PERİODONTAL HASTALIKLARDA MMP-8’İN ROLÜ

Öz

ÖZET 

Matriks metalloproteinazlar (MMP), organogenezis, büyüme ve normal doku yenilenmesi sırasında ekstraselüler matriks proteinlerinin yıkılmasından sorumlu enzim grubudur. Organizmada fizyolojik olayların sürdürülmesinde MMP aktivitesi ile onların spesifik endojen doku inhibitörleri arasında bir denge söz konusudur. Bu dengenin MMP aktivitesi yönüne kayması matriksin yıkılmasına ve patofizyolojik olayların oluşmasına neden olmaktadır. MMP sentezi ve aktivitesi sağlıklı dokularda düşükken enflamatuvar hastalıklar, tümoral oluşumlar ve metastazlar gibi birçok patolojik durumda seviyeleri artarak doku yıkımında rol oynamaktadırlar. Bu derleme, diş çürükleri ve oral kanserler gibi diğer oral hastalıklarla da ilişkili olan MMP-8 aktivitesinin periodontal hastalıklardaki rolünü sunmaktadır.

Anahtar Kelimeler

• Anahtar metalloproteinaz, periodontal hastalık Kelimeler: enflamasyon, matriks

THE ROLE OF MMP-8 IN PERIODONTAL DISEASES

Öz

Matrix metalloproteinases (MMP) are a group of enzymes that are responsible for the degradation of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. There is a balance between MMP activity and their specific endogenous tissue inhibitors in the maintenance of physiological processes in the organism. This balance shift in the direction of MMP activity leads to the degradation of extracellular pathophysiological events. MMP synthesis and its activity is low at healthy tissue but increased levels play a role in tissue destruction in inflammatory diseases and many pathological conditions such as tumor formation and metastasis. This review is presenting the role of MMP-8 activity in periodontal disease which is associated with other oral diseases such as dental caries and oral cancers

Anahtar Kelimeler

• inflammation, matrix metalloproteinases, periodontal disease

Kaynakça

1. Orbak R, Zihni M. Periodontal Hastalığın Başlangıç Tedavisi, Karşılaşılan Komplikasyonlar Ve Bu Komplikasyonların Giderilme Stratejileri. Atatürk Üniv Diş Hek Fak Derg 2006;16:33-41.
2. Çakmak H, Marakoğlu İ. İnterlökin-1 Ve Periodontal Hastalık Patogenezindeki Rolü. Atatürk Üniv Diş Hek Fak Derg 2002;12:70-81.
3. Oliver RC, Brown LJ, Loe H. Periodontal diseases in the United States population. J Periodontol 1998;69:269-78.
4. Kinane DF, Bartold PM. Clinical relevance of the host responses of periodontitis. Periodontology 2000 2007;43:278-93.
5. Çetiner E, Engel MU. Periodontal Teşhiste Hastalığa Ait Potansiyel Markerlar. Atatürk Üniv Diş Hek Fak Derg 2000;10:66-72.
6. Loesche WJ, Grossman NS. Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clin Microbiol Rev 2001;14:727-52.
7. Yıldırım TT, Kaya FA. Agresif periodontitis. Atatürk Üniv Diş Hek Fak Derg 2011, Supplement 4:15-23.
8. Offenbacher S: Periodontal diseases. pathogenesis. Ann Periodontol 1996;1:821-78.

9. Tsai IS, Tsai CC, Ho YP, Ho KY, Wu YM, Hung CC: Interleukin-12 and interleukin-16 in periodontal disease. Cytokine 2005;31:34-40.
10. Borges I, Jr., Moreira EA, Filho DW, de Oliveira TB, da Silva MB, Frode TS. Proinflammatory and oxidative stress markers in patients with periodontal 2007;2007:45794. Mediators Inflamm
11. Graves D. Cytokines that promote periodontal tissue destruction. J Periodontol 2008;79:1585-91.
12. Page RC, Offenbacher S, Schroeder HE, Seymour GJ, Kornman KS. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 2000 1997;14:216-48.
13. Massova I, Kotra LP, Fridman R, Mobashery S. Matrix metalloproteinases: structures, evolution, and diversification. FASEB J 1998;12:1075-95.
14. Nagase H, Woessner JF, Jr. Matrix metallopro- teinases. J Biol Chem. 1999;274:21491-4.
15. Lambert E, Dasse E, Haye B, Petitfrere E. TIMPs as multifacial proteins. Crit Rev Oncol Hematol
16. Sorsa T, Tjaderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis. 2004;10:311-8.
17. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 2003;92:827- 39.
18. Butler GS, Overall CM. Matrix metalloproteinase processing of signaling molecules to regulate inflammation. Periodontol 2000 2013;63:123-48.
19. Parks WC, Wilson CL, Lopez-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol. 2004;4:617-29. 20. McCawley LJ, Matrisian metalloproteinases: they're not just for matrix anymore Curr Opin Cell Biol. 2001, 13:534-40.
20. Çağlayan G. Periodontoloji. 1. Baskı; İstanbul: 2010. p. 116-7.
21. Jones CB, Sane DC, Herrington DM. Matrix metalloproteinases: a review of their structure and role in acute coronary syndrome. Cardiovasc Res 2003;59:812-23.
22. Nissinen L, Kahari VM. Matrix metalloproteinases in Biochim inflammation. 2014;1840:2571-80. Biophys Acta.
23. Uitto VJ, Overall CM, McCulloch C. Proteolytic host cell enzymes in gingival crevice fluid. Periodontol 2000 2003;31:77-104.
24. Potempa J, Banbula A, Travis J. Role of bacterial proteinases in matrix destruction and modulation of host responses. Periodontol 2000 2000;24:153- 92.
25. Weiss SJ. Tissue destruction by neutrophils. N Engl J Med. 1989;320:365-76.
26. Cox SW, Eley BM, Kiili M, Asikainen A, Tervahartiala T, Sorsa T. Collagen degradation by interleukin-1beta-stimulated gingival fibroblasts is accompanied by release and activation of multiple matrix proteinases. Oral Dis. 2006;12:34-40. and cysteine
27. Ding Y, Haapasalo M, Kerosuo E, Lounatmaa K, Kotiranta A, Sorsa T. Release and activation of human neutrophil matrix metallo- and serine proteinases during phagocytosis of Fusobacterium nucleatum, Treponema 1997;24:237-48. gingivalis J Clin Periodontol.
28. Ding Y, Uitto VJ, Haapasalo M, Lounatmaa K, Konttinen YT, Salo T, Grenier D, Sorsa T. Membrane components of Treponema denticola trigger polymorphonuclear leukocytes. J Dent Res. 1996;75:1986-93. from human
29. Hanemaaijer R, Sorsa T, Konttinen YT, Ding Y, Sutinen M, Visser H, van Hinsbergh VW, Helaakoski T, Kainulainen T, Ronka H, Tschesche H, Salo T. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline. J Biol Chem. 1997;272:31504-9.
30. Delaisse JM, Andersen TL, Engsig MT, Henriksen K, Troen T, Blavier L. Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic 2003;61:504-13. Microsc Res Tech.
31. Parikka V, Vaananen A, Risteli J, Salo T, Sorsa T, Vaananen HK, Lehenkari P. Human mesenchymal stem cell derived osteoblasts degrade organic bone matrix in vitro by matrix metalloproteinases.Matrix Biol. 2005;24:438-47.
32. Inui T, Ishibashi O, Origane Y, Fujimori K, Kokubo T, Nakajima M. Matrix metalloproteinases and lysosomal cysteine proteases in osteoclasts contribute to bone resorption through distinct modes of action. Biochem Biophys Res Commun. 1999;258:173-8.
33. Hannas AR, Pereira JC, Granjeiro JM, Tjaderhane L. The role of matrix metalloproteinases in the oral environment. Acta Odontol Scand. 2007;65:1-13.
34. Makela M, Salo T, Uitto VJ, Larjava H. Matrix metalloproteinases (MMP-2 and MMP-9) of the oral cavity: cellular origin and relationship to periodontal status. J Dent Res. 1994;73:1397-406.
35. Biyikoglu B, Buduneli N, Kardesler L, Aksu K, Pitkala M, Sorsa T. Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease. J Periodontol 2009;80:1307-14.
36. Palosaari H, Wahlgren J, Larmas M, Ronka H, Sorsa T, Salo T, Tjaderhane L. The expression of MMP-8 in human odontoblasts and dental pulp cells is down-regulated by TGF-beta1. J Dent Res. 2000;79:77-84.
37. Romanelli R, Mancini S, Laschinger C, Overall CM, Sodek J, McCulloch CA. Activation of neutrophil collagenase in periodontitis. Infect Immun.
38. Teles R, Sakellari D, Teles F, Konstantinidis A, Kent R, Socransky S, Haffajee A. Relationships among gingival crevicular fluid biomarkers, clinical parameters of periodontal disease, and the subgingival microbiota. J Periodontol 2010;81:89- 98.
39. Golub LM, Ryan ME, Williams RC. Modulation of the host response in the treatment of periodontitis. Dent Today. 1998;17:102-9.
40. Golub LM, Wolff M, Roberts S, Lee HM, Leung M, Payonk GS. Treating periodontal diseases by blocking tissue-destructive enzymes. J Am Dent Assoc. 1994;125:163-71.
41. Sorsa T, Mantyla P, Ronka H, Kallio P, Kallis GB, Lundqvist C, Kinane DF, Salo T, Golub LM, Teronen O, Tikanoja S. Scientific basis of a matrix metalloproteinase-8 specific chair-side test for monitoring periodontal and peri-implant health and disease. Ann N Y Acad Sci. 1999;878:130-40.
42. Aoki A, Sasaki KM, Watanabe H, Ishikawa I. Lasers in nonsurgical periodontal therapy. Periodontol 2000 2004;36:59-97.
43. Nomura T, Ishii A, Oishi Y, Kohma H, Hara K. Tissue inhibitors of metalloproteinases level and collagenase activity in gingival crevicular fluid: the relevance to periodontal diseases. Oral Dis. 1998;4:231-40.
44. Kraft-Neumarker M, Lorenz K, Koch R, Hoffmann T, Mantyla P, Sorsa T, Netuschil L. Full-mouth profile of active MMP-8 in periodontitis patients. J Periodontal Res. 2012;47:121-8.
45. Lee W, Aitken S, Sodek J, McCulloch CA. Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo: role of active enzyme in human periodontitis. J Periodontal Res. 1995;30:23-33.
46. Mantyla P, Stenman M, Kinane DF, Tikanoja S, Luoto H, Salo T, Sorsa T. Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis. J Periodontal Res. 2003;38:436-9.
47. Konopka L, Pietrzak A, Brzezinska-Blaszczyk E. Effect of scaling and root planing on interleukin- 1beta, interleukin-8 and MMP-8 levels in gingival crevicular fluid from chronic periodontitis patients. J Periodontal Res. 2012;47:681-8.
48. Eltas A, Orbak R. Effect of 1,064-nm Nd:YAG laser therapy on GCF IL-1beta and MMP-8 levels in patients with chronic periodontitis. Lasers Med Sci 2012;27:543-50.
49. Chen HY, Cox SW, Eley BM, Mantyla P, Ronka H, Sorsa T. Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients. J Clin Periodontol. 2000;27:366-9.
50. Kinane DF, Darby IB, Said S, Luoto H, Sorsa T, Tikanoja S, Mantyla P. Changes in gingival crevicular fluid matrix metalloproteinase-8 levels during periodontal treatment and maintenance. J Periodontal Res. 2003;38:400-4.
51. Soder B. Neutrophil elastase activity, levels of prostaglandin E2, and matrix metalloproteinase-8 in refractory periodontitis sites in smokers and non-smokers. Acta Odontol Scand. 1999;57:77-82.
52. Soder B, Jin LJ, Wickholm S. Granulocyte elastase, matrix metalloproteinase-8 and prostaglandin E2 in gingival crevicular fluid in matched clinical sites in smokers and non-smokers with persistent periodontitis. J Clin Periodontol. 2002;29:384-91.