PERİODONTAL HASTALIKLARDA MMP-8’İN ROLÜ

Abstract

ÖZET 

Matriks metalloproteinazlar (MMP), organogenezis, büyüme ve normal doku yenilenmesi sırasında ekstraselüler matriks proteinlerinin yıkılmasından sorumlu enzim grubudur. Organizmada fizyolojik olayların sürdürülmesinde MMP aktivitesi ile onların spesifik endojen doku inhibitörleri arasında bir denge söz konusudur. Bu dengenin MMP aktivitesi yönüne kayması matriksin yıkılmasına ve patofizyolojik olayların oluşmasına neden olmaktadır. MMP sentezi ve aktivitesi sağlıklı dokularda düşükken enflamatuvar hastalıklar, tümoral oluşumlar ve metastazlar gibi birçok patolojik durumda seviyeleri artarak doku yıkımında rol oynamaktadırlar. Bu derleme, diş çürükleri ve oral kanserler gibi diğer oral hastalıklarla da ilişkili olan MMP-8 aktivitesinin periodontal hastalıklardaki rolünü sunmaktadır.

Keywords

• Anahtar metalloproteinaz, periodontal hastalık Kelimeler: enflamasyon, matriks

THE ROLE OF MMP-8 IN PERIODONTAL DISEASES

Abstract

Matrix metalloproteinases (MMP) are a group of enzymes that are responsible for the degradation of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. There is a balance between MMP activity and their specific endogenous tissue inhibitors in the maintenance of physiological processes in the organism. This balance shift in the direction of MMP activity leads to the degradation of extracellular pathophysiological events. MMP synthesis and its activity is low at healthy tissue but increased levels play a role in tissue destruction in inflammatory diseases and many pathological conditions such as tumor formation and metastasis. This review is presenting the role of MMP-8 activity in periodontal disease which is associated with other oral diseases such as dental caries and oral cancers

Keywords

• inflammation, matrix metalloproteinases, periodontal disease

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