THE ROLE OF MATRIX METALLOPROTEINASES (MMPS) ENZYMES IN BONDING EFFECTIVENESS OF ADHESIVES

Abstract

Demineralized dentin contains bound matrix metalloproteinases -2, -3, -8, -9, and -20 (MMPs). These enzymes were activated by acids and can slowly degrade the collagen fibrils of hybrid layer. The contemporary dentin adhesives are very stable at the enamel surface, whereas lose their bond strength to dentin over time. This loss relates to the hydrolysis of collagen matrix of the hybrid layers. The preservation of the collagen matrix integrity is a key issue in the attempts to improve the dentin bonding durability. For this reason, MMPs that breakdown collagen fibrils must be inactivated or inhibited. The aim of this review was to evaluate functions of the matrix metalloproteinases enzymes, common MMPs inhibitors and current studies that evaluate of the inhibitory effect of these agents using this method

Keywords

• Dentin Bonding, Matrix

MATRİKS METALOPROTEİNAZ (MMPS) ENZİMLERİNİN ADEZİVLERİN BAĞLANMA ETKİNLİĞİ ÜZERİNDEKİ ROLÜ

Abstract

Demineralize dentin, matriks metalloproteinaz -2, -3, -8, -9, -20 (MMPs) enzimlerini içerir. Bu enzimler, asidik ortamda aktif hale gelirler ve hibrit tabakasında bulunan kollajen matriksin yavaşça yıkımına sebep olurlar. Günümüz adeziv sistemlerinin mineye bağlanma dayanımları oldukça stabil iken, dentine bağlanma dayanım değerleri süreye bağlı olarak azalır. Bu azalmada, hibrit tabakasındaki kollajen matriksin hidrolizisinin önemli rolü vardır. Kollajen matriks bütünlüğünün korunması, bağlanma dayanıklılığını geliştirmenin en önemli yoludur. Dolayısı ile kollajen matriksin çeşitli sebepler ile yıkımına neden olan enzimlerin inaktif hale getirilmesi ya da fonksiyonlarının inhibe edilmesi gereklidir. Bu makalede, matriks metalloproteinaz enzimlerinin fonksiyonu, bu enzimlerin günümüzde yaygın olarak kullanılan inhibitörleri ve bu inhibitörlerin etkinliğini inceleyen güncel çalışmalar derlenmiştir.

Anahtar Kelimeler: Dentin Bağlayıcı, Matriks Metalloproteinaz, Enzim İnhibitörleri, Bağlayıcı Yıkımı

Keywords

• Dentin Bağlayıcı, Matriks

References

1. Nagase H, Woessner JF. Matrix Metalloproteinases. J Bio Chem 1999;274:21491-4.
2. Hannas AR, Pereira JC, Granjeiro JM, Tjaderhane L. The role of matrix metalloproteinases in the oral environment. Acta Odontol Scand 2007;65:1-13.
3. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function and biochemistry. Cric Res 2003;92:827- 39.
4. Zhang SC, Kern Matthias. The role of host-derived dentinal matrix metalloproteinases in reducing dentin bonding of resin adhesives. Int J Oral Sci 2009;1:163-76.
5. Kreis T, Vale R. Matrix metalloproteinases. In: Sternlicht MD, Werb Z, editors. Guidebook to the extracellular matrix, anchor, and adhesion proteins, 2nd edn. San Francisco: Oxford University Press; 1999;519-42.
6. Shimada Y, Ichinose S, Sadr A, Burrow MF, Tagami J. Localization of matrix metalloproteinases (MMPs- 2, 8, 9 and 20) in normal and carious dentine. Austral Dent J 2009;54:347-54.
7. Birkedal-Hansen H. Role of matrix metalloproteinases in human periodontal diseases. J Periodontol 1993;/64:474-84.
8. Sorsa T, Tjäderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis 2004;10:311-8.

9. Vu TH, Werb Z. Matrix metalloproteinases: effectors of development and normal physiology. Genes Dev 2000;14:2123-33. MD,
10. Sternlicht Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001;17:463-516.
11. Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 2006;69:562-73.
12. Tjäderhane L, Larjava H, Sorsa T, Uitto V-J, Larmas M, Salo T. The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions. J Dent Res 1998;77:1622-9.
13. Caterina JJ, Skobe Z, Shi J, Ding Y, Simmer JP, Birkedal-Hansen metalloproteinase 20) deficient mice display an amelogenesis imperfecta phenotype. J Biol Chem 2002;277:49598-604. Enamelysin (matrix
14. Sulkala M, Larmas M, Sorsa T, Salo T, Tjaderhane L. The localization of matrix metalloproteinase -20 (MMP-20, enamelysin) in mature human teeth. J Dent Res 2002;81:603-7.
15. Katz S, Park KK, Palenick CJ. In vitro root surface caries studies. J Oral Med 1987;/42:40-8.
16. Tjaderhane L, Larjava H, Sorsa T, Uitto VJ, Larmas M, Salo T. The activation and function of host matrix metalloproteinases in dentin matrix breakdown Res,1998;77:1622-9. lesions. J Dent
17. Chaussain-Miller C, Fioretti F, Goldberg M, Menashi S. The role of matrix metalloproteinases (MMPs) in human caries. J Dent Res 2006;85:22-32.
18. Mazzoni A, Pashley DH, Nishitani Y, Breschi L, Mannello F, Tjäderhane L, Toledano M, Pashley EL, Tay FR. Reactivation of inactivated endogenous proteolytic activities in phosphoric asid-etched dentine by etch-and-rinse adhesives. Biomaterials 2006;27:4470-6.
19. Tezvergil-Mutluay A, Agee AA, Hoshika T, Uchiyama T, Tjäderhane L, Breshi L, Mazzoni A, Thompson JM, McCracken CE, Looney SW, Tay FR, Pashley DH. Inhibition of MMPs by alcohols. Dent Mater 2011;27:926-33.
20. Bella J, Brodsky B, Berman HM. Hydration structure of a collagen peptide. Structure 1995;3:893-906.
21. Tjaderhane L, Haapasalo M. Dentin–pulp border: dynamic interface between hard and soft tissues. Endo Topic 2012;20:52-84.
22. Pashley DH, Tay FR, Carvalho RM, Rueggeberg FA, Agee KA, Carrilho M. From dry bonding to water- wet bonding to ethanol-wet bonding. A review of the interactions between dentin matrix and solvated resins using a macromodel of the hybrid layer. Am J Dent 2007;20:7-21.
23. Wang Y, Spencer P. Effect of acid etching time and technique on interfacial characteristics of the adhesive-dentin bond using differential staining. Eur J Oral Sci 2004;112:293-9.
24. Sulkala M, Tervahartiala T, Sorsa T, Larmas M, Salo T, Tjaderhane L. Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin. Arch Oral Biol 2007;52: 121-7.
25. King NM, Tay FR, Pashley DH, Hashimoto M, Ito S, Brackett WW. Conversion of one-step to two-step self-etch adhesives for improved efficacy and extended application. Am J Dent 2005;18:126-34.
26. Ito S, Tay FR, Hashimoto M, Yoshiyama M, Saito T, Brackett WW, Waller JL, Pashley DH. Effects of multiple coatings of two all-in-one adhesives on dentin bonding. J Adhes Dent 2005;7:133-41.
27. Pashley EL, Agee KA, Pashley DH, Tay FR. Effects of one versus two applications of an unfilled, all-in- one adhesive on dentine bonding. J Dent 2002;30:83-90.
28. Reis A, de Carvalho Cardoso P, Vieira LC, et al. Effect of prolonged application times on the durability of resin-dentin bonds. Dent Mater
29. Cadenaro M, Antoniolli F, Sauro S, Tay FR, Di Lenarda R, Prati C. Degree of conversion and permeability of dental adhesives. Eur J Oral Sci 2005; 113:525-30.
30. Furuse AY, Peutzfeldt A, Asmussen E. Effect of evaporation of solvents from One-step self etching adhesives. J Adhes Dent 2008;10:35-9.
31. Hosaka K, Nishitani Y, Tagami J, Yoshiyama M, Brackett W.W, Agee KA, Tay FR, Pashley DH. Durability of resin-dentin bonds to water- vs.ethanol-saturated 2009;88:146-51. J Dent Res strategy. J Dent Res
32. Carrilho MRO, Geraldeli S, Tay FR, de Goes MF, Carvalho RM, Tjäderhane L, Reis AF, Hebling J, Mazzoni A, Breschi L, Pashley DH. In vivo preservation of the hybrit layer by chlorhexidine. J Dent Res 2007;86:529-33.
33. Armstrong SR, Vargas MA, Chung I, PAshley DH, Campbell JA, Laffoon JE, Qian F. Resin-dentin interfacial and microtensile bond strength after five-year water storage. Oper Dent 2004;29:705- 12.
34. Pashley DH, Tay FR, Breshi L, Tjäderhane L, Carvalho RM, Carrilho M, Tezvergil-Mutluay A. State of the art etch-and-rinse adhesives. 2011;27:1-16.
35. Hashimoto M, Tay FR, Ohno H, Sano H, Kaga M, Yiu C. SEM and TEM analysis of water degradation of human dentinal collagen. J Biomed Mater Res B Appl Biomater 2003;66:287-98.
36. Tay FR, Pashley DH, Suh BI, Hiraishi N, Yiu CK. Water treeing in simplified dentin adhesives- deja vu? Oper Dent 2005;30:561-79.
37. Pashley DH, Tay FR, Yiu C, Hashimoto M, Breschi L, Carvalho RM, Ito S. Collagen degradation by host-derived enzymes during aging. J Dent Res 2004;83:216-21.
38. Hashimoto M. A Review- Micromorphological evidence of degradation in resin-dentin bonds and potential preventional solutions. Appl Biomater 2010;92:268-80.
39. Breschi L, Mazzoni A, Ruggeri A, Cadenaro M, Di Lenarda R, Dorigo EDS. Dental adhesion review: Aging and stability of the bonded interface. Dent Mater 2008;24:90-101.
40. Liu Y, Tjaderhane L, Breschi L, Mazzoni A, Li N, Mao J, Pashley DH, Tay FR. Limitations in bonding to dentin and experimental strategies to prevent bond degradation. J Dent Res 2011;90:953-68.
41. Carrilho MR, Carvalho RM, Tay FR, Yiu C, Pashley DH. Durability of resin-dentin bonds related to water and oil storage. Am J Dent 2005;18:315-9.
42. Garcia-Godoy F, Tay FR, Pashley DH, Feilzer A, Tjäderhane L, Pashley EL. Degradation of resin- bonded human dentin after 3 years of storage. Am J Dent 2007;20:109-13.
43. Toledano M, Osorio R, Osorio E, Aguilera FS, Yamauti M, Pashley DH, Tay FR. Durability of resin-dentin bonds: Effects of direct/indirect exposure and storage media. Dent Mater 2007;23:885-92.
44. Tay FR, Pashley DH, Loushine RJ, Weller RN, Monticelli F, Osorio R. Self-etching adhesives increase collagenolytic activity in radicular dentin. J Endod 2006;32:862–8.
45. Nishitani Y, Yoshiyama M, Wadgaonkar B, Breschi L, Mannello F, Mazzoni A. Activation of gelatinolytic/collagenolytic activity in dentin by self- etching adhesives. Eur J Oral Sci 2006;114:160-6.
46. Mazzoni A, Mannello F, Tay FR, Tonti GA, Papa S, Zymographic characterization of MMP-2 and -9 forms in human sound dentin. J Dent Res 2007;86:436-40. and
47. Perdigao J, Lambrechts P, van Meerbeek B, Tome AR, Vanherle G, Lopes AB. Morphological field emission-SEM study of the effect of six phosphoric acid etching agents on human dentin. Dent Mater 1996;12:262-71.
48. De Munck J, Van den Steen PE, Mine A, Van Landuyt KL, Poitevin A, Opdenakker G, Van Meerbeek B. İnhibition of enzymatic degradation of adhesive-dentin interfaces. J Dent Res
49. Tjaderhane L, Nascimento FD, Breschi L, Mazzoni A, Tersariol ILS, Geraldeli S, Tezvergil-Mutluay A, Carrilho MR, Carvalho RM, Tay FR, Pashley DH. Optimizing dentin bond durability: Control of collagen degradation by matrix metalloproteinases and cysteine cathepsins. Dent Mater 2013;29:116- 35.
50. Hebling J, Pashley DH, Tjäderhane L, Tay FR. Chlorhexidine arrests subclinical degradation of dentin hybrid layers in vivo. J Dent Res 2005;84:741-6.
51. Mertz-Fairhurst EJ, Curtis JW Jr, Ergle JW, Rueggeberg FA, Adair SM. Ultraconservative and cariostatic sealed restorations: results at year 10. J Am Dent Assoc. 1998;129:55-66.
52. Tezvergil-Mutluay A, Mutluay M, Seseogullari- Dirihan R, Agee KA, Key WO, Scheffel DLS, Breschi L, Mazzoni A, Tjaderhane L, Nishitani Y, Tay FR, Pashley DH. Effect of phosphoric acid on the degradation of human dentin matrix. J Dent Res 2013;92:87-91.
53. Erhardt MCG, Osorio R, Toledano M. Dentin treatment with MMPs inhibitors does not alter bond strengths to caries-effected dentin. Journal of Dentistry 2008;36:1068-73.
54. Gendron R, Grenier D, Sorsa T, Mayrand D, Inhibition of matrixmetalloproteinases 2, 8 and 9 by clorhexidine. Clin Diagn Lan Immunol 1999;6:437- 9. activities of
55. Collares FM, Rodrigues SB, Leitune CVB, Celeste RK, Araujo FB, Samuel SMW. Chlorhexidine application in adhesive procedures: A metal- regression analysis. J Adhes Dent 2013;15:11-8.
56. Andrzejewska E, Photopolymerization kinetics of multifunctional monomers. Prog Polym Sci 2001;26:605-65.
57. Breschi L, Mazzoni A, Nato F, Carrilho M, Visintini E, Tjaderhane L, Ruggeri A Jr, Tay FR, Dorigo ES, Pashley DH. Chlorhexidine stabilizes the adhesive interface: A 2-year in vitro study. Dent Mater 2010;26:320-5.
58. De Munck J, Mine A, Van den Steen PE, Van Landuyt KL, Poitevin A, Opdenakker G, Van Meerbeek B. Enzymatic degradation of adhesive- dentin interfaces produced by mild self-etch adhesives. Eur J Oral Sci 2010;118:494-501.
59. Lenzi TL, Tedesco TK, Soares FZM, Loguercio AD, Rocha RO. Chlorhexidine does not increase immediate bond strength of etch-and-rinse adhesive to caries affected dentin of primary and permanent teeth. Braz Dent J 2012;23:438-42.
60. Sanabe ME, Costa CA, Hebling J. Exposed collagen in aged resin-dentin bonds produced on sound and caries-affected dentin in the presence of chlorhexidine. J Adhes Dent 2011;13:117-24.
61. Çelik Ç, Özel Y, Karabulut E. Kavite dezenfektanı uygulamasının farklı dentin adeziv sistemlerin mikrosızıntısına etkisi. Atatürk Üniv Diş Hek Fak Derg 2007;17:7-12.
62. Habelitz S, Balooch M, Marshall SJ, Balooch G, Marshall GW Jr. In situ atomic force microscopy of partially demineralized human dentin collagen fibrils. J Struct Biol 2002;138:227-36.
63. Sano H, Takatsu T, Ciucchi B, Russell CM, Pashley DH. Tensile properties of resin-infiltrated demineralized human dentin. J Dent Res 1995;74:1093-102.
64. Osorio R, Erhardt MCG, Pimenta LAF, Osorio E, Toledano M. EDTA treatment improves resin- dentin bonds resistance to degradation. J Dent Res 2005;84:736-40.
65. Sauro S, Toledano M, Aguilera FS, Mannocci F, Pashley DH, Tay FR, Watson TF, Osorio R. Resin- dentin bonds to EDTA-treated vs. acid-etched dentin using ethanol wet-bonding. Part II: Effects of mechanical cycling load on microtensile bond strengths. Dent Mater 2011;27:563-72.
66. Hosaka K, Nishitani Y, Tagami J, Yoshiyama M, Brackett W.W, Agee KA, Tay FR, Pashley DH. Durability of resin-dentin bonds to water- vs.ethanol-saturated 2009;88:146-51. J Dent Res
67. Kim J, Gu L, Breschi L, Tjaderhane L, Choi KK, Pashley DH, Tay FR. Implication of ethanol wet- bonding in hybrid layer remineralizition. J Dent Res 2010; 89(6):575-580.
68. Sauro S, Toledano M, Aguilera FS, Mannocci F, Pashley DH, Tay FR, Watson TF, Osorio R. Resin- dentin bonds to EDTA-treated vs. acid-etched dentin using ethanol wet-bonding. Dent Mater
69. Grobelny D, Poncz L, Galardy RE. Inhibition of human skin fibroblast collagenase, thermolysin, and pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 1992;31:7152-4.
70. Galardy RE, Cassabonne ME, Giese C, Gilbert JH, Lapierre F, Lopez H. Low molecular weight inhibitors in corneal ulseration. Ann N Y Acad Sci
71. Breschi L, Martin P, Mazzoni A, Nato F, Carrilho M, Tjaderhane L, Visintini E, Cadenaro M, Tay FR, Dorigo ES, Pashley DH. Use o a specific MMP- inhibitor(galardin) for preservation of hybrid layer. Dent Mater 2010;26:571-8.
72. Marple B, Roland P, Benninger M. Safety review of benzalkonium chloride used as a preservative in intranasal solitions: an overview of conflicting data and options. Otolaryngol Head Neck Surg 2004;130:131-41.
73. Kanca J. One step bond strength to enamel and dentin. Am J Dent 1997;9:5-8.
74. Tezvergil-Mutluay A, Mutluay MM, Gu L, Zhang K, Agee A, Carvalho RM, Manso A, Carrilho M, Tay FR, Breschi L, Suh B, Pashley DH. The anti-MMP activity of benzalkonium chloride. J Dent 2011;39:57-64.
75. Reis AF, Giannini M, Pereira PNR. Long-term TEM analysis of the nanoleakage patterns in resin– dentin interfaces produced by different bonding strategies. Dent Mater 2007;23:1164-72.