THE ROLE OF MATRIX METALLOPROTEINASES (MMPS) ENZYMES IN BONDING EFFECTIVENESS OF ADHESIVES

Öz

Demineralized dentin contains bound matrix metalloproteinases -2, -3, -8, -9, and -20 (MMPs). These enzymes were activated by acids and can slowly degrade the collagen fibrils of hybrid layer. The contemporary dentin adhesives are very stable at the enamel surface, whereas lose their bond strength to dentin over time. This loss relates to the hydrolysis of collagen matrix of the hybrid layers. The preservation of the collagen matrix integrity is a key issue in the attempts to improve the dentin bonding durability. For this reason, MMPs that breakdown collagen fibrils must be inactivated or inhibited. The aim of this review was to evaluate functions of the matrix metalloproteinases enzymes, common MMPs inhibitors and current studies that evaluate of the inhibitory effect of these agents using this method

Anahtar Kelimeler

• Dentin Bonding, Matrix

MATRİKS METALOPROTEİNAZ (MMPS) ENZİMLERİNİN ADEZİVLERİN BAĞLANMA ETKİNLİĞİ ÜZERİNDEKİ ROLÜ

Öz

Demineralize dentin, matriks metalloproteinaz -2, -3, -8, -9, -20 (MMPs) enzimlerini içerir. Bu enzimler, asidik ortamda aktif hale gelirler ve hibrit tabakasında bulunan kollajen matriksin yavaşça yıkımına sebep olurlar. Günümüz adeziv sistemlerinin mineye bağlanma dayanımları oldukça stabil iken, dentine bağlanma dayanım değerleri süreye bağlı olarak azalır. Bu azalmada, hibrit tabakasındaki kollajen matriksin hidrolizisinin önemli rolü vardır. Kollajen matriks bütünlüğünün korunması, bağlanma dayanıklılığını geliştirmenin en önemli yoludur. Dolayısı ile kollajen matriksin çeşitli sebepler ile yıkımına neden olan enzimlerin inaktif hale getirilmesi ya da fonksiyonlarının inhibe edilmesi gereklidir. Bu makalede, matriks metalloproteinaz enzimlerinin fonksiyonu, bu enzimlerin günümüzde yaygın olarak kullanılan inhibitörleri ve bu inhibitörlerin etkinliğini inceleyen güncel çalışmalar derlenmiştir.

Anahtar Kelimeler: Dentin Bağlayıcı, Matriks Metalloproteinaz, Enzim İnhibitörleri, Bağlayıcı Yıkımı

Anahtar Kelimeler

• Dentin Bağlayıcı, Matriks

Kaynakça

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