HIV Hastalarında Sarkopeni Sıklığı: Fonksiyonel Performans Üzerine Etkileri

Öz

Amaç: Bu çalışmanın amacı, İnsan İmmün Yetmezlik Virüsü (HIV) enfeksiyonu olan hastalarda sarkopeni prevalansını belirlemek ve sarkopeninin fonksiyonel performans üzerindeki etkisini değerlendirmektir. Gereç ve Yöntem: Çalışmaya 67 HIV hastası ve 50 sağlıklı kontrol dahil edildi. Sarkopeni değerlendirmesinde, ultrasonografi ile ölçülen bilateral rektus femoris ve vastus intermedius kas kalınlıklarının toplamına dayanan Modifiye Sonografik Uyluk Ayarlama Oranı (STAR) yöntemi kullanıldı. El kavrama kuvveti (HMS) dinamometre ile ölçüldü. Diz kas kuvveti (KMS) izokinetik kas testi ile değerlendirildi. Fiziksel performans; Timed Up-and-Go Testi (TUGT), 5 Tekrarlı Otur-Kalk Testi (5RSTS) ve 6 Dakika Yürüme Testi (6DYT) ile belirlendi. Bulgular: Vücut kitle indeksine göre düzeltilmiş STAR değerlerine göre, 57 erkek hastanın 10’unda (%17,5) sarkopeni saptandı. Kadın hastalarda sarkopeni tespit edilmedi. Gruplar arasında demografik özellikler açısından anlamlı fark yoktu. Ancak HMS, KMS, TUGT, 5RSTS ve 6DYT sonuçları açısından gruplar arasında anlamlı farklılık bulundu (p < 0,005). Sonuç: Bu çalışma, HIV ile yaşayan bireylerde, özellikle erkek hastalarda, sarkopeninin dikkate değer bir sıklıkta görüldüğünü ve kas gücü ile fonksiyonel performansta klinik olarak anlamlı azalmalarla ilişkili olduğunu göstermektedir. Ultrasonografi temelli Modifiye STAR skorunun, bu hasta grubunda bölgesel kas kaybını değerlendirmede pratik ve güvenilir bir yöntem olduğu görülmektedir.

Anahtar Kelimeler

• hıv hastaları
• sarkopeni
• fonksiyonel performans
• ultrasonografi
• Modifiye STAR skoru

The frequency of sarcopenia in HIV patients: Effects on functional performance

Öz

Aim: The present study aims to determine the prevalence of sarcopenia in Human Immunodeficiency Virus Infection (HIV) patients and to evaluate functional performance. Material and Methods: 67 patients with HIV and 50 healthy control were included in the study. For detection for sarcopenia, the thighs of both lower extremities were measured using the Modified Sonographic Tight Adjustment Ratio (STAR) method, which was obtained by adding the bilateral rectus femoris and vastus intermedius muscle thicknesses measured by ultrasound. Hand muscle strength (HMS) was measured with a dynamometer. Knee Muscle strength (KMS) was measured isokinetic muscle testing. Physical performance was determined using timed up-and-go test (TUGT), 5-repetition sit-to-stand test (5RSTS), and 6-min walk test (6MWT). Results: According to the STAR values calculated based on body mass index, sarcopenia was present in 10 (17.5%) of 57 male patients. Sarcopenia was not detected in female patients. There was no significant difference with respect to demographic characteristics among the two groups. HMS, KMS, TUGT, 5RSTS and 6MWT values were significantly different in two groups (p<0.005) Conclusions: This study confirms a significant prevalence of sarcopenia among people living with HIV, particularly in male patients, and demonstrates its association with clinically meaningful declines in muscle strength and functional performance. The use of the ultrasonography-based Modified STAR score provided a reliable and practical method for assessing region-specific muscle loss, offering a valuable diagnostic tool in this population

Anahtar Kelimeler

• hıv patients
• sarcopenia
• functional performance
• ultrasonography
• Modified STAR score

Kaynakça

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