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MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress

Year 2019, Volume: 9 Issue: 1, 113 - 118, 26.03.2019

Abstract

ÖZET
Amaç: Bu çalışma, evodiaminin mezenterik iskemi-reperfüzyonun neden olduğu intestinal dokudaki
oksidatif hasara karşı muhtemel yararlı etkisini göstermeyi amaçlamıştır.
Materyal ve Metod: Bu amaçla çalışmamızda deney hayvanlarında mezenterik iskemi-reperfüzyon
modeli yapıldı. İskemi-reperfüzyon ve evodiamin düşük ve yüksek doz tedavi gruplarında,
superior mezenterik arter 1 saat süreyle klemplendi. Daha sonra klemp açıldı ve 2 saatlik reperfüzyon
başlatıldı. Deney sürecinin sonlandırılmasından sonra, tüm hayvanlar sakrifiye edildi ve
intestinal doku örnekleri toplandı.
Bulgular: TOS, OSI, MDA düzeyleri ve MPO aktivitesinin sham grubuna göre mezenterik iskemireperfüzyon
grubunda arttığı görüldü. ''Ayrıca mezenterik iskemi-reperfüzyon grubunda SOD aktivitesi
ve TAS seviyesinin sham grubuna göre azaldığı tespit edildi. ''Düşük ve yüksek dozlarda
evodiamin (10 ve 20 mg / kg) uygulanan gruplarda mezenterik iskemi-reperfüzyon grubuna göre
TAS değeri ve SOD aktivitesi artarken, TOS, OSI değerleri, MPO aktivitesi ve MDA düzeyi azaldığı
belirlendi.
Sonuç: İki farklı evodiamin dozu mezenterik iskemi-reperfüzyonun neden olduğu intestinal dokunun
oksidatif hasarına karşı yararlı etkiler göstermiştir.
Anahtar Sözcükler: Mezenterik iskemi-reperfüzyon; Evodiamin; İntestinal doku hasarı; Sıçan
ABSTRACT
Purpose: This study aimed to show possible benefical effect of evodiamine against oxidative
damage of intestinal tissue induced by mesenteric ischemia-reperfusion.
Materials and Methods: For this purpose, in our study mesenteric ischemia-reperfusion model
was conducted in experimental animals. In low and high doses treatment of evodiamine and
ischemia-reperfusion groups, superior mesenteric artery was clamped for 1 h. Then, the clamp
was opened and reperfusion was started for 2 h. After the termination of the experimental
prosses, all animals were sacrificed and intestinal tissue samples were collected.
Results: It was seen that TOS, OSI, MDA levels and MPO activity increased in mesenteric ischemiareperfusion
group compared to sham group. Moreover, SOD activity and TAS level reduced in
mesenteric ischemia-reperfusion group compared to sham group. When compared to mesenteric
ischemia-reperfusion group, TAS value and SOD activity increased while TOS, OSI values, MPO
activity and MDA level decreased in groups treated with low and high doses of evodiamine (10
and 20 mg/kg).
Conclusion: Two different doses of evodiamine revealed benefical effects against oxidative
damage of intestinal tissue induced by mesenteric ischemia-reperfusion.
Keywords: Mesenteric ischemia-reperfusion; Evodiamine; Intestinal tissue damage; Rat

References

  • 1. Acosta S. Mesenteric ischemia. Curr Opin Crit Care. 2015;21(2):171-8. 2. Clair DG, Beach JM. Mesenteric Ischemia. New Engl J Med. 2016;374(10):959-68. 3. Campos VF, Miranda-Ferreira R, Taha NSA, Teixeira GD, Souza WTI, Carmo CEF, et al. Atenolol to Treat Intestinal Ischemia and Reperfusion in Rats. Transpl P. 2012;44(8):2313-6. 4. Khadaroo RG, Fortis S, Salim SY, Streutker C, Churchill TA, Zhang HB. I-FABP as Biomarker for the Early Diagnosis of Acute Mesenteric Ischemia and Resultant Lung Injury. Plos One. 2014;9(12). 5. Malek M, Nematbakhsh M. Renal ischemia/reperfusion injury; from pathophysiology to treatment. J Renal Inj Prev. 2015;4(2):20-7. 6. Mallick IH, Yang WX, Winslet MC, Seifalian AM. Ischemia-reperfusion injury of the intestine and protective strategies against injury. Digest Dis Sci. 2004;49(9):1359-77. 7. Granger DN, Hollwarth ME, Parks DA. Ischemia-Reperfusion Injury - Role of Oxygen-Derived Free-Radicals. Acta Physiol Scand. 1986;126:47-63. 8. Akcilar R, Akcilar A, Savran B, Ayada C, Kocak C, Kocak FE, et al. Effects of ukrain in rats with intestinal ischemia and reperfusion. J Surg Res. 2015;195(1):67-73. 9. Turan I, Ozacmak HS, Ozacmak VH, Barut F, Arasli M. Agmatine attenuates intestinal ischemia and reperfusion injury by reducing oxidative stress and inflammatory reaction in rats. Life Sci. 2017;189:23-8. 10. Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, Kamiya T. Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med. 2001;67(7):628-33.
Year 2019, Volume: 9 Issue: 1, 113 - 118, 26.03.2019

Abstract

References

  • 1. Acosta S. Mesenteric ischemia. Curr Opin Crit Care. 2015;21(2):171-8. 2. Clair DG, Beach JM. Mesenteric Ischemia. New Engl J Med. 2016;374(10):959-68. 3. Campos VF, Miranda-Ferreira R, Taha NSA, Teixeira GD, Souza WTI, Carmo CEF, et al. Atenolol to Treat Intestinal Ischemia and Reperfusion in Rats. Transpl P. 2012;44(8):2313-6. 4. Khadaroo RG, Fortis S, Salim SY, Streutker C, Churchill TA, Zhang HB. I-FABP as Biomarker for the Early Diagnosis of Acute Mesenteric Ischemia and Resultant Lung Injury. Plos One. 2014;9(12). 5. Malek M, Nematbakhsh M. Renal ischemia/reperfusion injury; from pathophysiology to treatment. J Renal Inj Prev. 2015;4(2):20-7. 6. Mallick IH, Yang WX, Winslet MC, Seifalian AM. Ischemia-reperfusion injury of the intestine and protective strategies against injury. Digest Dis Sci. 2004;49(9):1359-77. 7. Granger DN, Hollwarth ME, Parks DA. Ischemia-Reperfusion Injury - Role of Oxygen-Derived Free-Radicals. Acta Physiol Scand. 1986;126:47-63. 8. Akcilar R, Akcilar A, Savran B, Ayada C, Kocak C, Kocak FE, et al. Effects of ukrain in rats with intestinal ischemia and reperfusion. J Surg Res. 2015;195(1):67-73. 9. Turan I, Ozacmak HS, Ozacmak VH, Barut F, Arasli M. Agmatine attenuates intestinal ischemia and reperfusion injury by reducing oxidative stress and inflammatory reaction in rats. Life Sci. 2017;189:23-8. 10. Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, Kamiya T. Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med. 2001;67(7):628-33.
There are 1 citations in total.

Details

Primary Language Turkish
Journal Section Original Research
Authors

Ayhan Tanyeli This is me

Fazile Nur Ekinci Akdemir

Ersen Eraslan This is me

Mustafa Can Güler This is me

Ömer Topdağı This is me

Publication Date March 26, 2019
Published in Issue Year 2019 Volume: 9 Issue: 1

Cite

APA Tanyeli, A., Ekinci Akdemir, F. N., Eraslan, E., Güler, M. C., et al. (2019). MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress. Bozok Tıp Dergisi, 9(1), 113-118.
AMA Tanyeli A, Ekinci Akdemir FN, Eraslan E, Güler MC, Topdağı Ö. MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress. Bozok Tıp Dergisi. March 2019;9(1):113-118.
Chicago Tanyeli, Ayhan, Fazile Nur Ekinci Akdemir, Ersen Eraslan, Mustafa Can Güler, and Ömer Topdağı. “MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress”. Bozok Tıp Dergisi 9, no. 1 (March 2019): 113-18.
EndNote Tanyeli A, Ekinci Akdemir FN, Eraslan E, Güler MC, Topdağı Ö (March 1, 2019) MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress. Bozok Tıp Dergisi 9 1 113–118.
IEEE A. Tanyeli, F. N. Ekinci Akdemir, E. Eraslan, M. C. Güler, and Ö. Topdağı, “MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress”, Bozok Tıp Dergisi, vol. 9, no. 1, pp. 113–118, 2019.
ISNAD Tanyeli, Ayhan et al. “MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress”. Bozok Tıp Dergisi 9/1 (March 2019), 113-118.
JAMA Tanyeli A, Ekinci Akdemir FN, Eraslan E, Güler MC, Topdağı Ö. MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress. Bozok Tıp Dergisi. 2019;9:113–118.
MLA Tanyeli, Ayhan et al. “MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress”. Bozok Tıp Dergisi, vol. 9, no. 1, 2019, pp. 113-8.
Vancouver Tanyeli A, Ekinci Akdemir FN, Eraslan E, Güler MC, Topdağı Ö. MEZENTERİK İSKEMİ-REPERFÜZYONLA İNDÜKLENEN İNTESTİNAL DOKU HASARINA KARŞI EVODİAMİN’İN ETKİSİ: OKSİDATİF STRESİN ROLÜ The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of Oxidative Stress. Bozok Tıp Dergisi. 2019;9(1):113-8.
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