Abstract
Valproic acid (2-propyl valeric acid, VPA) is the drug of choice for the treatment of migraine, bipolar disorder, and epileptic disorders in both children and adults. Although VPA has beneficial effects, long-term administration is reported to damage many tissues and organs. VPA administration increases free-radical production. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one, EDA) is a potent antioxidant that protects against oxidative stress. The aim of our study was to investigate the protective effects of EDA against brain damage in VPA-treated rats. Male Sprague Dawley rats were used in our study. The rats were randomly divided into four groups: control, EDA, VPA, and VPA+EDA. EDA and VPA were administered intraperitoneally at doses of 30 mg/kg and 0.5 g/kg, respectively daily for 7 days. On day 8, all animals were sacrificed under anesthesia, and brain tissues were removed. VPA caused decreases in the levels of reduced glutathione (GSH, P<0.05), glutathione peroxidase (GPx, P<0.001), glutathione reductase (GR, P<0.001), and paraoxonase (PON, P<0.0001). On the other hand, VPA increased values of lipid peroxidation (LPO, P<0.05), catalase (CAT, P<0.05), superoxide dismutase (SOD, P<0.0001), glutathione-S-transferase (GST, P<0.01), xanthine oxidase (XO, P<0.01), adenosine deaminase (ADA, P<0.001), protein carbonyl (PC, P<0.0001), myeloperoxidase (MPO, P<0.0001), sialic acid (SA, P<0.0001), and acetylcholinesterase (AChE, P<0.0001) compared with the control group. EDA reversed all values. These results suggest that EDA administration potentially reduces VPA-induced brain injury.
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Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Biochemistry |
| Journal Section | Research Article |
| Authors | |
| Submission Date | July 8, 2025 |
| Acceptance Date | December 4, 2025 |
| Early Pub Date | January 25, 2026 |
| Publication Date | January 25, 2026 |
| DOI | https://doi.org/10.33988/auvfd.1738110 |
| IZ | https://izlik.org/JA78PE89AN |
| Published in Issue | Year 2026 Issue: Advanced Online Publication |
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The aim of the ‘Ankara Üniversitesi Veteriner Fakültesi Dergisi’ is to publish high quality original articles that will contribute to people working in the fields of animal health, welfare, and production at the international level.
Ankara Üniversitesi Veteriner Fakültesi Dergisi is one of the journals’ of Ankara University, which is the first well-established university in the Republic of Turkey. Research articles, short communications, case reports, and invited review articles are published, covering all aspects of animal health, welfare, and production. The journal is published on a quarterly since 1954 and indexing in Science Citation Index-Expanded (SCI-Exp) since April 2007.
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1. Adams DC, Rohlf FJ, Slice DE (2004): Geometric morphometrics: ten years of progress following the revolution. Ital J Zool, 71, 5-16.
2. AOAC (2000): Association of Official Analytical Chemists, Official Methods of Analysis, 17th ed. AOAC International Maryland USA.
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7. Sandstedt K, Ursing J (1991): Description of the Campylobacter upsaliensis previously known as CNW group. Syst Appl Microbiol, 14, 39-45.
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Lamont LA, Bulmer BJ, Sisson DD, et al (2002): Doppler echocardiographic effects of medetomidine on dynamic left ventricular outflow tract obstruction in cats. J Am Vet Med Assoc, 221, 1276-1281.
For proceedings:
Griban VG, Stepchenko LM, Zhorina LV (1988): The live weight gain and disease resistance of young cattle and poultry stock as influenced by physiologically active peat preparation. 45-50. In: Proceedings of 8th International Peat Congress. Leningrad, Russia.
For books:
Falconer DS (1960): Introduction to Quantitative Genetics. Oliver and Boyd Ltd, Edinburgh.
For book chapters:
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For thesis
Aladaş A (2013): Koyunlarda kırkım öncesi C vitamini ve humik asit uygulamasının kırkım stresini azaltmasındaki etkisinin incelenmesi. Yüksek Lisans Tezi. Afyon Kocatepe Üniversitesi Sağlık Bilimleri Enstitüsü, Afyonkarahisar.
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Li G, Hart A, Gregory J (1998): Flokülasyona hız gradyanı etkisi. Available at http://www.server.com/projects/paper2.html. (Accessed May 20, 2004).
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General rules
- Original research articles, reviews, case reports and short communications on all aspects of veterinary science, which had not been previously published elsewhere in whole or in part except abstract not exceeding 250 words, are published in the journal.
- All manuscripts are checking by plagiarism checker (iThenticate) and allowing for peer-review under %25 score after filtering the references.
- The manuscript copyright release form is signed by all authors.
- Ankara Üniversitesi Veteriner Fakültesi Dergisi uses a double-blind review procedure, in which both the reviewer and author identities are concealed from each other throughout the process. The authors approve to submit their manuscript in compliance with the double-blind review policy.
- The authors are responsible for the article published in the journal.
- Studies comparing products with trade names are not the interest of this journal.
- Any materials or products used in the study should not include their trade names.
- Studies based on animal experiments should include an approval statement of the Ethical Committee in the materials and methods section.
Please take into consideration the recommendations for following ethical codes:
• Authorship
• Plagiarism (including self-plagiarism)
• Data fabrication / data falsification
• Duplicate submission
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• Conflicts of interest / Competing interests
• Intellectual property
The Ethical Responsibilities of the Authors
It is expected that the author (s) who submit the study to the Ankara Üniversitesi Veteriner Fakültesi Dergisi comply with the following ethical responsibilities:
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- Authors cannot submit their work to the evaluation process of more than one journal at the same time.
Ethical Duties and Responsibilities of the Editors
The editor and field editors of the Ankara Üniversitesi Veteriner Fakültesi Dergisi should follow the the guidelines of "COPE Code of Conduct and Best Practice Guidelines for Journal Editors" and "COPE Best Practice Guidelines for Journal Editors" published by the Committee on Publication Ethics (COPE).
- Making efforts to meet the information needs of readers and authors,
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- Carrying out processes to improve the quality of the works published in the journal,
- Ensuring academic integrity,
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- The editors should not ignore the positive reviews of the referees unless there is a serious problem with the work.
- New editors should not change the decisions made by the previous editor (s) for the work unless there is a serious problem.
- The editor must determine the referees in accordance with the subject of the study.
- It is obliged to provide the information and guides that the referees will need during the evaluation phase.
Ethical Responsibilities of Referees
The process of evaluating the Ankara Üniversitesi Veteriner Fakültesi Dergisi is carried out with the principle of double-sided blind refereeing. Reviewers cannot communicate directly with the authors, and the reviews and comments are shared through the journal management system. In this process, the review forms and the referee comments on the full texts are sent to the author (s) through the editor. In this context, the reviewers who evaluate the study for the Ankara Üniversitesi Veteriner Fakültesi Dergisi are expected to have the following ethical responsibilities:
- The referee should only accept to evaluate work related to his area of expertise.
- The referee should evaluate the assessment in neutrality and confidentiality.
- If the referee thinks he/she is facing a conflict of interest during the evaluation process, he/she should refuse to review the study and inform the journal editor.
- The referee should make the assessment objectively only in relation to the content of the study. Nationality, gender, religious beliefs, political beliefs and commercial concerns should not affect the assessment.
- The assessment should be constructive and kindly.
- The referee should perform the evaluation on time.
If you encounter an unethical situation or content in the Ankara Üniversitesi Veteriner Fakültesi Dergisi, please report it to Vfdergi@veterinary.ankara.edu.tr
References
1. ALLEA - All European Academies (2017): European Code of Conduct for Research Integrity, Revised Edition. Available at
https://ec.europa.eu/research/participants/data/ref/h2020/other/hi/h2020-ethics_code-of-conduct_en.pdf
2. McNutt, MK, Bradford, M, Drazen, JM, et al (2018): Transparency in authors’ contributions and responsibilities to promote integrity in scientific publication. Proceedings of the National Academy of Sciences, 115, 2557-2560.
3. YÖK - Yükseköğretim Kurulu (2018): Yükseköğretim Kurumları Bilimsel Araştırma ve Yayın Etiği Yönergesi. Available at https://www.yok.gov.tr/Sayfalar/Kurumsal/mevzuat/bilimsel-arastirma-ve-etik-yonetmeligi.aspx
JOURNAL POLICY
- There are no submission fees, publication fees or page charges for publication in Ankara Üniversitesi Veteriner Fakültesi Dergisi.
- The journal employs double blind reviewing. For publication of articles, two positive reports are required. It is anticipated that the publication review process of the studies submitted to Ankara Üniversitesi Veteriner Fakültesi Dergisi be completed in 6 months. However, the period during which editors or reviewers ask the author(s) to do editing and the author(s) complete the editing is not included in this time frame.
- No correction can be made in a published article.
Price Policy
There are no submission fees, publication fees or page charges for publication in ‘Ankara Univ Vet Fak Derg’.
