Nephroprotective and antioxidative effects of royal jelly on ethylene glycol induced nephropathy in rats

Abstract

Antioxidative and nephroprotective effects of royal jelly against ethylene glycol induced renal injury were examined in this study. Five groups of rats were used. Rats in Group 1 served as control. Rats in Group 2 received ethylene glycol (1%) in drinking water, while those in Group 3 received 100 mg/kg of royal jelly through oral gavage. Group 4 served as protective group and received ethylene glycol 1% in drinking water and 100 mg/kg of royal jelly administered. Group 5 served as treatment group and received ethylene glycol 1% in the drinking water for the initial 15 days, followed by 100 mg/kg of royal jelly administered last 15 days. Oxidative stress was induced by ethylene glycol. Royal jelly was found to reduce renal damage with measured BUN and CREA (creatinine) levels. It was considered that royal jelly has positive effects on antioxidant system and decreased effects on lipid peroxidation. Royal jelly may have positive nephroprotective effects on the injury induced by ethylene glycol exposure. Particularly, the effects observed in the treatment group were remarkable.

Keywords

• Antioxidant
• calcium oxalate
• ethylene glycol
• nephropathy
• royal jelly

Ratlarda etilen glikolün indüklediği nefropatide arı sütünün nefroprotektif ve antioksidatif etkileri

Abstract

Bu çalışmada ratlarda etilen glikolün oluşturduğu renal hasara karşı arı sütünün antioksidatif etkileri incelendi. Ratlardan 5 çalışma grubu oluşturuldu. 1. grup kontrol grubu olarak belirlendi. 2. gruptaki ratlara etilen glikol, içme suyunda (%1 oranında) verildi. 3. gruptaki ratlara her gün oral gavajla 100 mg/kg arı sütü verildi. 4. grup koruyucu grup olarak belirlendi ve 30 gün boyunca içme suyunda etilen glikol (%1) verilirken, oral gavajla 100 mg/kg arı sütü verildi. 5. grup tedavi edici grup olarak belirlendi ve çalışmanın ilk 15 günü etilen glikol (%1) içme suyunda, son 15 gün 100 mg/kg arı sütü oral gavajla verildi. Etilen glikolün oksidatif stresi indüklediği görülmüştür. Ölçülen BUN ve CREA (kreatinin) düzeylerinden arı sütünün böbrek hasarını azalttığı bulundu. Arı sütünün antioksidatif sistemi desteklediği, lipid peroksidasyonunu azaltıcı etki gösterdiği düşünülmektedir. Etilen glikol maruziyetiyle oluşturulan hasara karşı arı sütünün olumlu etkileri olduğu söylenebilir. Arı sütü uygulamasıyla tedavi edici grupta elde edilen sonuçlar özellikle dikkat çekicidir

Keywords

• Antioksidan
• arı sütü
• etilen glikol
• kalsiyum okzalat
• nefropati

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