Structural Features and Laboratory Diagnosis of Monkeypox Virus

Abstract

Monkeypox virus is a zoonosis that was previously endemic in Africa and causes a smallpox-like disease. The disease has recently gained at- tention due to increasing human-to-human transmission and the occurrence of outbreaks outside of Africa. The disease is usually self-limiting, but up to 10% mortality and severe complications can occur. The clinical manifestations of the disease are not specific, and Monkeypox Virus exhibits structural similarity to some other virus strains. Since there is no specific vaccine and treatment yet, rapid and early recognition of this agent will be the most effective step in epidemic management. This review discusses the structure of monkeypox virus and the methods used in laboratory diagnosis.

Keywords

• Monkeypox virus
• Orthopoxvirus
• diagnosis
• outbreak.

Maymun Çiçeği Virüsünün Yapısal Özellikleri ve Laboratuvar Tanısı

Abstract

Maymun Çiçek Virüsü daha önce endemik olarak Afrika'da görülen ve çiçek hastalığı benzeri hastalığa neden olan bir zoonozdur. Son zamanlarda insandan insana bulaşların artışı ve Afrika'nın ötesindeki salgınların ortaya çıkması ile dikkatleri üzerine çekmiştir. Hastalık genellikle kendini sınırlamakta ancak %10‘a varan mortalite ve ciddi komplikasyonlar görülebilmektedir. Hastalığın spesifik bir klinik tablosu yoktur ve Maymun Çiçeği Virüsü diğer bazı virüs türleri ile yapısal benzerlik sergilemektedir. Henüz spesifik bir aşısı ve tedavisi olmayan bu etkenin hızlı ve erken tanınması salgın yönetimindeki en etkili basamak olacaktır. Bu derlemede Maymun çiçeği virüsünün yapısı ve laboratuvar tanısında kullanılan yöntemler gözden geçirilmiştir.

Keywords

• Maymun çiçek virüsü
• Orthopox virüs
• tanı
• salgın

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