Research Article
PDF EndNote BibTex RIS Cite

Evaluation of the Effects of Exercise on Mitotic Index and Activities of Daily Living in Elderly Patients with Alzheimer's Disease

Year 2022, Volume 15, Issue 3, 320 - 324, 15.12.2022
https://doi.org/10.46309/biodicon.2022.1167227

Abstract

The aim of the study was to show the effects of exercise on the mitotic index (MI) in Alzheimer's disease (AD) by using the relevant measurement tools. With a regular exercise program, improvement in memory, increase in learning capacity and improvement in sensorimotor functions can be achieved in older age groups, and increased the also increased independence level of Daily Living Activities (ADL) of elderly individuals. In the study, it was aimed to contribute to the diagnosis, treatment and care processes of the disease by examining the cognitive tests and daily living activities of 19 elderly patients with Alzheimer's disease in terms of mitotic index before and after exercise.

References

  • [1] Borges-Machado, F., Ribeiro, Ó., Sampaio, A., Marques-Aleixo, I., Meireles, J., & Carvalho, J. (2019). Feasibility and impact of a multicomponent exercise intervention in patients with Alzheimer’s disease: a pilot study. Amerikan Journal of Alzheimer's Disease & Other Dementias®, 34(2), 95-103.
  • [2] Cummings, J. L., & Cole, G. (2002). Alzheimer disease. Jama, 287(18), 2335-2338.
  • [3] Kamat, P. K., Rai, S., & Nath, C. (2013). Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology. Neurotoxicology, 37, 163-172.
  • [4] Živković, L., Plećaš, B., Bajić, V., Đelić, N., & Spremo-Potparević, B. (2011). Evaluation of DNA damages in peripheral blood leukocytes of Alzheimer's disease patients by Comet test. Arhiv za farmaciju, 61(1), 28-41.
  • [5] Kormann-Bortolotto, M. H., Smith, M. D. A. C., & Neto, J. T. (1993). Alzheimer's disease and ageing: a chromosomal approach. Gerontology, 39(1), 1-6.
  • [6] Pinto, T. C., Machado, L., Bulgacov, T. M., Rodrigues-Júnior, A. L., Costa, M. L., Ximenes, R. C., & Sougey, E. B. (2019). Is the Montreal Cognitive Assessment (MoCA) screening superior to the Mini-Mental State Examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer’s Disease (AD) in the elderly. International Psychogeriatrics, 31(4), 491-504.
  • [7] Chopra, K., Misra, S., & Kuhad, A. (2011). Neurobiological aspects of Alzheimer's disease. Expert Opinion on Therapeutic Targets, 15(5), 535-555.
  • [8] Jenkins, E. C., Ye, L., Gu, H., & Li, S. Y. (2000). Mitotic index and Alzheimer's disease. Neurobiology of Aging, (21), 22.
  • [9] Gomez-Cabrera, M. C., Ferrando, B., Brioche, T., Sanchis-Gomar, F., & Vina, J. (2013). Exercise and antioxidant supplements in the elderly. Journal of Sport and Health Science, 2(2), 94-100.
  • [10] Sefa, L., & Neslihan, L. Ö. K. (2015). Demansta fiziksel aktivite ve egzersiz. Psikiyatride Güncel Yaklaşımlar, 7(3), 289-294.
  • [11] Folstein M.F., Folstein S., Mc Hugh P.R. (1975). "Mini Mental State" A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res, 12, 189-198
  • [12] Güngen, C., Ertan, T., Eker, E., Yaşar, R., & Engin, F. (2002). Standardize mini mental test’in Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi, 13(4), 273-281.
  • [13] Kankaya, H., & Karadakovan, A. (2017). Yaşlı bireylerde günlük yaşam aktivite düzeylerinin yaşam kalitesi ve yaşam doyumuna etkisi. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 6(4), 21-29.
  • [14] Tel Aydın, H., Tel, H., & Sabancıoğulları, S. (2006). Evde ve kurumda yaşayan 60 yaş ve üzeri bireylerin günlük yaşam aktivitelerini sürdürme ve yalnızlık yaşama durumu. Türk Geriatri Dergisi, 9(1), 34-40.
  • [15] Alkan, A. (2019). Factors Associated with Activities Of Daily Living In Geriatric Patients With Cancer. Acta Oncologica Turcica, Doi: 10.5505/aot.2019.83702
  • [16] Bezrookove, V., Smits, R., Moeslein, G., Fodde, R., Tanke, H. J., Raap, A. K., & Darroudi, F. (2003). Premature chromosome condensation revisited: a novel chemical approach permits efficient cytogenetic analysis of cancers. Genes, Chromosomes and Cancer, 38(2), 177-186.
  • [17] Buckton, K. E., & Evans, H. J. (1973). Methods for the analysis of human chromosome aberrations.
  • [18] CDC, Physical Activity is Essential to Healthy Aging, 23.08.2022, https://www.cdc.gov/physicalactivity/basics/older_adults/index.htm#:~:text=Adults%20aged%2065%20and%20older,of%20activities%20that%20strengthen%20muscles.
  • [19] Chodzko-Zajko WJ, Procto DN, Fiatarone Singh MA, Minson CT, Nigg CR, Salem GJ, Skinner JS. (2009). American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc., 41(7),1510-30.
  • [20] Cindaş A. (2001). Yaşlılarda Egzersiz Uygulamasının Genel İlkeleri. Geriatri, 4 (2), 77-84.
  • [21] American College of Sports Medicine Position Stand. (1998). Exercise and physical activity for older adults. Med Sci Sports Exerc,30(6),992-1008.
  • [22] Moorhead, P. S., Heyman, A., & Opitz, J. M. (1983). Chromosome studies of patients with Alzheimer disease. American journal of medical genetics, 14(3), 545-556.
  • [23] Üstüner, D., Gunes, S., Sarıboyacı, A. E., Uysal, O., Sevimli, T. S., & Soykan, M. N. (2022). Rekombinant klotho proteininin insan kolorektal kanser hücreleri üzerindeki apoptotik etkilerinin değerlendirilmesi. Biyolojik Çeşitlilik ve Koruma, 15(2), 134-142.
  • [24] Petrozzi, L., Lucetti, C., Scarpato, R., Gambaccini, G., Trippi, F., Bernardini, S., ... & Bonuccelli, U. (2002). Cytogenetic alterations in lymphocytes of Alzheimer's disease and Parkinson's disease patients. Neurological Sciences, 23(2), s97-s98.
  • [25] Sasikalaa, K., SureshKumar, S., Balamuralikrishnana, B., Aruna, M., Karthickkumar, A., Ahmad, A. M., ... & Balachandar, V. (2016). Cytogenetic Analysis and Screening of ApoE and Neurotransmitters in Alzheimer’s Patients in Tamil Nadu Population. International Journal of Human Genetics, 16(3-4), 107-115.
  • [26] Jenkins, E. C., Ye, L., Gu, H., & Wisniewski, H. M. (1998). Mitotic index and Alzheimer's disease. NeuroReport, 9(17), 3857-3861.
  • [27] Ma, C. L., Ma, X. T., Wang, J. J., Liu, H., Chen, Y. F., & Yang, Y. (2017). Physical exercise induces hippocampal neurogenesis and prevents cognitive decline. Behavioural brain research, 317, 332-339.
  • [28] Şenışık, S. Ç. (2015). Egzersİz ve Bağişiklik Sistemi. Spor Hekimliği Dergisi, 50(1), 011-020.
  • [29] Farioli-Vecchioli, S., Sacchetti, S., di Robilant, N. V., & Cutuli, D. (2018). The role of physical exercise and omega-3 fatty acids in depressive illness in the elderly. Current neuropharmacology, 16(3), 308-326.
  • [30] Hamurcu, Z. (2009). Derleme: Egzersizin Dna Üzerine Etkileri. Spor Hekimliği Dergisi, 44(2), 051-059.
  • [31] Kidd, P. M. (2008). Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. Alternative Medicine Review, 13(2).
  • [32] Liang, J., Wang, C., Zhang, H., Huang, J., Xie, J., & Chen, N. (2021). Exercise-induced benefits for alzheimer’s disease by stimulating mitophagy and improving mitochondrial function. Frontiers in Aging Neuroscience, 13.
  • [33] Meray, J., & Yenice, I. S. (2018). Beyin ve Egzersiz. Journal of Physical Medicine & Rehabilitation Sciences/Fiziksel Tup ve Rehabilitasyon Bilimleri Dergisi, 21(2).
  • [34] Wales, K., Clemson, L., Lannin, N., & Cameron, I. (2016). Functional assessments used by occupational therapists with older adults at risk of activity and participation limitations: a systematic review. PloS one, 11(2), e0147980.
  • [35] Elsawy B, Higgins KE. (2010). Physical Activity Guidelines for Older Adults. Am. Fam. Physician, (81), 55-59.

Alzheimer Hastası Yaşlılarda Egzersizin Mitotik İndeks ve Günlük Yaşam Aktiviteleri Üzerine Etkilerinin Değerlendirilmesi

Year 2022, Volume 15, Issue 3, 320 - 324, 15.12.2022
https://doi.org/10.46309/biodicon.2022.1167227

Abstract

Araştırma, Alzheimer hastalığında (AD) egzersizin, mitotik indeks (MI) üzerine etkilerini ilgili ölçüm araçlarını kullanarak gösterebilmeyi amaçlamıştır. Düzenli egzersiz programı ile ileri yaş gruplarında hafızada düzelme, öğrenme kapasitesinde artış ve sensörimotor fonksiyonlarda iyileşme sağlanabilmekte aynı zamanda yaşlı bireylerin Günlük Yaşam Aktivitelerindeki (GYA) bağımsızlık seviyesi de artmaktadır. Araştırmada Alzheimer hastası 19 yaşlı birey egzersiz öncesi ve sonrası dönemde; bilişsel testler ve günlük yaşam aktiviteleri, mitotik indeks açısından incelenerek, hastalığın tanı, tedavi ve bakım süreçlerinde katkı oluşturulması hedeflenmiştir.

References

  • [1] Borges-Machado, F., Ribeiro, Ó., Sampaio, A., Marques-Aleixo, I., Meireles, J., & Carvalho, J. (2019). Feasibility and impact of a multicomponent exercise intervention in patients with Alzheimer’s disease: a pilot study. Amerikan Journal of Alzheimer's Disease & Other Dementias®, 34(2), 95-103.
  • [2] Cummings, J. L., & Cole, G. (2002). Alzheimer disease. Jama, 287(18), 2335-2338.
  • [3] Kamat, P. K., Rai, S., & Nath, C. (2013). Okadaic acid induced neurotoxicity: an emerging tool to study Alzheimer's disease pathology. Neurotoxicology, 37, 163-172.
  • [4] Živković, L., Plećaš, B., Bajić, V., Đelić, N., & Spremo-Potparević, B. (2011). Evaluation of DNA damages in peripheral blood leukocytes of Alzheimer's disease patients by Comet test. Arhiv za farmaciju, 61(1), 28-41.
  • [5] Kormann-Bortolotto, M. H., Smith, M. D. A. C., & Neto, J. T. (1993). Alzheimer's disease and ageing: a chromosomal approach. Gerontology, 39(1), 1-6.
  • [6] Pinto, T. C., Machado, L., Bulgacov, T. M., Rodrigues-Júnior, A. L., Costa, M. L., Ximenes, R. C., & Sougey, E. B. (2019). Is the Montreal Cognitive Assessment (MoCA) screening superior to the Mini-Mental State Examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer’s Disease (AD) in the elderly. International Psychogeriatrics, 31(4), 491-504.
  • [7] Chopra, K., Misra, S., & Kuhad, A. (2011). Neurobiological aspects of Alzheimer's disease. Expert Opinion on Therapeutic Targets, 15(5), 535-555.
  • [8] Jenkins, E. C., Ye, L., Gu, H., & Li, S. Y. (2000). Mitotic index and Alzheimer's disease. Neurobiology of Aging, (21), 22.
  • [9] Gomez-Cabrera, M. C., Ferrando, B., Brioche, T., Sanchis-Gomar, F., & Vina, J. (2013). Exercise and antioxidant supplements in the elderly. Journal of Sport and Health Science, 2(2), 94-100.
  • [10] Sefa, L., & Neslihan, L. Ö. K. (2015). Demansta fiziksel aktivite ve egzersiz. Psikiyatride Güncel Yaklaşımlar, 7(3), 289-294.
  • [11] Folstein M.F., Folstein S., Mc Hugh P.R. (1975). "Mini Mental State" A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res, 12, 189-198
  • [12] Güngen, C., Ertan, T., Eker, E., Yaşar, R., & Engin, F. (2002). Standardize mini mental test’in Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi, 13(4), 273-281.
  • [13] Kankaya, H., & Karadakovan, A. (2017). Yaşlı bireylerde günlük yaşam aktivite düzeylerinin yaşam kalitesi ve yaşam doyumuna etkisi. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 6(4), 21-29.
  • [14] Tel Aydın, H., Tel, H., & Sabancıoğulları, S. (2006). Evde ve kurumda yaşayan 60 yaş ve üzeri bireylerin günlük yaşam aktivitelerini sürdürme ve yalnızlık yaşama durumu. Türk Geriatri Dergisi, 9(1), 34-40.
  • [15] Alkan, A. (2019). Factors Associated with Activities Of Daily Living In Geriatric Patients With Cancer. Acta Oncologica Turcica, Doi: 10.5505/aot.2019.83702
  • [16] Bezrookove, V., Smits, R., Moeslein, G., Fodde, R., Tanke, H. J., Raap, A. K., & Darroudi, F. (2003). Premature chromosome condensation revisited: a novel chemical approach permits efficient cytogenetic analysis of cancers. Genes, Chromosomes and Cancer, 38(2), 177-186.
  • [17] Buckton, K. E., & Evans, H. J. (1973). Methods for the analysis of human chromosome aberrations.
  • [18] CDC, Physical Activity is Essential to Healthy Aging, 23.08.2022, https://www.cdc.gov/physicalactivity/basics/older_adults/index.htm#:~:text=Adults%20aged%2065%20and%20older,of%20activities%20that%20strengthen%20muscles.
  • [19] Chodzko-Zajko WJ, Procto DN, Fiatarone Singh MA, Minson CT, Nigg CR, Salem GJ, Skinner JS. (2009). American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc., 41(7),1510-30.
  • [20] Cindaş A. (2001). Yaşlılarda Egzersiz Uygulamasının Genel İlkeleri. Geriatri, 4 (2), 77-84.
  • [21] American College of Sports Medicine Position Stand. (1998). Exercise and physical activity for older adults. Med Sci Sports Exerc,30(6),992-1008.
  • [22] Moorhead, P. S., Heyman, A., & Opitz, J. M. (1983). Chromosome studies of patients with Alzheimer disease. American journal of medical genetics, 14(3), 545-556.
  • [23] Üstüner, D., Gunes, S., Sarıboyacı, A. E., Uysal, O., Sevimli, T. S., & Soykan, M. N. (2022). Rekombinant klotho proteininin insan kolorektal kanser hücreleri üzerindeki apoptotik etkilerinin değerlendirilmesi. Biyolojik Çeşitlilik ve Koruma, 15(2), 134-142.
  • [24] Petrozzi, L., Lucetti, C., Scarpato, R., Gambaccini, G., Trippi, F., Bernardini, S., ... & Bonuccelli, U. (2002). Cytogenetic alterations in lymphocytes of Alzheimer's disease and Parkinson's disease patients. Neurological Sciences, 23(2), s97-s98.
  • [25] Sasikalaa, K., SureshKumar, S., Balamuralikrishnana, B., Aruna, M., Karthickkumar, A., Ahmad, A. M., ... & Balachandar, V. (2016). Cytogenetic Analysis and Screening of ApoE and Neurotransmitters in Alzheimer’s Patients in Tamil Nadu Population. International Journal of Human Genetics, 16(3-4), 107-115.
  • [26] Jenkins, E. C., Ye, L., Gu, H., & Wisniewski, H. M. (1998). Mitotic index and Alzheimer's disease. NeuroReport, 9(17), 3857-3861.
  • [27] Ma, C. L., Ma, X. T., Wang, J. J., Liu, H., Chen, Y. F., & Yang, Y. (2017). Physical exercise induces hippocampal neurogenesis and prevents cognitive decline. Behavioural brain research, 317, 332-339.
  • [28] Şenışık, S. Ç. (2015). Egzersİz ve Bağişiklik Sistemi. Spor Hekimliği Dergisi, 50(1), 011-020.
  • [29] Farioli-Vecchioli, S., Sacchetti, S., di Robilant, N. V., & Cutuli, D. (2018). The role of physical exercise and omega-3 fatty acids in depressive illness in the elderly. Current neuropharmacology, 16(3), 308-326.
  • [30] Hamurcu, Z. (2009). Derleme: Egzersizin Dna Üzerine Etkileri. Spor Hekimliği Dergisi, 44(2), 051-059.
  • [31] Kidd, P. M. (2008). Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. Alternative Medicine Review, 13(2).
  • [32] Liang, J., Wang, C., Zhang, H., Huang, J., Xie, J., & Chen, N. (2021). Exercise-induced benefits for alzheimer’s disease by stimulating mitophagy and improving mitochondrial function. Frontiers in Aging Neuroscience, 13.
  • [33] Meray, J., & Yenice, I. S. (2018). Beyin ve Egzersiz. Journal of Physical Medicine & Rehabilitation Sciences/Fiziksel Tup ve Rehabilitasyon Bilimleri Dergisi, 21(2).
  • [34] Wales, K., Clemson, L., Lannin, N., & Cameron, I. (2016). Functional assessments used by occupational therapists with older adults at risk of activity and participation limitations: a systematic review. PloS one, 11(2), e0147980.
  • [35] Elsawy B, Higgins KE. (2010). Physical Activity Guidelines for Older Adults. Am. Fam. Physician, (81), 55-59.

Details

Primary Language Turkish
Subjects Biology, Medicine, Research and Experimental
Journal Section Research Articles
Authors

Derya AKYILDIZ ÜSTÜNER> (Primary Author)
ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU
0000-0002-8511-946X
Türkiye


Yasemin KAVLAK>
ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU
0000-0002-4143-0184
Türkiye


Selda YILDIZ>
ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU
0000-0002-3650-0539
Türkiye


Cihan TANRIKUT>
ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ
0000-0002-5692-1533
Türkiye


M.cengiz ÜSTÜNER>
ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, TIP FAKÜLTESİ
0000-0001-9802-3988
Türkiye

Early Pub Date December 16, 2022
Publication Date December 15, 2022
Submission Date August 26, 2022
Acceptance Date October 14, 2022
Published in Issue Year 2022, Volume 15, Issue 3

Cite

APA Akyıldız Üstüner, D. , Kavlak, Y. , Yıldız, S. , Tanrıkut, C. & Üstüner, M. (2022). Alzheimer Hastası Yaşlılarda Egzersizin Mitotik İndeks ve Günlük Yaşam Aktiviteleri Üzerine Etkilerinin Değerlendirilmesi . Biyolojik Çeşitlilik ve Koruma , 15 (3) , 320-324 . DOI: 10.46309/biodicon.2022.1167227

❖  Abstracted-Indexed in
Web of Science {Zoological Records Indexed] Clavariate Analytic, CiteFactor, Turkey Citation Index, JournalSeek Database, arastirmax, Medical Reads (RRS), CrossRef;10.46309/biodicon.

❖ Libraries
Aberystwyth University; All libraries; Bath University; Birmingham University; Cardiff University; City University London; CONSER (Not UK Holdings); Edinburgh University; Essex University; Exeter University; EZB Electronic Journals Library; Feng Chia University Library; GAZİ Gazi University Library; Glasgow University; HEC-National Digital Library; Hull University; Imperial College London; Kaohsinug Medical University Library; ANKOS; Anadolu University Library; Lancaster University; Libros PDF; Liverpool University; London Metropolitan University; London School of Economics and Political Science; Manchester University; National Cheng Kung University Library; National ILAN University Library; Nottingham University; Open University; Oxford University; Queen Mary,University of London;Robert Gordon University; Royal Botanic Gardens, Kew; Sheffield Hallam University; Sheffield University; Shih Hsin University Library; Smithsonian Institution Libraries; Southampton University; Stirling University; Strathclyde University; Sussex University; The National Agricultural Library (NAL); The Ohio Library and Information NetWork; Trinity College Dublin; University of Washington Libraries; Vaughan Memorial Library; York University..

❖ The article processing is free.

❖ Web of Science-Clarivate Analytics, Zoological Record
❖ This journal is registered to “Turkey Citation Index
❖ This journal is a CrossRef;10.46309/biodicon. member

❖ Please visit ” http:// www.biodicon.com“ for instructions about articles and all of the details about journal


❖  Correspondance Adres: Prof. Ersin YÜCEL, P.K. 86, İki Eylül PTT Merkez, 26000 Eskişehir / Türkiye
E-posta / E-mail: biodicon@gmail.com;
Web Address: http://www.biodicon.com; https://dergipark.org.tr/en/pub/biodicon
❖ Biological Diversity and Conservation/ Biyolojik Çeşitlilik ve Koruma
❖ ISSN 1308-5301 Print; ISSN 1308-8084 Online
❖ Start Date Published 2008
© Copyright by Biological Diversity and Conservation/Biyolojik Çeşitlilik ve Koruma-Available online at www.biodicon.com/All rights reserved
Publisher : Ersin YÜCEL
❖ This journal is published three numbers in a year. Printed in Eskişehir/Türkiye.
❖ All sorts of responsibilities of the articles published in this journal are belonging to the authors
Editör / Editor-In-Chief : Prof.Dr. Ersin YÜCEL, https://orcid.org/0000-0001-8274-7578