Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies

Damla Beyazgül; Nuray Esra Aksakal

doi:10.21673/anadoluklin.1410170

EN TR

Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies

Öz

Aim: Berberine, known for regulating blood glucose and reducing inflammation, also enhances gut microbiota diversity and repairs microbial profiles. However, comprehensive reviews on its disease-specific impacts are limited. This study aims to explore berberine’s influence on microbiota diversity in various diseases, offering a novel perspective. Methods: A literature review was conducted using PubMed, Web of Science, ScienceDirect, and Google Scholar, focusing on studies from 2018-2023. Keywords related to berberine and gut microbiota were used, excluding irrelevant topics. A total of 84 titles and abstracts were screened, with 33 articles meeting inclusion criteria for detailed review. Results: Berberine promotes beneficial species like Bacteroidetes and Akkermansia, shows antimicrobial properties, and targets specific pathogens. Studies, particularly in obese and Type 2 diabetic mice, suggest it can improve gut microbiota and diversity. However, the optimal dosage remains unclear, and individual microbial responses can vary, sometimes leading to dysbiotic profiles. Conclusion: Berberine shows promise in enhancing gut microbiota diversity and combating pathogens. Nevertheless, further studies are needed to confirm its therapeutic potential and establish optimal treatment protocols with long-term clinical outcomes.

Anahtar Kelimeler

Berberine, microbiota, microbial, microbiome

Berberin ve bağırsak mikrobiyomu arasındaki ilişkinin araştırılması: Son çalışmalara yakından bir bakış

Öz

Amaç: Berberin, kan şekeri düzenleme ve iltihap azaltma özellikleriyle bilinir ve ayrıca bağırsak mikrobiyota çeşitliliğini artırır ve mikrobiyal profilleri onarır. Ancak, hastalıklara özgü etkileri üzerine kapsamlı incelemeler sınırlıdır. Bu çalışma, berberinin çeşitli hastalıklardaki mikrobiyota çeşitliliği üzerindeki etkisini araştırmayı ve bu konuda yeni bir bakış açısı sunmayı amaçlamaktadır. Yöntem: 2018-2023 yılları arasında PubMed, Web of Science, ScienceDirect ve Google Scholar gibi veritabanlarında, berberin ve bağırsak mikrobiyotası ile ilgili anahtar kelimeler kullanılarak bir literatür taraması yapılmıştır. İlgisiz konular hariç tutularak 84 başlık ve özet incelenmiş, 33 makale belirlenen kriterlere göre detaylı olarak gözden geçirilmiştir. Bulgular: Berberin, Bacteroidetes ve Akkermansia gibi yararlı türleri destekler, antimikrobiyal özellikler gösterir ve belirli patojenleri hedef alır. Özellikle obez ve Tip 2 diyabetik farelerde yapılan çalışmalar, bağırsak mikrobiyotası ve çeşitliliğinde iyileşme potansiyeline işaret etmektedir. Ancak, optimal dozaj belirsizdir ve bireysel mikrobiyal yanıtlar farklılık gösterebilir, bazen disbiyotik profillere yol açabilir. Sonuç: Berberin, bağırsak mikrobiyota çeşitliliğini artırma ve patojenlerle mücadelede umut vadetmektedir. Bununla birlikte, terapötik potansiyelini doğrulamak ve uzun vadeli klinik sonuçlar elde etmek için daha fazla araştırma gereklidir.

Anahtar Kelimeler

Berberin, mikrobiyota, mikrobiyal, mikrobiyom

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Farmakoloji ve Terapötikler

Bölüm

Derleme

Yazarlar

Damla Beyazgül
0000-0002-6798-3828
Türkiye

Nuray Esra Aksakal ^*
0000-0002-2425-3198
Türkiye

Yayımlanma Tarihi

23 Eylül 2024

Gönderilme Tarihi

26 Aralık 2023

Kabul Tarihi

10 Temmuz 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 29 Sayı: 3

DOI

https://doi.org/10.21673/anadoluklin.1410170

IZ

https://izlik.org/JA47NS53TR

APA

Beyazgül, D., & Aksakal, N. E. (2024). Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies. Anatolian Clinic the Journal of Medical Sciences, 29(3), 372-386. https://doi.org/10.21673/anadoluklin.1410170

AMA

1.Beyazgül D, Aksakal NE. Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies. Anadolu Klin. 2024;29(3):372-386. doi:10.21673/anadoluklin.1410170

Chicago

Beyazgül, Damla, ve Nuray Esra Aksakal. 2024. “Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies”. Anatolian Clinic the Journal of Medical Sciences 29 (3): 372-86. https://doi.org/10.21673/anadoluklin.1410170.

EndNote

Beyazgül D, Aksakal NE (01 Eylül 2024) Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies. Anatolian Clinic the Journal of Medical Sciences 29 3 372–386.

IEEE

[1]D. Beyazgül ve N. E. Aksakal, “Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies”, Anadolu Klin, c. 29, sy 3, ss. 372–386, Eyl. 2024, doi: 10.21673/anadoluklin.1410170.

ISNAD

Beyazgül, Damla - Aksakal, Nuray Esra. “Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies”. Anatolian Clinic the Journal of Medical Sciences 29/3 (01 Eylül 2024): 372-386. https://doi.org/10.21673/anadoluklin.1410170.

JAMA

1.Beyazgül D, Aksakal NE. Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies. Anadolu Klin. 2024;29:372–386.

MLA

Beyazgül, Damla, ve Nuray Esra Aksakal. “Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies”. Anatolian Clinic the Journal of Medical Sciences, c. 29, sy 3, Eylül 2024, ss. 372-86, doi:10.21673/anadoluklin.1410170.

Vancouver

1.Damla Beyazgül, Nuray Esra Aksakal. Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies. Anadolu Klin. 01 Eylül 2024;29(3):372-86. doi:10.21673/anadoluklin.1410170

13151 This Journal licensed under a CC BY-NC (Creative Commons Attribution-NonCommercial 4.0) International License.

Exploring the relationship between berberine and the gut microbiome: A closer look at recent studies

Öz

Anahtar Kelimeler

Berberin ve bağırsak mikrobiyomu arasındaki ilişkinin araştırılması: Son çalışmalara yakından bir bakış

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster