HIV Hastalarında Sarkopeni Sıklığı: Fonksiyonel Performans Üzerine Etkileri

Year 2026, Volume: 16 Issue: 1, 107 - 114, 15.03.2026

Bora Uzuner , Erdal Hancı , Dilek Durmuş , Sertaç Ketenci , Muharrem Yüksel , Elifsu Beniç , Aydın Deveci

https://doi.org/10.16919/bozoktip.1878298

https://izlik.org/JA34LS87BF

Abstract

Amaç:
Bu çalışmanın amacı, İnsan İmmün Yetmezlik Virüsü (HIV) enfeksiyonu olan hastalarda sarkopeni prevalansını belirlemek ve sarkopeninin fonksiyonel performans üzerindeki etkisini değerlendirmektir.

Gereç ve Yöntem:
Çalışmaya 67 HIV hastası ve 50 sağlıklı kontrol dahil edildi. Sarkopeni değerlendirmesinde, ultrasonografi ile ölçülen bilateral rektus femoris ve vastus intermedius kas kalınlıklarının toplamına dayanan Modifiye Sonografik Uyluk Ayarlama Oranı (STAR) yöntemi kullanıldı. El kavrama kuvveti (HMS) dinamometre ile ölçüldü. Diz kas kuvveti (KMS) izokinetik kas testi ile değerlendirildi. Fiziksel performans; Timed Up-and-Go Testi (TUGT), 5 Tekrarlı Otur-Kalk Testi (5RSTS) ve 6 Dakika Yürüme Testi (6DYT) ile belirlendi.

Bulgular:
Vücut kitle indeksine göre düzeltilmiş STAR değerlerine göre, 57 erkek hastanın 10’unda (%17,5) sarkopeni saptandı. Kadın hastalarda sarkopeni tespit edilmedi. Gruplar arasında demografik özellikler açısından anlamlı fark yoktu. Ancak HMS, KMS, TUGT, 5RSTS ve 6DYT sonuçları açısından gruplar arasında anlamlı farklılık bulundu (p < 0,005).

Sonuç:
Bu çalışma, HIV ile yaşayan bireylerde, özellikle erkek hastalarda, sarkopeninin dikkate değer bir sıklıkta görüldüğünü ve kas gücü ile fonksiyonel performansta klinik olarak anlamlı azalmalarla ilişkili olduğunu göstermektedir. Ultrasonografi temelli Modifiye STAR skorunun, bu hasta grubunda bölgesel kas kaybını değerlendirmede pratik ve güvenilir bir yöntem olduğu görülmektedir.

Keywords

hıv hastaları , sarkopeni , fonksiyonel performans , ultrasonografi , Modifiye STAR skoru

The frequency of sarcopenia in HIV patients: Effects on functional performance

https://izlik.org/JA34LS87BF

Abstract

Aim: The present study aims to determine the prevalence of sarcopenia in Human Immunodeficiency Virus Infection (HIV) patients and to evaluate functional performance.
Material and Methods: 67 patients with HIV and 50 healthy control were included in the study. For detection for sarcopenia, the thighs of both lower extremities were measured using the Modified Sonographic Tight Adjustment Ratio (STAR) method, which was obtained by adding the bilateral rectus femoris and vastus intermedius muscle thicknesses measured by ultrasound. Hand muscle strength (HMS) was measured with a dynamometer. Knee Muscle strength (KMS) was measured isokinetic muscle testing. Physical performance was determined using timed up-and-go test (TUGT), 5-repetition sit-to-stand test (5RSTS), and 6-min walk test (6MWT).
Results:
According to the STAR values calculated based on body mass index, sarcopenia was present in 10 (17.5%) of 57 male patients. Sarcopenia was not detected in female patients. There was no significant difference with respect to demographic characteristics among the two groups. HMS, KMS, TUGT, 5RSTS and 6MWT values were significantly different in two groups (p<0.005)

Conclusions:
This study confirms a significant prevalence of sarcopenia among people living with HIV, particularly in male patients, and demonstrates its association with clinically meaningful declines in muscle strength and functional performance. The use of the ultrasonography-based Modified STAR score provided a reliable and practical method for assessing region-specific muscle loss, offering a valuable diagnostic tool in this population

Keywords

hıv patients , sarcopenia , functional performance , ultrasonography , Modified STAR score

Ethical Statement

Clinical Research Ethics Committee of Ondokuz Mayis University (no: 2022/175).

Supporting Institution

The authors declare that they have no known competing financial or personal interests that could have influenced the work reported in this paper.

Thanks

Author's covering letter for initial submission Title: The frequency of sarcopenia in HIV patients: Effects on functional performance Dear Editor, We are pleased to submit our "Research Article" entitled " The frequency of sarcopenia in HIV patients: Effects on functional performance " for your consideration for publication in Bozok Medicine journal. Our manuscript has not been published elsewhere, and if accepted in Bozok Medicine journal. We will not be republished in any other journal in the same or similar form, without the written consent of the Editor of Bozok Medicine journal. We declare no financial or other relationships leading to a conflict of interest. The manuscript has been read and approved by all authors. Sincerely Corresponding author: Bora Uzuner, M.D 1Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey Tel.: [phone]

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