An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes

Year 2020, , 357 - 365, 13.03.2020

Hilal Çelik Kazıcı

https://doi.org/10.17798/bitlisfen.558198

Abstract

Bu
çalışmada, propranololün elektrokimyasal davranışı, indirgenmiş grafen oksit
(rGO) ile modifiye edilmiş yüzey baskılı karbon elektrotlar (SPCE) ile
incelenmiştir. Oksidasyon işlemi, döngüsel voltametri (CV) ve diferansiyel puls
voltametri (DPV) teknikleri kullanılarak gerçekleştirilmiştir. Sonuçlar,
rGO'nun oksidasyon pik akımını artırarak bu ilaçları uygun potansiyellerde
oksitlediğini göstermiştir. Modifiye edilmiş SPCE, beta-blokerlerin, fosfat
tampon çözeltisinde (PBS) alışılmadık derecede pozitif bir potansiyelde
oksidasyonuna doğru mükemmel katalitik aktivite sergilemiştir. Propranololün
tespiti için önerilen sensörün doğrusal konsantrasyon aralığı ve tespit limiti,
sırasıyla, 50 µM ve 2.61 µM olarak elde edilmiştir.

Keywords

Beta-bloker, İndirgenmiş grafen oksit, Yüzey baskılı elektrot

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