Protective effect of alpha lipoic acid against oxidative damage caused by valproic acid on lung tissue in rats
Abstract
Valproic acid (VPA) is a short-chain fatty acid used to treat disorders of the brain. When VPA is used for long term, it causes damage, particularly through the formation of free radicals. The lungs are among the organs most affected by long-term VPA treatment. Some antioxidant substances are used to prevent damage caused by free radicals. One of these substances is alpha-lipoic acid (ALA), which occurs naturally. In our study, the protective effect of ALA against VPA-induced lung injury was investigated. In this study, female Sprague-Dawley rats were divided into four groups. The 1st group served as the control (1 mL olive oil); the 2nd group received ALA (50 mg/kg/day) for 15 days; the 3rd group received VPA (0.5 g/kg/day) for 15 days; and the 4th group received both VPA and ALA at the same doses and for the same duration. ALA and VPA were dissolved in olive oil. On day 16, all groups were euthanized under anesthesia. The lung tissues were collected and homogenized. In the prepared supernatants, the levels of reduced glutathione and total antioxidant status, and the activities of glutathione reductase, glutathione peroxidase, catalase, paraoxonase, carbonic anhydrase, aryl esterase, and superoxide dismutase were decreased in the VPA group, while sialic acid, lipid peroxidation, reactive oxygen species, total oxidant, oxidative stress index, hydroxyproline, glycoprotein levels, and xanthine oxidase activities were increased in the VPA group. These values were reversed in ALA when VPA was administered. As a result, it may be concluded that ALA exerts protective effects against VPA-induced lung damage.
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Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Biochemistry |
| Journal Section | Research Article |
| Authors | |
| Submission Date | June 30, 2025 |
| Acceptance Date | December 6, 2025 |
| Early Pub Date | January 22, 2026 |
| Publication Date | January 22, 2026 |
| Published in Issue | Year 2026 Issue: Advanced Online Publication |
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The aim of the ‘Ankara Üniversitesi Veteriner Fakültesi Dergisi’ is to publish high quality original articles that will contribute to people working in the fields of animal health, welfare, and production at the international level.
Ankara Üniversitesi Veteriner Fakültesi Dergisi is one of the journals’ of Ankara University, which is the first well-established university in the Republic of Turkey. Research articles, short communications, case reports, and invited review articles are published, covering all aspects of animal health, welfare, and production. The journal is published on a quarterly since 1954 and indexing in Science Citation Index-Expanded (SCI-Exp) since April 2007.
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1. Adams DC, Rohlf FJ, Slice DE (2004): Geometric morphometrics: ten years of progress following the revolution. Ital J Zool, 71, 5-16.
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7. Sandstedt K, Ursing J (1991): Description of the Campylobacter upsaliensis previously known as CNW group. Syst Appl Microbiol, 14, 39-45.
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Lamont LA, Bulmer BJ, Sisson DD, et al (2002): Doppler echocardiographic effects of medetomidine on dynamic left ventricular outflow tract obstruction in cats. J Am Vet Med Assoc, 221, 1276-1281.
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Griban VG, Stepchenko LM, Zhorina LV (1988): The live weight gain and disease resistance of young cattle and poultry stock as influenced by physiologically active peat preparation. 45-50. In: Proceedings of 8th International Peat Congress. Leningrad, Russia.
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Falconer DS (1960): Introduction to Quantitative Genetics. Oliver and Boyd Ltd, Edinburgh.
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Aladaş A (2013): Koyunlarda kırkım öncesi C vitamini ve humik asit uygulamasının kırkım stresini azaltmasındaki etkisinin incelenmesi. Yüksek Lisans Tezi. Afyon Kocatepe Üniversitesi Sağlık Bilimleri Enstitüsü, Afyonkarahisar.
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Li G, Hart A, Gregory J (1998): Flokülasyona hız gradyanı etkisi. Available at http://www.server.com/projects/paper2.html. (Accessed May 20, 2004).
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- Original research articles, reviews, case reports and short communications on all aspects of veterinary science, which had not been previously published elsewhere in whole or in part except abstract not exceeding 250 words, are published in the journal.
- All manuscripts are checking by plagiarism checker (iThenticate) and allowing for peer-review under %25 score after filtering the references.
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- Ankara Üniversitesi Veteriner Fakültesi Dergisi uses a double-blind review procedure, in which both the reviewer and author identities are concealed from each other throughout the process. The authors approve to submit their manuscript in compliance with the double-blind review policy.
- The authors are responsible for the article published in the journal.
- Studies comparing products with trade names are not the interest of this journal.
- Any materials or products used in the study should not include their trade names.
- Studies based on animal experiments should include an approval statement of the Ethical Committee in the materials and methods section.
Please take into consideration the recommendations for following ethical codes:
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It is expected that the author (s) who submit the study to the Ankara Üniversitesi Veteriner Fakültesi Dergisi comply with the following ethical responsibilities:
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The editor and field editors of the Ankara Üniversitesi Veteriner Fakültesi Dergisi should follow the the guidelines of "COPE Code of Conduct and Best Practice Guidelines for Journal Editors" and "COPE Best Practice Guidelines for Journal Editors" published by the Committee on Publication Ethics (COPE).
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References
1. ALLEA - All European Academies (2017): European Code of Conduct for Research Integrity, Revised Edition. Available at
https://ec.europa.eu/research/participants/data/ref/h2020/other/hi/h2020-ethics_code-of-conduct_en.pdf
2. McNutt, MK, Bradford, M, Drazen, JM, et al (2018): Transparency in authors’ contributions and responsibilities to promote integrity in scientific publication. Proceedings of the National Academy of Sciences, 115, 2557-2560.
3. YÖK - Yükseköğretim Kurulu (2018): Yükseköğretim Kurumları Bilimsel Araştırma ve Yayın Etiği Yönergesi. Available at https://www.yok.gov.tr/Sayfalar/Kurumsal/mevzuat/bilimsel-arastirma-ve-etik-yonetmeligi.aspx
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