Kırım-Kongo Kanamalı Ateşi Hastalarında Mortalitenin Belirleyicisi Olarak Laktat/Albümin Oranı

Year 2024, Volume: 13 Issue: 2, 339 - 345, 28.08.2024

Yusuf Kenan Tekin , Şimşek Çelik

https://doi.org/10.53424/balikesirsbd.1422074

Abstract

Amaç: Bu çalışma, KKH hastalarında laktat/albümin (L / A) oranının prognoz ve mortalite ile ilişkisini belirlemeyi amaçlamıştır. Gereç ve Yöntem: Ocak 2019 ile Aralık 2022 tarihleri arasında KKH tanısı almış, 36'sı mortalite, 224'ü canlı olmak üzere toplam 260 hasta retrospektif olarak çalışmaya dahil edildi. Sağ kalan ve sağ kalan olmayan hastaların bulguları karşılaştırıldı. Bulgular: Gruplar arasında yaş ve cinsiyet açısından anlamlı fark yoktu. KKKA nedeniyle ölen hasta grubunda albumin, glukoz ve trombosit düzeyleri oldukça düşük iken (p<0,001); Kanda beyaz kan hücreleri, üre nitrojen, kreatinin, alanin aminotransferaz, aspartat aminotransferaz, sodyum, laktat, L/A oranı ve yüksek duyarlıklı C-reaktif protein anlamlı düzeyde yüksek bulundu (p<0,05). ROC analizinde en yüksek duyarlılık ve özgüllük L/A oranı olarak hesaplandı. Sonuç: L/A oranının KKKA hastalarında fataliteyi öngörmede bir araç olarak kullanılabileceğini bulduk. Ek olarak, L/A oranı, fataliteyi öngörmede tek başına serum albümin ve serum laktat düzeylerine göre daha anlamlıydı.

Keywords

Acil Servis, Kırım-Kongo Kanamalı Ateşi, Laktat/Albumin Oranı, Fatalite

Project Number

Yok

Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Crimean-Congo Hemorrhagic Fever

Abstract

Objective:This study aimed to determine the relationship of lactate/albumin (L/A) ratio with prognosis and fatality in CCHF patients. Materials and Methods: A total of 260 patients diagnosed with CCHF between January 2019 and December 2022, 36 of whom were deceased and 224 of whom were alive, were retrospectively included in the study. The findings of survivor and non-survivor patients were compared. Results: There was no significant difference between the groups in terms of age and gender. While albumin, glucose and platelet levels were quite low in the patient group who died due to CCHF (p<0.001); White blood cells, urea nitrogen, creatinine, alanine aminotransferase, aspartate aminotransferase, sodium, lactate, L/A ratio and high-sensitivity C-reactive protein in the blood were found to be significantly high (p<0.05). In the ROC analysis, the highest sensitivity and specificity were calculated as the L/A ratio. Conclusion: We found that the L/A ratio can be used as a tool to predict fatality in CCHF patients. In addition, the L/A ratio was more significant in predicting fatality than serum albumin and serum lactate levels alone.

Keywords

Emergency Department, Crimean-Congo Hemorrhagic Fever, Lactate/Albumin Ratio, Fatality

Ethical Statement

The institutional ethics committee approved the Sivas Cumhuriyet University study protocol (2023-04/20)

Project Number

Yok

Thanks

The authors thank all the patients who agreed to participate in the study

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