA, et al. Human gut microbiota in health and disease: Unveiling the relationship. Front Microbiol. 2022;13:999001.
  • Hou K, Wu ZX, Chen XY, et al. Microbiota in health and diseases. Signal Transduct Target Ther. 2022;7(1):135.
  • Manor O, Dai CL, Kornilov SA, et al. Health and disease markers correlate with gut microbiome composition across thousands of people. Nat Commun. 2020;11(1):5206.
  • Johnson KV. Gut microbiome composition and diversity are related to human personality traits. Hum Microb J. 2020;15:None.
  • Singh RK, Chang HW, Yan D, et al. Influence of diet on the gut microbiome and implications for human health. J Transl Med. 2017;15(1):73.
  • Heiman ML, Greenway FL. A healthy gastrointestinal microbiome is dependent on dietary diversity. Mol Metab. 2016;5(5):317-20.
  • Wang H, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Metformin and berberine, two versatile drugs in treatment of common metabolic diseases. Oncotarget. 2017;9(11):10135-46.
  • Wang Y, Cui S, Zheng J, Li Y, Li P, Hou H. Berberine ameliorates intestinal mucosal barrier dysfunction in nonalcoholic fatty liver disease (NAFLD) rats. J King Saud Univ Sci. 2020;32(5):2534-9.
  • Arslan NÇ, Gündoğdu A, Tunali V, Topgül OH, Beyazgül D, Nalbantoğlu ÖU. Efficacy of AI-Assisted Personalized Microbiome Modulation by Diet in Functional Constipation: A Randomized Controlled Trial. J Clin Med. 2022;11(22):6612.
  • Karakan T, Gundogdu A, Alagözlü H, et al. Artificial intelligence-based personalized diet: A pilot clinical study for irritable bowel syndrome. Gut Microbes. 2022;14(1):2138672.
  • Wu M, Yang S, Wang S, et al. Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE-/- Mice. Front Pharmacol. 2020;11:223.

Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies

Year 2024, Volume: 29 Issue: 3, 372 - 386, 23.09.2024
https://doi.org/10.21673/anadoluklin.1410170

Abstract

Aim: Berberine, known for regulating blood glucose and reducing inflammation, also enhances gut microbiota diversity and repairs microbial profiles. However, comprehensive reviews on its disease-specific impacts are limited. This study aims to explore berberine’s influence on microbiota diversity in various diseases, offering a novel perspective.

Methods: A literature review was conducted using PubMed, Web of Science, ScienceDirect, and Google Scholar, focusing on studies from 2018-2023. Keywords related to berberine and gut microbiota were used, excluding irrelevant topics. A total of 84 titles and abstracts were screened, with 33 articles meeting inclusion criteria for detailed review.

Results: Berberine promotes beneficial species like Bacteroidetes and Akkermansia, shows antimicrobial properties, and targets specific pathogens. Studies, particularly in obese and Type 2 diabetic mice, suggest it can improve gut microbiota and diversity. However, the optimal dosage remains unclear, and individual microbial responses can vary, sometimes leading to dysbiotic profiles.

Conclusion: Berberine shows promise in enhancing gut microbiota diversity and combating pathogens. Nevertheless, further studies are needed to confirm its therapeutic potential and establish optimal treatment protocols with long-term clinical outcomes.

References

  • Zhang L, Wu X, Yang R, et al. Effects of Berberine on the Gastrointestinal Microbiota. Front Cell Infect Microbiol. 2021;10:588517.
  • Cheng H, Liu J, Tan Y, Feng W, Peng C. Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine. J Pharm Anal. 2022;12(4):541-55.
  • Singh A, Bajpai V, Srivastava M, Arya KR, Kumar B. Rapid screening and distribution of bioactive compounds in different parts of Berberis petiolaris using direct analysis in real time mass spectrometry. J Pharm Anal. 2015;5(5):332-5.
  • Potdar D, Hirwani RR, Dhulap S. Phyto-chemical and pharmacological applications of Berberis aristata. Fitoterapia. 2012;83(5):817-30.
  • Habtemariam S. The hidden treasure in Europe’s garden plants: Case examples; Berberis darwinni and Bergenia cordifolia. Med Aromat Plants. 2013;2(4):1000130.
  • Suau R, Rico R, López-Romero JM, Nájera F, Cuevas A. Isoquinoline alkaloids from Berberis vulgaris subsp. australis. Phytochemistry. 1998;49(8):2545-9.
  • Habtemariam S. The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches. Biomedicines. 2020;8(4):90.
  • Neag MA, Mocan A, Echeverría J, et al. Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders. Front Pharmacol. 2018;9:557.
  • Zhang X, Han Y, Huang W, Jin M, Gao Z. The influence of the gut microbiota on the bioavailability of oral drugs. Acta Pharm Sin B. 2021;11(7):1789-812.
  • Yang F, Gao R, Luo X, Liu R, Xiong D. Berberine influences multiple diseases by modifying gut microbiota. Front Nutr. 2023;10:1187718.
  • Xu X, Yi H, Wu J, et al. Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomed Pharmacother. 2021;133:110984.
  • Och A, Och M, Nowak R, Podgórska D, Podgórski R. Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease. Molecules. 2022;27(4):1351.
  • Ai X, Yu P, Peng L, et al. Berberine: A Review of its Pharmacokinetics Properties and Therapeutic Potentials in Diverse Vascular Diseases. Front Pharmacol. 2021;12:762654.
  • Zhao JV, Yeung WF, Chan YH, et al. Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial. Nutrients. 2021;13(8):2550.
  • Dehau T, Cherlet M, Croubels S, van Immerseel F, Goossens E. A High Dose of Dietary Berberine Improves Gut Wall Morphology, Despite an Expansion of Enterobacteriaceae and a Reduction in Beneficial Microbiota in Broiler Chickens. mSystems. 2023;8(1):e0123922.
  • Lotti S, Dinu M, Colombini B, Amedei A, Sofi F. Circadian rhythms, gut microbiota, and diet: Possible implications for health. Nutr Metab Cardiovasc Dis. 2023;33(8):1490-500.
  • Wang H, Zhang H, Gao Z, Zhang Q, Gu C. The mechanism of berberine alleviating metabolic disorder based on gut microbiome. Front Cell Infect Microbiol. 2022;12:854885.
  • Ilyas Z, Perna S, Al-Thawadi S, et al. The effect of Berberine on weight loss in order to prevent obesity: A systematic review. Biomed Pharmacother. 2020;127:110137.
  • Milani C, Duranti S, Bottacini F, et al. The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota. Microbiol Mol Biol Rev. 2017;81(4):e00036-17.
  • Wang Y, Zheng J, Hou H, et al. Effects of berberine on intestinal flora of non-alcoholic fatty liver induced by high-fat diet through 16S rRNA gene segmentation. J King Saud Univ Sci. 2020;32(5):2603-2609.
  • Li S, Wang N, Tan HY, et al. Modulation of gut microbiota mediates berberine-induced expansion of immuno-suppressive cells to against alcoholic liver disease. Clin Transl Med. 2020;10(4):e112.
  • Hu H, Xu K, Wang K, Zhang F, Bai X. Dissecting the Effect of Berberine on the Intestinal Microbiome in the Weaned Piglets by Metagenomic Sequencing. Front Microbiol. 2022;13:862882.
  • Habtemariam S. Berberine pharmacology and the gut microbiota: A hidden therapeutic link. Pharmacol Res. 2020;155:104722.
  • Yao Y, Chen H, Yan L, Wang W, Wang D. Berberine alleviates type 2 diabetic symptoms by altering gut microbiota and reducing aromatic amino acids. Biomed Pharmacother. 2020;131:110669.
  • Solnier J, Zhang Y, Kuo YC, et al. Characterization and Pharmacokinetic Assessment of a New Berberine Formulation with Enhanced Absorption In Vitro and in Human Volunteers. Pharmaceutics. 2023;15(11):2567.
  • Li C, Ai G, Wang Y, et al. Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: Impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-κB pathway. Pharmacol Res. 2020;152:104603.
  • Xu JH, Liu XZ, Pan W, Zou DJ. Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels. Mol Med Rep. 2017;15(5):2765-87.
  • Huang M, He Y, Tian L, et al. Gut microbiota-SCFAs-brain axis associated with the antidepressant activity of berberine in CUMS rats. J Affect Disord. 2023;325:141-50.
  • Zhang F, Ma T, Cui P, et al. Diversity of the Gut Microbiota in Dihydrotestosterone-Induced PCOS Rats and the Pharmacologic Effects of Diane-35, Probiotics, and Berberine. Front Microbiol. 2019;10:175.
  • Fang X, Wu H, Wang X, et al. Modulation of Gut Microbiota and Metabolites by Berberine in Treating Mice With Disturbances in Glucose and Lipid Metabolism. Front Pharmacol. 2022;13:870407.
  • Zhang Y, Gu Y, Ren H, et al. Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). Nat Commun. 2020;11(1):5015.
  • Wang S, Ren H, Zhong H, et al. Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study. Gut Microbes. 2022;14(1):2003176.
  • Dehau T, Cherlet M, Croubels S, Van De Vliet M, Goossens E, Van Immerseel F. Berberine-microbiota interplay: orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites. Front Pharmacol. 2023;14:1281090.
  • Habtemariam S. Berberine and inflammatory bowel disease: A concise review. Pharmacol Res. 2016;113(Pt A):592-9.
  • Wu C, Zhao Y, Zhang Y, et al. Gut microbiota specifically mediates the anti-hypercholesterolemic effect of berberine (BBR) and facilitates to predict BBR’s cholesterol-decreasing efficacy in patients. J Adv Res. 2021;37:197-208.
  • Yang YN, Wang QC, Xu W, Yu J, Zhang H, Wu C. The berberine-enriched gut commensal Blautia producta ameliorates high-fat diet (HFD)-induced hyperlipidemia and stimulates liver LDLR expression. Biomed Pharmacother. 2022;155:113749.
  • Wang Y, Shou JW, Li XY, et al. Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism. Metabolism. 2017;70:72-84.
  • Dong C, Yu J, Yang Y, et al. Berberine, a potential prebiotic to indirectly promote Akkermansia growth through stimulating gut mucin secretion. Biomed Pharmacother. 2021;139:111595.
  • Hong B, Jiang JD. Treating chronic diseases by regulating the gut microbiota. Engineering. 2022;18:17-20.
  • Zhu L, Zhang D, Zhu H, et al. Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe-/- mice. Atherosclerosis. 2018;268:117-26.
  • Zhang W, Xu JH, Yu T, Chen QK. Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice. Biomed Pharmacother. 2019;118:109131.
  • Sun H, Wang N, Cang Z, et al. Modulation of microbiota-gut-brain axis by berberine resulting in improved metabolic status in high-fat diet-fed rats. Obes Facts. 2017;9(6):365-78.
  • Ming J, Yu X, Xu X, et al. Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. Genome Med. 2021;13(1):125.
  • Lyu Y, Li D, Yuan X, et al. Effects of combination treatment with metformin and berberine on hypoglycemic activity and gut microbiota modulation in db/db mice. Phytomedicine. 2022;101:154099.
  • Zhang X, Zhao Y, Xu J, et al. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. Sci Rep. 2015;5:14405.
  • Huang T, Yan X, Yan X, et al. Modulation of gut microbiota by berberine and decocted Coptis chinensis Franch. in a high-fat diet-induced metabolic syndrome rat model. J Tradit Chin Med. 2017;4(2):149-57.
  • Shi Y, Hu J, Geng J, et al. Berberine treatment reduces atherosclerosis by mediating gut microbiota in apoE-/- mice. Biomed Pharmacother. 2018;107:1556-63.
  • Shu X, Li M, Cao Y, et al. Berberine Alleviates Non-alcoholic Steatohepatitis Through Modulating Gut Microbiota Mediated Intestinal FXR Activation. Front Pharmacol. 2021;12:750826.
  • Xie Z, Liu X, Huang X, et al. Remodelling of gut microbiota by Berberine attenuates trimethylamine N-oxide-induced platelet hyperreaction and thrombus formation. Eur J Pharmacol. 2021;911:174526.
  • Li J, Li J, Ni J, et al. Berberine Relieves Metabolic Syndrome in Mice by Inhibiting Liver Inflammation Caused by a High-Fat Diet and Potential Association With Gut Microbiota. Front Microbiol. 2022;12:752512.
  • Zhao JD, Li Y, Sun M, et al. Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats. World J Gastroenterol. 2021;27(8):708-24.
  • Wang H, Guan L, Li J, Lai M, Wen X. The Effects of Berberine on the Gut Microbiota in Apc min/+ Mice Fed with a High Fat Diet. Molecules. 2018;23(9):2298.
  • Wang Z, Wu F, Zhou Q, et al. Berberine Improves Vascular Dysfunction by Inhibiting Trimethylamine-N-oxide via Regulating the Gut Microbiota in Angiotensin II-Induced Hypertensive Mice. Front Microbiol. 2022;13:814855.
  • Cui H, Cai Y, Wang L, et al. Berberine Regulates Treg/Th17 Balance to Treat Ulcerative Colitis Through Modulating the Gut Microbiota in the Colon. Front Pharmacol. 2018;9:571.
  • Guo HH, Shen HR, Wang LL, et al. Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases. Biomed Pharmacother. 2023;163:114754.
  • Ding Y, Yanagi K, Cheng C, Alaniz RC, Lee K, Jayaraman A. Interactions between gut microbiota and non-alcoholic liver disease: The role of microbiota-derived metabolites. Pharmacol Res. 2019;141:521-9.
  • Guo Y, Zhang Y, Huang W, Selwyn FP, Klaassen CD. Dose-response effect of berberine on bile acid profile and gut microbiota in mice. BMC Complement Altern Med. 2016;16(1):394.
  • Li J, Meng P, Zhang J, He M. Effect of Berberine Hydrochloride on the Diversity of Intestinal Flora in Parkinson’s Disease Patients. Contrast Media Mol Imaging. 2022;2022:8381870.
  • Yue SJ, Liu J, Wang WX, et al. Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis. Biomed Pharmacother. 2019;116:109002.
  • Hitch TCA, Hall LJ, Walsh SK, et al. Microbiome-based interventions to modulate gut ecology and the immune system. Mucosal Immunol. 2022;15(6):1095-113.
  • Shreiner AB, Kao JY, Young VB. The gut microbiome in health and in disease. Curr Opin Gastroenterol. 2015;31(1):69-75.
  • Sudheer S, Gangwar P, Usmani Z, et al. Shaping the gut microbiota by bioactive phytochemicals: An emerging approach for the prevention and treatment of human diseases. Biochimie. 2022;193:38-63.
  • Afzaal M, Saeed F, Shah YA, et al. Human gut microbiota in health and disease: Unveiling the relationship. Front Microbiol. 2022;13:999001.
  • Hou K, Wu ZX, Chen XY, et al. Microbiota in health and diseases. Signal Transduct Target Ther. 2022;7(1):135.
  • Manor O, Dai CL, Kornilov SA, et al. Health and disease markers correlate with gut microbiome composition across thousands of people. Nat Commun. 2020;11(1):5206.
  • Johnson KV. Gut microbiome composition and diversity are related to human personality traits. Hum Microb J. 2020;15:None.
  • Singh RK, Chang HW, Yan D, et al. Influence of diet on the gut microbiome and implications for human health. J Transl Med. 2017;15(1):73.
  • Heiman ML, Greenway FL. A healthy gastrointestinal microbiome is dependent on dietary diversity. Mol Metab. 2016;5(5):317-20.
  • Wang H, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Metformin and berberine, two versatile drugs in treatment of common metabolic diseases. Oncotarget. 2017;9(11):10135-46.
  • Wang Y, Cui S, Zheng J, Li Y, Li P, Hou H. Berberine ameliorates intestinal mucosal barrier dysfunction in nonalcoholic fatty liver disease (NAFLD) rats. J King Saud Univ Sci. 2020;32(5):2534-9.
  • Arslan NÇ, Gündoğdu A, Tunali V, Topgül OH, Beyazgül D, Nalbantoğlu ÖU. Efficacy of AI-Assisted Personalized Microbiome Modulation by Diet in Functional Constipation: A Randomized Controlled Trial. J Clin Med. 2022;11(22):6612.
  • Karakan T, Gundogdu A, Alagözlü H, et al. Artificial intelligence-based personalized diet: A pilot clinical study for irritable bowel syndrome. Gut Microbes. 2022;14(1):2138672.
  • Wu M, Yang S, Wang S, et al. Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE-/- Mice. Front Pharmacol. 2020;11:223.
There are 73 citations in total.

Details

Primary Language English
Subjects Clinical Pharmacology and Therapeutics
Journal Section REVİEW
Authors

Damla Beyazgül 0000-0002-6798-3828

Nuray Esra Aksakal 0000-0002-2425-3198

Publication Date September 23, 2024
Submission Date December 26, 2023
Acceptance Date July 10, 2024
Published in Issue Year 2024 Volume: 29 Issue: 3

Cite

Vancouver Beyazgül D, Aksakal NE. Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies. Anatolian Clin. 2024;29(3):372-86.

13151 This Journal licensed under a CC BY-NC (Creative Commons Attribution-NonCommercial 4.0) International License.