Quantitative LC-MS/MS profiling of Onobrychis viciifolia leaf metabolites, antioxidant evaluation, and molecular docking study

Esma Nur Geçer; İlyas Yıldız; Messaoud Nacer Imene; Süleyman Muhammed Çelik; Belkıs Muca

doi:10.53445/batd.1814612

TR EN

Onobrychis viciifolia yaprak metabolitlerinin kantitatif LC-MS/MS profili, antioksidan değerlendirmesi ve moleküler kenetlenme çalışması

Abstract

Onobrychis viciifolia’da bulunan fenolik bileşiklerin, besin değerini ve biyoaktif potansiyelini belirlemede önemli bir rol oynadığı bilinmektedir. O. viciifolia yapraklarının fenolik bileşikleri LC-MS/MS ile kantitatif olarak belirlenmiştir. Rutin (29932,5 µg/g özüt), hesperidin (10703,6 µg/g özüt), şikimik asit (210,1 µg/g özüt) ve kumarin (193,8 µg/g özüt) başlıca bileşikler olarak belirlenmiştir. Metanol özütünün antioksidan potansiyeli, DPPH ve ABTS radikal giderici analizleri kullanılarak değerlendirilmiştir. O. viciifolia yaprak özütünün DPPH radikal temizleme aktivitesi, 14,8 µg/mL’lik bir IC50 değeri sergilerken, standart antioksidan BHT’nin IC50 değeri 11,68 µg/mL olarak bulunmuştur. ABTS deneyinde, metanol özütü 11,34 µg/mL’lik bir IC50 değeriyle güçlü bir antioksidan aktivite sergilerken, BHT 10,17 µg/mL’lik bir IC50 değeri sergilemiştir. O. viciifolia yaprak özütünün dikkate değer antioksidan aktivitesi, bitki yapraklarındaki biyoaktif fenolik bileşiklerin varlığına bağlanabilir. Moleküler kenetlenme analizi, şikimik asidin karboksilesteraz 2 (CES2) enziminin aktif bölgesine karşı kararlı bir bağlanma afinitesi (–5,8 kcal/mol) sergilediğini ortaya koymuştur. Bileşik, anahtar kalıntılarla (Ser139, Asp169 ve Val170) güçlü hidrojen bağları oluşturmuş, bu da CES2 aktivitesinin doğal bir modülatörü olarak potansiyelini ortaya koymuştur.

Keywords

Onobrychis viciifolia, LC-MS/MS analizi, biyoaktif bileşikler, antioksidan aktivite, moleküler kenetlenme

Quantitative LC-MS/MS profiling of Onobrychis viciifolia leaf metabolites, antioxidant evaluation, and molecular docking study

Abstract

The phenolic compounds present in Onobrychis viciifolia are believed to play a significant role in determining its nutritive value and bioactive potential. The phenolic compounds of O. viciifolia leaves were determined quantitatively by LC-MS/MS. Rutin (29932.5 µg/g extract), hesperidin (10703.6 µg/g extract), shikimic acid (210.1 µg/g extract), and coumarin (193.8 µg/g extract) were determined as major compounds. The antioxidant potential of the methanol extract was evaluated using DPPH and ABTS radical scavenging assays. The DPPH radical scavenging activity of O. viciifolia leaf extract exhibited an IC50 value of 14.8 µg/mL, compared to the standard antioxidant BHT, which showed an IC50 value of 11.68 µg/mL. In the ABTS assay, the methanol extract showed vigorous antioxidant activity with an IC50 of 11.34 µg/mL, while BHT had an IC50 of 10.17 µg/mL. The notable antioxidant activity of the O. viciifolia leaf extract can be attributed to the presence of bioactive phenolic compounds within the plant leaves. Molecular docking analysis revealed that shikimic acid exhibited a stable binding affinity (–5.8 kcal/mol) toward the active site of the carboxylesterase 2 (CES2) enzyme. The compound formed strong hydrogen bonds with key residues (Ser139, Asp169, and Val170), suggesting its potential as a natural modulator of CES2 activity.

Keywords

Onobrychis viciifolia, LC-MS/MS analysis, bioactive compounds, antioxidant activity, molecular docking

Supporting Institution

The Scientific Research Unit of Tokat Gaziosmanpaşa University supported (BAP-2025-29).

Thanks

The authors gratefully acknowledge the financial support provided by the Scientific Research Unit of Tokat Gaziosmanpaşa University (BAP-2025-29).

References

Aksit, H., Çelik, S. M., Sen, Ö., Erenler, R., Demirtas, I., Telci, I., & Elmastas, M. (2014). Complete isolation and characterization of polar portion of Mentha dumetorum water extract. Records of Natural Products, 8(3), 277-280.
Atalar, M. N., Erenler, R., Turkan, F., Alma, M. H., Demirtas, I., Baran, A., Kandemir, S. I., Kekec, A. I., & Saltan, F. Z. (2023). Phytochemical analysis and biological activity of Corchorus olitorius L.: Quantitative analysis of bioactive compounds by LC–MS/MS, antibacterial, enzyme inhibition, and cytotoxic activities. European Journal of Integrative Medicine, 62, 102290. https://doi.org/10.1016/j.eujim.2023.102290
Başar, Y., & Erenler, R. (2024). Phytochemical analysis of Silybum marianum flowers: Quantitative analysis of natural compounds and molecular docking application. [Silybum marianum çiçeklerinin fitokimyasal analizi: Doğal bileşiklerin kantitatif analizi ve moleküler yerleştirme uygulaması]. Turkish Journal of Biodiversity, 7(1), 20-31. https://doi.org/10.38059/biodiversity.1450643
Başar, Y., Gök, M., Erenler, R., & Demirtas, İ. (2025). Phytochemical profiling, molecular docking and ADMET prediction of essential oil of Ocimum basilicum. International Journal of Secondary Metabolite, 12(1), 146-157. https://doi.org/10.21448/ijsm.1441857
Başar, Y., Yıldız, I., Hosaflioglu, I., Erenler, R., & Alma, M. H. (2025). Phytochemical Study of Astragalus onobrychis: Bioactive Compounds, Antioxidant Activity, in silico Molecular Docking, PASS and DFT Study. Brazilian Archives of Biology and Technology, 68, e25240574. https://doi.org/10.1590/1678-4324-2025240574
Bayir, B., Gündüz, H., Usta, T., Şahin, E., Özdemir, Z., Kayır, Ö., Sen, Ö., Akşit, H., Elmastaş, M., & Erenler, R. (2014). Chemical Composition of Essential Oil from Marrubium Vulgare L. Leaves. Journal of New Results in Science, 6(6), 44-50.
Boufera, I., Chouitah, O., Kiari, F. Z., Khelef, Y., Erenler, R., Demirtas, I., & Alma, M. H. (2025). Valorization of Apple Waste from Cold Storage Through Seed Oil Extractions in Western Algeria. Waste and Biomass Valorization, 1-14. https://doi.org/10.1007/s12649-025-03101-w
Bounaas, J., Basli, A., El Hassen Mokrani, I. O., Benzazia, S., Tevfik, Ö., Sarmad, M., Ramazan, E., Ilyas, Y., & Chawki, B. (2025). Phytochemical analysis of hydromethanolic extract and its fractions of myrtus communis leaves from Skikda, Algeria: LC-MS/MS analysis, antioxidant capacities, in-vitro and in silico assessment of anticholinesterase and antidiabetic activities. Global NEST Journal, 27(2), 1-12. https://doi.org/10.30955/gnj.06823
Cakmak, O., Erenler, R., Tutar, A., & Celik, N. (2006). Synthesis of new anthracene derivatives. The Journal of organic chemistry, 71(5), 1795-1801. https://doi.org/10.1021/jo051846u
Dag, B. (2022). Green synthesis, characterization, and antioxidant activity of silver nanoparticles using Stachys annua L. subsp. annua var. annua. Particulate Science and Technology, 40(4), 512-520. https://doi.org/10.1080/02726351.2021.1966689

Dede, E., Genc, N., Elmastas, M., Aksit, H., & Erenler, R. (2019). Chemical Constituents Isolated from Rhododendron ungernii with Antioxidant Profile. The Natural Products Journal, 9(3), 238-243. https://doi.org/10.2174/2210315508666181024114812
Demirtas, I., Erenler, R., Elmastas, M., & Goktasoglu, A. (2013). Studies on the antioxidant potential of flavones of Allium vineale isolated from its water-soluble fraction. Food Chemistry, 136(1), 34-40. https://doi.org/10.1016/j.foodchem.2012.07.086
Djermane, N., Brahmi, M., Adli, D. E., Gliozzi, M., Musolino, V., Khellaf, R., Erenler, R., Arhab, R., & Garzoli, S. (2025). Chemical Composition, Antioxidant, Antimicrobial, Antidiabetic, and Butyrylcholinesterase Inhibitory Activities in Vitro of the Essential Oil and Crude Extracts of the Aerial Parts of Thymus ciliatus. Chemistry & Biodiversity, e202403318. https://doi.org/10.1002/cbdv.202403318
Elmastas, M., Erenler, R., Isnac, B., Aksit, H., Sen, O., Genc, N., & Demirtas, I. (2016). Isolation and identification of a new neo-clerodane diterpenoid from Teucrium chamaedrys L. Natural Product Research, 30(3), 299-304. https://doi.org/10.1080/14786419.2015.1057583
Elmastas, M., Ozturk, L., Gokce, I., Erenler, R., & Aboul‐Enein, H. Y. (2004). Determination of antioxidant activity of marshmallow flower (Althaea officinalis L.). Analytical Letters, 37(9), 1859-1869. https://doi.org/10.1081/AL-120039431
Erenler, R., Atalar, M. N., Yıldız, İ., Geçer, E. N., Yıldırım, A., Demirtas, İ., & Alma, M. H. (2023). Quantitative analysis of bioactive compounds by LC-MS/MS from Inula graveolens. Bütünleyici ve Anadolu Tıbbı Dergisi, 4(3), 3-10. https://doi.org/10.53445/batd.1278048
Erenler, R., & Dag, B. (2022). Biosynthesis of silver nanoparticles using Origanum majorana L. and evaluation of their antioxidant activity. Inorganic and Nano-Metal Chemistry, 52(4), 485-492. https://doi.org/10.1080/24701556.2021.1952263
Erenler, R., Demirtas, I., Buyukkidan, B., & Cakmak, O. (2006). Synthesis of hydroxy, epoxy, nitrato and methoxy derivatives of tetralins and naphthalenes. Journal of Chemical Research, 2006(12), 753-757. https://doi.org/10.3184/030823406780199721
Erenler, R., & Gecer, E. N. (2022a). Green synthesis of silver nanoparticles from Astragalus logopodioides L. leaves. Turkish Journal of Agriculture-Food Science and Technology, 10(6), 1112-1115. https://doi.org/10.24925/turjaf.v10i6.1112-1115.5190
Erenler, R., & Gecer, E. N. (2022b). Synthesis of Silver Nanoparticles Using Sideritis montana L. Leaf Extract: Characterization, Catalytic Degradation of Methylene Blue and Antioxidant Activity. Journal of Nano Research, 75, 17-28. https://doi.org/10.4028/p-333bjm
Erenler, R., Gecer, E. N., Genc, N., & Yanar, D. (2021). Antioxidant activity of silver nanoparticles synthesized from Tagetes erecta L. leaves. International Journal of Chemistry and Technology, 5(2), 141-146. https://doi.org/10.32571/ijct.1005275
Erenler, R., Geçer, E. N., & Moran Bozer, B. (2022). Cytotoxic, apoptotic, and necrotic effects of silver nanoparticles biosynthesized using Origanum majorana extract. International Journal of Chemistry and Technology, 6(2), 142-146. https://doi.org/10.32571/ijct.1187754
Erenler, R., Karan, T., & Hosaflioglu, İ. (2023). Phytochemical analysis of Syringa vulgaris: Quantitative analysis of natural compounds by LC-ESI-MS/MS. Turkish Journal of Biodiversity, 6(2), 75-78. https://doi.org/10.38059/biodiversity.1312872
Erenler, R., Pabuccu, K., Yaglioglu, A. S., Demirtas, I., & Gul, F. (2016). Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 71(3-4), 87-92. https://doi.org/10.1515/znc-2016-0010
Erenler, R., Sen, O., Aksit, H., Demirtas, I., Yaglioglu, A. S., Elmastas, M., & Telci, İ. (2016). Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities. Journal of the Science of Food and Agriculture, 96(3), 822-836. https://doi.org/10.1002/jsfa.7155
Erenler, R., Sen, O., Yaglioglu, A. S., & Demirtas, I. (2016). Bioactivity-guided isolation of antiproliferative sesquiterpene lactones from Centaurea solstitialis l. ssp. solstitialis. Combinatorial Chemistry & High Throughput Screening, 19(1), 66-72. https://doi.org/10.2174/1386207319666151203002117
Erenler, R., Telci, İ., Elmastaş, M., Akşit, H., Gül, F., Tüfekçi, A. R., Demirtaş, İ., & Kayir, Ö. (2018). Quantification of flavonoids isolated from Mentha spicata in selected clones of Turkish mint landraces. Turkish Journal of Chemistry, 42(6), 1695-1705. https://doi.org/10.3906/kim-1712-3
Erenler, R., Telci, I., Ulutas, M., Demirtas, I., Gul, F., Elmastas, M., & Kayir, O. (2015). Chemical Constituents, Quantitative Analysis and Antioxidant Activities of Echinacea purpurea (L.) Moench and Echinacea pallida (Nutt.) Nutt. Journal of food biochemistry, 39(5), 622-630. https://doi.org/10.1111/jfbc.12168
Erenler, R., Temiz, C., Yildiz, I., Yanar, Y., & Ozyigit, C. (2021). Green synthesis and characterization of silver nanoparticles from Tagetes erecta flowers. Journal of Optoelectronics and Advanced Materials, 23(September-October 2021), 503-507.
Erenler, R., Uno, M., Goud, T. V., & Biellmanna, J. F. (2009). Preparation of some heterocyclic enones and ynones by isomerisation of the propargylic alcohols. Journal of Chemical Research, 2009(7), 459-464. https://doi.org/10.3184/030823409X464467
Erenler, R., Yıldız, İ., Geçer, E. N., Hosaflıoğlu, İ., & Çelik, S. M. (2025). Quantitative analysis and antioxidant activity of Trifolium pratense L. stem. Journal of Integrative and Anatolian Medicine, 6(1), 1-8. https://doi.org/10.53445/batd.1669871
Ganeshpurkar, A., & Saluja, A. K. (2017). The Pharmacological Potential of Rutin. Saudi Pharmaceutical Journal, 25(2), 149-164. https://doi.org/10.1016/j.jsps.2016.04.025
Garg, A., Garg, S., Zaneveld, L., & Singla, A. (2001). Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytotherapy Research, 15(8), 655-669. https://doi.org/10.1002/ptr.1074
Gecer, E. N. (2021). Green Synthesis of Silver Nanoparticles from Salvia aethiopis L. and Their Antioxidant Activity. Journal of Inorganic and Organometallic Polymers and Materials, 31(11), 4402-4409. https://doi.org/10.1007/s10904-021-02057-3
Gecer, E. N., & Erenler, R. (2022a). Biosynthesis of silver nanoparticles using Dittrichia graveolens (Asteraceae) leaves extract: characterisation and assessment of their antioxidant activity. Turkish Journal of Biodiversity, 5(1), 50-56. https://doi.org/10.38059/biodiversity.1090549
Gecer, E. N., & Erenler, R. (2022b). Biosynthesis of Silver Nanoparticles using Echinacea pallida (Nutt.) Nutt. and Antioxidant Activity Thereof. Journal of The Chemical Society of Pakistan, 44(6), 610-617. https://doi.org/10.52568/001187/JCSP/44.06.2022
Gecer, E. N., Erenler, R., Temiz, C., Genc, N., & Yildiz, I. (2022). Green synthesis of silver nanoparticles from Echinacea purpurea (L.) Moench with antioxidant profile. Particulate Science and Technology, 40(1), 50-57. https://doi.org/10.1080/02726351.2021.1904309
Genc, N., Yildiz, I., Chaoui, R., Erenler, R., Temiz, C., & Elmastas, M. (2021). Biosynthesis, characterization and antioxidant activity of oleuropein-mediated silver nanoparticles. Inorganic and Nano-Metal Chemistry, 51(3), 411-419. https://doi.org/10.1080/24701556.2020.1792495
Kamah, F., Basli, A., Erenler, R., Bouzana, A., Bensouici, C., Richard, T., Al-Mekhlafi, F., Wadaan, M., Al-Khalifa, M., & Boulkenafet, F. (2025). Phenolic compounds and biological activities of grape (Vitis vinifera L.) seeds at different ripening stages: insights from Algerian varieties. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 77(01), e13361. https://doi.org/10.1590/1678-4162-13361
Karan, T., Erenler, R., & Bozer Moran, B. (2022). Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines. Zeitschrift für Naturforschung C, 77(7-8), 343-350. https://doi.org/10.1515/znc-2021-0298
Karan, Y. B., & Erenler, R. (2024). Synthesis of Silver Nanoparticles Using Potato Cultivars with Their Antioxidant Activity. Communications in Soil Science and Plant Analysis, 55(9), 1249–1257. https://doi.org/10.1080/00103624.2024.2303105
Kaya, G., Karakaya, R., Tilgel, E., Sandikci, M., Yucel, E., Cicek, G., Kayir, O., Aksit, H., Telci, I., & Guzel, A. (2014). Essential Oil Constituents of Thuja orientalis Berries. Journal of New Results in Science, 7(7), 1-6.
Koysu, P., Genc, N., Elmastas, M., Aksit, H., & Erenler, R. (2018). Isolation, identification of secondary metabolites from Salvia absconditiflora and evaluation of their antioxidative properties. Natural Product Research, 33(24), 3592–3595. https://doi.org/10.1080/14786419.2018.1488700
Lu, J., Maezawa, I., Weerasekara, S., Erenler, R., Nguyen, T. D. T., Nguyen, J., Swisher, L. Z., Li, J., Jin, L. W., Ranjan, A., Srivastava, S. K., & Hua, D. H. (2014). Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines. Bioorganic and Medicinal Chemistry Letters, 24(15), 3392-3397. https://doi.org/10.1016/j.bmcl.2014.05.085
Merzouki, S., Boukeria, S., Louafi, F., Alma, M. H., Erenler, R., Yildiz, I., Boulkroune, M., & Mouats, C. (2024). Physico-chemical and Biological Investigations of Ocimum Basilicum L. Cultivated in Algeria. Current Chemical Biology, 18(1), 1-12. https://doi.org/10.2174/0122127968300108240527090556
Nayel, N. H., Marah, S., Yenigun, S., Ozen, T., Yıldız, I., Erenler, R., & Behcet, L. (2025). Green-chemically synthesized silver nanoparticles using Lactuca anatolica leaf extract: Characterization, biological assessment, molecular docking study, DFT calculation. Inorganic Chemistry Communications, 114821. https://doi.org/10.1016/j.inoche.2025.114821
Negahdari, R., Bohlouli, S., Sharifi, S., Maleki Dizaj, S., Rahbar Saadat, Y., Khezri, K., Jafari, S., Ahmadian, E., Gorbani Jahandizi, N., & Raeesi, S. (2021). Therapeutic benefits of rutin and its nanoformulations. Phytotherapy Research, 35(4), 1719-1738. https://doi.org/10.1002/ptr.6904
Sahin Yaglioglu, A., Akdulum, B., Erenler, R., Demirtas, I., Telci, I., & Tekin, S. (2013). Antiproliferative activity of pentadeca-(8E, 13Z) dien-11-yn-2-one and (E)-1,8-pentadecadiene from Echinacea pallida (Nutt.) Nutt. roots. Medicinal Chemistry Research, 22(6), 2946-2953. https://doi.org/10.1007/s00044-012-0297-2
Sahin Yaglioglu, A., Erenler, R., Gecer, E. N., & Genc, N. (2022). Biosynthesis of Silver Nanoparticles Using Astragalus flavesces Leaf: Identification, Antioxidant Activity, and Catalytic Degradation of Methylene Blue. Journal of Inorganic and Organometallic Polymers and Materials, 32, 3700-3707. https://doi.org/10.1007/s10904-022-02362-5
Topçu, G., Erenler, R., Çakmak, O., Johansson, C. B., Çelik, C., Chai, H.-B., & Pezzuto, J. M. (1999). Diterpenes from the berries of Juniperus excelsa. Phytochemistry, 50(7), 1195-1199. https://doi.org/10.1016/S0031-9422(98)00675-X
Türkmen, N., Öz, A., Sönmez, A., Erol, T., Gülümser, D., Yurdakul, B., Kayır, Ö., Elmastas, M., & Erenler, R. (2014). Chemical Composition of Essential Oil from Rosmarinus Officinalis L. Leaves. Journal of New Results in Science, 6(6), 27-31.
Yaman, C., Erenler, R., Atalar, M. N., Adem, Ş., & Çalişkan, U. K. (2024). Phytochemical Properties, Antioxidant and in Vitro/in Silico Anti-Acetylcholinesterase Activities of Hypericum heterophyllum Leaf from Türkiye. Brazilian Archives of Biology and Technology, 67, e24230043. https://doi.org/10.1590/1678-4324-2024230043

Details

Primary Language

English

Subjects

Plant Biotechnology

Journal Section

Research Article

Authors

Esma Nur Geçer ^*
0000-0002-0095-079X
Türkiye

İlyas Yıldız
0000-0003-1254-1069
Türkiye

Messaoud Nacer Imene
0009-0009-0028-8685
Algeria

Süleyman Muhammed Çelik
0000-0001-6025-8298
Türkiye

Belkıs Muca
0000-0002-3966-4774
Türkiye

Publication Date

December 30, 2025

Submission Date

November 1, 2025

Acceptance Date

December 2, 2025

Published in Issue

Year 2025 Volume: 6 Number: 3

DOI

https://doi.org/10.53445/batd.1814612

IZ

https://izlik.org/JA45WL39NX

APA

Geçer, E. N., Yıldız, İ., Imene, M. N., Çelik, S. M., & Muca, B. (2025). Quantitative LC-MS/MS profiling of Onobrychis viciifolia leaf metabolites, antioxidant evaluation, and molecular docking study. Journal of Integrative and Anatolian Medicine, 6(3), 155-163. https://doi.org/10.53445/batd.1814612

AMA

1.Geçer EN, Yıldız İ, Imene MN, Çelik SM, Muca B. Quantitative LC-MS/MS profiling of Onobrychis viciifolia leaf metabolites, antioxidant evaluation, and molecular docking study. J. Integr. Anatol. Med. 2025;6(3):155-163. doi:10.53445/batd.1814612

Chicago

Geçer, Esma Nur, İlyas Yıldız, Messaoud Nacer Imene, Süleyman Muhammed Çelik, and Belkıs Muca. 2025. “Quantitative LC-MS MS Profiling of Onobrychis Viciifolia Leaf Metabolites, Antioxidant Evaluation, and Molecular Docking Study”. Journal of Integrative and Anatolian Medicine 6 (3): 155-63. https://doi.org/10.53445/batd.1814612.

EndNote

Geçer EN, Yıldız İ, Imene MN, Çelik SM, Muca B (December 1, 2025) Quantitative LC-MS/MS profiling of Onobrychis viciifolia leaf metabolites, antioxidant evaluation, and molecular docking study. Journal of Integrative and Anatolian Medicine 6 3 155–163.

IEEE

[1]E. N. Geçer, İ. Yıldız, M. N. Imene, S. M. Çelik, and B. Muca, “Quantitative LC-MS/MS profiling of Onobrychis viciifolia leaf metabolites, antioxidant evaluation, and molecular docking study”, J. Integr. Anatol. Med., vol. 6, no. 3, pp. 155–163, Dec. 2025, doi: 10.53445/batd.1814612.

ISNAD

Geçer, Esma Nur - Yıldız, İlyas - Imene, Messaoud Nacer - Çelik, Süleyman Muhammed - Muca, Belkıs. “Quantitative LC-MS MS Profiling of Onobrychis Viciifolia Leaf Metabolites, Antioxidant Evaluation, and Molecular Docking Study”. Journal of Integrative and Anatolian Medicine 6/3 (December 1, 2025): 155-163. https://doi.org/10.53445/batd.1814612.

JAMA

1.Geçer EN, Yıldız İ, Imene MN, Çelik SM, Muca B. Quantitative LC-MS/MS profiling of Onobrychis viciifolia leaf metabolites, antioxidant evaluation, and molecular docking study. J. Integr. Anatol. Med. 2025;6:155–163.

MLA

Geçer, Esma Nur, et al. “Quantitative LC-MS MS Profiling of Onobrychis Viciifolia Leaf Metabolites, Antioxidant Evaluation, and Molecular Docking Study”. Journal of Integrative and Anatolian Medicine, vol. 6, no. 3, Dec. 2025, pp. 155-63, doi:10.53445/batd.1814612.

Vancouver

1.Esma Nur Geçer, İlyas Yıldız, Messaoud Nacer Imene, Süleyman Muhammed Çelik, Belkıs Muca. Quantitative LC-MS/MS profiling of Onobrychis viciifolia leaf metabolites, antioxidant evaluation, and molecular docking study. J. Integr. Anatol. Med. 2025 Dec. 1;6(3):155-63. doi:10.53445/batd.1814612

J. Integr. Anatol. Med. (Abbreviated Title)

◆◆◆

e-ISSN: 2687-6345

◆◆◆

This work is licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).

Onobrychis viciifolia yaprak metabolitlerinin kantitatif LC-MS/MS profili, antioksidan değerlendirmesi ve moleküler kenetlenme çalışması

Abstract

Keywords

Quantitative LC-MS/MS profiling of Onobrychis viciifolia leaf metabolites, antioxidant evaluation, and molecular docking study

Abstract

Keywords

Supporting Institution

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

J. Integr. Anatol. Med. (Abbreviated Title)