Abstract
Giriş: Trombosit/lenfosit oranı (PLR) ve Platelet/Lenfosit oranı ile monosit oranı (PLT/LY+MO) değerlerinin Respiratuvar Sinsitiyal Virüs (RSV) enfeksiyonundaki rolünü incelemeyi amaçlıyoruz.
Materyal-Metot: 0-12 yaş arası 76 hastanın tam kan sayımı ve RSV Antijen test sonuçları geriye dönük olarak incelendi. PLR değerleri Trombosit Sayısı / Lenfosit Sayısı formülü kullanılarak hesaplanırken, PLMR değerleri Trombosit Sayısı / Lenfosit Sayısı + Monosit Sayısı kullanılarak hesaplandı.
Bulgular: 76 hastanın 32'sine RSV Antijen test sonuçlarına göre RSV enfeksiyonu teşhisi konmuştur. Lenfosit ve monosit yüzdesi ve trombosit sayısı, RSV pozitif grupta anlamlı derecede yüksek bulunmuştur. Alt solunum yolu RSV enfeksiyonunda monosit yüzdesi, üst solunum yolu RSV enfeksiyonuna göre anlamlı derecede düşük saptanmıştır.
Sonuç: Çalışmamız bu kan parametrelerinin klinisyen için RSV enfeksiyonu için önemli bir ipucu olabileceğini ve ileri teknikler öncesinde yol gösterici bir rol oynayabileceğini ortaya koymuştur.
References
- Centers for Disease Control and Prevention, https://www.cdc.gov/rsv/about/index.html, 2018
- Dawson-Caswell M, Muncie HL, Respiratory Syncytial Virus Infection in Children, American Family Physician, 2011; 83(2): 141-146.
- De Weerd W, TwilhaarWN, Kimpen JLL, T Cell Subset Analysis in Peripheral Blood of Children with RSV Bronchiolitis, Scand J Infect Dis, 1998; 30: 77-80. https://doi.org/10.1080/003655498750002349
- Gern JE, Viral Respiratory Infection and the Link to Asthma, Pediatr Infect Dis J., 2008; 27(10 0) : 97-103. https://doi.org/10.1097/INF.0b013e318168b718
- Gokce S, Kurugol Z, Koturoglu G, Aslan A, Polater S, Cicek C, Diagnostic Value of the Mean Platelet Volume in the Prediction of Respiratory Syncytial Virus in Acute Bronchiolitis, J Pediatr Res, 2019;6(1):51-55. https://doi.org/10.4274/jpr.galenos.2018.53325
- Handforth J, Friedland JS, Sharland M, Basic epidemiology and immunopathology of RSV in children, Paediatric Respiratory Reviews, 2000; 1: 210–214. https://doi.org/10.1053/prrv.2000.0050
- Hervás D, Reina J, Yañez, del Valle JM, Figuerola J, Hervás JA, Epidemiology of hospitalization for acute bronchiolitis in children: differences between RSV and non-RSV bronchiolitis, Eur J Clin Microbiol Infect Dis, 2012; 31: 1975-1981. https://doi.org/10.1007/s10096-011-1529-y
- Leung AKC, Kellner JD, Davies HD, Respiratory Syncytial Virus Bronchiolitis, Journal of the National Medical Association, 2005; 97(12): 1708-1713.
- McCarthy CA, Hall CB, Respiratory Syncytial Virus: Concerns and Control, Pediatrics in Review, 2003; 24(9): 301-308. https://doi.org/10.1542/pir.24-9-301
- O’Donnell DR, Carrington D, Peripheral Blood Lymphopenia and Neutrophilia in Children with Severe Respiratory Syncytial Virus Disease, Pediatric Pulmonology, 2002; 34: 128-130. https://doi.org/10.1002/ppul.10140.
- Respiratory Syncytial Virus Testing, Available on line 2018: https://labtestsonline.org/understanding/analytes/rsv/tab/test/
- Ruubsamen-Waigmann H, Deres K , Hewlett G, Welker R (2003). Viral Infections and Treatment. In: Informa Healthcare (Ed), 1ST ed., 95-98, Marcel Dekker Inc, New York.
- Tatli Gunes B, Respiratuar Sinsityal Virüs İle Respiratuar Sinsityal Virüs Dışı Bronşiyolit Geçiren Çocuklarda Tekrarlayan Hışıltı, Atopi Riski Ve Serum İnterlökin-4, İnterlökin-13, İnterferon-Gama Düzeylerinin Karşılaştırılması, Dokuz Eylül Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Thesis, İzmir, 2010.
- Tayman C, Özmen S, Badur S, Arslan Z, Blood eosinophil counts, ECP levels, ECP/eosinophil ratios in the acute asthma exacerbations triggered by upper respiratory tract infections, Asthma Allergy Immunol, 2010; 8: 13-22
Abstract
Introduction: We aim to examine the role of Platelet to lymphocyte ratio (PLR) and Platelet to Lymphocyte and monocyte ratio (PLT/LY+MO) values in Respiratory Syncytial Virus (RSV) infection.
Methodology: Complete blood counts and RSV Antigen test results of 76 patients, between the age of 0-12 were investigated retrospectively. PLR values are calculated using Platelet Count / Lymphocyte Count formula, whereas PLMR values are calculated using Platelet Count / Lymphocyte Count + Monocyte Count.
Results: Out of 76, 32 patients were diagnosed as RSV infected. Lymphocyte and monocyte percentage and platelet count were significantly higher in RSV positive group. Monocyte percentage in lower respiratory tract RSV infection was significantly lower compared to upper respiratory tract RSV infection.
Conclusions: Our study revealed that these blood parameters may be an important clue for the clinician for RSV infection and also play a role as a guide before advanced techniques.
References
- Centers for Disease Control and Prevention, https://www.cdc.gov/rsv/about/index.html, 2018
- Dawson-Caswell M, Muncie HL, Respiratory Syncytial Virus Infection in Children, American Family Physician, 2011; 83(2): 141-146.
- De Weerd W, TwilhaarWN, Kimpen JLL, T Cell Subset Analysis in Peripheral Blood of Children with RSV Bronchiolitis, Scand J Infect Dis, 1998; 30: 77-80. https://doi.org/10.1080/003655498750002349
- Gern JE, Viral Respiratory Infection and the Link to Asthma, Pediatr Infect Dis J., 2008; 27(10 0) : 97-103. https://doi.org/10.1097/INF.0b013e318168b718
- Gokce S, Kurugol Z, Koturoglu G, Aslan A, Polater S, Cicek C, Diagnostic Value of the Mean Platelet Volume in the Prediction of Respiratory Syncytial Virus in Acute Bronchiolitis, J Pediatr Res, 2019;6(1):51-55. https://doi.org/10.4274/jpr.galenos.2018.53325
- Handforth J, Friedland JS, Sharland M, Basic epidemiology and immunopathology of RSV in children, Paediatric Respiratory Reviews, 2000; 1: 210–214. https://doi.org/10.1053/prrv.2000.0050
- Hervás D, Reina J, Yañez, del Valle JM, Figuerola J, Hervás JA, Epidemiology of hospitalization for acute bronchiolitis in children: differences between RSV and non-RSV bronchiolitis, Eur J Clin Microbiol Infect Dis, 2012; 31: 1975-1981. https://doi.org/10.1007/s10096-011-1529-y
- Leung AKC, Kellner JD, Davies HD, Respiratory Syncytial Virus Bronchiolitis, Journal of the National Medical Association, 2005; 97(12): 1708-1713.
- McCarthy CA, Hall CB, Respiratory Syncytial Virus: Concerns and Control, Pediatrics in Review, 2003; 24(9): 301-308. https://doi.org/10.1542/pir.24-9-301
- O’Donnell DR, Carrington D, Peripheral Blood Lymphopenia and Neutrophilia in Children with Severe Respiratory Syncytial Virus Disease, Pediatric Pulmonology, 2002; 34: 128-130. https://doi.org/10.1002/ppul.10140.
- Respiratory Syncytial Virus Testing, Available on line 2018: https://labtestsonline.org/understanding/analytes/rsv/tab/test/
- Ruubsamen-Waigmann H, Deres K , Hewlett G, Welker R (2003). Viral Infections and Treatment. In: Informa Healthcare (Ed), 1ST ed., 95-98, Marcel Dekker Inc, New York.
- Tatli Gunes B, Respiratuar Sinsityal Virüs İle Respiratuar Sinsityal Virüs Dışı Bronşiyolit Geçiren Çocuklarda Tekrarlayan Hışıltı, Atopi Riski Ve Serum İnterlökin-4, İnterlökin-13, İnterferon-Gama Düzeylerinin Karşılaştırılması, Dokuz Eylül Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Thesis, İzmir, 2010.
- Tayman C, Özmen S, Badur S, Arslan Z, Blood eosinophil counts, ECP levels, ECP/eosinophil ratios in the acute asthma exacerbations triggered by upper respiratory tract infections, Asthma Allergy Immunol, 2010; 8: 13-22
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | December 27, 2022 |
| Submission Date | April 11, 2022 |
| Published in Issue | Year 2023 Volume: 6 Issue: 1 |
