Berberin ve bağırsak mikrobiyomu arasındaki ilişkinin araştırılması: Son çalışmalara yakından bir bakış

Yıl 2024, Cilt: 29 Sayı: 3, 372 - 386, 23.09.2024

Damla Beyazgül , Nuray Esra Aksakal

https://doi.org/10.21673/anadoluklin.1410170

Öz

Amaç: Berberin, kan şekeri düzenleme ve iltihap azaltma özellikleriyle bilinir ve ayrıca bağırsak mikrobiyota çeşitliliğini artırır ve mikrobiyal profilleri onarır. Ancak, hastalıklara özgü etkileri üzerine kapsamlı incelemeler sınırlıdır. Bu çalışma, berberinin çeşitli hastalıklardaki mikrobiyota çeşitliliği üzerindeki etkisini araştırmayı ve bu konuda yeni bir bakış açısı sunmayı amaçlamaktadır.

Yöntem: 2018-2023 yılları arasında PubMed, Web of Science, ScienceDirect ve Google Scholar gibi veritabanlarında, berberin ve bağırsak mikrobiyotası ile ilgili anahtar kelimeler kullanılarak bir literatür taraması yapılmıştır. İlgisiz konular hariç tutularak 84 başlık ve özet incelenmiş, 33 makale belirlenen kriterlere göre detaylı olarak gözden geçirilmiştir.

Bulgular: Berberin, Bacteroidetes ve Akkermansia gibi yararlı türleri destekler, antimikrobiyal özellikler gösterir ve belirli patojenleri hedef alır. Özellikle obez ve Tip 2 diyabetik farelerde yapılan çalışmalar, bağırsak mikrobiyotası ve çeşitliliğinde iyileşme potansiyeline işaret etmektedir. Ancak, optimal dozaj belirsizdir ve bireysel mikrobiyal yanıtlar farklılık gösterebilir, bazen disbiyotik profillere yol açabilir.

Sonuç: Berberin, bağırsak mikrobiyota çeşitliliğini artırma ve patojenlerle mücadelede umut vadetmektedir. Bununla birlikte, terapötik potansiyelini doğrulamak ve uzun vadeli klinik sonuçlar elde etmek için daha fazla araştırma gereklidir.

Anahtar Kelimeler

Berberin, mikrobiyota, mikrobiyal, mikrobiyom

Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies

Öz

Aim: Berberine, known for regulating blood glucose and reducing inflammation, also enhances gut microbiota diversity and repairs microbial profiles. However, comprehensive reviews on its disease-specific impacts are limited. This study aims to explore berberine’s influence on microbiota diversity in various diseases, offering a novel perspective.

Methods: A literature review was conducted using PubMed, Web of Science, ScienceDirect, and Google Scholar, focusing on studies from 2018-2023. Keywords related to berberine and gut microbiota were used, excluding irrelevant topics. A total of 84 titles and abstracts were screened, with 33 articles meeting inclusion criteria for detailed review.

Results: Berberine promotes beneficial species like Bacteroidetes and Akkermansia, shows antimicrobial properties, and targets specific pathogens. Studies, particularly in obese and Type 2 diabetic mice, suggest it can improve gut microbiota and diversity. However, the optimal dosage remains unclear, and individual microbial responses can vary, sometimes leading to dysbiotic profiles.

Conclusion: Berberine shows promise in enhancing gut microbiota diversity and combating pathogens. Nevertheless, further studies are needed to confirm its therapeutic potential and establish optimal treatment protocols with long-term clinical outcomes.

Anahtar Kelimeler

Berberine, microbiota, microbial, microbiome

Kaynakça

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